#ubiquitin — Public Fediverse posts

Recent studies have shown that ADP-ribosyl modifications can be further modified by #ubiquitin (ADPr-Ub). This study biochemically characterizes the amino acid specificity for ADPr-Ub production and its recognition by E3 ubiquitin ligases @PLOSBiology https://plos.io/4t43UJK

Great talk by Satpal Virdee at #Biochemistry2026. He talked about methods to identify and characterize ubiquitin(-like) E1 and E3 enzymes by crosslinking to tools based on (Ubl-modified) E2s.

https://pubs.acs.org/doi/10.1021/acschembio.5b00118
https://www.nature.com/articles/nchembio.2045
#Biochemistry #ChemBio #ubiquitin #tools #Chemistry
CC: @gdch, @GDCh_BioChem

`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1

#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain

`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1

#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain

`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1

#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain

`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1

#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain

`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1

#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain

Great talk by Martijn Verdoes at the #iCNS meeting. He talked about the many exciting research lines of his group including the work on using the ubiquitination machinery to make highly defined, site-specifically modified antibodies.

https://www.nature.com/articles/s41551-025-01368-x
#Chemistry #ChemBio #antibodies #ubiquitin

Great talk by Bianca van Tol at #NWOCHAINS. She talked about the development of neutron-encoded ubiquitins and diubiquitins to study the linkage selectivity of E2 enzymes, E3 ligases and deubiquitinating enzymes.

https://www.nature.com/articles/s41467-023-37363-6
#Chemistry #ChemBio #Ubiquitin

🧬 Ubiquitin Precursor: A Key to Healthy Aging?
Researchers from the #UniCologne and the Heinrich-Heine-Universität Düsseldorf have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging. This discovery opens up potentially new perspectives for the treatment of cancer and age-related diseases.

Read more ▶️ https://uni.koeln/BLXJA

📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373

#uniköln #unicologne #Research #Ubiquitin #Cancer #Aging #Health #proteostasis

🧬 Ubiquitin-Vorläufer: Ein Schlüssel zum gesunden Altern?
Forscher*innen der #UniKöln und der @HHU haben eine neue Form des Proteins Ubiquitin identifiziert, die für die Proteostase und gesundes Altern verantwortlich ist. Diese Entdeckung eröffnet potenziell neue Perspektiven für die Behandlung von Krebs und altersbedingten Krankheiten.

Mehr dazu ▶️ https://uni.koeln/AALLM

📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373

#uniköln #unicologne #Forschung #Krebs #Altern #Gesundheit #Ubiquitin

🦠🔬 Forschungsteam entdeckt Trick von Bakterien zum Überleben in der Wirtszelle
Ein Forschungsteam der Universität zu Köln und Leiden hat eine Strategie von Bakterien entdeckt, um sich langfristig in Wirtszellen einzunisten. Sie haben herausgefunden, dass spezielle Enzyme es ihnen ermöglichen, die Ubiquitin-Markierung, die sie für die Zerstörung markieren, dauerhaft zu entfernen.

Mehr dazu ➡️ https://uni.koeln/SVNDW

#UniKöln #UniCologne #Bakterien #Ubiquitin #Forschung #Mikrobiologie

Moving averages on the switch, small bins statistics on the router? I like the blinkenlights. #StreamingMedia #Ubiquitin #HomeNetworking

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=83899

Post doc

Lund university

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82914

#hematopoiesis #leukemia #protein_degradation #ubiquitin #ScienceJobs #hiring #research
https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82914

Post doc

Lund university

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82907

#hematopoiesis #leukemia #protein_degradation #ubiquitin #ScienceJobs #hiring #research
https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82907

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=81143

How can the #ubiquitin #ligase APC/C recognize and inactivate the major kinase, CDK1-Cyclin B1, as soon as the spindle checkpoint is switched off?
Luca Cirillo, Rose Young et al identify chromosome as the key platform, recruiting both Cyclin B1 and APC3 via arginine anchor motifs in their sequences
Jon Pines, Claudio Alfieri and coworkers
https://www.embopress.org/doi/full/10.1038/s44318-024-00194-2

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=79736

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#Cancer #research: New Collaborative Research Centre #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE investigates the role of the protein #Ubiquitin in cancer. Funded with 18 million euros @dfg_public
https://nachrichten.idw-online.de/2024/05/31/new-collaborative-research-centre-seeks-innovative-therapies-against-cancer

#Cancer #research: New Collaborative Research Centre #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE investigates the role of the protein #Ubiquitin in cancer. Funded with 18 million euros @dfg_public
https://nachrichten.idw-online.de/2024/05/31/new-collaborative-research-centre-seeks-innovative-therapies-against-cancer

Krebsforschung: Neuer Sonderforschungsbereich #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE erforscht die Rolle des Proteins #Ubiquitin bei Krebserkrankungen. Gefördert mit 18 Mio Euro @dfg_public
https://nachrichten.idw-online.de/2024/05/31/neuer-sonderforschungsbereich-sucht-innovative-therapien-gegen-krebs

