#antibiotics — Public Fediverse posts

God I love my Spanish and Greek friends but like always when I get an infection I need to sit in pain for 2 weeks because doctors in those countries and more fling out #antibiotics like its candy. My mum sick in cancer have to lie in pain as they try to find antibiotics that still works because places like #espana and #greece just hand stuff out like its candy and now strains of bacteria are resistant... Gah!

God I love my Spanish and Greek friends but like always when I get an infection I need to sit in pain for 2 weeks because doctors in those countries and more fling out #antibiotics like its candy. My mum sick in cancer have to lie in pain as they try to find antibiotics that still works because places like #espana and #greece just hand stuff out like its candy and now strains of bacteria are resistant... Gah!

God I love my Spanish and Greek friends but like always when I get an infection I need to sit in pain for 2 weeks because doctors in those countries and more fling out #antibiotics like its candy. My mum sick in cancer have to lie in pain as they try to find antibiotics that still works because places like #espana and #greece just hand stuff out like its candy and now strains of bacteria are resistant... Gah!

God I love my Spanish and Greek friends but like always when I get an infection I need to sit in pain for 2 weeks because doctors in those countries and more fling out #antibiotics like its candy. My mum sick in cancer have to lie in pain as they try to find antibiotics that still works because places like #espana and #greece just hand stuff out like its candy and now strains of bacteria are resistant... Gah!

Chemical properties of colistin: amphiphilicity #colistin #antibiotics #amphiphilicity #chemistry ... Continue to: https://www.youtube.com/watch?v=bGI-6_bnMyI

What is colistin? #pharmacology #colistin #antibiotics #chemistry ... Continue to: https://www.youtube.com/watch?v=sK6eqxlUY5A

What is colistin? #pharmacology #colistin #antibiotics #chemistry ... Continue to: https://www.youtube.com/watch?v=0j9nPOAqdRA

Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.

https://doi.org/10.1039/D6SC00250A

@ScienceAlert @sciencealert-ScienceAlert One wonders what antibiotics, if any, these bacteria will be sensitive to. #GlobalWarmng #antibiotics

Go-to #therapy for #chronic #sinus condition doesn't work that well

#Surgery, not #antibiotics, might be the best way to treat chronic #rhinosinusitis, a condition that leaves people with a permanently blocked or #runnynose and a reduced #senseofsmell

https://www.newscientist.com/article/2494299-go-to-therapy-for-chronic-sinus-condition-doesnt-work-that-well/

Andrew Jones and Joshua Prince at Duke University developed a model that replicates #PeripherySequestration in #biofilms by accounting for heterogeneity of antibiotic attachment sites and porosity.

In the image we show how the heterogeneous distribution of the different matrix elements and the #bacteria themselves act as barrier against #antibiotics (in red), hindering their effect.

✏ Check out the paper at: https://www.pnas.org/doi/full/10.1073/pnas.2312995120

#SciArt #SciComm

Filamentous Phage Shields https://schaechter.asmblog.org/schaechter/2024/03/filamentous-phage-shields.html @STCmicrobeblog

Phage liquid crystalline droplets form occlusive sheaths that encapsulate and protect infectious rod-shaped #bacteria (2020) https://www.pnas.org/doi/full/10.1073/pnas.1917726117

"in #biofilms and due to the presence of #ExtracellularMatrix #polymers, Pf4 #phage particles form highly ordered yet dynamic #LiquidCrystals (tactoids) that surround the cells. Quite interestingly, these #tactoids confer on the cells an increased tolerance to #antibiotics."

I had never heard of melatonin as a way to prevent renal injury with colistin!

Didn't work in this RCT, although stopped early as ran out of colistin during #COVID19! 😔

#IDMastodon #AMR #antibiotics #antimicrobialstewardship #Renal #Colistin #PolymixinB

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00641-3/fulltext?dgcid=raven_jbs_aip_email

@rbreich Other major issues at work are: 1. Easy $$ on existing revenue streams protected by gov't rules (FDA, etc) that limit competition; 2. Little C-level $$ incentive to pursue risky research projects (why risk bonus $$?). This has major downstream consequences to world-wide health as evidenced by virtually no #R&D on new #antibiotics & major focus on #diseases that can be addressed by #monoclonal #antibodies, which cost much less for big Pharma to develop. Profit margins on #mAbs are HUGE.