#proteinengineering — Public Fediverse posts

🦠 Could decoding bacterial regulatory proteins help us stay ahead of drug resistance?

🔗 Conserved Motifs in the Ligand-Binding Domain of TetR Family Regulators: Identification and Analysis. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0100

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Microbiology #MolecularBiology #Bioinformatics #AntimicrobialResistance #DrugDiscovery #ProteinEngineering #StructuralBiology #Genomics #ComputationalBiology

🦠 Could decoding bacterial regulatory proteins help us stay ahead of drug resistance?

🔗 Conserved Motifs in the Ligand-Binding Domain of TetR Family Regulators: Identification and Analysis. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0100

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Microbiology #MolecularBiology #Bioinformatics #AntimicrobialResistance #DrugDiscovery #ProteinEngineering #StructuralBiology #Genomics #ComputationalBiology

🦠 Could decoding bacterial regulatory proteins help us stay ahead of drug resistance?

🔗 Conserved Motifs in the Ligand-Binding Domain of TetR Family Regulators: Identification and Analysis. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0100

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Microbiology #MolecularBiology #Bioinformatics #AntimicrobialResistance #DrugDiscovery #ProteinEngineering #StructuralBiology #Genomics #ComputationalBiology

🦠 Could decoding bacterial regulatory proteins help us stay ahead of drug resistance?

🔗 Conserved Motifs in the Ligand-Binding Domain of TetR Family Regulators: Identification and Analysis. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0100

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Microbiology #MolecularBiology #Bioinformatics #AntimicrobialResistance #DrugDiscovery #ProteinEngineering #StructuralBiology #Genomics #ComputationalBiology

🦠 Could decoding bacterial regulatory proteins help us stay ahead of drug resistance?

🔗 Conserved Motifs in the Ligand-Binding Domain of TetR Family Regulators: Identification and Analysis. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0100

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Microbiology #MolecularBiology #Bioinformatics #AntimicrobialResistance #DrugDiscovery #ProteinEngineering #StructuralBiology #Genomics #ComputationalBiology

https://www.europesays.com/ie/491908/ MIDAS platform accelerates protein engineering through rapid PCR-based screening #bacteria #Bioengineering #cloning #DNA #Éire #food #Gene #Genes #Genetic #IE #Ireland #labor #MammalianCells #Manufacturing #medicine #MolecularBiology #oncology #Plasmid #Protein #ProteinEngineering #Reagents #Research #Science #Students #Tsai #Yeast

⚛️ Can spherical voxelization improve how AI interprets protein chemistry and interactions?

🔗 SpheronizaTor: Spherical Voxelization for Interpretable Protein Microenvironment Modeling. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0076

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #Bioinformatics #ComputationalBiology #ProteinStructure #ArtificialIntelligence #ProteinEngineering #ProteinModeling

⚛️ Can spherical voxelization improve how AI interprets protein chemistry and interactions?

🔗 SpheronizaTor: Spherical Voxelization for Interpretable Protein Microenvironment Modeling. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0076

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #Bioinformatics #ComputationalBiology #ProteinStructure #ArtificialIntelligence #ProteinEngineering #ProteinModeling

⚛️ Can spherical voxelization improve how AI interprets protein chemistry and interactions?

🔗 SpheronizaTor: Spherical Voxelization for Interpretable Protein Microenvironment Modeling. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0076

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #Bioinformatics #ComputationalBiology #ProteinStructure #ArtificialIntelligence #ProteinEngineering #ProteinModeling

⚛️ Can spherical voxelization improve how AI interprets protein chemistry and interactions?

🔗 SpheronizaTor: Spherical Voxelization for Interpretable Protein Microenvironment Modeling. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0076

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #Bioinformatics #ComputationalBiology #ProteinStructure #ArtificialIntelligence #ProteinEngineering #ProteinModeling

⚛️ Can spherical voxelization improve how AI interprets protein chemistry and interactions?

🔗 SpheronizaTor: Spherical Voxelization for Interpretable Protein Microenvironment Modeling. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0076

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #Bioinformatics #ComputationalBiology #ProteinStructure #ArtificialIntelligence #ProteinEngineering #ProteinModeling

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=11433

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=11433

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=11433

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=11433

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=11433

New method boosts AI-driven protein engineering with massive data https://www.byteseu.com/1937560/ #AI #ArtificialIntelligence #Biotechnology #dna #MachineLearning #Protein #ProteinEngineering #Research #Technology

⚛️ Could life itself be a quantum phenomenon disguised as biology?

🔗 Quantum Biology Using Ultrafast Integrative and Molecular Engineering Tools: A Perspective. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0024

📚 CSBJ Quantum Biology and Biophotonics: https://spj.science.org/journal/csbj/qbio

#QuantumBiology #QuantumPhysics #MolecularBiology #ProteinEngineering #Biophysics #Biochemistry #Bioinformatics #SystemsBiology #MolecularDynamics #Lifesciences

⚛️ Could life itself be a quantum phenomenon disguised as biology?

