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GLP-1 users say the drugs quiet food noise but do not replace lifestyle change

Interviews with patients across 15 US states revea…
#dining #cooking #diet #food #Food #cardiovasculardisease #chronic #Diabetes #drugs #Efficacy #Glucagon #glucagonlikepeptide1 #Healthcare #metabolism #nausea #obesity #receptor #Research #sleep #stomach #type2diabetes #weightloss #WeightManagement
https://www.diningandcooking.com/2676729/glp-1-users-say-the-drugs-quiet-food-noise-but-do-not-replace-lifestyle-change/

GLP-1 users say the drugs quiet food noise but do not replace lifestyle change https://www.diningandcooking.com/2676729/glp-1-users-say-the-drugs-quiet-food-noise-but-do-not-replace-lifestyle-change/ #CardiovascularDisease #chronic #Diabetes #diet #drugs #Efficacy #food #Glucagon #GlucagonLikePeptide1 #Healthcare #metabolism #nausea #obesity #receptor #Research #sleep #stomach #Type2Diabetes #WeightLoss #WeightManagement

Multiple Entities Show Peak Performance in Recent Exhibitions

Siege Courageous, Kalamitsi, Power Of Beauty, and Valiant Stream show strong performance in recent reports up to April 2026. Find out why.

#SiegeCourageous, #Efficacy, #PerformanceReport, #April2026, #AnimalRacing

https://newsletter.tf/siege-courageous-peak-performance-april-2026/

Siege Courageous and other entities like Kalamitsi and Power Of Beauty have shown top performance in recent exercises. This is a continuation of strong showings seen since late 2024.

#SiegeCourageous, #Efficacy, #PerformanceReport, #April2026, #AnimalRacing
https://newsletter.tf/siege-courageous-peak-performance-april-2026/

"Idk, I think it's less about empathy or compassion, and more about making sure the (hopefully small) group of uncaring people who enter medicine or allied health professions are incentivised to act pro-socially.
Like, in your region, what studying conditions and working conditions are clinicians expected to tolerate? Do they receive a living wage throughout study and work? Is their livelihood for a single person or big enough they can build a household?

Do they feel comfortable being a whistleblower when something goes wrong? (Numbers-wise, mistakes will happen over time.)
How robust is the inspection or regulation? How flexible are the logistics of each sector?
How many crises at once can be weathered without change to patient care? How long will it take to build back up that 'extra' capacity / contingency margin?

Who (in what position, in which teams) is responsible (or in what order) for noticing angels of death? What about anyone with less final but still harmful motives?

How severe are the consequences for failure? How many people feel compelled to hide errors rather than remedy them? What options for remediation are accessible to all staff, including contractors?"

#MedMastodon #DoLessHarm #SystemsThinking #HarmReduction #Medical #Medicine #MD #Systems #NonExpert #LayPerson #RubberNecking #Risk #RiskAssessment #RiskManagement #Risk_Management #Audit #Efficiency #Efficacy #Flexibility #TrueCrime #Crime

"Idk, I think it's less about empathy or compassion, and more about making sure the (hopefully small) group of uncaring people who enter medicine or allied health professions are incentivised to act pro-socially.
Like, in your region, what studying conditions and working conditions are clinicians expected to tolerate? Do they receive a living wage throughout study and work? Is their livelihood for a single person or big enough they can build a household?

Do they feel comfortable being a whistleblower when something goes wrong? (Numbers-wise, mistakes will happen over time.)
How robust is the inspection or regulation? How flexible are the logistics of each sector?
How many crises at once can be weathered without change to patient care? How long will it take to build back up that 'extra' capacity / contingency margin?

Who (in what position, in which teams) is responsible (or in what order) for noticing angels of death? What about anyone with less final but still harmful motives?

How severe are the consequences for failure? How many people feel compelled to hide errors rather than remedy them? What options for remediation are accessible to all staff, including contractors?"

#MedMastodon #DoLessHarm #SystemsThinking #HarmReduction #Medical #Medicine #MD #Systems #NonExpert #LayPerson #RubberNecking #Risk #RiskAssessment #RiskManagement #Risk_Management #Audit #Efficiency #Efficacy #Flexibility #TrueCrime #Crime

Nanovaccine design boosts immune attack on HPV tumors

Throughout the past decade, Northwestern University scientists have uncovered a striking principle of vaccine design: Performance depends not…
#NewsBeep #News #Health #Antigen #AU #Australia #Cancer #Cell #CpG #dna #Drugs #Efficacy #headandneckcancer #ImmuneSystem #medicine #Molecule #Nanomedicine #Nanoparticle #Neck #NucleicAcid #Receptor #research #T-Cell #Tumor #Vaccine
https://www.newsbeep.com/au/474531/

