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#dnadamage — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #dnadamage, aggregated by home.social.

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  1. New funding backs pioneering research to make brain cancer treatment more effective

    Adelaide researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more…
    #NewsBeep #News #Health #AU #Australia #Brain #braincancer #Cancer #CancerTreatment #dna #DNADamage #ImmuneSystem #RadiationTherapy #research #therapy #Tumor
    newsbeep.com/au/870261/

  2. New funding backs pioneering research to make brain cancer treatment more effective

    Adelaide researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more…
    #NewsBeep #News #Health #AU #Australia #Brain #braincancer #Cancer #CancerTreatment #dna #DNADamage #ImmuneSystem #RadiationTherapy #research #therapy #Tumor
    newsbeep.com/au/870261/

  3. 🎉🚬 Breaking news: DNA damage might cause cancer! But wait, only for *some* people! #Cambridge researchers crack the complex code of "why the unlucky stay unlucky." 🤷‍♂️ Must be those Brits again, solving mysteries we never asked for. 🔍🔬
    cam.ac.uk/research/news/study- #DNAdamage #cancer #research #genetics #health #discoveries #HackerNews #ngated

  4. 🎉🚬 Breaking news: DNA damage might cause cancer! But wait, only for *some* people! #Cambridge researchers crack the complex code of "why the unlucky stay unlucky." 🤷‍♂️ Must be those Brits again, solving mysteries we never asked for. 🔍🔬
    cam.ac.uk/research/news/study- #DNAdamage #cancer #research #genetics #health #discoveries #HackerNews #ngated

  5. 🎉🚬 Breaking news: DNA damage might cause cancer! But wait, only for *some* people! #Cambridge researchers crack the complex code of "why the unlucky stay unlucky." 🤷‍♂️ Must be those Brits again, solving mysteries we never asked for. 🔍🔬
    cam.ac.uk/research/news/study- #DNAdamage #cancer #research #genetics #health #discoveries #HackerNews #ngated

  6. 🎉🚬 Breaking news: DNA damage might cause cancer! But wait, only for *some* people! #Cambridge researchers crack the complex code of "why the unlucky stay unlucky." 🤷‍♂️ Must be those Brits again, solving mysteries we never asked for. 🔍🔬
    cam.ac.uk/research/news/study- #DNAdamage #cancer #research #genetics #health #discoveries #HackerNews #ngated

  7. 🎉🚬 Breaking news: DNA damage might cause cancer! But wait, only for *some* people! #Cambridge researchers crack the complex code of "why the unlucky stay unlucky." 🤷‍♂️ Must be those Brits again, solving mysteries we never asked for. 🔍🔬
    cam.ac.uk/research/news/study- #DNAdamage #cancer #research #genetics #health #discoveries #HackerNews #ngated

  8. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  9. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  10. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  11. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  12. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  13. Ancient animals reveal sleep’s original role in maintaining brain health

    A groundbreaking new study from Bar-Ilan University shows that one of sleep’s core functions originated hundreds of millions…
    #Israel #News #brain #DNA #DNADamage #evolution #neurons #reproduction #research #sleep #Stress
    europesays.com/2684722/

  14. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  15. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  16. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  17. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  18. Reverse Aging? This Scientist Has The Answer!

    Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

    Follow @biohackingpathway for more

    #aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

  19. [PDF] National Association of Marine Laboratories
    Position Paper

    Scientific opposition to Japan’s planned release of over 1.3 million tons of radioactively contaminated water from the #FukushimaDaiIchi #NuclearPowerPlant
    disaster into the #PacificOcean.

    December 2022

    “The National Association of Marine Laboratories (#NAML), an organization of more than
    100 member laboratories, opposes Japan’s plans to begin releasing over 1.3 million tons of radioactively contaminated water from the Fukushima-Daiichi Nuclear Power Plant into the Pacific Ocean commencing in 2023. This opposition is based on the fact that there is a lack of adequate and accurate scientific data supporting Japan’s assertion of safety.

    "Furthermore, there is an abundance of data demonstrating serious concerns about releasing radioactively contaminated water.

