#peptide — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #peptide, aggregated by home.social.
-
AI-Designed Antimicrobial Peptide Arcinin Matches Top Antibiotics With Minimal Toxicity
https://1ban.news/arcinin-ai-antimicrobial-peptide/
#1ban #arcinin #antimicrobial #peptide #science #research -
AI-Designed Antimicrobial Peptide Arcinin Matches Top Antibiotics With Minimal Toxicity
https://1ban.news/arcinin-ai-antimicrobial-peptide/
#1ban #arcinin #antimicrobial #peptide #science #research -
America's Unregulated Peptide Craze: Biohackers, Bodybuilders and the Gray Market Boom
https://1ban.news/unregulated-peptide-craze/
#1ban #unregulated #peptide #craze #science #research -
America's Unregulated Peptide Craze: Biohackers, Bodybuilders and the Gray Market Boom
https://1ban.news/unregulated-peptide-craze/
#1ban #unregulated #peptide #craze #science #research -
New paper out: Meet Psysol 3—a novel #cyclotide #NaturalProduct from Psychotria solitudinum. A #cystine_knot #peptide that potently inhibits prolyl oligopeptidase, expanding chemical space for POP #pharmacology and #DrugDiscovery. #ChemicalBiology @univienna #PeptAIDes #ZK81B @fwf
-
Stanford researchers identify peptide that may suppress appetite with fewer side effects than Ozempic
📰 Original title: Stanford scientists discover “natural Ozempic” without side effects
🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️View full AI summary: https://killbait.com/en/stanford-researchers-identify-peptide-that-may-suppress-appetite-with-fewer-side-effects-than-ozempic/?redirpost=81b8211e-6a97-47c7-ba59-707b4f139927
-
Stanford researchers identify peptide that may suppress appetite with fewer side effects than Ozempic
📰 Original title: Stanford scientists discover “natural Ozempic” without side effects
🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️View full AI summary: https://killbait.com/en/stanford-researchers-identify-peptide-that-may-suppress-appetite-with-fewer-side-effects-than-ozempic/?redirpost=81b8211e-6a97-47c7-ba59-707b4f139927
-
Single-molecule #peptide #sequencing through reverse translation of peptides into DNA
https://www.nature.com/articles/s41587-026-03061-zeverything that can be bound with/converted to DNA can be "sequenced": it's sort of like SBS, but here DNA oligos are used instead of individual DNA bases and later actual SBS is performed to decode each oligo sequence... every read will inform about single aa at single position from single protein.
to sequence a protein with 300 aa, you'll need to sequence at least 300 reads!
neat! -
Single-molecule #peptide #sequencing through reverse translation of peptides into DNA
https://www.nature.com/articles/s41587-026-03061-zeverything that can be bound with/converted to DNA can be "sequenced": it's sort of like SBS, but here DNA oligos are used instead of individual DNA bases and later actual SBS is performed to decode each oligo sequence... every read will inform about single aa at single position from single protein.
to sequence a protein with 300 aa, you'll need to sequence at least 300 reads!
neat! -
Nevada Regulators Fine Peptide Providers at Anti-Aging Festival Where Two Women Became Critically Ill
---Three individuals, along with the group accused of supplying the peptides, were fined between $5,000 and $10,000 for their involvement in an incident at the Revolution Against Aging and Death Festival in Las Vegas last summer.
https://www.propublica.org/article/raadfest-peptide-injections-nevada-fines?utm_source=mastodon&utm_medium=social&utm_campaign=mastodon-post -
Nevada Regulators Fine Peptide Providers at Anti-Aging Festival Where Two Women Became Critically Ill
---Three individuals, along with the group accused of supplying the peptides, were fined between $5,000 and $10,000 for their involvement in an incident at the Revolution Against Aging and Death Festival in Las Vegas last summer.
https://www.propublica.org/article/raadfest-peptide-injections-nevada-fines?utm_source=mastodon&utm_medium=social&utm_campaign=mastodon-post -
Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis. -
Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis. -
How can we improve peptide- and protein-based drugs and equip them with new functions?
In #Lunteren2026, Jeffrey Bode talked about the synthesis of challenging, chemically modified proteins using a combination of solid-phase peptide synthesis, recombinant expression and ligation strategies like the KAHA ligation.
https://pubs.acs.org/doi/abs/10.1021/acs.accounts.7b00277He also talked about the synthesis of defined ubiquitin multimers using a chemoenzymatic strategy.
https://chemrxiv.org/doi/10.26434/chemrxiv-2025-943j7 -
How can we improve peptide- and protein-based drugs and equip them with new functions?