Nanovaccine design boosts immune attack on HPV tumors

Throughout the past decade, Northwestern University scientists have uncovered a striking principle of vaccine design: Performance depends not…
#NewsBeep #News #Health #Antigen #AU #Australia #Cancer #Cell #CpG #dna #Drugs #Efficacy #headandneckcancer #ImmuneSystem #medicine #Molecule #Nanomedicine #Nanoparticle #Neck #NucleicAcid #Receptor #research #T-Cell #Tumor #Vaccine
https://www.newsbeep.com/au/474531/

A common diabetes drug may prevent long COVID when taken early

Large clinical trials and real-world data point to a familiar diabetes drug as a simple, safe way to…
#NewsBeep #News #Health #AU #Australia #chestpain #coronavirus #covid-19 #diabetes #Efficacy #Fatigue #Healthcare #infectiousdiseases #Laboratory #medicine #metformin #Pain #pandemic #Placebo #Respiratory #SARS #SARS-CoV-2 #SevereAcuteRespiratory #SevereAcuteRespiratorySyndrome #Syndrome #virus
https://www.newsbeep.com/au/455705/

A common diabetes drug may prevent long COVID when taken early

Large clinical trials and real-world data point to a familiar diabetes drug as a simple, safe way to…
#NewsBeep #News #Health #AU #Australia #chestpain #coronavirus #covid-19 #diabetes #Efficacy #Fatigue #Healthcare #infectiousdiseases #Laboratory #medicine #metformin #Pain #pandemic #Placebo #Respiratory #SARS #SARS-CoV-2 #SevereAcuteRespiratory #SevereAcuteRespiratorySyndrome #Syndrome #virus
https://www.newsbeep.com/au/455705/

🚨 In a new #preprint with Walid El-Ajou & Isabelle Stadelmann-Steffen, we report on an experiment using a #SeriousGame as an #immersive #information #treatment to understand the role of #knowledge and #efficacy in #PublicOpinion formation on the #GreenTransition #EnergySky #politicalscience

📖 osf.io/x5u6b

💬 Feedback welcome!

🚨 In a new #preprint with Walid El-Ajou & Isabelle Stadelmann-Steffen, we report on an experiment using a #SeriousGame as an #immersive #information #treatment to understand the role of #knowledge and #efficacy in #PublicOpinion formation on the #GreenTransition #EnergySky #politicalscience

📖 osf.io/x5u6b

💬 Feedback welcome!

Protective #efficacy of a genetically modified attenuated #vaccinia virus #Tiantan strain against #monkeypox virus challenge in a small animal #model, https://etidiohnew.blogspot.com/2026/01/protective-efficacy-of-genetically.html

Protective #efficacy of a genetically modified attenuated #vaccinia virus #Tiantan strain against #monkeypox virus challenge in a small animal #model, https://etidiohnew.blogspot.com/2026/01/protective-efficacy-of-genetically.html

Over 80% of Sunscreen Performed Below Their Labelled Efficacy

https://www.consumer.org.hk/en/press-release/528-sunscreen-test

#HackerNews #sunscreen #safety #sunscreen #efficacy #consumer #awareness #skincare #health

Over 80% of Sunscreen Performed Below Their Labelled Efficacy

https://www.consumer.org.hk/en/press-release/528-sunscreen-test

#HackerNews #sunscreen #safety #sunscreen #efficacy #consumer #awareness #skincare #health

Long-term #efficacy of an inactivated #H5N1 whole-particle #influenza #vaccine in nonhuman #primates, https://etidiohnew.blogspot.com/2025/07/long-term-efficacy-of-inactivated-h5n1.html

Long-term #efficacy of an inactivated #H5N1 whole-particle #influenza #vaccine in nonhuman #primates, https://etidiohnew.blogspot.com/2025/07/long-term-efficacy-of-inactivated-h5n1.html

AI turns old diabetes drug Halicin into a potent weapon against superbugs

Can an AI-repurposed diabetes drug tackle our toughest superbugs? Researchers reveal Halicin’s powerful actio…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Artificialintelligence #AI #antibacterialtherapy #antibiotic #ArtificialIntelligence #Assay #Bacteria #Bacterial #Diabetes #Drugdiscovery #E.coli #Efficacy #medicine #Pharmaceuticals #Staphylococcusaureus #Technology
https://www.newsbeep.com/us/25151/

Wear a respirator or good quality face mask. Yes, you can develop Long Covid.
Yes, you are at risk of infecting other people.
Yes, you may host the next new coronavirus variant.
You are not magic, but you have people around you who care about you.
You interact with other people who have others who care about them.

