#celldeath — Public Fediverse posts

Erebosis is a non-apoptotic, non-autophagic & non-necrotic #CellDeath process in the #Drosophila gut. This study shows that a decrease in cytoplasmic heme is a critical step in initiating #enterocyte erebosis & coordinating cell proliferation @PLOSBiology https://plos.io/4hFGl72

Fully Funded Postdoc Position in Cancer Research
Hebrew University of Jerusalem

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-postdoc-position-in-cancer-research/

#BasicdrugDiscovery #cancer #celldeath #mitochondria #mitophagy #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-postdoc-position-in-cancer-research/?fsp_sid=1313

Fully Funded Postdoc Position in Cancer Research
Hebrew University of Jerusalem

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-postdoc-position-in-cancer-research/

#BasicdrugDiscovery #cancer #celldeath #mitochondria #mitophagy #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-postdoc-position-in-cancer-research/?fsp_sid=683

From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival

#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine

https://youtube.com/shorts/rHr1BIBV5yg?feature=share

Viruses face selective pressures, but some inefficiencies can be masked. @jkpfeiff &co reveal an inefficiency in #norovirus exit from cells that can be overcome by a mutation in the virus NS3 protein, enhancing #CellDeath & progeny release @PLOSBiology https://plos.io/3ZQIDqi

Now available ahead of print! "Disentangling the Factors Selecting for Unicellular Programmed Cell Death" by J. David Van Dyken & Peter C. Zee https://www.journals.uchicago.edu/doi/10.1086/732199

#cellDeath #factors #unicellular

📣 A new star is born in the cilia world and cell death galaxy: Emilia Kieckhöfer brilliantly defended her PhD today! Congratulations!!! 🎉🥳👍

#cilia #necroptosis #bbs #raredisease #ciliopathies #celldeath #apoptosis #kidney #cysts #Nphp #Zilien

@cilia
@SFB1403 @CECAD
@UniKoeln

The Role of Amino Acid Metabolism of Tumor Associated Macrophages in the Development of Colorectal Cancer. https://doi.org/10.3390/cells11244106 #ColorectalCancer #TumorMicroenvironment #AminoAcidMetabolism #TumorAssociatedMacrophages #CellDeath

ER stress induces #caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with #herpes simplex #virus type 2

#HSV type 2 infection promotes #neuronal #celldeath and #inflammatory responses via #ERstress-dependent #gasdermin E activation.

Søren Paludan and colleagues

https://www.embopress.org/doi/full/10.15252/embj.2022113118

Bak is a critical Bcl-2 family executor of #apoptosis. Structural, biochemical & cellular analyses reveal how Pxt1, a male #GermCell-specific protein, recognizes Bak to activate its pro-apoptotic activity and induce #CellDeath #PLOSBiology https://plos.io/43HVjQb

🦠 Although #CellDeath is essential for defense against viral infections, it can also lead to severe disease. Manolis Pasparakis @UniCologne explains more
👉 https://bit.ly/42jdlHS

@HorizonMagEU @CECAD_ @UniCologne_D7
#inflammatorydiseases #immunology https://www.youtube.com/shorts/q2UtCbyhWUg

🐦🔗: https://n.respublicae.eu/ERC_Research/status/1658004326172991488

Join us Thursday, May 11, at noon CT/1 pm ET as Dr. Gerald Crabtree of #StanfordUniversity presents “Rewiring Cancer Drivers to Activate Apoptosis.” Register today. https://bit.ly/SOCC23-MAS #SOCC23 #Stanford #Apoptosis #CellDeath #ChildhoodCancer

#Gasdermins (GSDMs) are pore-forming proteins involved in #CellDeath & #inflammation. @jianbin_ruan explores a #PLOSBiology study of the evolution of GSDMs in metazoa, highlighting the role of GSDME in #pyroptosis. Primer: https://plos.io/3nyd4By Paper: https://plos.io/3p6klcm

#Gasdermins (GSDMs) are pore-forming proteins involved in #CellDeath & #inflammation. @jianbin_ruan explores a #PLOSBiology study of the evolution of GSDMs in metazoa, highlighting the role of GSDME in #pyroptosis. Primer: https://plos.io/3nyd4By Paper: https://plos.io/3p6klcm

#Gasdermins (GSDMs) are pore-forming proteins involved in #CellDeath & #inflammation. @jianbin_ruan explores a #PLOSBiology study of the evolution of GSDMs in metazoa, highlighting the role of GSDME in #pyroptosis. Primer: https://plos.io/3nyd4By Paper: https://plos.io/3p6klcm

A long & winding road.

"However, our efforts to identify a chemical inhibitor of apoptosis floundered. Whatever we tested either did not work or had only a marginal effect. We wondered whether components of the pathway might have built-in redundancies. If so, the project was dead."
#Apoptosis #CellDeath

https://www.science.org/doi/10.1126/sciadv.adi2011#.ZEmbzTtPNQI.twitter

Researchers at #StJude have developed an #algorithm inspired by #evolutionary principles to #design new #protein pairs that interact exclusively. With this approach, it might be possible, for example, to design proteins or short #peptides that can inhibit or activate #celldeath proteins, which would be useful to help treat a variety of #metabolicdiseases. Learn more. https://bit.ly/3ZBy9sr
#StJudeResearch #DataScience

The past 20 years have revealed several new #InnateImmune sensing & #CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential #PLOSBiology https://plos.io/40O9xxQ

The past 20 years have revealed several new #InnateImmune sensing & #CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential #PLOSBiology https://plos.io/40O9xxQ

The past 20 years have revealed several new #InnateImmune sensing & #CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential #PLOSBiology https://plos.io/40O9xxQ

Thirumala-Devi Kanneganti, PhD, has been named a Fellow of the American Association for the Advancement of Science for achievements in innate immunity, developing new concepts in inflammasome biology and identifying an inflammatory cell-death pathway called PANoptosis. https://bit.ly/Kanneganti-AAAS
#StJude #StJudeResearch #Immunology #WomenInSTEM #CellDeath