#refereedpreprint — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #refereedpreprint, aggregated by home.social.
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Ultrastructure expansion microscopy reveals nanoscale organization of tubulin PTMs in mammalian photoreceptors, and the role of glutamylation balance for ciliary architecture
#RefereedPreprint c/o @ReviewCommons by Virginie Hamel, Paul Guichard @Centriolelab, Carsten Janke et al
https://www.embopress.org/doi/full/10.1038/s44318-024-00284-1 -
Cross-species analysis in Oryzias fish, measuring the timing of embryonic body axis segmentation and overall organismal size, suggests that timing and size control are dissociable modules
Alexander Aulehla, Ewan Birney @ewanbirney et al
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/full/10.1038/s44318-024-00186-2 -
Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics
#RefereedPreprint c/o @ReviewCommons by Véronique Le Cabec, Sébastien Carréno, Renaud Poincloux and colleagues shows that #macrophages do not require the ERM family proteins for phagocytosis and cell migration, suggesting divergence of macrophage cortical properties
https://www.embopress.org/doi/full/10.1038/s44318-024-00173-7
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New #RefereedPreprint c/o @ReviewCommons:
John O’Neill, Andrew Beale and colleauges show that protein homeostasis is maintained by circadian rhythms in protein synthesis and degradation rates, leading to daily proteome renewal
https://www.embopress.org/doi/full/10.1038/s44318-024-00121-5 -
Apicomplexan parasites do have G2 cell cycle phases – as long as they undergo binary division like Toxoplasma gondii!
Lauren Hawkins, Elena Suvorova et al find its control by CDK/cyclin pair Crk4-Cyc4 and a Cdt1-related inhibitor of reduplication
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/full/10.1038/s44318-024-00095-4 -
TLDc-domain proteins Rtc5 and Oxr1 regulate assembly and subcellular localization of the yeast V-ATPase
Ayelén González Montoro and coworkers
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/full/10.1038/s44318-024-00097-2 -
What’s the role of RNAi for antiviral immunity?
Human Dicer lacking its self-restraining helicase domain can in fact activate antiviral and inflammatory responses independent of RNAi#RefereedPreprint c/o @ReviewCommons by Sébastien Pfeffer and colleagues
https://www.embopress.org/doi/full/10.1038/s44318-024-00035-2
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#Centrosome growth in Drosophila embryos is connected to nuclear division cycles and regulated by the cell-cycle oscillator, rather than by a limiting component as in worms
#RefereedPreprint c/o @ReviewCommons by Jordan Raff and coworkers
https://www.embopress.org/doi/full/10.1038/s44318-023-00022-z
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Next #RefereedPreprint c/o @ReviewCommons published in @embojournal
Gönczy et al @epfl_en show that #centriole elimination during C. #elegans #oogenesis occurs in two steps, initiated by loss of central tube protein SAS-1
https://www.embopress.org/doi/full/10.15252/embj.2023115076 -
Next #RefereedPreprint c/o @ReviewCommons published in @embojournal
Gönczy et al @epfl_en show that #centriole elimination during C. #elegans #oogenesis occurs in two steps, initiated by loss of central tube protein SAS-1
https://www.embopress.org/doi/full/10.15252/embj.2023115076 -
Next #RefereedPreprint c/o @ReviewCommons published in @embojournal
Gönczy et al @epfl_en show that #centriole elimination during C. #elegans #oogenesis occurs in two steps, initiated by loss of central tube protein SAS-1
https://www.embopress.org/doi/full/10.15252/embj.2023115076 -
Next #RefereedPreprint c/o @ReviewCommons published in @embojournal
Gönczy et al @epfl_en show that #centriole elimination during C. #elegans #oogenesis occurs in two steps, initiated by loss of central tube protein SAS-1
https://www.embopress.org/doi/full/10.15252/embj.2023115076 -
#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics
#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al
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#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics
#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al
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#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics
#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al
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#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics
#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al
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#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics
#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al
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#Ovariancancer cells lacking tumor suppressor #PTEN require an ARF #GTPase module for #integrin-dependent #invasiveness
A #RefereedPreprint c/o @ReviewCommons by Konstantina Nikolatou, David Bryant et al
https://www.embopress.org/doi/full/10.15252/embj.2023113987 -
#Ovariancancer cells lacking tumor suppressor #PTEN require an ARF #GTPase module for #integrin-dependent #invasiveness
A #RefereedPreprint c/o @ReviewCommons by Konstantina Nikolatou, David Bryant et al
https://www.embopress.org/doi/full/10.15252/embj.2023113987 -
#Ovariancancer cells lacking tumor suppressor #PTEN require an ARF #GTPase module for #integrin-dependent #invasiveness
A #RefereedPreprint c/o @ReviewCommons by Konstantina Nikolatou, David Bryant et al
https://www.embopress.org/doi/full/10.15252/embj.2023113987 -
#Ovariancancer cells lacking tumor suppressor #PTEN require an ARF #GTPase module for #integrin-dependent #invasiveness
A #RefereedPreprint c/o @ReviewCommons by Konstantina Nikolatou, David Bryant et al
https://www.embopress.org/doi/full/10.15252/embj.2023113987 -
How & why are #circadian rhythms maintained in red blood cells? Novel #haemoglobin #oxidation assay reveals it to be linked to body temperature regulation