🔗 Quantum Biology Using Ultrafast Integrative and Molecular Engineering Tools: A Perspective. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0024

📚 CSBJ Quantum Biology and Biophotonics: https://spj.science.org/journal/csbj/qbio

#QuantumBiology #QuantumPhysics #MolecularBiology #ProteinEngineering #Biophysics #Biochemistry #Bioinformatics #SystemsBiology #MolecularDynamics #Lifesciences

⚛️ Could life itself be a quantum phenomenon disguised as biology?

🔗 Quantum Biology Using Ultrafast Integrative and Molecular Engineering Tools: A Perspective. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0024

📚 CSBJ Quantum Biology and Biophotonics: https://spj.science.org/journal/csbj/qbio

#QuantumBiology #QuantumPhysics #MolecularBiology #ProteinEngineering #Biophysics #Biochemistry #Bioinformatics #SystemsBiology #MolecularDynamics #Lifesciences

⚛️ Could life itself be a quantum phenomenon disguised as biology?

🔗 Quantum Biology Using Ultrafast Integrative and Molecular Engineering Tools: A Perspective. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0024

📚 CSBJ Quantum Biology and Biophotonics: https://spj.science.org/journal/csbj/qbio

#QuantumBiology #QuantumPhysics #MolecularBiology #ProteinEngineering #Biophysics #Biochemistry #Bioinformatics #SystemsBiology #MolecularDynamics #Lifesciences

⚛️ Could life itself be a quantum phenomenon disguised as biology?

🔗 Quantum Biology Using Ultrafast Integrative and Molecular Engineering Tools: A Perspective. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0024

📚 CSBJ Quantum Biology and Biophotonics: https://spj.science.org/journal/csbj/qbio

#QuantumBiology #QuantumPhysics #MolecularBiology #ProteinEngineering #Biophysics #Biochemistry #Bioinformatics #SystemsBiology #MolecularDynamics #Lifesciences

https://www.europesays.com/africa/162428/ Endonuclease Enzymes Market in Algeria | Report – IndexBox #Algeria #BiopharmaMarketReport #Cloning&VectorConstruction #CRISPRBasedGeneEditing #CRISPRCasSystemDiscovery&Engineering #EndonucleaseEnzymes #forecast #Genotyping&SNPAnalysis #HighFidelityEnzymeFormulations #Lyophilization&Stabilization #MarketAnalysis #ProteinEngineering&DirectedEvolution #ViralClearanceInBiomanufacturing

🧩 Could structural AI finally decode the complex language of T-cell antigen recognition?

🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #ProteinLanguageModels #Immunotherapy #ComputationalBiology #Bioinformatics #MachineLearning #Immunology #ProteinEngineering #TCR #HLA #DrugDiscovery #AI

🧩 Could structural AI finally decode the complex language of T-cell antigen recognition?

🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #ProteinLanguageModels #Immunotherapy #ComputationalBiology #Bioinformatics #MachineLearning #Immunology #ProteinEngineering #TCR #HLA #DrugDiscovery #AI

🚀 What role does protein design play in advancing next-gen optogenetic tools?

🔗 Protein design accelerates the development and application of optogenetic tools. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.014

📚 CSBJ: https://www.csbj.org/

#Optogenetics #ProteinEngineering #Neuroscience #AlphaFold #ProteinDesign #SyntheticBiology

How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures

https://kemal.yaylali.uk/from-bioreactors-to-ai-how-i-built-a-machine-learning-tool-to-predict-drug-manufacturing-failures/

Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University

Join us to work on AI for drug discovery!

See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/

#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=5646

Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University

Join us to work on AI for drug discovery!

See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/

#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=4463

Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University

Join us to work on AI for drug discovery!

See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/

#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=2489

Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University

Join us to work on AI for drug discovery!

See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/

#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=1789

Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University

Join us to work on AI for drug discovery!

See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/

#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=1768

🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.

🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling

re-#Introduction with new handle after move to fediscience.org #ScienceMastodon

Hi, I'm Sven, a #structural #biochemist who recently moved from #Dundee, Scotland to #Boston, MA to start a #postdoc in the Brown lab at #HarvardMedicalSchool.

My broad interests are #structuralbiology
#cryoEM
#cilia
#ubiquitin
#biophysics
#proteinfolding #proteinengineering
#methods
#CellBiology

Looking to build a network on here! 🤝 😄

🤖 How can artificial intelligence help us outsmart rapidly evolving viruses like H5N1?

🔗 AI-based antibody design targeting recent H5N1 avian influenza strains. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.06.026

📚 CSBJ: https://www.csbj.org/

#H5N1 #AIforHealth #AntibodyDesign #Biotech #ComputationalBiology #Influenza #AI4Biotech #GenerativeBiology #PandemicPrep #SyntheticBiology #ProteinEngineering #ComputationalBiology #DrugDiscovery

From Bioreactors to AI: How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures

https://kemal.yaylali.uk/from-bioreactors-to-ai-how-i-built-a-machine-learning-tool-to-predict-drug-manufacturing-failures/

From Bioreactors to AI: How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures

https://kemal.yaylali.uk/from-bioreactors-to-ai-how-i-built-a-machine-learning-tool-to-predict-drug-manufacturing-failures/

⚛️ Is the secret to circular rare earth recovery hidden in molecular motion?

