#cellsize — Public Fediverse posts

Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @PLOSBiology https://plos.io/3QubUVG

Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @PLOSBiology https://plos.io/3QubUVG

Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @PLOSBiology https://plos.io/3QubUVG

Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @PLOSBiology https://plos.io/3QubUVG

Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @PLOSBiology https://plos.io/3QubUVG

Studying the relationship between the size and the #anatomy and #physiology of #living organisms has proven useful in order to decipher what the key #physical constraints are that apply to them.

Here we consider both variations of #cellSize, using a drug that blocks mitosis without inhibiting growth, and of the interactions with the substrate, by considering the different stages of the quasi-static process of #cellSpreading, but also by using confinement, and thus presenting more than one substrate for the #cell to spread on. The fibroblasts used in this study present the archetypal shape of a cell spreading on a substrate, with a central cell body which, while flattening, retains a spherical cap shape, and is surrounded by a flat #lamella. We show that this shape is preserved isometrically between the cell size and cell confinement conditions. Moreover, the length ratio that characterises it establishes early during spreading, at the time when #focalAdhesion with the substrate develop. These #adhesion patches also collectively follow an isometric scaling with respect to cell spread area, in spite of having individually a shape, size and density which is insensitive to the global cell shape. We show that this isometry follows from the restriction of the distribution of focal adhesions to the flat lamella.

Since adhesion distribution is crucially important for maintaining the cell shape, we suggest that the observed allometry may be important for the cell to face the #mechanical challenges of physiological function.

Studying the relationship between the size and the #anatomy and #physiology of #living organisms has proven useful in order to decipher what the key #physical constraints are that apply to them.

Here we consider both variations of #cellSize, using a drug that blocks mitosis without inhibiting growth, and of the interactions with the substrate, by considering the different stages of the quasi-static process of #cellSpreading, but also by using confinement, and thus presenting more than one substrate for the #cell to spread on. The fibroblasts used in this study present the archetypal shape of a cell spreading on a substrate, with a central cell body which, while flattening, retains a spherical cap shape, and is surrounded by a flat #lamella. We show that this shape is preserved isometrically between the cell size and cell confinement conditions. Moreover, the length ratio that characterises it establishes early during spreading, at the time when #focalAdhesion with the substrate develop. These #adhesion patches also collectively follow an isometric scaling with respect to cell spread area, in spite of having individually a shape, size and density which is insensitive to the global cell shape. We show that this isometry follows from the restriction of the distribution of focal adhesions to the flat lamella.

Since adhesion distribution is crucially important for maintaining the cell shape, we suggest that the observed allometry may be important for the cell to face the #mechanical challenges of physiological function.

Studying the relationship between the size and the #anatomy and #physiology of #living organisms has proven useful in order to decipher what the key #physical constraints are that apply to them.

Here we consider both variations of #cellSize, using a drug that blocks mitosis without inhibiting growth, and of the interactions with the substrate, by considering the different stages of the quasi-static process of #cellSpreading, but also by using confinement, and thus presenting more than one substrate for the #cell to spread on. The fibroblasts used in this study present the archetypal shape of a cell spreading on a substrate, with a central cell body which, while flattening, retains a spherical cap shape, and is surrounded by a flat #lamella. We show that this shape is preserved isometrically between the cell size and cell confinement conditions. Moreover, the length ratio that characterises it establishes early during spreading, at the time when #focalAdhesion with the substrate develop. These #adhesion patches also collectively follow an isometric scaling with respect to cell spread area, in spite of having individually a shape, size and density which is insensitive to the global cell shape. We show that this isometry follows from the restriction of the distribution of focal adhesions to the flat lamella.

Since adhesion distribution is crucially important for maintaining the cell shape, we suggest that the observed allometry may be important for the cell to face the #mechanical challenges of physiological function.

Studying the relationship between the size and the #anatomy and #physiology of #living organisms has proven useful in order to decipher what the key #physical constraints are that apply to them.

Here we consider both variations of #cellSize, using a drug that blocks mitosis without inhibiting growth, and of the interactions with the substrate, by considering the different stages of the quasi-static process of #cellSpreading, but also by using confinement, and thus presenting more than one substrate for the #cell to spread on. The fibroblasts used in this study present the archetypal shape of a cell spreading on a substrate, with a central cell body which, while flattening, retains a spherical cap shape, and is surrounded by a flat #lamella. We show that this shape is preserved isometrically between the cell size and cell confinement conditions. Moreover, the length ratio that characterises it establishes early during spreading, at the time when #focalAdhesion with the substrate develop. These #adhesion patches also collectively follow an isometric scaling with respect to cell spread area, in spite of having individually a shape, size and density which is insensitive to the global cell shape. We show that this isometry follows from the restriction of the distribution of focal adhesions to the flat lamella.

Since adhesion distribution is crucially important for maintaining the cell shape, we suggest that the observed allometry may be important for the cell to face the #mechanical challenges of physiological function.

Studying the relationship between the size and the #anatomy and #physiology of #living organisms has proven useful in order to decipher what the key #physical constraints are that apply to them.

Here we consider both variations of #cellSize, using a drug that blocks mitosis without inhibiting growth, and of the interactions with the substrate, by considering the different stages of the quasi-static process of #cellSpreading, but also by using confinement, and thus presenting more than one substrate for the #cell to spread on. The fibroblasts used in this study present the archetypal shape of a cell spreading on a substrate, with a central cell body which, while flattening, retains a spherical cap shape, and is surrounded by a flat #lamella. We show that this shape is preserved isometrically between the cell size and cell confinement conditions. Moreover, the length ratio that characterises it establishes early during spreading, at the time when #focalAdhesion with the substrate develop. These #adhesion patches also collectively follow an isometric scaling with respect to cell spread area, in spite of having individually a shape, size and density which is insensitive to the global cell shape. We show that this isometry follows from the restriction of the distribution of focal adhesions to the flat lamella.

Since adhesion distribution is crucially important for maintaining the cell shape, we suggest that the observed allometry may be important for the cell to face the #mechanical challenges of physiological function.

Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS

Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS

Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS

Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS

Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS

Fantastic news for the lab! Thanks to all the collaborators: @[email protected] @[email protected] lab and Koichi Funato and @[email protected] for the award! #cellsize #yeast #ceramides