#brca1 — Public Fediverse posts

Un batterio che tutti abbiamo in bocca viaggia nel sangue, arriva al seno e accelera i tumori. Se poi hai la mutazione BRCA1, le tue cellule gli aprono la porta. Johns Hopkins ha trovato il meccanismo: e collega il dentista all'oncologo in modo inaspettato.

https://www.futuroprossimo.it/2026/03/cancro-al-seno-brca1-e-gengive-il-legame-che-nessuno-notava

#futuroprossimo #BRCA1 #cancro

Un batterio che tutti abbiamo in bocca viaggia nel sangue, arriva al seno e accelera i tumori. Se poi hai la mutazione BRCA1, le tue cellule gli aprono la porta. Johns Hopkins ha trovato il meccanismo: e collega il dentista all'oncologo in modo inaspettato.

https://www.futuroprossimo.it/2026/03/cancro-al-seno-brca1-e-gengive-il-legame-che-nessuno-notava

#futuroprossimo #BRCA1 #cancro

Un batterio che tutti abbiamo in bocca viaggia nel sangue, arriva al seno e accelera i tumori. Se poi hai la mutazione BRCA1, le tue cellule gli aprono la porta. Johns Hopkins ha trovato il meccanismo: e collega il dentista all'oncologo in modo inaspettato.

https://www.futuroprossimo.it/2026/03/cancro-al-seno-brca1-e-gengive-il-legame-che-nessuno-notava

#futuroprossimo #BRCA1 #cancro

Un batterio che tutti abbiamo in bocca viaggia nel sangue, arriva al seno e accelera i tumori. Se poi hai la mutazione BRCA1, le tue cellule gli aprono la porta. Johns Hopkins ha trovato il meccanismo: e collega il dentista all'oncologo in modo inaspettato.

https://www.futuroprossimo.it/2026/03/cancro-al-seno-brca1-e-gengive-il-legame-che-nessuno-notava

#futuroprossimo #BRCA1 #cancro

#GumDisease bacteria can promote #cancer growth in mice
Human #breastcancer cells with a #BRCA1 mutation could be more susceptible to damage, lab experiments suggest
The work suggests that harmful bacteria in the mouth may enter the bloodstream, make a beeline for breast tissue and then whomp healthy cells like a wrecking ball. Previous studies have turned up correlations between oral disease and breast cancer, but “now we have a direct connection”
https://www.sciencenews.org/article/gum-disease-bacteria-breast-cancer
https://archive.ph/XZLwp

#GumDisease bacteria can promote #cancer growth in mice
Human #breastcancer cells with a #BRCA1 mutation could be more susceptible to damage, lab experiments suggest
The work suggests that harmful bacteria in the mouth may enter the bloodstream, make a beeline for breast tissue and then whomp healthy cells like a wrecking ball. Previous studies have turned up correlations between oral disease and breast cancer, but “now we have a direct connection”
https://www.sciencenews.org/article/gum-disease-bacteria-breast-cancer
https://archive.ph/XZLwp

#GumDisease bacteria can promote #cancer growth in mice
Human #breastcancer cells with a #BRCA1 mutation could be more susceptible to damage, lab experiments suggest
The work suggests that harmful bacteria in the mouth may enter the bloodstream, make a beeline for breast tissue and then whomp healthy cells like a wrecking ball. Previous studies have turned up correlations between oral disease and breast cancer, but “now we have a direct connection”
https://www.sciencenews.org/article/gum-disease-bacteria-breast-cancer
https://archive.ph/XZLwp

#GumDisease bacteria can promote #cancer growth in mice
Human #breastcancer cells with a #BRCA1 mutation could be more susceptible to damage, lab experiments suggest
The work suggests that harmful bacteria in the mouth may enter the bloodstream, make a beeline for breast tissue and then whomp healthy cells like a wrecking ball. Previous studies have turned up correlations between oral disease and breast cancer, but “now we have a direct connection”
https://www.sciencenews.org/article/gum-disease-bacteria-breast-cancer
https://archive.ph/XZLwp

#GumDisease bacteria can promote #cancer growth in mice
Human #breastcancer cells with a #BRCA1 mutation could be more susceptible to damage, lab experiments suggest
The work suggests that harmful bacteria in the mouth may enter the bloodstream, make a beeline for breast tissue and then whomp healthy cells like a wrecking ball. Previous studies have turned up correlations between oral disease and breast cancer, but “now we have a direct connection”
https://www.sciencenews.org/article/gum-disease-bacteria-breast-cancer
https://archive.ph/XZLwp

SciTech Chronicles. . . . . . . . .Mar 8th, 2025

https://bit.ly/stc030825

#BRCA1 #BRCA2 #PARPi #cytotoxicity #Basra #Mesopotamia #irrigation #Euphrates #diabetes #gut #beta-cells #C.dubliniensis #ionosphere #thermosphere # Meridian-Project #TIEGCM #kelps #micronutrients #biosorption #phytomining

SciTech Chronicles. . . . . . . . .Mar 8th, 2025

https://bit.ly/stc030825

#BRCA1 #BRCA2 #PARPi #cytotoxicity #Basra #Mesopotamia #irrigation #Euphrates #diabetes #gut #beta-cells #C.dubliniensis #ionosphere #thermosphere # Meridian-Project #TIEGCM #kelps #micronutrients #biosorption #phytomining