In #Lunteren2026, Jeffrey Bode talked about the synthesis of challenging, chemically modified proteins using a combination of solid-phase peptide synthesis, recombinant expression and ligation strategies like the KAHA ligation.
https://pubs.acs.org/doi/abs/10.1021/acs.accounts.7b00277He also talked about the synthesis of defined ubiquitin multimers using a chemoenzymatic strategy.
https://chemrxiv.org/doi/10.26434/chemrxiv-2025-943j7 -
How can peptide-based drugs be modified at a late stage for further biological evaluation?
At #Lunteren2026, Eva Meeus told us about her amazing work on modifying the skeleton of tryptophan in peptides through nitrogen atom insertion.
https://pubs.acs.org/doi/abs/10.1021/jacs.5c16498
#Chemistry #ChemBio #Peptide -
How can peptide-based drugs be modified at a late stage for further biological evaluation?
At #Lunteren2026, Eva Meeus told us about her amazing work on modifying the skeleton of tryptophan in peptides through nitrogen atom insertion.
https://pubs.acs.org/doi/abs/10.1021/jacs.5c16498
#Chemistry #ChemBio #Peptide -
How can LDL-cholesterol ("bad" cholesterol) be lowered in patients? Danila Branca gave an exciting talk at #Lunteren2026 on the development of orally bioavailable, macrocyclic peptide-based inhibitors of PCSK9 that were initially discovered by mRNA display and investigated by Merck in a clinical phase 3 study as enlicitide.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01084
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01599 -
Dieser Artikel hat besonders viele Abonnent:innen interessiert. (+)
-
Dieser Artikel hat besonders viele Abonnent:innen interessiert. (+)
-
5-Mar-2026
Toxic #evolution: How #wasps and #frogs mimic #pain molecules to deter predators
Certain species of wasps and frogs share a pain and inflammation #peptide similar to one found in vertebrates to help defend against #predators – a discovery researchers say contributes to a shifting view of how evolution works. -
5-Mar-2026
Toxic #evolution: How #wasps and #frogs mimic #pain molecules to deter predators
Certain species of wasps and frogs share a pain and inflammation #peptide similar to one found in vertebrates to help defend against #predators – a discovery researchers say contributes to a shifting view of how evolution works. -
Peptide sind zum Mainstream-Hype in den USA geworden. Doch die Vorteile und Risiken vieler dieser Verbindungen sind weitgehend unbekannt. Die FDA könnte ihre Herstellung trotzdem erlauben. (+)
-
Peptide sind zum Mainstream-Hype in den USA geworden. Doch die Vorteile und Risiken vieler dieser Verbindungen sind weitgehend unbekannt. Die FDA könnte ihre Herstellung trotzdem erlauben. (+)
-
Researchers at UC Santa Barbara developed an efficient technique to synthesize non-natural amino acids that are immediately ready for direct use in #peptide construction without extra modification steps.
#Biochemistry #Pharmaceutical #MaterialScience #sflorg
https://www.sflorg.com/2026/02/bchm02192601.html -
Researchers at UC Santa Barbara developed an efficient technique to synthesize non-natural amino acids that are immediately ready for direct use in #peptide construction without extra modification steps.
#Biochemistry #Pharmaceutical #MaterialScience #sflorg
https://www.sflorg.com/2026/02/bchm02192601.html -
📢 Call for papers | @FrontiersIn
"Rational Design of Peptide-Based Therapeutics for GPCRs"We invite original research, reviews & perspectives — from #peptidechemistry and #GPCR biology to #drugdiscovery .
#Peptides #peptide-conjugates #Peptidomimetics -
Interesting paper by the groups of Bill Morandi and Nathalie Grob in JACS. They developed a method to convert the indole of tryptophan into a quinazoline on peptides and peptide-based drugs, while tolerating most other amino acids present. https://pubs.acs.org/doi/10.1021/jacs.5c16498
#Chemistry #ChemBio #Peptide -
Interesting paper by the groups of Bill Morandi and Nathalie Grob in JACS. They developed a method to convert the indole of tryptophan into a quinazoline on peptides and peptide-based drugs, while tolerating most other amino acids present. https://pubs.acs.org/doi/10.1021/jacs.5c16498
#Chemistry #ChemBio #Peptide -
Interesting article by the American Peptide Society about the recent publication by the group of Sebastian Pomplun of our @LED3hub on using BindCraft to predict #peptide binders to high value protein targets.
https://americanpeptidesociety.org/aps-news/binders-by-design/ -
Interesting article by the American Peptide Society about the recent publication by the group of Sebastian Pomplun of our @LED3hub on using BindCraft to predict #peptide binders to high value protein targets.
https://americanpeptidesociety.org/aps-news/binders-by-design/ -
Interesting article by the American Peptide Society about the recent publication by the group of @[email protected] of our @[email protected] on using BindCraft to predict #peptide binders to high value protein targets. americanpeptidesociety.org/aps-news/bin...