Act like the responsible person you want to believe you are.
Mask up, don a respirator, or pretend you're a secret agent, astronaut, cosmonaut, laboratory scientist, or whatever else.

Reduce your health hazards towards living beings around you.
(Cats and dogs can get covid too.
Filtered air reduces infections for colds, influenza viruses, and other pathogens.)

Me when outside or talking to anyone: https://lgbtqia.space/@[email protected]/114727553231833613

#CovidIsNotOver #corona #viral #InfectionPrevention #epidemiology #PublicHealth #responsibility #care #empathy #efficacy #impact #sci #SciPost #science #ScienceMastodon #research #real #reality #comfort

Wear a respirator or good quality face mask. Yes, you can develop Long Covid.
Yes, you are at risk of infecting other people.
Yes, you may host the next new coronavirus variant.
You are not magic, but you have people around you who care about you.
You interact with other people who have others who care about them.

Act like the responsible person you want to believe you are.
Mask up, don a respirator, or pretend you're a secret agent, astronaut, cosmonaut, laboratory scientist, or whatever else.

Reduce your health hazards towards living beings around you.
(Cats and dogs can get covid too.
Filtered air reduces infections for colds, influenza viruses, and other pathogens.)

Me when outside or talking to anyone: https://lgbtqia.space/@[email protected]/114727553231833613

#CovidIsNotOver #corona #viral #InfectionPrevention #epidemiology #PublicHealth #responsibility #care #empathy #efficacy #impact #sci #SciPost #science #ScienceMastodon #research #real #reality #comfort

Mediterranean plants show promise for cardiovascular disease treatment

A study initiated from a final degree project at the Universitat Autònoma de Barce…
#dining #cooking #diet #food #mediterranean #MediterraneanDiet #MediterraneanFood #atherosclerosis #drugs #Efficacy #Garlic #Mediterranean #Mortality #Pharmacology #Pharmacy #Preclinical #Research #Saffron #Therapeutics #toxicology
https://www.diningandcooking.com/2139856/mediterranean-plants-show-promise-for-cardiovascular-disease-treatment/

Immunogenicity and protective #efficacy of an #intranasal NA-based #influenza virus #vaccine adjuvanted ..., https://etidiohnew.blogspot.com/2025/02/immunogenicity-and-protective-efficacy.html

Immunogenicity and protective #efficacy of an #intranasal NA-based #influenza virus #vaccine adjuvanted ..., https://etidiohnew.blogspot.com/2025/02/immunogenicity-and-protective-efficacy.html

#Efficacy and #safety of #sipavibart for #prevention of #COVID19 in individuals who are immunocompromised (SUPERNOVA)..., https://etidiohnew.blogspot.com/2025/02/efficacy-and-safety-of-sipavibart-for.html

#Efficacy and #safety of #sipavibart for #prevention of #COVID19 in individuals who are immunocompromised (SUPERNOVA)..., https://etidiohnew.blogspot.com/2025/02/efficacy-and-safety-of-sipavibart-for.html

#Efficacy of the #H7N9 #vaccine as a candidate for the #Korean avian #influenza #antigen bank

Source: Veterinary Immunology and Immunopathology, AbstractThe avian influenza A virus (H7N9), first detected in China in 2013, is a zoonotic virus that remains persistent in bird populations despite a decline in human cases owing to control measures. Therefore, this study aimed to develop a vaccine as one preventive strategy in anticipation of the potential entry of H7N9 into…

https://etidioh.wordpress.com/2024/11/03/efficacy-of-the-h7n9-vaccine-as-a-candidate-for-the-korean-avian-influenza-antigen-bank/

#Efficacy of the #H7N9 #vaccine as a candidate for the #Korean avian #influenza #antigen bank

Source: Veterinary Immunology and Immunopathology, AbstractThe avian influenza A virus (H7N9), first detected in China in 2013, is a zoonotic virus that remains persistent in bird populations despite a decline in human cases owing to control measures. Therefore, this study aimed to develop a vaccine as one preventive strategy in anticipation of the potential entry of H7N9 into…

https://etidioh.wordpress.com/2024/11/03/efficacy-of-the-h7n9-vaccine-as-a-candidate-for-the-korean-avian-influenza-antigen-bank/

#Treatment #efficacy of #cidofovir & #brincidofovir vs clade II #mpox virus isolates, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224002043?via%3Dihub

Cidofovir & brincidofovir display broad-spectrum #antiviral activity vs MPXV clades I, IIa, and IIb in vitro. Systemic administration of active compound cidofovir prevents MPXV replication in mouse #respiratory tract. Oral treatment with brincidofovir limits viral replication in vivo vs a non-lethal MPXV clade IIb challenge.

