#splicing — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #splicing, aggregated by home.social.
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https://www.europesays.com/ie/419483/ Toxic RNA drives progressive heart damage in myotonic dystrophy #AnimalModel #Brain #CellularBiology #DNA #Éire #fibrosis #GastrointestinalTract #Gene #Genetic #GeneticDisorder #Health #Heart #HeartDisease #IE #Immunology #Ireland #medicine #Mortality #Muscle #MuscularDystrophy #Mutation #MyotonicDystrophy #Pathology #Physiology #Research #RNA #Splicing
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`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`
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`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`
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`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`
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`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`
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`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`
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What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @PLOSBiology https://plos.io/3Pcs2e6
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FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy
Researchers have discovered that mutations in the FOXJ3 gene act as a “master switch” failure, disrupting how the…
#NewsBeep #News #Health #AU #Australia #Brain #Cell #Cortex #dna #Dysplasia #Epilepsy #Frequency #Gene #Genetic #Genetics #Hospital #Imaging #immunohistochemistry #morphology #Neurology #Neurons #Phenotype #research #SignalingPathway #Splicing #Tsai
https://www.newsbeep.com/au/528775/ -
FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy
Researchers have discovered that mutations in the FOXJ3 gene act as a “master switch” failure, disrupting how the…
#NewsBeep #News #Health #AU #Australia #Brain #Cell #Cortex #dna #Dysplasia #Epilepsy #Frequency #Gene #Genetic #Genetics #Hospital #Imaging #immunohistochemistry #morphology #Neurology #Neurons #Phenotype #research #SignalingPathway #Splicing #Tsai
https://www.newsbeep.com/au/528775/ -
https://www.europesays.com/ie/375815/ FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy #Brain #Cell #Cortex #DNA #Dysplasia #Éire #Epilepsy #Frequency #Gene #Genetic #Genetics #Health #hospital #IE #imaging #Immunohistochemistry #Ireland #Morphology #neurology #Neurons #Phenotype #Research #SignalingPathway #Splicing #Tsai
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https://www.europesays.com/ie/187498/ New clues reveal how gestational diabetes affects offspring #diabetes #DiabetesMellitus #Éire #Genes #Genetic #GestationalDiabetes #Health #IE #Ireland #medicine #Placenta #Pregnancy #Protein #Research #RNA #Splicing
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https://www.europesays.com/uk/445343/ Scientists uncover 53 genetic clues that shape math ability beyond IQ #amygdala #brain #CentralNervousSystem #DNA #Gene #Genes #Genetic #Genetics #Genome #Genomic #NervousSystem #Neuron #Nucleotide #Psychiatry #Research #Science #Splicing #Students #UK #UnitedKingdom
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Insights into clinical features and genetic variants of Cornelia de Lange syndrome in China
Cornelia de Lange syndrome (CdLS) is a rare genetic disorder with symptoms, including facial anomalies (such as fus…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #children #CorneliaDeLangeSyndrome #Craniofacial #Exomesequencing #Gene #Genes #Genetic #geneticdisorder #hair #Microcephaly #Mutation #protein #Research #Science #Splicing #Syndrome
https://www.newsbeep.com/us/119866/ -
Insights into clinical features and genetic variants of Cornelia de Lange syndrome in China
Cornelia de Lange syndrome (CdLS) is a rare genetic disorder with symptoms, including facial anomalies (such as fus…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #children #CorneliaDeLangeSyndrome #Craniofacial #Exomesequencing #Gene #Genes #Genetic #geneticdisorder #hair #Microcephaly #Mutation #protein #Research #Science #Splicing #Syndrome
https://www.newsbeep.com/us/119866/ -
https://www.europesays.com/uk/383971/ Insights into clinical features and genetic variants of Cornelia de Lange syndrome in China #Children #CorneliaDeLangeSyndrome #Craniofacial #ExomeSequencing #Gene #Genes #Genetic #GeneticDisorder #Genetics #Hair #Microcephaly #Mutation #Protein #Research #Science #Splicing #Syndrome #UK #UnitedKingdom
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Alzheimer’s gene risks differ by ancestry, major study reveals 133 new variants
New genome study uncovers 133 previously unknown dementia-linked variants and shows how genetic risks vary across global populations,…
#NewsBeep #News #Genetics #Apolipoprotein #AU #Australia #Dementia #Gene #Genes #Genetic #Genome #Locus #Metabolism #QualityControl #research #Science #Splicing
https://www.newsbeep.com/au/78155/ -
Alzheimer’s gene risks differ by ancestry, major study reveals 133 new variants
New genome study uncovers 133 previously unknown dementia-linked variants and shows how genetic risks vary across global populations,…
#NewsBeep #News #Genetics #Apolipoprotein #dementia #Gene #Genes #Genetic #Genome #Locus #Metabolism #QualityControl #research #Science #Splicing #UK #UnitedKingdom
https://www.newsbeep.com/uk/75695/ -
Alzheimer’s gene risks differ by ancestry, major study reveals 133 new variants