-
Interesting article by the American Peptide Society about the recent publication by the group of @[email protected] of our @[email protected] on using BindCraft to predict #peptide binders to high value protein targets. americanpeptidesociety.org/aps-news/bin...
-
Exciting to see the study on the prediction of high-affinity #peptide binders to proteins-of-interests by the group of Sebastian Pomplun of our LED3hub highlighted by Derek Lowe in his "In the Pipeline" blog at Science.
https://www.science.org/content/blog-post/cheap-computation-small-peptide-binders
-
Are you interested in computationally predicting peptide binders to a protein-of interest?
Check out this Science blog post by Derek Lowe on the work by Sebastian Pomplun of our @LED3hub on predicting peptide binders using BindCraft.
https://www.science.org/content/blog-post/cheap-computation-small-peptide-binders
#Chemistry #ChemBio #Peptide #BindCraft #Prediction #DrugDiscovery
-
Are you interested in computationally predicting peptide binders to a protein-of interest?
Check out this Science blog post by Derek Lowe on the work by Sebastian Pomplun of our @LED3hub on predicting peptide binders using BindCraft.
https://www.science.org/content/blog-post/cheap-computation-small-peptide-binders
#Chemistry #ChemBio #Peptide #BindCraft #Prediction #DrugDiscovery
-
Interesting talk by Florian Ort from the group of Floris Rutjes at #NWOCHAINS. He talked about the use of #mechanochemistry for solvent-free, racemization-free #peptide #ligation. Exciting applications for #NativeChemicalLigation of insoluble peptides.
-
Exciting talk by Kevin Neumann at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.
https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3548
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ceur.202500273
#Chemistry #ChemBio #DrugDiscovery -
Looking for a high-affinity #peptide binder for your favorite target?
According to the newest paper by the group of Sebastian Pomplun, the software tool #BindCraft allows you to predict such binders with high success rates.
https://pubs.acs.org/doi/10.1021/acschembio.5c00774
#Chemistry #ChemBio #DrugDiscovery -
Il corpo umano nasconde la sua versione personale di Ozempic: una molecola di soli 12 aminoacidi chiamata BRP. I ricercatori Stanford l'hanno isolata tra 20.000 geni e funziona esclusivamente sul cervello, dimezzando l'appetito senza effetti collaterali. Nei test animali? Perdita di peso senza nausea o complicazioni. Niente farmaci sintetici: la prossima svolta anti-obesità è già dentro di noi.
#Ozempic #Dimagrimento #Peptide #Stanford #Obesità
https://www.futuroprossimo.it/2025/03/stanford-svela-un-ozempic-naturale-senza-effetti-collaterali/
-
Il corpo umano nasconde la sua versione personale di Ozempic: una molecola di soli 12 aminoacidi chiamata BRP. I ricercatori Stanford l'hanno isolata tra 20.000 geni e funziona esclusivamente sul cervello, dimezzando l'appetito senza effetti collaterali. Nei test animali? Perdita di peso senza nausea o complicazioni. Niente farmaci sintetici: la prossima svolta anti-obesità è già dentro di noi.
#Ozempic #Dimagrimento #Peptide #Stanford #Obesità
https://www.futuroprossimo.it/2025/03/stanford-svela-un-ozempic-naturale-senza-effetti-collaterali/
-
Design and validation of a #frugal, #automated, #OpenSource solid-phase #peptide #synthesizer (#SPPS):
-#Raspi/#Python-controlled
-hardware cost: US $300 to $600
-yield: µmoles of peptide at a cost of ~$1/residuehttps://doi.org/10.1371/journal.pone.0237473
#DIYbio #lab #instruments #chemistry #fluidics -
Design and validation of a #frugal, #automated, #OpenSource solid-phase #peptide #synthesizer (#SPPS):
-#Raspi/#Python-controlled
-hardware cost: US $300 to $600
-yield: µmoles of peptide at a cost of ~$1/residuehttps://doi.org/10.1371/journal.pone.0237473
#DIYbio #lab #instruments #chemistry #fluidics -
#AI model generates #antimicrobial #peptide structures for screening against treatment-resistant microbes
https://phys.org/news/2025-02-ai-generates-antimicrobial-peptide-screening.html
-
Eine nachhaltige #Recyclingmethode für Palladium-haltige Katalysatoren gibt es bislang nicht. Angela Thewes und Dr. Nora Schönberger vom #HZDR wollen das ändern. Mit #Pep2Rec entwickeln sie ein biologisches Trennverfahren, das auf #Peptide mit besonderen Eigenschaften setzt.