Everyone has #BRCA1 and #BRCA2 genes, but mutations in these #genes - which can be inherited - increase the risk of #breast and #ovarian #cancer
#Genetics #Biology #Medical #sflorg
https://www.sflorg.com/2024/03/gen03292401.html

Everyone has #BRCA1 and #BRCA2 genes, but mutations in these #genes - which can be inherited - increase the risk of #breast and #ovarian #cancer
#Genetics #Biology #Medical #sflorg
https://www.sflorg.com/2024/03/gen03292401.html

Everyone has #BRCA1 and #BRCA2 genes, but mutations in these #genes - which can be inherited - increase the risk of #breast and #ovarian #cancer
#Genetics #Biology #Medical #sflorg
https://www.sflorg.com/2024/03/gen03292401.html

Everyone has #BRCA1 and #BRCA2 genes, but mutations in these #genes - which can be inherited - increase the risk of #breast and #ovarian #cancer
#Genetics #Biology #Medical #sflorg
https://www.sflorg.com/2024/03/gen03292401.html

Everyone has #BRCA1 and #BRCA2 genes, but mutations in these #genes - which can be inherited - increase the risk of #breast and #ovarian #cancer
#Genetics #Biology #Medical #sflorg
https://www.sflorg.com/2024/03/gen03292401.html

I #learned from my own #diagnosis you can still get #BreastCancer with no #familyhistory.

The author thought no family history of breast cancer meant she wasn't at risk for the disease. But then she was diagnosed with stage-one #cancer.

#Women #Transgender #LGBTQ #LGBTQIA #Health #Healthcare #Cancer #BreastCancer #BRCA1 #BRCA2

https://www.insider.com/no-family-history-breast-cancer-diagnosis-2023-10

I #learned from my own #diagnosis you can still get #BreastCancer with no #familyhistory.

The author thought no family history of breast cancer meant she wasn't at risk for the disease. But then she was diagnosed with stage-one #cancer.

#Women #Transgender #LGBTQ #LGBTQIA #Health #Healthcare #Cancer #BreastCancer #BRCA1 #BRCA2

https://www.insider.com/no-family-history-breast-cancer-diagnosis-2023-10

I #learned from my own #diagnosis you can still get #BreastCancer with no #familyhistory.

The author thought no family history of breast cancer meant she wasn't at risk for the disease. But then she was diagnosed with stage-one #cancer.

#Women #Transgender #LGBTQ #LGBTQIA #Health #Healthcare #Cancer #BreastCancer #BRCA1 #BRCA2

https://www.insider.com/no-family-history-breast-cancer-diagnosis-2023-10

I #learned from my own #diagnosis you can still get #BreastCancer with no #familyhistory.

The author thought no family history of breast cancer meant she wasn't at risk for the disease. But then she was diagnosed with stage-one #cancer.

#Women #Transgender #LGBTQ #LGBTQIA #Health #Healthcare #Cancer #BreastCancer #BRCA1 #BRCA2

https://www.insider.com/no-family-history-breast-cancer-diagnosis-2023-10

I #learned from my own #diagnosis you can still get #BreastCancer with no #familyhistory.

The author thought no family history of breast cancer meant she wasn't at risk for the disease. But then she was diagnosed with stage-one #cancer.

#Women #Transgender #LGBTQ #LGBTQIA #Health #Healthcare #Cancer #BreastCancer #BRCA1 #BRCA2

https://www.insider.com/no-family-history-breast-cancer-diagnosis-2023-10

A #transcription-independent mechanism -#RBM10-mediated RNA alternative #splicing coupled to nonsense-mediated #mRNA decay- determines rapid periodic fluctuations of #BRCA1 expression throughout the #cellcycle

https://www.embopress.org/doi/full/10.15252/embj.2022111951

Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565

Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565

Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565

Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565

Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565

Mutations of #BRCA1 and #BRCA2 #genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as #ovarian, #breast, #pancreatic and #prostate #cancer.
#Medical #Biology #sflorg
https://www.sflorg.com/2022/11/med11282201.html

Mutations of #BRCA1 and #BRCA2 #genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as #ovarian, #breast, #pancreatic and #prostate #cancer.
#Medical #Biology #sflorg
https://www.sflorg.com/2022/11/med11282201.html

Mutations of #BRCA1 and #BRCA2 #genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as #ovarian, #breast, #pancreatic and #prostate #cancer.
#Medical #Biology #sflorg
https://www.sflorg.com/2022/11/med11282201.html

Mutations of #BRCA1 and #BRCA2 #genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as #ovarian, #breast, #pancreatic and #prostate #cancer.
#Medical #Biology #sflorg
https://www.sflorg.com/2022/11/med11282201.html

Mutations of #BRCA1 and #BRCA2 #genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as #ovarian, #breast, #pancreatic and #prostate #cancer.
#Medical #Biology #sflorg
https://www.sflorg.com/2022/11/med11282201.html

Here's a Friday afternoon #science image for everyone to be in awe of, harvested from one of my open browser tabs.

#BRCA1 is a gene responsible for DNA repair, and those who inherit a #mutation in BRCA1 are predisposed to developing #cancer.

Understanding how mutations alter BRCA1 function is important, so publications like this one are vital: https://doi.org/10.1038/s41586-018-0461-z

The authors created every possible mutation in BRCA1 to see its effect, and they summarized the results in this figure.