#enzymes — Public Fediverse posts

19-Aug-2026
The dynamic duo: “Weaving” hierarchical #DNA materials with two classes of biomolecular #nanomachines
Chemically fueled #enzymes and #molecularMotors synthesize and actively assemble DNA networks

https://www.eurekalert.org/news-releases/1140286

#science #nanoworld DNAnanotechnology

19-Aug-2026
A viral 'loose cannon' enzyme helps phages shut down bacterial defenses
Scientists have found how #phages, #viruses that infect bacteria, orchestrate an explosion of protein modifications inside host cells that helps them evade the bacteria’s immune systems

https://www.eurekalert.org/news-releases/1140693

#science #microbialEcology #phageTherapy #bacteriophages #proteins #enzymes

Not every DNA mistake gets fixed. We know that; that's how mutations enter the gene pool. But it gets more interesting to look at what does get fixed, because repair enzymes apparently have a priority list.

Link: https://www.nature.com/articles/s41467-026-74090-0

#DNA #Genetics #Enzymes

💁🏻‍♀️ TIL: 🌱🌿 Arya Satheesh developed a #bioplastic called Eco Purge that biodegrades in two weeks.

The material releases specific #enzymes designed to break down existing #microplastics in #soil and #water. Her #research and prototype earned her the European category win at the 2026 #EarthPrize.

👉 https://www.smithsonianmag.com/innovation/this-high-schooler-invented-a-plant-based-plastic-that-removes-microplastics-from-the-environment-as-it-biodegrades-180989254/

#science #innovation #environment #biotechnology #sustainability #ecology #materials #pollution #nature

Artificial Enzymes Assembled Inside Living Cells Achieve Asymmetric Synthesis

https://1ban.news/artificial-enzymes-living-cells/
#1ban #artificial #enzymes #living #cells #science

Breakthrough in tailor-made enzyme design
https://www.uni-bayreuth.de/en/press-releases/tailor-made-enzyme
#Research #Enzymes #ProteinDesign #Biotechnology #Sustainability #UniversityOfBayreuth

Breakthrough in tailor-made enzyme design
https://www.uni-bayreuth.de/en/press-releases/tailor-made-enzyme
#Research #Enzymes #ProteinDesign #Biotechnology #Sustainability #UniversityOfBayreuth

Breakthrough in tailor-made enzyme design
https://www.uni-bayreuth.de/en/press-releases/tailor-made-enzyme
#Research #Enzymes #ProteinDesign #Biotechnology #Sustainability #UniversityOfBayreuth

Breakthrough in tailor-made enzyme design
https://www.uni-bayreuth.de/en/press-releases/tailor-made-enzyme
#Research #Enzymes #ProteinDesign #Biotechnology #Sustainability #UniversityOfBayreuth

Breakthrough in tailor-made enzyme design
https://www.uni-bayreuth.de/en/press-releases/tailor-made-enzyme
#Research #Enzymes #ProteinDesign #Biotechnology #Sustainability #UniversityOfBayreuth

The video 🎥 of the #BeilsteinTalk “Tungsten aldehyde #oxidoreductase – a new type #hydrogenase” with Maciej Szaleniec from the Polish Academy of Sciences is NOW available 🔓 in the video portal @TIB_AVPortal of the @tibhannover:
🔗 https://av.tib.eu/media/73257

#biochemistry #biotechnology #EnzymeKinetics #EnzymeAssays #biocatalysis #enzymes #BeilsteinTalks

Researchers Identify Enzyme IDOL as a Potential Target for Alzheimer’s Treatment

📰 Original title: Scientists found a hidden Alzheimer’s trigger and shut it down

🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️

View full AI summary: https://en.killbait.com/researchers-identify-enzyme-idol-as-a-potential-target-for-alzheimer-s-treatment.html?utm_source=mastodon_world&utm_medium=social&utm_campaign=killbait.mastodon_world

#health #alzheimers #enzymes

Researchers Discover How Plants Produce the Cancer-Fighting Compound Mitraphylline

