#biosynthesis — Public Fediverse posts

https://medicalxpress.com/news/2026-04-millions-birth-uncover-autism-surge.html

(if past is prologue US litigiousness will not take long to board this train, this time perhaps deservedly)

Prenatal exposure to medications that inhibit #sterol #biosynthesis, including certain #antidepressants, #antipsychotics, #betablockers, and #statins, is associated with a significantly increased risk of #autism spectrum disorder in offspring, with risk rising in a dose-dependent manner…pregnancies with such exposure increased from 4.3% in 2014 to 16.8% in 2023.

https://medicalxpress.com/news/2026-04-millions-birth-uncover-autism-surge.html

(if past is prologue US litigiousness will not take long to board this train, this time perhaps deservedly)

Prenatal exposure to medications that inhibit #sterol #biosynthesis, including certain #antidepressants, #antipsychotics, #betablockers, and #statins, is associated with a significantly increased risk of #autism spectrum disorder in offspring, with risk rising in a dose-dependent manner…pregnancies with such exposure increased from 4.3% in 2014 to 16.8% in 2023.

New publication: #Plant Coumarins #Modulate Natural Product #Biosynthesis in a #Streptomyces #Root #Endophyte.
https://doi.org/10.1021/acs.jnatprod.5c01626

New publication: #Plant Coumarins #Modulate Natural Product #Biosynthesis in a #Streptomyces #Root #Endophyte.
https://doi.org/10.1021/acs.jnatprod.5c01626

🧪Phillyrin is a unique #antiviral lignan with potent anti-#flu activity only found in Forsythia suspensa.
Wang et al. reveal key steps in its #biosynthesis, bringing us one step closer to a valuable #drug.
🔗https://doi.org/10.1111/jipb.70216
@WileyLifeSci
#PlantSci #JIPB #plant #medicine #botany

🧪Phillyrin is a unique #antiviral lignan with potent anti-#flu activity only found in Forsythia suspensa.
Wang et al. reveal key steps in its #biosynthesis, bringing us one step closer to a valuable #drug.
🔗https://doi.org/10.1111/jipb.70216
@WileyLifeSci
#PlantSci #JIPB #plant #medicine #botany

Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.

https://doi.org/10.1039/D6SC00250A

Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.

https://doi.org/10.1039/D6SC00250A

🎃 Have you picked your Halloween costume? 🎃 And more importantly, have you submitted your papers to our upcoming special issue on Advances in Plant Natural Products: #Biosynthesis, #Bioengineering, and Applications.

https://jipb.net/EN/news/news863.shtml

#PlantScience #medicine #food #beauty #agriculture #botany #SynBio

Genetic and biochemical insights into siderophore biosynthesis in the marine fish pathogen Tenacibaculum maritimum

Identification of the gene cluster…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #Bacterialgenetics #Biosynthesis #Desferrioxamine #HumanitiesandSocialSciences #Ironacquisition #Marinesiderophores #Metabolicpathways #Metals #multidisciplinary #nTenacibaculummaritimumn #Naturalproducts #Pathogens #Science #Tenacibaculosis
https://www.newsbeep.com/us/22444/

Most #biosynthetic gene clusters remain uncharacterized. @marnixmedema @gillesvanwezel &co integrate #GRN analysis & global expression data to identify desJGH as an operon essential for #biosynthesis of #desferrioxamineB in Streptomyces @PLOSBiology https://plos.io/43UVUPB

Most #biosynthetic gene clusters remain uncharacterized. @marnixmedema @gillesvanwezel &co integrate #GRN analysis & global expression data to identify desJGH as an operon essential for #biosynthesis of #desferrioxamineB in Streptomyces @PLOSBiology https://plos.io/43UVUPB

3-Jun-2025
Two plant species invent the same chemically complex and medically interesting substance
The elucidation of the biosynthetic pathway of #ipecacuanha #alkaloids shows how two distantly related plant species could develop the same substance independently

https://www.eurekalert.org/news-releases/1085960 #science #plants #bioactives #biosynthesis #evolution #plantPhysiology

3-Jun-2025
Two plant species invent the same chemically complex and medically interesting substance
The elucidation of the biosynthetic pathway of #ipecacuanha #alkaloids shows how two distantly related plant species could develop the same substance independently

https://www.eurekalert.org/news-releases/1085960 #science #plants #bioactives #biosynthesis #evolution #plantPhysiology

Biosynthesis of ascorbic acid in animals and plants
Only humans cannot synthesize ascorbic acid, but plants and animals are very good at this task. In plants, biosynthesis begins with D-glucose, D-fructose is obtained, after D-mannose, from which, through other processes, ascorbic acid is obtained.
In animals, this process occurs differently, everything starts with D-glucose and ends with ascorbic acid.