    “The Pacific Ocean is the largest continuous body of water on our planet, containing the greatest biomass of organisms of ecological, economic, and cultural value, including 70 percent of the world’s #fisheries. The health of all the world’s #OceanEcosystems is in documented decline due
    to a variety of stressors, including climate change, over-exploitation of resources, and pollution.

    "The proposed release of this #contaminated water is a #transboundary and #transgenerational issue of concern for the health of marine ecosystems and those whose lives and livelihoods depend on them. We are concerned about the absence of critical data on the radionuclide content of each tank, the Advanced Liquid Processing System, which is used to remove radionuclides, and the assumption that upon the release of the contaminated wastewater,
    ‘dilution is the solution to pollution.’

    “The underlying rationale of #dilution ignores the reality of biological processes of #OrganicBinding,
    #bioaccumulation, and #bioconcentration, as well as accumulation in local seafloor sediments. Many of the radionuclides contained in the accumulated waste cooling water have half-lives ranging from decades to centuries, and their deleterious effects range from #DNADamage and
    #cellular stress to elevated #cancer risks in people who eat affected marine organisms, such as clams, oysters, crabs, lobster, shrimp, and fish.

    "Additionally, the effectiveness of the Advanced Liquid Processing System in almost completely removing the over 60 different #radionuclides present in the affected wastewater—some of which have an affinity to target specific tissues, glands, organs, and metabolic pathways in #LivingOrganisms, including people—remains a
    serious concern due to the absence of critical data.

    "The supporting data provided by the Tokyo Electric Power Company and the #JapaneseGovernment are insufficient and, in some cases, incorrect, with flaws in sampling protocols, statistical design, sample analyses, and assumptions, which in turn lead to flaws in the
    conclusion of safety and prevent a more thorough evaluation of better alternative approaches to disposal. A full range of approaches to addressing the problem of safely containing, storing, and disposing of the radioactive waste have not been adequately explored, and alternatives to ocean dumping should be examined in greater detail and with extensive scientific rigor.

    “NAML calls on the Government of #Japan and International Atomic Energy Agency (#IAEA) scientists to more fully and adequately consider the options recommended by the #PacificIslandsForum’s Expert Panel. We believe public policy decisions, regulations, and actions must keep pace with and make use of relevant advancements in our scientific understanding of the #environment and human health. In this case, we believe policy makers have not fully availed themselves of the available science and should do so before making any final decisions on releasing this contaminated water into the Pacific. NAML members are unified in our concern about use of the oceans as a dumping ground for radioactively contaminated water and other #pollutants because such actions can negatively affect the long-term health and sustainability of
    our planet.

    “We urge the Government of Japan to stop pursuing their planned and precedent-setting release of the radioactively contaminated water into the Pacific Ocean and to work with the broader scientific community to pursue other approaches [like #ClosedLoop systems or binding radionuclides in concerete] that protect #OceanLife; human health; and
    those communities who depend on ecologically, economically, and culturally valuable marine
    resources. “

    Adopted by the NAML Board of Directors, December 12, 2022

    naml.org/policy/documents/2022

    #WaterIsLife #OceansAreLife
    #IAEAHides #TEPCOLies
    #FukushimaIsntOver #NoDumping #NuclearPowerPlants #RadioactiveWater #RethinkNotRestart #PacificOcean #DataFalsification #ALPSSystem

  20. [PDF] National Association of Marine Laboratories
    Position Paper

    Scientific opposition to Japan’s planned release of over 1.3 million tons of radioactively contaminated water from the #FukushimaDaiIchi #NuclearPowerPlant
    disaster into the #PacificOcean.

    December 2022

    “The National Association of Marine Laboratories (#NAML), an organization of more than
    100 member laboratories, opposes Japan’s plans to begin releasing over 1.3 million tons of radioactively contaminated water from the Fukushima-Daiichi Nuclear Power Plant into the Pacific Ocean commencing in 2023. This opposition is based on the fact that there is a lack of adequate and accurate scientific data supporting Japan’s assertion of safety.

    "Furthermore, there is an abundance of data demonstrating serious concerns about releasing radioactively contaminated water.

