#apoptosis — Public Fediverse posts

https://www.europesays.com/ie/376820/ Enzyme helps maintain retinal progenitor cells during eye development #Apoptosis #Brain #Cell #Chromatin #DNA #DNADamage #Éire #Enzyme #eye #Gene #Genes #IE #Ireland #Laboratory #Neurons #ProgenitorCells #Proliferation #Protein #Research #Science #Technology

`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1

#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain

What are the effects of #centrosome amplification in #cancer? @basto_lab &co show that extra centrosomes prime #OvarianCancer cells for #apoptosis, acting in synergy with #chemotherapy to induce cell death, correlating with improved survival #PLOSBiology https://plos.io/4dbmpD7

~60% of germ cells in #Celegans hermaphrodites are eliminated in meiotic prophase to maintain tissue homeostasis, but how? This study shows that size of meiotic #GermCells is reduced by apical #actomyosin constriction, leading to #apoptosis #PLOSBiology https://plos.io/4g4hpTE

How does the Wnt pathway promote resistance to #DNAdamage induced by #IonizingRadiation? @BenForWard3 &co show that #WntSignaling modulates DNA damage response via EGFR in #Drosophila, protecting cells from #apoptosis induced by DNA ds breaks #PLOSBiology https://plos.io/4dduEiq

How does the Wnt pathway promote resistance to #DNAdamage induced by #IonizingRadiation? @BenForWard3 &co show that #WntSignaling modulates DNA damage response via EGFR in #Drosophila, protecting cells from #apoptosis induced by DNA ds breaks #PLOSBiology https://plos.io/4dduEiq

#Flies 🦟 exposed to #μg conditions show behavioral and #neuronal deficits, #glial alterations, #oxidative damage, and #apoptosis https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01099-3

Glial cells : cells in the central nervous system (brain and spinal cord) and the peripheral nervous system https://en.wikipedia.org/wiki/Glia
Apoptosis : programmed cell #death ☠️ that occurs in multicellular organisms https://en.wikipedia.org/wiki/Apoptosis

#Spaceflight #microgravity

Check out our recent paper on #vascular cell apoptotic vulnerabilities to #cancer therapeutics, including #radiotherapy, #chemotherapy and targeted agents (e.g. #proteasome inhibitors, #BH3mimetics). We find that #EndothelialCells remain primed for #apoptosis throughout development into adulthood and may represent a “weakest link” vulnerability in multiple tissues for development of toxicities. https://www.science.org/doi/full/10.1126/sciadv.abn6579

#Celldeath #CardioOncology #VigiBase #RadioBiology #BH3Profiling

My #Introduction - I am a postdoc doing #Research on #Apoptosis in health and disease, in particular concerning #CardioVascular #Toxicity and #Immunogenic #Celldeath in #CancerTherapy. Transitioning from #HarvardSchoolOfPublicHealth to #UniversityOfGothenburg to start up research on combined #Radiotherapy and #Immunotherapy in #BreastCancer.

#RadioBiology #Cancer #BH3Profiling #Caspases #CardioOncology