#sod1 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #sod1, aggregated by home.social.
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Mutations in SOD1 gene can cause #familialALS in a process involving dissociation of the #SOD1 dimer. This study shows that a novel cyclic thiosulfinate cross-linker can stabilize the SOD1 dimer in vivo, with therapeutic implications for fALS #PLOSBiology https://plos.io/3UpT8yL
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Mutations in SOD1 gene can cause #familialALS in a process involving dissociation of the #SOD1 dimer. This study shows that a novel cyclic thiosulfinate cross-linker can stabilize the SOD1 dimer in vivo, with therapeutic implications for fALS #PLOSBiology https://plos.io/3UpT8yL
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#FDA just approved Qalsody (tofersen) for #ALS with #SOD1 mutation (~2% of ALS cases), based on a ⬇️ of the #biomarker neurofilament (NFL) in the plasma.
🔹 ALS is a progressive neurodegenerative disorder, attacking nerve cells that control voluntary muscles (e.g., breathing)
🔹 Qalsody is given intrathecally (in the spine) with 3 initial doses at 14-day intervals and maintenance every 28 days
🔹 Most common side effects were pain, fatigue, joint pain, ⬆️ white blood cells in the CSF, and muscle pain -
#FDA just approved Qalsody (tofersen) for #ALS with #SOD1 mutation (~2% of ALS cases), based on a ⬇️ of the #biomarker neurofilament (NFL) in the plasma.
🔹 ALS is a progressive neurodegenerative disorder, attacking nerve cells that control voluntary muscles (e.g., breathing)
🔹 Qalsody is given intrathecally (in the spine) with 3 initial doses at 14-day intervals and maintenance every 28 days
🔹 Most common side effects were pain, fatigue, joint pain, ⬆️ white blood cells in the CSF, and muscle pain -
Cover feature in issue 42/2:
#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.comAnd:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2 -
Cover feature in issue 42/2:
#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.comAnd:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2