    “The Pacific Ocean is the largest continuous body of water on our planet, containing the greatest biomass of organisms of ecological, economic, and cultural value, including 70 percent of the world’s #fisheries. The health of all the world’s #OceanEcosystems is in documented decline due
    to a variety of stressors, including climate change, over-exploitation of resources, and pollution.

    "The proposed release of this #contaminated water is a #transboundary and #transgenerational issue of concern for the health of marine ecosystems and those whose lives and livelihoods depend on them. We are concerned about the absence of critical data on the radionuclide content of each tank, the Advanced Liquid Processing System, which is used to remove radionuclides, and the assumption that upon the release of the contaminated wastewater,
    ‘dilution is the solution to pollution.’

    “The underlying rationale of #dilution ignores the reality of biological processes of #OrganicBinding,
    #bioaccumulation, and #bioconcentration, as well as accumulation in local seafloor sediments. Many of the radionuclides contained in the accumulated waste cooling water have half-lives ranging from decades to centuries, and their deleterious effects range from #DNADamage and
    #cellular stress to elevated #cancer risks in people who eat affected marine organisms, such as clams, oysters, crabs, lobster, shrimp, and fish.

    "Additionally, the effectiveness of the Advanced Liquid Processing System in almost completely removing the over 60 different #radionuclides present in the affected wastewater—some of which have an affinity to target specific tissues, glands, organs, and metabolic pathways in #LivingOrganisms, including people—remains a
    serious concern due to the absence of critical data.

    "The supporting data provided by the Tokyo Electric Power Company and the #JapaneseGovernment are insufficient and, in some cases, incorrect, with flaws in sampling protocols, statistical design, sample analyses, and assumptions, which in turn lead to flaws in the
    conclusion of safety and prevent a more thorough evaluation of better alternative approaches to disposal. A full range of approaches to addressing the problem of safely containing, storing, and disposing of the radioactive waste have not been adequately explored, and alternatives to ocean dumping should be examined in greater detail and with extensive scientific rigor.

    “NAML calls on the Government of #Japan and International Atomic Energy Agency (#IAEA) scientists to more fully and adequately consider the options recommended by the #PacificIslandsForum’s Expert Panel. We believe public policy decisions, regulations, and actions must keep pace with and make use of relevant advancements in our scientific understanding of the #environment and human health. In this case, we believe policy makers have not fully availed themselves of the available science and should do so before making any final decisions on releasing this contaminated water into the Pacific. NAML members are unified in our concern about use of the oceans as a dumping ground for radioactively contaminated water and other #pollutants because such actions can negatively affect the long-term health and sustainability of
    our planet.

    “We urge the Government of Japan to stop pursuing their planned and precedent-setting release of the radioactively contaminated water into the Pacific Ocean and to work with the broader scientific community to pursue other approaches [like #ClosedLoop systems or binding radionuclides in concerete] that protect #OceanLife; human health; and
    those communities who depend on ecologically, economically, and culturally valuable marine
    resources. “

    Adopted by the NAML Board of Directors, December 12, 2022

    naml.org/policy/documents/2022

    #WaterIsLife #OceansAreLife
    #IAEAHides #TEPCOLies
    #FukushimaIsntOver #NoDumping #NuclearPowerPlants #RadioactiveWater #RethinkNotRestart #PacificOcean #DataFalsification #ALPSSystem

  21. [PDF] National Association of Marine Laboratories
    Position Paper

    Scientific opposition to Japan’s planned release of over 1.3 million tons of radioactively contaminated water from the #FukushimaDaiIchi #NuclearPowerPlant
    disaster into the #PacificOcean.

    December 2022

    “The National Association of Marine Laboratories (#NAML), an organization of more than
    100 member laboratories, opposes Japan’s plans to begin releasing over 1.3 million tons of radioactively contaminated water from the Fukushima-Daiichi Nuclear Power Plant into the Pacific Ocean commencing in 2023. This opposition is based on the fact that there is a lack of adequate and accurate scientific data supporting Japan’s assertion of safety.

    "Furthermore, there is an abundance of data demonstrating serious concerns about releasing radioactively contaminated water.

    “The Pacific Ocean is the largest continuous body of water on our planet, containing the greatest biomass of organisms of ecological, economic, and cultural value, including 70 percent of the world’s #fisheries. The health of all the world’s #OceanEcosystems is in documented decline due
    to a variety of stressors, including climate change, over-exploitation of resources, and pollution.

