#splicing — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #splicing, aggregated by home.social.
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#Recombination suppression leads to genomic erosion via accumulation of deleterious #mutations. This Primer explores a @PLOSBiology study that reveals an massive increase in aberrant #splicing in non-recombining genomic regions in green #algae. Paper: https://plos.io/44vbDFI Primer: https://plos.io/4f6pIQ2
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#Recombination suppression leads to genomic erosion via accumulation of deleterious #mutations. This Primer explores a @PLOSBiology study that reveals an massive increase in aberrant #splicing in non-recombining genomic regions in green #algae. Paper: https://plos.io/44vbDFI Primer: https://plos.io/4f6pIQ2
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#Splicing dysfunction may represent a cryptic form of #genome erosion. This study shows that intron retention freq is much higher in #recombination -suppressed #MatingType regions in 4 #phytoplankton species, producing aberrant transcripts & functional decay @PLOSBiology https://plos.io/44vbDFI
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#Splicing dysfunction may represent a cryptic form of #genome erosion. This study shows that intron retention freq is much higher in #recombination -suppressed #MatingType regions in 4 #phytoplankton species, producing aberrant transcripts & functional decay @PLOSBiology https://plos.io/44vbDFI
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`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`
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`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`
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What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @PLOSBiology https://plos.io/3Pcs2e6
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What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @PLOSBiology https://plos.io/3Pcs2e6
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A cold North East wind today (over 20kts) so we did a quick trip to our shipping container, then Jane has been #splicing the first #dyneema main mast chainplate loop (much harder splicing 12mm than 9mm).
After some writing for work I've been working on wiring diagrams (learning and using #QElectroTech). I like that I can pretty easily create basic custom elements such as our Batteries, #Victron boxes etc. -
A cold North East wind today (over 20kts) so we did a quick trip to our shipping container, then Jane has been #splicing the first #dyneema main mast chainplate loop (much harder splicing 12mm than 9mm).
After some writing for work I've been working on wiring diagrams (learning and using #QElectroTech). I like that I can pretty easily create basic custom elements such as our Batteries, #Victron boxes etc. -
Is the #World Ready? - #2025 #SolarStorm : Medium
#MIT #Biologists #Discover a new type of control over #RNA #Splicing : MIT
#Physicists capture a strange #Fractal ‘#Butterfly’ for the first time : New Sci
Check our latest #KnowledgeLinks
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Is the #World Ready? - #2025 #SolarStorm : Medium
#MIT #Biologists #Discover a new type of control over #RNA #Splicing : MIT
#Physicists capture a strange #Fractal ‘#Butterfly’ for the first time : New Sci
Check our latest #KnowledgeLinks
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Undersea Cable Repair - The bottom of the sea is a mysterious and inaccessible place, and anything unfortu... - https://hackaday.com/2024/07/30/undersea-cable-repair/ #engineering #originalart #underwater #featured #internet #splicing #cable #ocean #boat
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Undersea Cable Repair - The bottom of the sea is a mysterious and inaccessible place, and anything unfortu... - https://hackaday.com/2024/07/30/undersea-cable-repair/ #engineering #originalart #underwater #featured #internet #splicing #cable #ocean #boat
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A 6 months internship (M2) is open in our laboratory for January 2025 to work on #RNA, the genetics and biochemistry of its #splicing, export from the nucleus and degradation in the cytoplasm. With new tools and exciting preliminary results in #Cryptococcus neoformans, an intron-rich and fascinating human #fungal pathogen.
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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#Genes spatially organize for efficient #mRNA #splicing, study shows.
https://phys.org/news/2024-05-genes-spatially-efficient-mrna-splicing.html
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#Genes spatially organize for efficient #mRNA #splicing, study shows.
https://phys.org/news/2024-05-genes-spatially-efficient-mrna-splicing.html
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Hong Cheng and collaborators identify #SAP30BP as a novel critical activator of #CDK11-#CyclinL complexes, required of regulation of pre-mRNA #splicing in cells
https://www.embopress.org/doi/full/10.15252/embj.2023114051 -
Hong Cheng and collaborators identify #SAP30BP as a novel critical activator of #CDK11-#CyclinL complexes, required of regulation of pre-mRNA #splicing in cells
https://www.embopress.org/doi/full/10.15252/embj.2023114051 -
Nice work on #chromatin and #splicing by the lab of Gil Ast:
Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation
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Nice work on #chromatin and #splicing by the lab of Gil Ast:
Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation
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Julia Salzman from Stanford
http://salzmanlab.stanford.edu/now explaining
SPLASH: Statistically Primary aLignment Agnostic Sequence HomingWe want to rapidly survey large #genomic areas, for regulatory sites, #splicing, etc. How do we look at sequencing data today? Through a lens of alignment with reference genomes. This can fail (e.g. cancer cells with shattered genomes, #V(D)J #recombination in immune cells)
Her metaphor: we need ground penetrating radar for #genomics
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Julia Salzman from Stanford
http://salzmanlab.stanford.edu/now explaining
SPLASH: Statistically Primary aLignment Agnostic Sequence HomingWe want to rapidly survey large #genomic areas, for regulatory sites, #splicing, etc. How do we look at sequencing data today? Through a lens of alignment with reference genomes. This can fail (e.g. cancer cells with shattered genomes, #V(D)J #recombination in immune cells)
Her metaphor: we need ground penetrating radar for #genomics
1/2
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We are pleased to announce that registration to this year's annual meeting in memory of Prof. Yossi Sperling is now open, at the link below. The meeting will take place in the Lopatie Hall at the Weizmann Institute on 16 Oct, 2023. We will be celebrating local RNA science, and enjoy contributions from our two wonderful keynote speakers for this year - Marvin Tannenabum and Christin Mayr (see attached poster)
#RNA #mRNA #lncRNA #translation #splicing #transcriptionhttps://erez.weizmann.ac.il/apx/r/ws1/101/101/?P101_PKNS_CODE=2604
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A #transcription-independent mechanism -#RBM10-mediated RNA alternative #splicing coupled to nonsense-mediated #mRNA decay- determines rapid periodic fluctuations of #BRCA1 expression throughout the #cellcycle
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A #transcription-independent mechanism -#RBM10-mediated RNA alternative #splicing coupled to nonsense-mediated #mRNA decay- determines rapid periodic fluctuations of #BRCA1 expression throughout the #cellcycle
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A very nice review on RNA granules from Geraldine Seydoux's lab at Genes & Development.
"RNA granules: functional compartments or incidental condensates?"
#RNA #granules #mRNA #phaseseparation #translation #splicing #Pbodies #StressGranules
#GermGranules -
LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis
Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8
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LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis
Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8
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Can someone suggest software/pipelines for analysis of alternative #splicing from long-read #RNAseq (from #Nanopore #MinION)? Basically, I'd like to quantify abundance of different splicing variants in different samples. #bioinformatics
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#Splicing factor YBX1 regulates bone marrow stromal cell fate during aging
Reduced expression of #YBX1 in #aging #bonemarrow stromal cells induces their #senescence and bone loss due to mRNA mis-splicing
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Postdoctoral position - RNA Biology
https://jobrxiv.org/job/sabnp-laboratory-paris-saclay-university-27778-postdoctoral-position-rna-biology/?feed_id=32872
#ScienceJobs #Life Science #Postdoc #RNA #Splicing #France
Evry, #France #PostdoctoralFellow
https://jobrxiv.org/job/sabnp-laboratory-paris-saclay-university-27778-postdoctoral-position-rna-biology/?feed_id=32872