A #RefereedPreprint c/o @ReviewCommons by John O‘Neill, Michael Hastings and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2023114164 -
New microscopy assay by Sue Biggins and collaborators #fredhutch enables direct observation of coordinated de novo assembly of native #CENPA #nucleosomes driven by several protein cofactors and the AT run content of #centromeric DNA
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023114534 -
New microscopy assay by Sue Biggins and collaborators #fredhutch enables direct observation of coordinated de novo assembly of native #CENPA #nucleosomes driven by several protein cofactors and the AT run content of #centromeric DNA
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023114534 -
New microscopy assay by Sue Biggins and collaborators #fredhutch enables direct observation of coordinated de novo assembly of native #CENPA #nucleosomes driven by several protein cofactors and the AT run content of #centromeric DNA
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023114534 -
New microscopy assay by Sue Biggins and collaborators #fredhutch enables direct observation of coordinated de novo assembly of native #CENPA #nucleosomes driven by several protein cofactors and the AT run content of #centromeric DNA
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023114534 -
Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation
Jan Kadlec Hamida Laroussi et al
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Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway
Jean-Léon Maître and coworkers
#RefereedPreprint c/o @ReviewCommonsProximity of chromosomes to the cell cortex induces excessive contractions of the actomyosin cortex and cell fragmentation in the early mouse embryo
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#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348 -
#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348 -
#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348 -
#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348 -
How can #metabolic & #environmental cues modulate the #DNAdamage response? María Moriel-Carretero et al find master kinase #Tel1/ATM to bind #PI4P at the #Golgi, altering its availability in the nucleus and impacting kinetics, intensity and persistence of DNA DSB responses in yeast and human cells
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How can #metabolic & #environmental cues modulate the #DNAdamage response? María Moriel-Carretero et al find master kinase #Tel1/ATM to bind #PI4P at the #Golgi, altering its availability in the nucleus and impacting kinetics, intensity and persistence of DNA DSB responses in yeast and human cells
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How can #metabolic & #environmental cues modulate the #DNAdamage response? María Moriel-Carretero et al find master kinase #Tel1/ATM to bind #PI4P at the #Golgi, altering its availability in the nucleus and impacting kinetics, intensity and persistence of DNA DSB responses in yeast and human cells
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How can #metabolic & #environmental cues modulate the #DNAdamage response? María Moriel-Carretero et al find master kinase #Tel1/ATM to bind #PI4P at the #Golgi, altering its availability in the nucleus and impacting kinetics, intensity and persistence of DNA DSB responses in yeast and human cells
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#Proteolysis of a subset of DNA-bound proteins #DPCs by the yeast #Wss1 #SPRTN #protease requires the #Cdc48/#p97 adaptor #Ubx5
Audrey Noireterre, Françoise Stutz et al
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#Proteolysis of a subset of DNA-bound proteins #DPCs by the yeast #Wss1 #SPRTN #protease requires the #Cdc48/#p97 adaptor #Ubx5
Audrey Noireterre, Françoise Stutz et al
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#Proteolysis of a subset of DNA-bound proteins #DPCs by the yeast #Wss1 #SPRTN #protease requires the #Cdc48/#p97 adaptor #Ubx5
Audrey Noireterre, Françoise Stutz et al
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#Proteolysis of a subset of DNA-bound proteins #DPCs by the yeast #Wss1 #SPRTN #protease requires the #Cdc48/#p97 adaptor #Ubx5
Audrey Noireterre, Françoise Stutz et al
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The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion
Petr Chlanda and colleagues
Previously a #RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023113578 -
ATP-induced conformational change of #axonemal outer #dynein arms revealed by cryo-electron #tomography
#RefereedPreprint via @ReviewCommons by Takashi Ishikawa et al
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#Transcription #preinitiation complex formation and composition is not as uniform as we thought:
@stark_lab @IMPvienna finds distinct PICs acting at housekeeping genes vs. #developmentally-regulated #promoters in #Drosophila cells
Another former #RefereedPreprint c/o @ReviewCommons
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How is #biomass production controlled during cell growth and the cell cycle?
New assay by Clovis Basier & Paul Nurse @thecrick using unperturbed exponentially growing populations shows how #cellcycle and cell size affect global rates of RNA and protein synthesis in #fissionyeast
#RefereedPreprint c/o @ReviewCommons now published in revised form!
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Regulation of branched versus linear #Arp2/3-generated #actin filaments
#RefereedPreprint via @ReviewCommons by Luyan Cao et al
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How do select pre-#mRNAs escape 3’ end-processing inhibition by #DNAdamage?
Stephan Vagner and colleagues (Institut Curie) invoke rescue by a #cotranscriptional cleavage that allows subsequent #posttranscriptional #polyadenylation site processing in the nucleoplasmNow published, previously a #RefereedPreprint via @ReviewCommons