📰 Original title: A rare cancer-fighting plant compound has been decoded

🤖 IA: It's not clickbait ✅
👥 Users: It's not clickbait ✅

View full AI summary: https://en.killbait.com/researchers-discover-how-plants-produce-the-cancer-fighting-compound-mitraphylline.html?utm_source=mastodon_world&utm_medium=social&utm_campaign=killbait

#science #mitraphylline #cancer #enzymes

https://www.nextplatform.com/hpc/2026/05/06/cleveland-clinic-simulates-large-proteins-with-quantum-centric-supercomputing/5219579

quantum computers can be networked now, more usable qubits will be able to be connected

more 'breakthroughs' will end up happening, things go slow at the start

#ibm #cleveland clinic #folding #enzymes #trypsin #catalysts #sims #merck index #buffer systems #chirality #nextplatform.com

The #microbial #diversity of #dynamic #ecosystems can today be assessed using more efficient methods. M. F. Peña-Valencia et al. (2026) identified potential #polyethyleneterephthalate (#PET)-degrading #enzymes from #mangrove #soil using #AI, #3D #structuralanalysis and #metagenomics. Some of these enzymes could be assigned to the bacterial genus #Microbulbifer.

© #StefanFWirth

Please support me
https://ko-fi.com/sfwirth

Ref
https://doi.org/10.1038/s41467-026-71548-z

#Illustrations
©S.F.Wirth, AI assisted

https://nkvssp.thecomicseries.com/comics/659/
#fun #MedicalFact by Ralph!

#Ralph #Puppy #Jello #whydoyouknowthis #tuesdayvibes #funfacts #webcomics #webcomicchat #comicbookhour #comics #NKVSSP #gelatine #medical #silly #temperature #enzymes #orifices #thinkaboutit #tuesdaymorning #QuestionOfTheWeek #vibecheck

Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @PLOSBiology https://plos.io/3QubUVG

@danish_akhtar7
Despite all of man's inventions, the miracle of digestion has not been fully replicated. It is impossible for a machine to digest food.... unless it has enzymes, and these enzymes can only be created by living organisms. No enzymes used in manufacturing can be produced without life, even single-celled organisms, which must be alive to produce enzymes. The power of food cannot be unlocked without life.

http://john1126.com/705

#digestion #enzymes #robots #yeast

"What she gave us was a way of looking at #enzymes that remains absolutely fundamental to our discipline": Maren Nattermann, Research Group Leader at the Max Planck Institute for Terrestrial Microbiology, on Marjory Stephenson (1885–1948), the pioneer of chemical #microbiology whose work on bacterial metabolic physiology established the field as an independent discipline. https://www.mpg.de/26210626/marjory-stephenson-maren-nattermann @MPI_TM #WomeninScience

There's still time to register for TOMORROW's FREE online #BeilsteinTalk “Accelerating evolution of biocatalyzed oxidation reactions” with Joelle N. Pelletier, University of Montreal 🇨🇦.

📅 March 19, 2026
🕒 3–4 pm CET
🔗 https://www.beilstein-institut.de/en/talks/biochemistry-accelerating-evolution-of-biocatalyzed-oxidation-reactions/?M=y

Registration is FREE!

#EnzymeEngineering #biocatalysis #enzymes #biochemistry #BeilsteinTalks

How can enzymes efficiently be evolved to have a broad substrate scope for #OrganicSynthesis?

In his talk at #Biochemistry2026, Stephan Hammer addressed this question on the example of methyl transferases.

https://onlinelibrary.wiley.com/doi/10.1002/anie.202510300
#Biochemistry #Evolution #Enzymes

😈 Enzymes work as 'Maxwell's demon' by using memory stored as motion

https://phys.org/news/2026-02-enzymes-maxwell-demon-memory-motion.html

#enzymes #thermodynamics #catalyst #chemistry #biology

Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.

https://doi.org/10.1039/D6SC00250A

Invitation to join the online #BeilsteinTalk “Accelerating evolution of biocatalyzed oxidation reactions” with Joelle N. Pelletier, University of Montreal 🇨🇦.