    "The proposed release of this #contaminated water is a #transboundary and #transgenerational issue of concern for the health of marine ecosystems and those whose lives and livelihoods depend on them. We are concerned about the absence of critical data on the radionuclide content of each tank, the Advanced Liquid Processing System, which is used to remove radionuclides, and the assumption that upon the release of the contaminated wastewater,
    ‘dilution is the solution to pollution.’

    “The underlying rationale of #dilution ignores the reality of biological processes of #OrganicBinding,
    #bioaccumulation, and #bioconcentration, as well as accumulation in local seafloor sediments. Many of the radionuclides contained in the accumulated waste cooling water have half-lives ranging from decades to centuries, and their deleterious effects range from #DNADamage and
    #cellular stress to elevated #cancer risks in people who eat affected marine organisms, such as clams, oysters, crabs, lobster, shrimp, and fish.

    "Additionally, the effectiveness of the Advanced Liquid Processing System in almost completely removing the over 60 different #radionuclides present in the affected wastewater—some of which have an affinity to target specific tissues, glands, organs, and metabolic pathways in #LivingOrganisms, including people—remains a
    serious concern due to the absence of critical data.

    "The supporting data provided by the Tokyo Electric Power Company and the #JapaneseGovernment are insufficient and, in some cases, incorrect, with flaws in sampling protocols, statistical design, sample analyses, and assumptions, which in turn lead to flaws in the
    conclusion of safety and prevent a more thorough evaluation of better alternative approaches to disposal. A full range of approaches to addressing the problem of safely containing, storing, and disposing of the radioactive waste have not been adequately explored, and alternatives to ocean dumping should be examined in greater detail and with extensive scientific rigor.

    “NAML calls on the Government of #Japan and International Atomic Energy Agency (#IAEA) scientists to more fully and adequately consider the options recommended by the #PacificIslandsForum’s Expert Panel. We believe public policy decisions, regulations, and actions must keep pace with and make use of relevant advancements in our scientific understanding of the #environment and human health. In this case, we believe policy makers have not fully availed themselves of the available science and should do so before making any final decisions on releasing this contaminated water into the Pacific. NAML members are unified in our concern about use of the oceans as a dumping ground for radioactively contaminated water and other #pollutants because such actions can negatively affect the long-term health and sustainability of
    our planet.

    “We urge the Government of Japan to stop pursuing their planned and precedent-setting release of the radioactively contaminated water into the Pacific Ocean and to work with the broader scientific community to pursue other approaches [like #ClosedLoop systems or binding radionuclides in concerete] that protect #OceanLife; human health; and
    those communities who depend on ecologically, economically, and culturally valuable marine
    resources. “

    Adopted by the NAML Board of Directors, December 12, 2022

    naml.org/policy/documents/2022

    #WaterIsLife #OceansAreLife
    #IAEAHides #TEPCOLies
    #FukushimaIsntOver #NoDumping #NuclearPowerPlants #RadioactiveWater #RethinkNotRestart #PacificOcean #DataFalsification #ALPSSystem

  22. [PDF] National Association of Marine Laboratories
    Position Paper

    Scientific opposition to Japan’s planned release of over 1.3 million tons of radioactively contaminated water from the #FukushimaDaiIchi #NuclearPowerPlant
    disaster into the #PacificOcean.

    December 2022

    “The National Association of Marine Laboratories (#NAML), an organization of more than
    100 member laboratories, opposes Japan’s plans to begin releasing over 1.3 million tons of radioactively contaminated water from the Fukushima-Daiichi Nuclear Power Plant into the Pacific Ocean commencing in 2023. This opposition is based on the fact that there is a lack of adequate and accurate scientific data supporting Japan’s assertion of safety.

    "Furthermore, there is an abundance of data demonstrating serious concerns about releasing radioactively contaminated water.

    “The Pacific Ocean is the largest continuous body of water on our planet, containing the greatest biomass of organisms of ecological, economic, and cultural value, including 70 percent of the world’s #fisheries. The health of all the world’s #OceanEcosystems is in documented decline due
    to a variety of stressors, including climate change, over-exploitation of resources, and pollution.

