#ubiquitin — Public Fediverse posts

Protein modification network plays vital role in cancer development

A review published in Genes & Diseases highlights the complex interplay between protein arginine methylation and ubiquitination, two…
#NewsBeep #News #Health #Apoptosis #Arginine #AU #Australia #Cancer #Cell #cellbiology #CellProliferation #Gene #Genes #Proliferation #protein #research #Ubiquitin
https://www.newsbeep.com/au/904146/

https://www.europesays.com/ie/626384/ Two-gene interaction reveals metastatic risk in breast cancer #Biomarker #Biomedicine #BreastCancer #cancer #Éire #Enzyme #Gene #Genes #Health #IE #Ireland #Ligase #Metastasis #Reproduction #Research #Ubiquitin

A New Approach For Difficult Cancers

A new drug destroys one of cancer’s most common driver proteins instead of simply blocking it, demonstrating the…
#NewsBeep #News #Health #CA #Canada #first-in-classKRASdegradertrial #KRAS #KRASG12Ddegradersetidegrasib #next-generationKRAStherapy #overcomingKRASinhibitorresistance #pancreaticandlungcancerKRAS #PROTAC-styleKRAStargeting #Setidegrasib #targetedproteindegradationcancer #ubiquitin-proteasomecancerdrugs
https://www.newsbeep.com/ca/848333/

https://www.europesays.com/ie/580916/ New viral library helps scientists study thousands of proteins #Cell #DNA #Éire #Genes #Genetic #Genetics #Hepatitis #HepatitisB #hospital #IE #ImmuneResponse #ImmuneSystem #Ireland #MedicalSchool #medicine #Pandemic #Protein #Research #Science #Therapeutics #Ubiquitin #Virology #virus

Recent studies have shown that ADP-ribosyl modifications can be further modified by #ubiquitin (ADPr-Ub). This study biochemically characterizes the amino acid specificity for ADPr-Ub production and its recognition by E3 ubiquitin ligases @PLOSBiology https://plos.io/4t43UJK

Great talk by Satpal Virdee at #Biochemistry2026. He talked about methods to identify and characterize ubiquitin(-like) E1 and E3 enzymes by crosslinking to tools based on (Ubl-modified) E2s.

https://pubs.acs.org/doi/10.1021/acschembio.5b00118
https://www.nature.com/articles/nchembio.2045
#Biochemistry #ChemBio #ubiquitin #tools #Chemistry
CC: @gdch, @GDCh_BioChem

https://www.europesays.com/ie/322205/ Study elucidates key steps in the ubiquitin tagging of mutated huntingtin protein #Cell #Éire #Gene #Genetic #Genetics #Health #Huntington'sDisease #IE #Ireland #Mutation #Protein #Ubiquitin

`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1

#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain

Great talk by Martijn Verdoes at the #iCNS meeting. He talked about the many exciting research lines of his group including the work on using the ubiquitination machinery to make highly defined, site-specifically modified antibodies.

https://www.nature.com/articles/s41551-025-01368-x
#Chemistry #ChemBio #antibodies #ubiquitin

Great talk by Bianca van Tol at #NWOCHAINS. She talked about the development of neutron-encoded ubiquitins and diubiquitins to study the linkage selectivity of E2 enzymes, E3 ligases and deubiquitinating enzymes.

https://www.nature.com/articles/s41467-023-37363-6
#Chemistry #ChemBio #Ubiquitin

🧬 Ubiquitin Precursor: A Key to Healthy Aging?
Researchers from the #UniCologne and the Heinrich-Heine-Universität Düsseldorf have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging. This discovery opens up potentially new perspectives for the treatment of cancer and age-related diseases.

Read more ▶️ https://uni.koeln/BLXJA

📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373

#uniköln #unicologne #Research #Ubiquitin #Cancer #Aging #Health #proteostasis

🧬 Ubiquitin-Vorläufer: Ein Schlüssel zum gesunden Altern?
Forscher*innen der #UniKöln und der @HHU haben eine neue Form des Proteins Ubiquitin identifiziert, die für die Proteostase und gesundes Altern verantwortlich ist. Diese Entdeckung eröffnet potenziell neue Perspektiven für die Behandlung von Krebs und altersbedingten Krankheiten.

Mehr dazu ▶️ https://uni.koeln/AALLM

📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373

#uniköln #unicologne #Forschung #Krebs #Altern #Gesundheit #Ubiquitin

🦠🔬 Forschungsteam entdeckt Trick von Bakterien zum Überleben in der Wirtszelle
Ein Forschungsteam der Universität zu Köln und Leiden hat eine Strategie von Bakterien entdeckt, um sich langfristig in Wirtszellen einzunisten. Sie haben herausgefunden, dass spezielle Enzyme es ihnen ermöglichen, die Ubiquitin-Markierung, die sie für die Zerstörung markieren, dauerhaft zu entfernen.

Mehr dazu ➡️ https://uni.koeln/SVNDW

#UniKöln #UniCologne #Bakterien #Ubiquitin #Forschung #Mikrobiologie

Moving averages on the switch, small bins statistics on the router? I like the blinkenlights. #StreamingMedia #Ubiquitin #HomeNetworking

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=83899

Post doc

Lund university

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82914

#hematopoiesis #leukemia #protein_degradation #ubiquitin #ScienceJobs #hiring #research
https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82914

Post doc

Lund university

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82907

#hematopoiesis #leukemia #protein_degradation #ubiquitin #ScienceJobs #hiring #research
https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82907

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=81143

How can the #ubiquitin #ligase APC/C recognize and inactivate the major kinase, CDK1-Cyclin B1, as soon as the spindle checkpoint is switched off?
Luca Cirillo, Rose Young et al identify chromosome as the key platform, recruiting both Cyclin B1 and APC3 via arginine anchor motifs in their sequences
Jon Pines, Claudio Alfieri and coworkers
https://www.embopress.org/doi/full/10.1038/s44318-024-00194-2