#ascorbicacid #biochemistry #vitaminc #Biosynthesis

New publication: Biomimetic Total Synthesis and Paired Omics Identify an Intermolecular Diels-Alder Reaction as the Key Step in Lugdunomycin Biosynthesis. #bacteria #biosynthesis #chemicalreactions #genetics
https://doi.org/10.1021/jacs.5c01883

Mapping the #yerba_mate #genome reveals surprising facts about the #evolution of #caffeine.

#Ilex #genome_duplication #biosynthesis

https://phys.org/news/2025-02-yerba-genome-reveals-facts-evolution.html

Mapping the #yerba_mate #genome reveals surprising facts about the #evolution of #caffeine.

#Ilex #genome_duplication #biosynthesis

https://phys.org/news/2025-02-yerba-genome-reveals-facts-evolution.html

#Microbial #cell factories may help get to the root of understudied #plant #molecules

#metabolomics #biosynthesis #strigolactones

https://phys.org/news/2025-01-microbial-cell-factories-root-understudied.html

#Microbial #cell factories may help get to the root of understudied #plant #molecules

#metabolomics #biosynthesis #strigolactones

https://phys.org/news/2025-01-microbial-cell-factories-root-understudied.html

I am thrilled to announce that our lab has joined @Uni_Stuttgart and I have accepted the position as Professor of Technical Biochemistry! 🔬🥂 I am honored to follow in the footsteps of Prof. Bernhard Hauer, whose contributions to the field are truly inspiring.
We look forward to continue working on #EnzymeDesign, #Biocatalysis, #Biosynthesis and #NonribosomalPeptides. Thanks to Dr Kirti Sharma, Maximilian Müll, and Kexin Zhang for joining me on the journey from @LeibnizHKI to Stuttgart.

⏳New year, new #PlantScience!🥳
#Starch #biosynthesis is critical for🍞#wheat quality and yield. Here, Liu et al. reveal the crucial role of TaDL and identify the elite allele TaDL-BI associated with starch content. 👇🔓https://doi.org/10.1111/jipb.13815
@wileyplantsci
#JIPB #CropSci #PlantScience #botany #OpenAccess

🌽#Maize #plants produce #terpene compounds when attacked by Asian corn borer larvae, but when #genes involved in #biosynthesis of these plant volatiles are knocked out, plants are made less attractive to herbivory.🔓⬇️
https://doi.org/10.1111/jipb.13763
@wileyplantsci
#JIPB #PlantSci #openaccess #botany

Find out which #cytochrome P450 is responsible for the de novo #biosynthesis of two types of aporphine #alkaloid in #yeast!
Li et al. lay a foundation for using #SynBio to produce these valuable compounds.
https://doi.org/10.1111/jipb.13724
@wileyplantsci
#JIPB #PlantSci #pharmacology #botany #syntheticbiology

#Biosynthesis of #cellulose, #lignin, and #hemicelluloses in #plants is regulated by a transcriptional regulatory network featuring orthologous shared TFs of #poplar and #Arabidopsis.

#Wood you like to know more?😉https://doi.org/10.1111/jipb.13717
@wileyplantsci
#PlantSci #JIPB #forest #botany

New discovery reveals that ocean #algae unexpectedly help cool the Earth https://phys.org/news/2024-06-discovery-reveals-ocean-algae-unexpectedly.html #protists #microbes

Alternative #dimethylsulfoniopropionate #biosynthesis enzymes in diverse and abundant microorganisms https://www.nature.com/articles/s41564-024-01715-9

"They identified the bloom-forming #Pelagophyceae algae as potentially abundant, important producers of a compound called #DMSP... this is the main source of a #climate active gas called #dimethylsulfide (#DMS), which is known as the smell of the seaside."

