#glycosylation — Public Fediverse posts

Gut #bacteria can alter #brain #proteins: New #glycosylation method uncovers link.

#microbiome

https://phys.org/news/2025-02-gut-bacteria-brain-proteins-glycosylation.html

The #evolution of #hemagglutinin-158 and #neuraminidase-88 #glycosylation sites modulates antigenicity and #pathogenicity of clade 2.3.2.1 #H5N1 avian #influenza viruses, https://etidiohnew.blogspot.com/2024/12/the-evolution-of-hemagglutinin-158-and.html

Immune Evasion, #Cell-Cell #Fusion, and #Spike Stability of the #SARS-CoV-2 #XEC #Variant: Role of #Glycosylation #Mutations at the N-terminal Domain

Source: BioRxIV, AbstractSARS-CoV-2 continues to evolve, producing new variants that drive global COVID-19 surges. XEC, a recombinant of KS.1.1 and KP.3.3, contains T22N and F59S mutations in the spike protein's N-terminal domain (NTD). The T22N mutation, similar to the DelS31 mutation in KP.3.1.1, introduces a potential…

https://etidioh.wordpress.com/2024/11/14/immune-evasion-cell-cell-fusion-and-spike-stability-of-the-sars-cov-2-xec-variant-role-of-glycosylation-mutations-at-the-n-terminal-domain/

Glycosylation Modulates the Structure and Functions of Collagen: A Review (2024)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11012932/

#collagen #ConnectiveTissue #ExtracellularMatrix #glycosylation #glycobiology

#Hemagglutinin #glycosylation pattern-specific effects: implications for the #fitness of H9.4.2.5-branched #H9N2 avian #influenza viruses, Emerg Microbes Infect.: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2364736

Overall, our study provides a systematic insight into how changes in HA glycosylation patterns regulate the evolutionary fitness and epidemiological dominance drift of h9.4.2.5-branched H9N2 AIVs, which will be of great benefit for the glycosylation-dependent vaccine design.

Avian #influenza virus #NA #stalk length & #HA #glycosylation patterns reveal molecularly directed #reassortment promoting emergence of highly pathogenic #clade 2.3.4.4b A (#H5N1) viruses http://biorxiv.org/cgi/content/short/2024.05.22.595329v1?rss=1

These observations led us to establish and validate hypothesis that pairing of avian virus HA & NA subtypes is not stochastic but is rather molecularly programmed by HA glycosylation & NA stalk length, modulating fitness & emergence of novel avian influenza viruses.

Many #Asgard #Archaea have a multiprotein complex #oligosaccharyltransferase https://www.nature.com/articles/s41586-023-06186-2 This is wild! The established view was that the ancestral eukaryote had a single protein Stt3 enzyme and subunits were added during eukaryotic evolution to regulate #glycosylation.

The #MGAT5 #glycosylation #enzyme plays a crucial role in #brain development, according to a study by University of California, Irvine researchers, a discovery that may contribute to new therapeutic purposes for #neural stem cells.
#Neuroscience #Biology #sflorg
https://www.sflorg.com/2023/05/ns05162301.html

Do you know the mammalian monosaccharides? Most people who know their #aminoacids and #nucleotides answer no to this quesion... Want to learn? Download our new #glycogang #glycotime poster today! http://glyco-alberta.ca/educational-resources/ (in the for educators tab). Learn more about #glycosylation #education #biochemistry

'Blockade of the inhibitory FcγRIIB in combination with anti–PD-L1 improved antitumor responses. Similarly, afucosylation of the IgG1 Fc region improved antitumor responses, and this was due to alterations in the tumor microenvironment.'

#immunology #immunotherapy #glycosylation

https://www.science.org/doi/10.1126/sciimmunol.add8005

Cover feature in issue 42/2:

#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.com

And:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2

What determines specificity of #flagellin #glycosylation in #bacteria?
Patrick Viollier, Nicolas Kint et al reveal #stereoisomer selectivity wired into species-specific C-terminal domain of #FlmG #glycosyltransferases

https://www.embopress.org/doi/10.15252/embj.2022112880

"Our results suggest that, in a cellular context, Fab glycans inhibit IgG–hFcRn interaction and thus negatively affect the transplacental transfer of IgG. As Fab-glycosylated Abs are frequently associated with autoimmune and malignant disorders and may be potentially harmful, this might encompass a regulatory mechanism, limiting the half-life and transport of such Abs."

#immunology #glycosylation

https://journals.aai.org/jimmunol/article-abstract/210/2/158/237585/IgG-Fab-Glycans-Hinder-FcRn-Mediated-Placental?redirectedFrom=fulltext

#Introduction time! I'm a professor at the #UniversityOfQueensland interested in #glycosylation #glycotime #MassSpectrometry #virology #yeast #wine and #beer! https://scmb.uq.edu.au/profile/75/benjamin-schulz

May also have traces of #chickens #cats #dogs and #fungi

An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.