Targeted protein degradation #PROTAC is a promising avenue for drug development. This study shows that alkenyl oxindole compounds act as novel #E3ligase ligands & recruit the CRL4-DCAF11 E3 #ubiquitin ligase complex for substrate degradation #PLOSBiology https://plos.io/3WV1U9q

How does E3 #ubiquitin ligase RFDW3 regulate #ReplicationFork progression & stability? This study reveals that RFWD3 ubiquitylates SMARCAL1, disengaging it from RPA, limiting its activity at stalled forks & preventing fork collapse #PLOSBiology https://plos.io/3TsE6q5

PEX5 transports new proteins from cytosol to #peroxisome, where it is reversibly mono-Ub'ed at Cys11 for return to the #cytosol; longer #ubiquitin chains attached to Cys11 are rapidly removed by the enzyme E2D3, ensuring correct function #PLOSBiology https://plos.io/4a9gWf4

How do pro-oncogenic MAGE protein interact with RING #ubiquitin ligases?
Simonne Griffith-Jones, Sagar Bhogaraju et al (EMBL Grenoble) extract molecular insights from paradigm MAGE4A that binds and protects DNA repair E3 RAD18 from autoubiquitination
https://www.embopress.org/doi/full/10.1038/s44318-024-00058-9

Postdoctoral Positions in Plant Proteostasis

RWTH Aachen University

Come and join us! Great opportunity for #postdoc or #phd in @TrujilloLab @RWTH to work in targeted protein degradation #TPD #endocytosis #ubiquitin

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=72561

#end...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=72561

Postdoctoral Positions in Plant Proteostasis

RWTH Aachen University

Come and join us! Great opportunity for #postdoc or #phd in @TrujilloLab @RWTH to work in targeted protein degradation #TPD #endocytosis #ubiquitin

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=71644

#end...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=71644

#Ubiquitin research provides new insights into the cell's labeling machine.

#HACE1 #signalling #RAC1

https://phys.org/news/2024-02-ubiquitin-insights-cell-machine.html

Tagging of proteins for their inducible degradation is a great tool for the study of gene function. A systematic investigation of what sequence triggers protein degradation in #yeast is timely:

https://pubmed.ncbi.nlm.nih.gov/38102142/

#ubiquitin #proteindegradation #molecularbiology #genetics

Global histone H2B degradation regulates #insulin/#IGF signaling-mediated nutrient stress

The #ubiquitin-#proteasome system regulates #histone #H2B exchange in mammalian cells and in C. elegans during development and starvation.

https://www.embopress.org/doi/full/10.15252/embj.2022113328

What can bacteria teach us about unexplored areas of #ubiquitin signaling and regulation?
John Pruneda and colleagues discuss how #pathogens subvert the host cell #ubiquitination system by either adopting or breaking its rules
New review article as #weekendreading!

https://www.embopress.org/doi/full/10.15252/embj.2023114318

#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348

#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348

#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348

#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348

#LncRNA NRON promotes #tumorigenesis by regulating #MDM2/#MDMX heterodimerization and enhancing their #ubiquitin-dependent degradation of multiple #tumorsuppressor proteins
Erwei Song, Man-Li Luo and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022112414

Are there functions specific to #CUL4A and #CUL4B-based #ubiquitin E3 #ligases?

Matthias Peter Lab, Anna Stier et al find a CUL4B-specific N-terminal extension undergoing heavy #mitotic #phosphorylation, and promoting recruitment of a specific set of #DCAF substrate receptors involved in #cytoskeleton regulation

https://www.embopress.org/doi/10.15252/embj.2022112847

Chloroplast protein import is controlled not just by the #ubiquitin-#proteasome system, but also by selective #NBR1-mediated selective #autophagy of translocon components in #Arabidopsis upon UV light or heat stress
https://www.embopress.org/doi/10.15252/embj.2022112534

How are specific dysfunctional #mitochondria removed under steady-state conditions?

Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

https://www.embopress.org/doi/10.15252/embj.2022112767

Tribute to a long-standing member of the Advisory Editorial Board of @embojournal:
Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the #ubiquitin-#proteasome system

https://www.embopress.org/doi/10.15252/embj.2023114222

Termination of STING responses is mediated via #ESCRT- and #ubiquitin-dependent degradation to prevent unwarranted #inflammation
Katherine Balka, Dominic De Nardo et al @monashuni
https://www.embopress.org/doi/10.15252/embj.2022112712

What controls basal, #Parkin-independent #mitophagy?

E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively

https://www.embopress.org/doi/10.15252/embj.2022112799

One root, two root, short root, long root! Root toot!
Ma et al. report that The F-box protein SHORT PRIMARY ROOT in #rice modulates primary #root #meristem activity by targeting SEUSS-LIKE protein for degradation.
https://doi.org/10.1111/jipb.13492
@wileyplantsci
#JIPB #PlantScience #DevBio #ubiquitin