#antibiotics — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #antibiotics, aggregated by home.social.
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⚛️ Would today’s antibiotics still work if bacterial biology were flipped at the molecular level?
🔗 Molecular Dynamics Simulations Demonstrate Reduced Antibiotic Affinity to Mirror Bacterial Targets. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0198
📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj
#MolecularDynamics #Antibiotics #Biosecurity #ComputationalBiology #SyntheticBiology #DrugDiscovery #AntimicrobialResearch #ComputationalChemistry
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⚛️ Would today’s antibiotics still work if bacterial biology were flipped at the molecular level?
🔗 Molecular Dynamics Simulations Demonstrate Reduced Antibiotic Affinity to Mirror Bacterial Targets. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0198
📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj
#MolecularDynamics #Antibiotics #Biosecurity #ComputationalBiology #SyntheticBiology #DrugDiscovery #AntimicrobialResearch #ComputationalChemistry
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https://www.theguardian.com/environment/2026/jun/03/antibiotics-use-in-livestock-rise-un-fao. "The use of #antibiotics on #livestock will rise by nearly a third in the next 15 years without #Government #intervention, according to new global estimates, with potentially disastrous #impacts on #human #resistance to essential #medicines." The @guardian means #bacterial resistance to medicines used to treat human & #veterinary #diseases!
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Venom and Hot Peppers Offer a Key to Killing Resistant Bacteria
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Andrew Jones and Joshua Prince at Duke University developed a model that replicates #PeripherySequestration in #biofilms by accounting for heterogeneity of antibiotic attachment sites and porosity.
In the image we show how the heterogeneous distribution of the different matrix elements and the #bacteria themselves act as barrier against #antibiotics (in red), hindering their effect.
✏ Check out the paper at: https://www.pnas.org/doi/full/10.1073/pnas.2312995120
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Filamentous Phage Shields https://schaechter.asmblog.org/schaechter/2024/03/filamentous-phage-shields.html @STCmicrobeblog
Phage liquid crystalline droplets form occlusive sheaths that encapsulate and protect infectious rod-shaped #bacteria (2020) https://www.pnas.org/doi/full/10.1073/pnas.1917726117
"in #biofilms and due to the presence of #ExtracellularMatrix #polymers, Pf4 #phage particles form highly ordered yet dynamic #LiquidCrystals (tactoids) that surround the cells. Quite interestingly, these #tactoids confer on the cells an increased tolerance to #antibiotics."
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Mum thought she had chest infection - months later she was diagnosed with 'first cancer of its kind in world'
https://www.msn.com/en-gb/health/other/mum-thought-she-had-chest-infection-months-later-she-was-diagnosed-with-first-cancer-of-its-kind-in-world/ar-BB1k5Fzj?ocid=winp2fptaskbarhover&cvid=e4383d23362f4cd99697124ecea0970c&ei=12#Cancer
#Chest
#Ovaries
#FluidOnTheLung
#ChestInfection
#Antibiotics
#Appendix
#Bowel
#Rectum
#GobletCell
#UniversalCredit
#Donations -
3 days of antibiotics from pharmacists could lead to chronic UTIs, experts warn
https://www.msn.com/en-gb/health/other/3-days-of-antibiotics-from-pharmacists-could-lead-to-chronic-utis-experts-warn/ar-BB1hHNyI?cvid=ced4fc8c028a458efdfbdfc08d7a77c8&ocid=winp2fptaskbarhover&ei=8#Antibiotics
#Pharmacy
#Chemists
#UTIs
#NHSPharmacyFirstScheme
#PharmacyFirstScheme
#ChronicUTIs
#Cystitis
#NICE
#Women
#PharmacistsDefenseAssociation
#BladderHealthUK
#InadequateCourseLength -
We may be losing #cefiderocol far sooner than we hoped.
Timely meta-analysis. Look at those #resistance rates in #carbapenem resistant Enterobacterales!
#microbiology #AMR #antibiotics #antibiotic #CriticalCare #Pseudomonas #Acenitobacter #infectiousdiseases #IDMastodon #medicine
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Important we consider how resistance is selected for these new antibiotics. Need to make them last!
#AMR #cefiderocol #antibiotics #IDMastodon #MedMastodon #cysticfibrosis #antimicrobialstewardship #WAAW2022
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A bit more real-world data on #cefiderocol use.
Outcomes not great but equally it's used in patients with poor expected outcomes. Accurate susceptibility testing clearly also remains an issue. #WAAW2022 #AMR #antibiotics
https://www.sciencedirect.com/science/article/pii/S1198743X22005717