#centrosomes — Public Fediverse posts

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

Centrosome linker diversity: #Ninein, #Rootletin & #CNap1 contribute specific functions to #centrosome clustering and spindle formation, some of which matter in cells with extra #centrosomes
Laura Theile, Xue Li, Elmar Schiebel et al #UniHeidelberg
https://www.embopress.org/doi/full/10.15252/embj.2021109738

Centrosome linker diversity: #Ninein, #Rootletin & #CNap1 contribute specific functions to #centrosome clustering and spindle formation, some of which matter in cells with extra #centrosomes
Laura Theile, Xue Li, Elmar Schiebel et al #UniHeidelberg
https://www.embopress.org/doi/full/10.15252/embj.2021109738

Spindle in dividing cells,
single when it sleeps.
Bids goodbye in fusing cells,
so many secrets to reveal!
Our Opinion on the cilium-centrosome axis buzzing with activity during fate choice! Now @J_Cell_Sci

#cilia #centrosomes #centriolarsatellites #RNA

https://journals.biologists.com/jcs/article-abstract/136/9/jcs260454/308872/The-cilium-centrosome-axis-in-coupling-cell-cycle?redirectedFrom=fulltext

Welcome to the #Fediverse @BazziLab :blobfoxwave: ! Glad you are here! #Cilia #Centrioles #Centrosomes #DevBiol #Mouse

We know that #centrosomes are not required for mitotic division, so what are they good for?

New preprint from grad student KC Farrell shows that having two duplicated centrosomes at the beginning of #mitosis facilitates rapid bipolar spindle formation. In the absence of centrosomes there is a checkpoint-mediated delay that is required to give enough time to sort things out and assemble the spindle.

#CellBiology
https://www.biorxiv.org/content/10.1101/2022.11.08.515699v1.full.pdf

#introduction
Hello #ScienceMastodon community!

I am a professor at Rockefeller University in #NYC and dean of the graduate school. Interested in all things #science, but especially #CellBiology, #centrosomes, #cilia, #CellCycle, the #cytoskeleton and #microscopy.

I also want to make science a better place for students and postdocs, and am interested in science education, outreach, publishing and policy. #ScienceEducation

Occasional infrared and film #photography posts to keep it interesting

#introduction
Hello #ScienceMastodon community!

I am a professor at Rockefeller University in #NYC and dean of the graduate school. Interested in all things #science, but especially #CellBiology, #centrosomes, #cilia, #CellCycle, the #cytoskeleton and #microscopy.

I also want to make science a better place for students and postdocs, and am interested in science education, outreach, publishing and policy. #ScienceEducation

Occasional infrared and film #photography posts to keep it interesting