#proteinengineering — Public Fediverse posts

Raygun is reshaping protein engineering at Duke University using an AI “shrink ray” approach that speeds up design cycles and enhances precision. Essential read for biotech professionals and researchers thinking about AI-driven design workflows. Learn more: https://wix.to/HRvwEYI

#Research
#Innovation
#AIinBiotech
#DukeUniversity
#ProteinEngineering

Scientist — Protein Engineering & Computational Biology (remote, US Based)
Breach Bio

See the full job description on jobRxiv: https://jobrxiv.org/job/breach-bio-27778-scientist-protein-engineering-computational-biology/

#aiandcomputationalbiology #Aiinpharmacyandbiotechnology #BioinformaticsandComputationalBiology #proteinengineering #proteinstructureandfunction #ScienceJobs #hiring...
https://jobrxiv.org/job/breach-bio-27778-scientist-protein-engineering-computational-biology/?fsp_sid=13888

Scientist — Protein Engineering & Computational Biology (remote, US Based)
Breach Bio

See the full job description on jobRxiv: https://jobrxiv.org/job/breach-bio-27778-scientist-protein-engineering-computational-biology/

#aiandcomputationalbiology #Aiinpharmacyandbiotechnology #BioinformaticsandComputationalBiology #proteinengineering #proteinstructureandfunction #ScienceJobs #hiring...
https://jobrxiv.org/job/breach-bio-27778-scientist-protein-engineering-computational-biology/?fsp_sid=13457

Scientist — Protein Engineering & Computational Biology (remote)
Breach Bio

See the full job description on jobRxiv: https://jobrxiv.org/job/breach-bio-27778-scientist-protein-engineering-computational-biology/

#aiandcomputationalbiology #Aiinpharmacyandbiotechnology #BioinformaticsandComputationalBiology #proteinengineering #proteinstructureandfunction #ScienceJobs #hiring #research
https://jobrxiv.org/job/breach-bio-27778-scientist-protein-engineering-computational-biology/?fsp_sid=13344

🧬 Can AI help researchers discover better proteins faster?

The Software Campus project ProtAl combines active learning and protein language models to explore new approaches for protein engineering—while putting transparency and usability at the center. 🚀🔬☁️

Participant: Sebastian Franz
Research Partners: @tu_muenchen / LMU Munich
Industry Partner: #Merck

Learn more via the link! 👇
https://softwarecampus.de/en/projekt/protal-an-active-learning-platform-for-protein-engineering/

#SoftwareCampus #Bioinformatics #ProteinEngineering #AI #Biotech

🤖 Have we built AI powerful enough to design proteins, but too complicated for most scientists to use?

🔗 BioPipelines: Accessible Computational Protein and Ligand Design for Chemical Biologists. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0129

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#BioPipelines #ProteinEngineering #ComputationalBiology #ProteinDesign #SyntheticBiology #Bioinformatics #AlphaFold #SystemsBiology #AI

🦠 Can a redesigned bacterial platform reshape the future of protein engineering?

🔗 Optimized Quantitative Bacterial Two-Hybrid (qB2H) for Protein–Protein Interaction Assessment. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0098

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#ProteinEngineering #SyntheticBiology #ProteinDesign #DrugDiscovery #ProteinInteractions #TherapeuticDiscovery

🦠 Could decoding bacterial regulatory proteins help us stay ahead of drug resistance?

🔗 Conserved Motifs in the Ligand-Binding Domain of TetR Family Regulators: Identification and Analysis. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0100

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Microbiology #MolecularBiology #Bioinformatics #AntimicrobialResistance #DrugDiscovery #ProteinEngineering #StructuralBiology #Genomics #ComputationalBiology

⚛️ Can spherical voxelization improve how AI interprets protein chemistry and interactions?

🔗 SpheronizaTor: Spherical Voxelization for Interpretable Protein Microenvironment Modeling. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0076

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #Bioinformatics #ComputationalBiology #ProteinStructure #ArtificialIntelligence #ProteinEngineering #ProteinModeling

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=11433

⚛️ Could life itself be a quantum phenomenon disguised as biology?