New discovery reveals that ocean #algae unexpectedly help cool the Earth https://phys.org/news/2024-06-discovery-reveals-ocean-algae-unexpectedly.html #protists #microbes

Alternative #dimethylsulfoniopropionate #biosynthesis enzymes in diverse and abundant microorganisms https://www.nature.com/articles/s41564-024-01715-9

"They identified the bloom-forming #Pelagophyceae algae as potentially abundant, important producers of a compound called #DMSP... this is the main source of a #climate active gas called #dimethylsulfide (#DMS), which is known as the smell of the seaside."

Scientists uncover a multibillion-year epic written into the #chemistry_of_life.

#purine #biosynthesis #KEGG #evolution #ATP

https://phys.org/news/2024-05-scientists-uncover-multibillion-year-epic.html

Scientists uncover a multibillion-year epic written into the #chemistry_of_life.

#purine #biosynthesis #KEGG #evolution #ATP

https://phys.org/news/2024-05-scientists-uncover-multibillion-year-epic.html

Ronja from PuckerLab presented at London Calling 2024, highlighting our work on unravelling the biosynthetic potential of medicinal plants! 🌿✨ #londoncalling2024 #medicinalplants #biosynthesis

Unveiling the molecular functions of #lipid #droplet proteins in #Arabidopsis thaliana #leaves.

#micelles #proteomes #myosin #MYOB #furan #fatty_acid #biosynthesis

https://phys.org/news/2024-04-unveiling-molecular-functions-lipid-droplet.html

Postdoctoral Researcher

John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wilkinson Group at the John Innes Centre.

See the full job description on jobRxiv: https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=74500

#bioinformatics #biosynthesis #chemical_biology #microbiology #molecular_biology #ScienceJobs #hiring #researc...
https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=74500

Postdoctoral Researcher

John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wilkinson Group at the John Innes Centre.

See the full job description on jobRxiv: https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=74500

#bioinformatics #biosynthesis #chemical_biology #microbiology #molecular_biology #ScienceJobs #hiring #researc...
https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=74500

Postdoctoral Researcher

John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wilkinson Group at the John Innes Centre.

See the full job description on jobRxiv: https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=74318

#bioinformatics #biosynthesis #chemical_biology #microbiology #molecular_biology #ScienceJobs #hiring #researc...
https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=74318

Postdoctoral Researcher

John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wilkinson Group at the John Innes Centre.

See the full job description on jobRxiv: https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=74318

#bioinformatics #biosynthesis #chemical_biology #microbiology #molecular_biology #ScienceJobs #hiring #researc...
https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=74318

🍅Welcome back to #TomatoTuesday!🍅
In a new #JIPB paper,🍅He et al. report that two🍅members of the APETALA2🍅family mediate a🍅🍅#transcriptional cascade that orchestrates #carotenoid #biosynthesis🍅in #tomato.
https://doi.org/10.1111/jipb.13650🍅
@wileyplantsci
#PlantSci🍅#lycopene #fruit #botany

Postdoctoral Researcher

John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wilkinson Group at the John Innes Centre.

See the full job description on jobRxiv: https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=73982

#bioinformatics #biosynthesis #chemical_biology #microbiology #molecular_biology #ScienceJobs #hiring #researc...
https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=73982

Postdoctoral Researcher

John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wilkinson Group at the John Innes Centre.

See the full job description on jobRxiv: https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=73982

#bioinformatics #biosynthesis #chemical_biology #microbiology #molecular_biology #ScienceJobs #hiring #researc...
https://jobrxiv.org/job/john-innes-centre-27778-postdoctoral-researcher-24/?feed_id=73982

'Genetic regulation and manipulation of #nicotine #biosynthesis in #tobacco: strategies to eliminate addictive #alkaloids' - Tsubasa Shoji, Takashi Hashimoto, Kazuki Saito https://bit.ly/48TacRw

This diagram shows the biosynthesis of nicotine and related alkaloids in tobacco. Putrescine N-methyltransferase (PMT) and N-methylputrescine oxidase (MPO) have been proposed to have evolved from spermidine synthase (SPDS) and diamine oxidase (DAO), respectively.

Alternative #splicing and #transcription factor interplay in #blood_orange #anthocyanin #biosynthesis.