New genome study uncovers 133 previously unknown dementia-linked variants and shows how genetic risks vary across global populations,…
#NewsBeep #News #Health #Apolipoprotein #CA #Canada #Dementia #Gene #genes #Genetic #Genetics #Genome #Locus #Metabolism #QualityControl #research #Splicing
https://www.newsbeep.com/ca/77832/ -
Alzheimer’s gene risks differ by ancestry, major study reveals 133 new variants
New genome study uncovers 133 previously unknown dementia-linked variants and shows how genetic risks vary across global populations,…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #Apolipoprotein #dementia #Gene #Genes #Genetic #Genome #Locus #Metabolism #QualityControl #Research #Science #Splicing
https://www.newsbeep.com/us/90888/ -
Alzheimer’s gene risks differ by ancestry, major study reveals 133 new variants
New genome study uncovers 133 previously unknown dementia-linked variants and shows how genetic risks vary across global populations,…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #Apolipoprotein #dementia #Gene #Genes #Genetic #Genome #Locus #Metabolism #QualityControl #Research #Science #Splicing
https://www.newsbeep.com/us/90888/ -
Australian scientists uncover new way to halt aggressive cancer growth
Australian researchers have discovered a promising new strategy to suppress the growth of aggressive and hard-to-treat cancers by…
#NewsBeep #News #Genetics #AU #Australia #Cancer #Cell #CellDeath #dna #DNADamage #drugdiscovery #Gene #Genes #Genetic #Genome #Liver #MedicalResearch #protein #research #RNA #Science #Splicing #Stomach
https://www.newsbeep.com/au/27669/ -
https://www.europesays.com/uk/298384/ Australian scientists uncover new way to halt aggressive cancer growth #Cancer #Cell #CellDeath #DNA #DNADamage #DrugDiscovery #Gene #Genes #Genetic #Genetics #Genome #liver #MedicalResearch #Protein #Research #rna #Science #Splicing #stomach #UK #UnitedKingdom
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A cold North East wind today (over 20kts) so we did a quick trip to our shipping container, then Jane has been #splicing the first #dyneema main mast chainplate loop (much harder splicing 12mm than 9mm).
After some writing for work I've been working on wiring diagrams (learning and using #QElectroTech). I like that I can pretty easily create basic custom elements such as our Batteries, #Victron boxes etc. -
A cold North East wind today (over 20kts) so we did a quick trip to our shipping container, then Jane has been #splicing the first #dyneema main mast chainplate loop (much harder splicing 12mm than 9mm).
After some writing for work I've been working on wiring diagrams (learning and using #QElectroTech). I like that I can pretty easily create basic custom elements such as our Batteries, #Victron boxes etc. -
A cold North East wind today (over 20kts) so we did a quick trip to our shipping container, then Jane has been #splicing the first #dyneema main mast chainplate loop (much harder splicing 12mm than 9mm).
After some writing for work I've been working on wiring diagrams (learning and using #QElectroTech). I like that I can pretty easily create basic custom elements such as our Batteries, #Victron boxes etc. -
A cold North East wind today (over 20kts) so we did a quick trip to our shipping container, then Jane has been #splicing the first #dyneema main mast chainplate loop (much harder splicing 12mm than 9mm).
After some writing for work I've been working on wiring diagrams (learning and using #QElectroTech). I like that I can pretty easily create basic custom elements such as our Batteries, #Victron boxes etc. -
A cold North East wind today (over 20kts) so we did a quick trip to our shipping container, then Jane has been #splicing the first #dyneema main mast chainplate loop (much harder splicing 12mm than 9mm).
After some writing for work I've been working on wiring diagrams (learning and using #QElectroTech). I like that I can pretty easily create basic custom elements such as our Batteries, #Victron boxes etc. -
Is the #World Ready? - #2025 #SolarStorm : Medium
#MIT #Biologists #Discover a new type of control over #RNA #Splicing : MIT
#Physicists capture a strange #Fractal ‘#Butterfly’ for the first time : New Sci
Check our latest #KnowledgeLinks
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Undersea Cable Repair - The bottom of the sea is a mysterious and inaccessible place, and anything unfortu... - https://hackaday.com/2024/07/30/undersea-cable-repair/ #engineering #originalart #underwater #featured #internet #splicing #cable #ocean #boat
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A 6 months internship (M2) is open in our laboratory for January 2025 to work on #RNA, the genetics and biochemistry of its #splicing, export from the nucleus and degradation in the cytoplasm. With new tools and exciting preliminary results in #Cryptococcus neoformans, an intron-rich and fascinating human #fungal pathogen.
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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#Genes spatially organize for efficient #mRNA #splicing, study shows.
https://phys.org/news/2024-05-genes-spatially-efficient-mrna-splicing.html
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Researchers study role of #post_transcriptional #splicing in #plant response to #light.
#spliceosome #AtPRMT5 #photosynthesis
https://phys.org/news/2024-02-role-transcriptional-splicing-response.html
