#nfkb — Public Fediverse posts

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

Happy to announce this #preprint , the culmination of last 10 years. 🥳

We find that #antimicrobialpeptides are evolved to control specific #microbiome #bacteria. This example is a textbook case of host #immune #evolution being shaped by the microbiome 🦠 which depends on host #ecology.

Thanks for comments! Bit of an experiment: we are posting pre-submit to get feedback 🙂.

https://www.biorxiv.org/content/10.1101/2022.12.23.521774v2.full
#immunity #Drosophila #EvolutionaryBiology #inflammation #NFkB

"Preprint #Immunology #HumanGenetics #PrimaryImmuneDeficiency #NFKB

'We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 genome-wide association studies in 9,611 participants from UK Biobank, we identified NFKB1 as a locus associated with quantitative antibody responses to multiple pathogens including those from the herpes, retro- and polyoma-virus families.'

https://www.medrxiv.org/content/10.1101/2022.11.24.22282707v1

Hi all! Just started and trying to figure out what server is best for me 🙂

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation & #NFkB in #aging and #senescence .

Focus on #Drosophila but work in other #species whenever possible to improve evolutionary context.

Swiss #SNSF mobility fellow in #UoE UK.

Hi all! Just started and trying to figure out what server is best for me 🙂

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation & #NFkB in #aging and #senescence .

Focus on #Drosophila but work in other #species whenever possible to improve evolutionary context.

Swiss #SNSF mobility fellow in #UoE UK.

Hi all! Just started and trying to figure out what server is best for me 🙂

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation & #NFkB in #aging and #senescence .

Focus on #Drosophila but work in other #species whenever possible to improve evolutionary context.

Swiss #SNSF mobility fellow in #UoE UK.

Hi all! Just started and trying to figure out what server is best for me 🙂

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation & #NFkB in #aging and #senescence .

Focus on #Drosophila but work in other #species whenever possible to improve evolutionary context.

Swiss #SNSF mobility fellow in #UoE UK.

Hi all! Just started and trying to figure out what server is best for me 🙂

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation & #NFkB in #aging and #senescence .

Focus on #Drosophila but work in other #species whenever possible to improve evolutionary context.

Swiss #SNSF mobility fellow in #UoE UK.

Didn't spam # properly, but now realize how useful that is in 🐘 #introduction :

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation involved in #NFkB signalling.

Work with #Drosophila incl other #species when possible to improve #evolutionarybiology context.

Swiss #SNSF mobility fellow in #UoE UK.

Didn't spam # properly, but now realize how useful that is in 🐘 #introduction :

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation involved in #NFkB signalling.

Work with #Drosophila incl other #species when possible to improve #evolutionarybiology context.

Swiss #SNSF mobility fellow in #UoE UK.

Didn't spam # properly, but now realize how useful that is in 🐘 #introduction :

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation involved in #NFkB signalling.

Work with #Drosophila incl other #species when possible to improve #evolutionarybiology context.

Swiss #SNSF mobility fellow in #UoE UK.

Didn't spam # properly, but now realize how useful that is in 🐘 #introduction :

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation involved in #NFkB signalling.

Work with #Drosophila incl other #species when possible to improve #evolutionarybiology context.

Swiss #SNSF mobility fellow in #UoE UK.

Didn't spam # properly, but now realize how useful that is in 🐘 #introduction :

I study #immunity #genes and #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are #antibiotics coded by the #genome . A key focus in #microbiome 🦠 , and #inflammation involved in #NFkB signalling.

Work with #Drosophila incl other #species when possible to improve #evolutionarybiology context.

Swiss #SNSF mobility fellow in #UoE UK.