#antibiotics — Public Fediverse posts

As antibiotic resistance grows, researchers are turning to copper as a weapon against bacterial infections

https://phys.org/news/2026-09-antibiotic-resistance-copper-infections.html

#science #health #antibiotics

💊 If antibiotic courses tend to be longer (and thus risker) than necessary, whose responsibility is it to shorten them?

🏥 I argue it's not just doctors that have duties to minimize and shorten antibiotic courses. Why? Because antibiotic prescriptions are influenced by events that occur both before and after a doctor decides whether to order #antibiotics.

📄 Now in The American Journal of #Bioethics: https://doi.org/10.1080/15265161.2026.2709547

🎙️ Free audio and text…

https://byrdnick.com/archives/31046/upon-reflection-ep-17-two-sides-of-shorter-is-better-antibiotic-stewardship

Venom and Hot Peppers Offer a Key to Killing Resistant Bacteria

https://web.brid.gy/r/https://www.wired.com/story/mexican-science-transforms-scorpion-venom-and-habanero-chile-into-antibiotics-against-resistant-bacteria/

#Antibiotics can treat #appendicitis for many patients, no surgery needed
A quarter of a million people get appendicitis every year in the United States, when a blockage or infection inflames the #appendix. For more than a century, doctors treating appendicitis have usually removed the organ, for fear it might rupture and cause severe infection. After 10 years, more than half still did not need an #appendectomy, new data show
https://www.sciencenews.org/article/antibiotics-appendicitis-no-surgery
https://archive.ph/1uhm0

Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.

https://doi.org/10.1039/D6SC00250A

Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

Interesting talk by Lei Wang at #ISCPDD. He talked about the application and synthetic optimization of natural products as #antibiotics against the most relevant #bacteria.

https://www.nature.com/articles/s41467-024-49629-8
#Chemistry #ChemBio #DrugDiscovery

Interesting talk by Yun He at #ISCPDD. He talked about his group’s work on small molecule-drug conjugates for targeting specific cells. Great insights into the use of siderophore conjugates to get molecules into Gram-negative #bacteria.

https://onlinelibrary.wiley.com/doi/10.1002/anie.202204139
#Antibiotics #Chemistry #ChemBio #DrugDiscovery

Go-to #therapy for #chronic #sinus condition doesn't work that well

#Surgery, not #antibiotics, might be the best way to treat chronic #rhinosinusitis, a condition that leaves people with a permanently blocked or #runnynose and a reduced #senseofsmell

https://www.newscientist.com/article/2494299-go-to-therapy-for-chronic-sinus-condition-doesnt-work-that-well/

Lolamicin: The Selective antibiotic against Gram-negative infections that spares gut microbiome  
Current antibiotics used in clinical practice, in addition to neutralising target pathogens also harm healthy bacteria in the gut............
#Antibiotics #Gramnegativebacteria #GutBacteria #Lolamicin #microbiome #NewsinBrief
SCIEU Team

https://www.scientificeuropean.co.uk/medicine/lolamicin-the-selective-antibiotic-against-gram-negative-infections-that-spares-gut-microbiome/

Mum thought she had chest infection - months later she was diagnosed with 'first cancer of its kind in world'
https://www.msn.com/en-gb/health/other/mum-thought-she-had-chest-infection-months-later-she-was-diagnosed-with-first-cancer-of-its-kind-in-world/ar-BB1k5Fzj?ocid=winp2fptaskbarhover&cvid=e4383d23362f4cd99697124ecea0970c&ei=12

#Cancer
#Chest
#Ovaries
#FluidOnTheLung
#ChestInfection
#Antibiotics
#Appendix
#Bowel
#Rectum
#GobletCell
#UniversalCredit
#Donations

A culprit of antibiotic resistance is the agricultural industry, through widespread use of antibiotics. Today, I discovered they also contribute to antifungal resistance.

https://ift.tt/Uv0VACW

#antibioticresistance #antimicrobialresistance #AMR #antifungal #antibiotic #antifungals #antibiotics #antifungalresistance #candidaauris #candida #fungalinfection #agriculture #farming #organic #organicfarming #biologisch

Drug-resistant infection - The agricultural sector has escaped scrutiny

"The issue of untreatable infections is no longer an abstract notion; it is now a reality."

"The Joint Expert Advisory Committee on Antibiotic Resistance (JETACAR) said "the transfer of antibiotic-resistant bacteria along the meat chain is believed to be one of the most significant sources of antibiotic-resistant bacteria from animals", and the scientific consensus since then has only hardened."

"For decades, the meat industry used the drugs with relative abandon. The majority of this use had been not to treat sick animals, but as a key ingredient in animal feed to promote rapid growth and act as a prophylactic."

"JETACAR revealed two-thirds of Australia's antibiotics were being used in animals, and most of that for "subtherapeutic doses" to increase growth, prevent disease and "reduce feed requirements"."

"It was only a few weeks ago, three years into the new strategy, that the Department of Health finally awarded a $438,000 contract to big-four consultancy KPMG for the design of the surveillance system."
>>
https://www.abc.net.au/news/2023-11-28/antibiotic-resistance-amr-growing-threat-no-data/103154464

The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs
https://www.pnas.org/doi/10.1073/pnas.2307773120
#antibiotics #mdr #EmergingPathogens #meat #MeatChain #livestock #industry #animal #antimicrobials #Streptococcus #food #AnimalIndustry #lobbying #BigFour #regulation #OneHealth

UN report on 'silent pandemic' shows factory farming needs an overhaul
#FactoryFarming
#Fertilisers
#pesticides
#Antibiotics
#antimicrobials
#AMR
#SuperBugs
#Plants
#Animals https://www.thecanary.co/global/world-analysis/2023/02/08/un-silent-pandemic-factory-farming/
>To meaningfully tackle the AMR superbug threat, along with most other environmental crises of our time, intensive farming will have to change

#DirectedEvolution is a powerful method but has not been easy to do with gigantic #nonribosomal biocatalysts that make important #antibiotics. We have developed a #microfluidics screen that uses liposomes as sensors for membrane active peptides. Bacteria are grown in tiny droplets. If they make gramicidin S, the sensor liposomes burst, liberate calcein, and generate fluorescence. This was tested for screening mutants and may become a useful tool for directed evolution. https://www.biorxiv.org/content/10.1101/2023.01.13.523969v1

Subcutaneously administered #antibiotics: a review

via Journal of Antimicrobial Chemotherapy

#PKPD

https://academic.oup.com/jac/article-abstract/78/1/1/6827323

Scarlet fever is soaring in UK after pandemic lull; invasive infections kill 8 - Enlarge / A microscope image of Streptococcus pyogenes, a common type o... - https://arstechnica.com/?p=1902735 #invasivegroupastrep #groupastreptococci #respiratoryviruses #infectiousdisease #publichealth #scarletfever #antibiotics #groupastrep #strepthroat #children #science #viruses #strepa #cdc #nhs #uk

RT @PatientAmr: Have a look at the new data from the @ECDC_EU and @EurobarometerEU about the use of #antibiotics.

While the overall use of #antibiotics has decreased, there is still a worrying lack of knowledge about the consequences of #antibioticmisuse.

#KeepAntibiotics #EAAD #WAAW

🐦🔗: https://nitter.eu/ECDC_EU/status/1593736887436394496