#antibiotics — Public Fediverse posts

As antibiotic resistance grows, researchers are turning to copper as a weapon against bacterial infections

https://phys.org/news/2026-09-antibiotic-resistance-copper-infections.html

#science #health #antibiotics

New publication: Inducible #CRISPRi enables efficient and high-fidelity #genome editing in #Streptomyces. #antibiotics
https://doi.org/10.1093/nar/gkag560

Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.

https://doi.org/10.1039/D6SC00250A

Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

During her work at Rutgers University microbiologist Elizabeth Bugie (1920-2001) was involved in the discovery of streptomycin, the first antibiotic effective against tuberculosis. While her boss received the Nobel Prize for this discovery, she wasn’t mentioned. Honouring her work on the discovery and evaluation of antibiotics, DSMZ researchers named the strain Streptomyces bugieae (DSM 41528) after her.

#herstory #HonoringWomenInSTEM #WomenInScience #streptomyces #microbiology #antibiotics

Um, since cavities haven't been a problem for me (I've had just one), I think I'll switch back to using baking soda and peroxide again (with my own dried mint if I want mintiness).

Some Tom's of Maine toothpaste may be contaminated with #HarmfulBacteria, FDA says

#FDA's warning about multiple types of bacteria and "a black mold-like substance" found in a facility that makes #TomsOfMaine toothpaste has consumers worried about a possible recall.

November 20, 2024

"A recent inspection of a Tom's of Maine facility found 'significant violations' that included different types of bacteria detected in the water and the company's toothpaste, as well as a '#BlackMold-like substance' located behind a water storage tank, according to the Food and Drug Administration.

"The FDA determined the company's response to its findings was 'inadequate' and called for a 'thorough review of all #microbiological hazards,' according to a letter sent by the agency to the brand's parent company, Colgate-Palmolive.

"An inspection in May of a facility in #SanfordMaine, discovered the bacteria #PseudomonasAeruginosa in #water used to manufacture Tom’s Simply White Clean Mint Paste and to clean equipment. The bacteria can cause infections in the blood, lungs and urinary tract, according to the Centers for Disease Control and Prevention.

"The letter also stated that there were multiple incidents of finding a bacteria called #RalstoniaInsidiosa in water in the facility. A third type of bacteria, #ParacoccusYeei, was found in the finished product of the company's Wicked Cool! Anticavity Toothpaste, per the FDA. The type of Paracoccus yeei found can cause infection that may be resistant to #antibiotics.

"An FDA inspector also found 'a black mold-like substance' at the base of a hose reel behind a water storage tank within one foot of stainless-steel pails used to manufacture the toothpaste, according to the letter. 'Powder residues' were also seen in a stainless-steel tray next to a batch of #TomsSillyStrawberryAnticavity toothpaste.

"The company told the FDA that the room was thoroughly cleaned to remove the black substance and the powder residue, but the FDA called for more to be done."

https://www.today.com/health/recall/toms-of-maine-toothpaste-bacteria-rcna180976

#Toothpaste #ProductRecall #AntibioticResistantBacteria

‘Drug-resistant typhoid is the final warning sign’: disease spreads in Pakistan as antibiotics fail | Global development | The Guardian
https://www.theguardian.com/global-development/2024/sep/24/drug-resistant-typhoid-disease-pakistan-antibiotics-superbugs-children?CMP=Share_iOSApp_Other

#DrugResistantBacteria
#AntimicrobialResistantBacteria
#AntibioticResistance
#Antibiotics
#Typhoid
#TyphoidFever
#Pakistan
#Sanitation
#DirtyDrinkingWater
#CleanDrinkingWater
#DrinkingWater
#Water
#Meropenem

Lolamicin: The Selective antibiotic against Gram-negative infections that spares gut microbiome  
Current antibiotics used in clinical practice, in addition to neutralising target pathogens also harm healthy bacteria in the gut............
#Antibiotics #Gramnegativebacteria #GutBacteria #Lolamicin #microbiome #NewsinBrief
SCIEU Team

https://www.scientificeuropean.co.uk/medicine/lolamicin-the-selective-antibiotic-against-gram-negative-infections-that-spares-gut-microbiome/

18-JUL-2024
Small animals acquire genes from #bacteria that can produce #antibiotics

https://www.eurekalert.org/news-releases/1051402 #science #rotifers #HorizontalGeneTransfer

Katherine Duncan from Strathclyde University:

Linking genes and metabolites for informed antibiotic discovery

#jgi2023 #actinomycetes #streptomyces #antibiotics #jgi

@LBNLBioSci

@rbreich Other major issues at work are: 1. Easy $$ on existing revenue streams protected by gov't rules (FDA, etc) that limit competition; 2. Little C-level $$ incentive to pursue risky research projects (why risk bonus $$?). This has major downstream consequences to world-wide health as evidenced by virtually no #R&D on new #antibiotics & major focus on #diseases that can be addressed by #monoclonal #antibodies, which cost much less for big Pharma to develop. Profit margins on #mAbs are HUGE.

The Gene-Synthesis Revolution - Researchers can now design and mass-produce genetic material — a technique that helped bu... - https://www.nytimes.com/2021/11/24/magazine/gene-synthesis.html #biotechnologyandbioengineering #dna(deoxyribonucleicacid) #biologyandbiochemistry #geneticsandheredity #2021techanddesign #ginkgobioworksinc #syntheticbiology #crispr(dna) #antibiotics #chemistry #bacteria