📅 March 19, 2026
🕒 3–4 pm CET
🔗 https://www.beilstein-institut.de/en/talks/biochemistry-accelerating-evolution-of-biocatalyzed-oxidation-reactions/?M=y

Registration is FREE!

#EnzymeEngineering #biocatalysis #enzymes #biochemistry #BeilsteinTalks

Save the date 📅 March 19, 2026 🕒 3–4 pm CET

Online #BeilsteinTalk “Accelerating evolution of biocatalyzed oxidation reactions” with Joelle N. Pelletier, University of Montreal 🇨🇦.

🔗 https://www.beilstein-institut.de/en/talks/biochemistry-accelerating-evolution-of-biocatalyzed-oxidation-reactions/?M=y

#EnzymeEngineering #biocatalysis #enzymes #biochemistry #BeilsteinTalks

I just learned that #termites contain bacteria in their gut that produce lots of #CO2 and #H2 from the wood fibers they eat. AND THEN they have ANOTHER type of bacteria that feeds on the #CO2 and #H2 , to produce acetate that in turn THE #termites THEMSELF eat! How cool!

https://doi.org/10.1371/journal.pone.0019316

https://doi.org/10.1126/science.257.5075.1384

#CODH #enzymes #microbiome

14-Jan-2026
Exploring how gut #bacteria alter the flavor of Black Ivory #coffee beans
Bacterial #enzymes in #elephants’ #guts may digest pectin and give beans a smooth, chocolaty, and less bitter flavor

https://www.eurekalert.org/news-releases/1112641

#science #microbiome #ecology #foodScience

According to a new #study published in The ISME Journal, #marine #bacteria are starting to develop #enzymes capable of breaking down #polyethylene #terephthalate (#PET), one of the most common #plastics.

https://nautil.us/some-bacteria-have-evolved-the-ability-to-degrade-plastic-1246780/

Plastic-eating bacteria discovered in the ocean | ScienceDaily https://share.google/YbRWLLU9iRIvH3pMn
#pet #biology #plastic #Enzymes

(31 Oct) Neural network finds an enzyme that can break down polyurethane

Given a dozen hours, the enzyme can turn a foam pad into reusable chemicals.

https://s.faithcollapsing.com/b3v19
Archive: ia: https://s.faithcollapsing.com/sydso

#ai #biochemistry #biology #chemistry #enzymes #neural-networks #polymers #polyurethane #protein-design #proteins #science

(31 Oct) Neural network finds an enzyme that can break down polyurethane https://s.faithcollapsing.com/b3v19 Archive: ia: https://s.faithcollapsing.com/sydso #ai #biochemistry #biology #chemistry #enzymes #neural-networks #polymers #polyurethane #protein-design #proteins #science

#Articular #cartilage, which is a type of #tissue found in #joints, allows for nearly frictionless motion and can absorb large loads. Unfortunately, when it is damaged, it cannot repair itself. #Tissueengineering is a promising approach to repair the damage, but it falls short of creating functional tissue. This is because the tissue-engineered constructs do not have the same mechanical properties as native articular cartilage, which is due to the insufficient accumulation of #extracellular matrix components. To address this, researchers have been exploring the use of adenosine triphosphate (#ATP) to directly harness the underlying mechanotransduction pathways responsible. ATP is a molecule that is released as a result of mechanical stimulation and acts as an autocrine/paracrine signaling #molecule. It acts on P2 receptors on the #plasma #membrane to promote extracellular matrix #synthesis. However, high doses of ATP can lead to an increase in matrix #metalloproteinase 13 (MMP-13) activity and extracellular inorganic pyrophosphate (ePPi) accumulation, which can lead to undesirable effects such as #mineralization of articular cartilage. Therefore, the purpose of this study is to identify the mechanism of ATP-mediated #catabolism and to determine a therapeutic dose range to maximize the #anabolic effect.

Materials & Methods

Cell Isolation: This is the process of separating cells from a tissue sample. It is usually done using #enzymes to break down the tissue and then filtering the cells out.

3-Dimensional Culture: This is a type of #cellculture where the cells are grown in a three-dimensional environment, rather than in a flat layer. This allows the cells to interact with each other in a more natural way.

