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#antibiotics — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #antibiotics, aggregated by home.social.

  1. ⚛️ Would today’s antibiotics still work if bacterial biology were flipped at the molecular level?

    🔗 Molecular Dynamics Simulations Demonstrate Reduced Antibiotic Affinity to Mirror Bacterial Targets. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0198

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #MolecularDynamics #Antibiotics #Biosecurity #ComputationalBiology #SyntheticBiology #DrugDiscovery #AntimicrobialResearch #ComputationalChemistry

  2. Now in Chem Sci! 🎉
    We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
    Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.

    doi.org/10.1039/D6SC00250A

  3. "Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

    Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

    #Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

  4. Researchers at Sandia National Laboratories have combined earlier work on painless #microneedles with #nanoscale #sensors to create a wearable sensor patch capable of continuously monitoring the levels of one of these #antibiotics.
    #Engineering #Nanotechnology #Medical #Microbiology
    sflorg.com/2023/10/eng10032301

  5. Katherine Duncan from Strathclyde University:

    Linking genes and metabolites for informed antibiotic discovery

    #jgi2023 #actinomycetes #streptomyces #antibiotics #jgi

    @LBNLBioSci

  6. AGATHOKAKOLOGICAL

    I learned a new word.

    Keynote by Dianne Newman from CalTech at #JGI2023

    (besides fancy words also covering new phenazine "antibiotics" and the pathways that make them)

    @LBNLBioSci #phenazine #metabolites #Pathways #antibiotics

  7. Ukraine war spurs horrifying rise in extensively drug-resistant bacteria - Enlarge / Ukrainian medics of the battalion "Da Vinci Wolves" and "Ulf"... - arstechnica.com/?p=1953090 #antimicrobialresistance #nosocomialinfection #drugresistance #antibiotics #infection #bacteria #ukraine #health #war

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