#agriculture #RUBY1 #MBW #CsTT8 #signalling

https://phys.org/news/2024-03-alternative-splicing-transcription-factor-interplay.html

The first articles of the thematic issue “Young investigators in #naturalproductschemistry, #biosynthesis, and #enzymology” edited by Jeffrey Rudolf, University of Florida, Lena Barra, University of Konstanz and Takayoshi Awakawa, Riken CSRS are ONLINE:

👉 https://www.beilstein-journals.org/bjoc/series/129?M=y

More to come soon!

💎🔓 #DiamondOpenAccess #BJOC

The first articles of the thematic issue “Young investigators in #naturalproductschemistry, #biosynthesis, and #enzymology” edited by Jeffrey Rudolf, University of Florida, Lena Barra, University of Konstanz and Takayoshi Awakawa, Riken CSRS are ONLINE:

👉 https://www.beilstein-journals.org/bjoc/series/129?M=y

More to come soon!

💎🔓 #DiamondOpenAccess #BJOC

How SARPs regulate #antibiotic #biosynthesis in Streptomyces. This study combines #cryoEM structures with biochemical assays to explain how the #Streptomyces coelicolor SARP AfsR activates transcription #PLOSBiology https://plos.io/3P5DWUe

How SARPs regulate #antibiotic #biosynthesis in Streptomyces. This study combines #cryoEM structures with biochemical assays to explain how the #Streptomyces coelicolor SARP AfsR activates transcription #PLOSBiology https://plos.io/3P5DWUe

#CRISPR/Cas9-mediated targeted #mutagenesis of #inulin #biosynthesis in rubber #dandelion.

#Taraxacum #1_FFT

https://phys.org/news/2024-02-crisprcas9-mutagenesis-inulin-biosynthesis-rubber.html

Exploring the unseen: #Microbial wonders in Earth's saltiest waters https://phys.org/news/2024-02-exploring-unseen-microbial-earth-saltiest.html

Unravelling #biosynthesis and #biodegradation potentials of #MicrobialDarkMatters in #hypersaline lakes https://www.sciencedirect.com/science/article/pii/S2666498423001242

"This research not only expands our knowledge of life in extreme conditions but also opens exciting possibilities for new technologies and medical breakthroughs, leveraging the untapped resources of these unique microbial communities."

Exploring the unseen: #Microbial wonders in Earth's saltiest waters https://phys.org/news/2024-02-exploring-unseen-microbial-earth-saltiest.html

Unravelling #biosynthesis and #biodegradation potentials of #MicrobialDarkMatters in #hypersaline lakes https://www.sciencedirect.com/science/article/pii/S2666498423001242

"This research not only expands our knowledge of life in extreme conditions but also opens exciting possibilities for new technologies and medical breakthroughs, leveraging the untapped resources of these unique microbial communities."

Zhang et al. use #chemoproteomics to identify the epoxidase enzyme responsible for #biosynthesis of the #anticancer #drug #camptothecin in Ophiorrhiza pumila.
https://doi.org/10.1111/jipb.13594
@wileyplantsci
#JIPB #PlantSci #medicine #PlantScience #botany #cancer #CancerResearch

#Biosynthesis of #magnetic #sensor in magnetic #bacteria revealed through expression of foreign proteins.

#MamK #magnetosome #Magnetospirillum

https://phys.org/news/2023-10-biosynthesis-magnetic-sensor-bacteria-revealed.html

Guy Polturak from the John Innes Center at #JGI2023:

Genomics-Driven Search for Defense-Related Biosynthetic Gene Clusters in Wheat

#wheat #genomics #plants #biosynthesis #BGCs
@LBNLBioSci

Carbene chemistry built into microbe’s metabolism in first for biosynthesis.

https://www.chemistryworld.com/news/carbene-chemistry-built-into-microbes-metabolism-in-first-for-biosynthesis/4017449.article

#Biosynthesis #Carbene #Organometallic #Chemistry

Adenosine, a #biochemical that is found in cells and is essential for many processes. Adenosine is made up of an adenine nitrogenous base linked to a #ribose sugar #molecule. It is involved in the #biosynthesis and #replication of #DNA and #RNA, and is also a component of an #enzyme called S-adenosyl-L-methionine (SAM) and cyano-cobalamin (vitamin B-12). #Adenosine was once thought to only modify #cardiovascular #physiology, but now it is known to have many other effects on physiology.