Exogenous ATP Supplementation: ATP (adenosine triphosphate) is a molecule that is important for energy production in cells. Exogenous ATP supplementation is the process of adding ATP to the cell culture from an outside source. This can help the cells to grow and function better.

MMP-13 Protein Activity is a type of protein that is found inside cells. It was extracted from 3-D cultured constructs and then frozen and pulverized. It was then homogenized in a buffer solution with a protease inhibitor. After that, it was centrifuged and stored at a low temperature. To measure the amount of active MMP-13, a FRET-based assay was used. This assay uses a fluorophore and quencher to measure the amount of MMP-13 that is present. To measure the amount of ECM synthesis, a range of exogenous ATP doses were used. To measure the effect of PPi on MMP-13 activity, chondrocyte monolayer cultures were established and PPi was added to the cultures. To investigate the underlying mechanisms, inhibitors were added to the cultures. Finally, Transmission Electron #Microscopy (TEM) was used to determine the presence of CPPD #crystal accumulation in the engineered tissue constructs. Statistical analyses were then used to analyze the collected data.

The researchers found that when they added ATP to the cultures, MMP-13 activity increased in a dose-dependent manner. This means that the more ATP they added, the more MMP-13 activity increased. They also found that the levels of PPi in the media increased significantly when they added a high dose of ATP, but the levels of PPi in the tissue did not appear to be affected. To determine the best dose of ATP to use, the researchers tested a range of doses and measured the effects on ECM synthesis (collagen and proteoglycans) and MMP-13 activity. They found that ECM synthesis and MMP-13 activity increased in response to intermediate doses of ATP, and further increased in response to higher doses of ATP.

In this study, the researchers wanted to see if they could use ATP to improve tissue growth and mechanical properties without the need for mechanical loading. They found that while high doses of ATP (250 μM) had a positive effect, it also caused a catabolic response, which is when the tissue breaks down. To find the optimal dose of ATP, the researchers tested different doses (31.25, 62.5, and 125 μM) to see which one had the best effect on tissue growth and mechanical properties without causing a catabolic response.

#Calcium is an important factor in the ATP-mediated catabolism process. The researchers found that when they added 10 μM PPi to #chondrocyte cultures, there was a 32% increase in MMP-13 activity compared to unstimulated controls. This effect appeared to require calcium and could be inhibited by the MEK1/2 inhibitor U0126. Additionally, TEM imaging was conducted on engineered cartilaginous tissues supplemented with 0, 62.5 and 250 μM ATP but no mineralization or CPPD crystals were observed which suggests that these doses of ATP did not cause any catabolic response due to crystal formation.

The text is discussing a method of improving tissue growth and mechanical properties of engineered cartilage constructs by applying mechanical loading. However, this approach has limitations when dealing with irregular geometry and high radii of curvature. An alternative approach is to use the known mechanotransduction pathways responsible to achieve the same effect without externally applied forces. In a recent study, it was demonstrated that direct stimulation of the ATP-purinergic receptor pathway through exogenous supplementation of ATP can elicit a comparable anabolic response and be used to improve both tissue growth and mechanical properties of the developed tissue. However, high doses of ATP (250 μM) resulted in a simultaneous catabolic response characterized by an increase in MMP-13 expression, potentially due to the accumulation of ePPi. The present study determined a therapeutic dose range of exogenous ATP to maximize the anabolic response and minimize the catabolic effect of exogenous ATP. It was found that the dose range of ATP between 62.5 and 125 μM was optimal for maximizing the anabolic effect and minimizing the catabolic effect of exogenous ATP. It was also found that calcium and pyrophosphate were key factors involved in the PPi-mediated catabolic response, and that CPPD crystals could potentially be endocytosed and elicit changes through a MAPK-dependent pathway.

#explainpaper #med #MedMastodon

The Therapeutic Potential of Exogenous Adenosine Triphosphate (ATP) for Cartilage Tissue Engineering

authors : Jenna Usprech , Gavin Chu , Renata Giardini-Rosa , Kathleen Martin , and Stephen D. Waldman