🔗 Quantum Biology Using Ultrafast Integrative and Molecular Engineering Tools: A Perspective. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0024

📚 CSBJ Quantum Biology and Biophotonics: https://spj.science.org/journal/csbj/qbio

#QuantumBiology #QuantumPhysics #MolecularBiology #ProteinEngineering #Biophysics #Biochemistry #Bioinformatics #SystemsBiology #MolecularDynamics #Lifesciences

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=10761

Can the functions of #metalloenzymes be further improved using non-canonical amino acids?

In her talk at #Biochemistry2026, Alexandra Deliz Liang talked about the usage of genetic code expansion in order to improve the activity of metalloenzymes using e.g. hydrophobic tuning.

https://www.biorxiv.org/content/10.1101/2025.02.09.636911v1
#Chemistry #ChemBio #Biochemistry #BioinorganicChemistry #ProteinEngineering
CC: @gdch, @GDCh_BioChem

How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures

https://kemal.yaylali.uk/from-bioreactors-to-ai-how-i-built-a-machine-learning-tool-to-predict-drug-manufacturing-failures/

🧩 Could structural AI finally decode the complex language of T-cell antigen recognition?

🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #ProteinLanguageModels #Immunotherapy #ComputationalBiology #Bioinformatics #MachineLearning #Immunology #ProteinEngineering #TCR #HLA #DrugDiscovery #AI

✨ Is it time to rethink allosteric site prediction using internal protein nanoenvironments?

🔗 Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.036

📚 CSBJ: https://www.csbj.org/

#DrugDiscovery #ComputationalBiology #StructuralBiology #ProteinEngineering #Biophysics #Cheminformatics

Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University

Join us to work on AI for drug discovery!

See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/

#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=5646

💧 Is your MD simulation lying to you because of the water model you picked?

🔗 Impact of water models on the structure and dynamics of enzyme tunnels. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.051

📚 CSBJ: https://www.csbj.org/

#ComputationalBiology #MolecularDynamics #Enzymology #StructuralBiology #ProteinEngineering #Biophysics #WaterModels #EnzymeTunnels #MolecularSimulation #ProteinDynamics

🧬 Can molecular simulations transform the future of long-acting diabetes treatments?

🔗 In silico investigations of albumin-GLP-1 receptor agonist complexes for diabetes drug delivery applications. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.007

📚 CSBJ: https://www.csbj.org/

#MolecularDynamics #DiabetesResearch #Biotherapeutics #GLP1 #Albumin #DrugDelivery #Biomaterials #ComputationalBiology #ProteinEngineering

💡 Can AI find the viral “on switch” that triggers infection?

🔗 Machine and deep learning to predict viral fusion peptides. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.011

📚 CSBJ: https://www.csbj.org/

#MachineLearning #Virology #AI #ProteinEngineering #Bioinformatics

🧬 Can AI build peptides that tell your cells to fight back against oxidative stress?

🔗 RoseTTAFold diffusion-guided short peptide design: a case study of binders against Keap1/Nrf2. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.032

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #PeptideTherapeutics #RoseTTAFold #ProteinEngineering #MolecularDynamics #AIinDrugDiscovery #AntioxidantResearch #DrugDesign #Bioinformatics #ComputationalBiology

⚛️ Is the secret to circular rare earth recovery hidden in molecular motion?

🔗 Computationally derived structural insights into Rare Earth selectivity in lanmodulin and its variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.005

📚 CSBJ: https://www.csbj.org/

#RareEarths #Lanmodulin #ComputationalBiology #Sustainability #CircularEconomy #RareEarthElements #MolecularDynamics #ProteinEngineering #MolecularModeling #MolecularSimulation

Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University

Join us to work on AI for drug discovery!

See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/

#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=4463

Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University

Join us to work on AI for drug discovery!

See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/

#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=2489

IntegrateRNA launches revolutionary Aminoacyl-tRNA Synthesis Service enabling custom protein engineering with non-canonical amino acids, transforming research across pharma, biotech, and synthetic biology #Biotechnology #ProteinEngineering

🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.

🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling

#ProteinEngineering #TRPChannels #SyntheticBiology #VisionRestoration #Retina #GeneTherapy