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=79736

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#Cancer #research: New Collaborative Research Centre #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE investigates the role of the protein #Ubiquitin in cancer. Funded with 18 million euros @dfg_public
https://nachrichten.idw-online.de/2024/05/31/new-collaborative-research-centre-seeks-innovative-therapies-against-cancer

#Cancer #research: New Collaborative Research Centre #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE investigates the role of the protein #Ubiquitin in cancer. Funded with 18 million euros @dfg_public
https://nachrichten.idw-online.de/2024/05/31/new-collaborative-research-centre-seeks-innovative-therapies-against-cancer

Krebsforschung: Neuer Sonderforschungsbereich #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE erforscht die Rolle des Proteins #Ubiquitin bei Krebserkrankungen. Gefördert mit 18 Mio Euro @dfg_public
https://nachrichten.idw-online.de/2024/05/31/neuer-sonderforschungsbereich-sucht-innovative-therapien-gegen-krebs

Targeted protein degradation #PROTAC is a promising avenue for drug development. This study shows that alkenyl oxindole compounds act as novel #E3ligase ligands & recruit the CRL4-DCAF11 E3 #ubiquitin ligase complex for substrate degradation #PLOSBiology https://plos.io/3WV1U9q

How does E3 #ubiquitin ligase RFDW3 regulate #ReplicationFork progression & stability? This study reveals that RFWD3 ubiquitylates SMARCAL1, disengaging it from RPA, limiting its activity at stalled forks & preventing fork collapse #PLOSBiology https://plos.io/3TsE6q5

PEX5 transports new proteins from cytosol to #peroxisome, where it is reversibly mono-Ub'ed at Cys11 for return to the #cytosol; longer #ubiquitin chains attached to Cys11 are rapidly removed by the enzyme E2D3, ensuring correct function #PLOSBiology https://plos.io/4a9gWf4

How do pro-oncogenic MAGE protein interact with RING #ubiquitin ligases?
Simonne Griffith-Jones, Sagar Bhogaraju et al (EMBL Grenoble) extract molecular insights from paradigm MAGE4A that binds and protects DNA repair E3 RAD18 from autoubiquitination
https://www.embopress.org/doi/full/10.1038/s44318-024-00058-9

Postdoctoral Positions in Plant Proteostasis

RWTH Aachen University

Come and join us! Great opportunity for #postdoc or #phd in @TrujilloLab @RWTH to work in targeted protein degradation #TPD #endocytosis #ubiquitin

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=72561

#end...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=72561

Postdoctoral Positions in Plant Proteostasis

RWTH Aachen University

Come and join us! Great opportunity for #postdoc or #phd in @TrujilloLab @RWTH to work in targeted protein degradation #TPD #endocytosis #ubiquitin

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=71644

#end...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=71644

#Ubiquitin research provides new insights into the cell's labeling machine.

#HACE1 #signalling #RAC1

https://phys.org/news/2024-02-ubiquitin-insights-cell-machine.html

Q&A: Research visualizes a precise mechanism for how #cells sort their trash.

#Cullin_RING_ligases #ubiquitin

https://phys.org/news/2024-02-qa-visualizes-precise-mechanism-cells.html

Non-canonical role of the E3 #ubiquitin ligase FBXO3 in PI3K-induced #BreastCancer #metastasis: FBXO3 binds & protects USP4 from DNPEP-mediated degradation, resulting in Twist1 protein stabilization & increased #tumor metastasis #PLOSBiology https://plos.io/3twkOan

Is there a common mechanism underlying pathophysiology of polyalanine expansion mutations?
Gad Vatine, Avraham Ashkenazi and coworkers find proper recognition of polyalanine tracts in #ubiquitin-conjugating E2 enzyme #USE1 important for its #UBA6-dependent charging and degradation of downstream targets
https://www.embopress.org/doi/full/10.1038/s44318-023-00018-9

Tagging of proteins for their inducible degradation is a great tool for the study of gene function. A systematic investigation of what sequence triggers protein degradation in #yeast is timely:

https://pubmed.ncbi.nlm.nih.gov/38102142/

#ubiquitin #proteindegradation #molecularbiology #genetics

From infamy to ingenuity—#bacterial hijack mechanisms as advanced #genetic tools.

#phytoplasma #biotechnology #SAP05 #26S_proteasome #ubiquitin

https://phys.org/news/2023-12-infamy-ingenuitybacterial-hijack-mechanisms-advanced.html

Are you headed for the Keystone Symposium on #Ubiquitin biology next week? So is our editor @HVodermaier - make sure to say Hi and discuss your work with him!

New mouse models by Hamid Kashkar and coworkers show that #ubiquitin ligase activities of #cIAP1/2 regulate #RIPK1 activity for embryonic survival, but not #TNF-induced systemic #inflammation in adult mice

https://www.embopress.org/doi/full/10.15252/embj.2023113614

Global histone H2B degradation regulates #insulin/#IGF signaling-mediated nutrient stress

The #ubiquitin-#proteasome system regulates #histone #H2B exchange in mammalian cells and in C. elegans during development and starvation.

https://www.embopress.org/doi/full/10.15252/embj.2022113328

What can bacteria teach us about unexplored areas of #ubiquitin signaling and regulation?
John Pruneda and colleagues discuss how #pathogens subvert the host cell #ubiquitination system by either adopting or breaking its rules
New review article as #weekendreading!

https://www.embopress.org/doi/full/10.15252/embj.2023114318

How are specific dysfunctional #mitochondria removed under steady-state conditions?

Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

https://www.embopress.org/doi/10.15252/embj.2022112767