🔗 Computationally derived structural insights into Rare Earth selectivity in lanmodulin and its variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.005

📚 CSBJ: https://www.csbj.org/

#RareEarths #Lanmodulin #ComputationalBiology #Sustainability #CircularEconomy #RareEarthElements #MolecularDynamics #ProteinEngineering #MolecularModeling #MolecularSimulation

🔬 New Review Published!
Explore the exciting world of enzymatic protein fusion—where we combine enzymes to enhance biological activity and precision. From biocatalysis to gene therapy and biosensing, fusion proteins are reshaping biotech innovation.
🧬 Read the full article: https://doi.org/10.1016/j.cis.2025.103473

#FusionProteins #ProteinEngineering #EnzymeTechnology #SyntheticBiology #Biocatalysis #GeneTherapy #Biosensing #Bioengineering #Biotechnology #MolecularBiology #NextGenBiotech #ScienceMastodon

🔬 New Review Published!
Explore the exciting world of enzymatic protein fusion—where we combine enzymes to enhance biological activity and precision. From biocatalysis to gene therapy and biosensing, fusion proteins are reshaping biotech innovation.
🧬 Read the full article: https://doi.org/10.1016/j.cis.2025.103473

#FusionProteins #ProteinEngineering #EnzymeTechnology #SyntheticBiology #Biocatalysis #GeneTherapy #Biosensing #Bioengineering #Biotechnology #MolecularBiology #NextGenBiotech #ScienceMastodon

🔬 New Review Published!
Explore the exciting world of enzymatic protein fusion—where we combine enzymes to enhance biological activity and precision. From biocatalysis to gene therapy and biosensing, fusion proteins are reshaping biotech innovation.
🧬 Read the full article: https://doi.org/10.1016/j.cis.2025.103473

#FusionProteins #ProteinEngineering #EnzymeTechnology #SyntheticBiology #Biocatalysis #GeneTherapy #Biosensing #Bioengineering #Biotechnology #MolecularBiology #NextGenBiotech #ScienceMastodon

Excited to share my very first paper which was just published in #JACS:

https://pubs.acs.org/doi/10.1021/jacs.2c10673

In this work carried out during my PhD together with Jamie Klein, Tomasz Kaminski, and Pierre-Yves Colin in the Hollfelder Lab at #UniversityofCambridge we evolve a #phosphotriesterase with a new, metal-independent mechanism by using droplet #microfluidics.

Comments and feedback welcome! A thread: (1/6)

#EnzymeEngineering #ProteinEngineering #EnzymeMechanism #DirectedEvolution #Bioremediation

01/2023 Issue ➡️ http://bit.ly/3CMpyKi
On the cover: Engineered bacteria expressing a designed single-chain IL-10 prevent severe inflammation in Pseudomonas aeruginosa lung infection
Luis Serrano lab, CRG
#proteinengineering #immunomodulation #synbio #SystemsBiology

Computer-designed single-chain IL-10 molecules expressed in the mouse lung by an engineered attenuated bacterium have an anti-inflammatory effect on #Pseudomonas aeruginosa lung #infection ➡️ http://bit.ly/3GiCAQz
Luis Serrano lab, CRG
#proteinengineering #immunomodulation
#SynBio #SyntheticBiology

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=10761

Can the functions of #metalloenzymes be further improved using non-canonical amino acids?

In her talk at #Biochemistry2026, Alexandra Deliz Liang talked about the usage of genetic code expansion in order to improve the activity of metalloenzymes using e.g. hydrophobic tuning.

https://www.biorxiv.org/content/10.1101/2025.02.09.636911v1
#Chemistry #ChemBio #Biochemistry #BioinorganicChemistry #ProteinEngineering
CC: @gdch, @GDCh_BioChem

Synthetic Biology for Light-Activated Smart Materials

Design and characterise light-responsive proteins and demonstrate light-controlled behaviour of cell-free biology in materials.

#SynBio, #StructuralBiology, #ProteinEngineering, and #biomaterials.

#PhD Studentships are fully funded for 4yrs, with minimum of 3 months at the industry partner. Funding for home (UK) students = tax-free stipend (indicative in year 1 in 2026-27 (£21,383), research costs and tuition fees.
https://www.findaphd.com/phds/project/synthetic-biology-for-light-activated-smart-materials/?p193808

✨ Is it time to rethink allosteric site prediction using internal protein nanoenvironments?

🔗 Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.036

📚 CSBJ: https://www.csbj.org/

#DrugDiscovery #ComputationalBiology #StructuralBiology #ProteinEngineering #Biophysics #Cheminformatics

💧 Is your MD simulation lying to you because of the water model you picked?

🔗 Impact of water models on the structure and dynamics of enzyme tunnels. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.051

📚 CSBJ: https://www.csbj.org/

#ComputationalBiology #MolecularDynamics #Enzymology #StructuralBiology #ProteinEngineering #Biophysics #WaterModels #EnzymeTunnels #MolecularSimulation #ProteinDynamics