    "The proposed release of this #contaminated water is a #transboundary and #transgenerational issue of concern for the health of marine ecosystems and those whose lives and livelihoods depend on them. We are concerned about the absence of critical data on the radionuclide content of each tank, the Advanced Liquid Processing System, which is used to remove radionuclides, and the assumption that upon the release of the contaminated wastewater,
    ‘dilution is the solution to pollution.’

    “The underlying rationale of #dilution ignores the reality of biological processes of #OrganicBinding,
    #bioaccumulation, and #bioconcentration, as well as accumulation in local seafloor sediments. Many of the radionuclides contained in the accumulated waste cooling water have half-lives ranging from decades to centuries, and their deleterious effects range from #DNADamage and
    #cellular stress to elevated #cancer risks in people who eat affected marine organisms, such as clams, oysters, crabs, lobster, shrimp, and fish.

    "Additionally, the effectiveness of the Advanced Liquid Processing System in almost completely removing the over 60 different #radionuclides present in the affected wastewater—some of which have an affinity to target specific tissues, glands, organs, and metabolic pathways in #LivingOrganisms, including people—remains a
    serious concern due to the absence of critical data.

    "The supporting data provided by the Tokyo Electric Power Company and the #JapaneseGovernment are insufficient and, in some cases, incorrect, with flaws in sampling protocols, statistical design, sample analyses, and assumptions, which in turn lead to flaws in the
    conclusion of safety and prevent a more thorough evaluation of better alternative approaches to disposal. A full range of approaches to addressing the problem of safely containing, storing, and disposing of the radioactive waste have not been adequately explored, and alternatives to ocean dumping should be examined in greater detail and with extensive scientific rigor.

    “NAML calls on the Government of #Japan and International Atomic Energy Agency (#IAEA) scientists to more fully and adequately consider the options recommended by the #PacificIslandsForum’s Expert Panel. We believe public policy decisions, regulations, and actions must keep pace with and make use of relevant advancements in our scientific understanding of the #environment and human health. In this case, we believe policy makers have not fully availed themselves of the available science and should do so before making any final decisions on releasing this contaminated water into the Pacific. NAML members are unified in our concern about use of the oceans as a dumping ground for radioactively contaminated water and other #pollutants because such actions can negatively affect the long-term health and sustainability of
    our planet.

    “We urge the Government of Japan to stop pursuing their planned and precedent-setting release of the radioactively contaminated water into the Pacific Ocean and to work with the broader scientific community to pursue other approaches [like #ClosedLoop systems or binding radionuclides in concerete] that protect #OceanLife; human health; and
    those communities who depend on ecologically, economically, and culturally valuable marine
    resources. “

    Adopted by the NAML Board of Directors, December 12, 2022

    naml.org/policy/documents/2022

    #WaterIsLife #OceansAreLife
    #IAEAHides #TEPCOLies
    #FukushimaIsntOver #NoDumping #NuclearPowerPlants #RadioactiveWater #RethinkNotRestart #PacificOcean #DataFalsification #ALPSSystem

  23. Today Tim gave a quite vibrant presentation of the #biopixR package at our faculty at the #BTUCS. It was great to hear that some colleagues find it useful and want to use it for their research.

    #bioimageinformatics #microbeads #microplastic #DNAdamage

  24. Today Tim gave a quite vibrant presentation of the #biopixR package at our faculty at the #BTUCS. It was great to hear that some colleagues find it useful and want to use it for their research.

    #bioimageinformatics #microbeads #microplastic #DNAdamage

  25. How does the Wnt pathway promote resistance to #DNAdamage induced by #IonizingRadiation? @BenForWard3 &co show that #WntSignaling modulates DNA damage response via EGFR in #Drosophila, protecting cells from #apoptosis induced by DNA ds breaks #PLOSBiology plos.io/4dduEiq

  26. How does the Wnt pathway promote resistance to #DNAdamage induced by #IonizingRadiation? @BenForWard3 &co show that #WntSignaling modulates DNA damage response via EGFR in #Drosophila, protecting cells from #apoptosis induced by DNA ds breaks #PLOSBiology plos.io/4dduEiq