#Treatment #efficacy of #cidofovir & #brincidofovir vs clade II #mpox virus isolates, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224002043?via%3Dihub

Cidofovir & brincidofovir display broad-spectrum #antiviral activity vs MPXV clades I, IIa, and IIb in vitro. Systemic administration of active compound cidofovir prevents MPXV replication in mouse #respiratory tract. Oral treatment with brincidofovir limits viral replication in vivo vs a non-lethal MPXV clade IIb challenge.

Immunogenicity and #efficacy of #XBB15 rS #vaccine against the #EG51 #variant of #SARS-CoV-2 in Syrian #hamsters, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00528-24?af=R

Thus, based on these study results, the protein-based XBB.1.5 vaccine is immunogenic and increased the breadth of protection against the Omicron EG.5.1 variant in the Syrian hamster model.

Immunogenicity and #efficacy of #XBB15 rS #vaccine against the #EG51 #variant of #SARS-CoV-2 in Syrian #hamsters, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00528-24?af=R

Thus, based on these study results, the protein-based XBB.1.5 vaccine is immunogenic and increased the breadth of protection against the Omicron EG.5.1 variant in the Syrian hamster model.

Fc-dependent protective #efficacy of non-inhibitory #antibodies targeting #influenza A virus #neuraminidase is limited by epitope availability, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.09.03.611041v1

We aimed to isolate Abs with cross-subtype reactivity vs human #H1N1 & #H3N2 IAVs from transgenic #mice bearing genes encoding human Ig variable regions. We immunized these mice with recombinant N1 & N2 NA proteins, presenting them either as unconjugated soluble proteins or conjugated protein nanoparticles.

Fc-dependent protective #efficacy of non-inhibitory #antibodies targeting #influenza A virus #neuraminidase is limited by epitope availability, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.09.03.611041v1

We aimed to isolate Abs with cross-subtype reactivity vs human #H1N1 & #H3N2 IAVs from transgenic #mice bearing genes encoding human Ig variable regions. We immunized these mice with recombinant N1 & N2 NA proteins, presenting them either as unconjugated soluble proteins or conjugated protein nanoparticles.

#Efficacy of late-onset #antiviral #treatment in immunocompromised hosts with persistent #SARS-CoV-2 infection, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00905-24?af=R

These data indicate that late-onset DAA therapy significantly shortens #duration of persistent virus #replication in an immunocompromised host, which may have implications for clinical use of antiviral therapeutics to alleviate the risk of progression to severe disease in highly vulnerable patients.

#Efficacy of late-onset #antiviral #treatment in immunocompromised hosts with persistent #SARS-CoV-2 infection, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00905-24?af=R

These data indicate that late-onset DAA therapy significantly shortens #duration of persistent virus #replication in an immunocompromised host, which may have implications for clinical use of antiviral therapeutics to alleviate the risk of progression to severe disease in highly vulnerable patients.

#Safety & #efficacy of PfSPZ #Vaccine against #malaria in healthy adults and women anticipating pregnancy in #Mali: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00360-8/fulltext?rss=yes

PfSPZ Vaccine without presumptive antimalarial treatment before the first vaccine dose did not show efficacy.

#Efficacy and #safety of #Butantan-DV {#dengue #vaccine} in participants aged 2–59 years through an extended follow-up: results from a double-blind, randomised, placebo-controlled, phase 3, multicentre trial in #Brazil https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00376-1/fulltext?rss=yes

A single dose of Butantan-DV was generally well tolerated & efficacious vs symptomatic VCD (caused by DENV1 & DENV2) for a mean of 3·7 yrs.

#Efficacy of commercial #recombinant HVT #vaccines against a North #American clade 2.3.4.4b #H5N1 highly pathogenic avian #influenza virus in #chickens, PLOS One: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0307100

Both vaccines provided #protection from challenge to both types of chickens and ELLA-NI was sensitive at identifying #antibodies to the challenge virus therefore should be evaluated further for DIVA-VI.

An ex vivo #human precision-cut #lung slice #platform provides insight into #SARS-CoV-2 #pathogenesis and #antiviral drug #efficacy, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00794-24?af=R

We identified early induction of specific #cytokines, especially IP-10 and IL-8, as potential predictors for severe #COVID19, & uncovered a hitherto unrecognized phenomenon that while infectious virus disappears at late times of infection, viral #RNA persists and lung histopathology commences.

A unifying #model to explain frequent #SARS-CoV-2 #rebound after #nirmatrelvir #treatment and limited prophylactic #efficacy https://www.nature.com/articles/s41467-024-49458-9

Here authors develop a mathematical model for viral-immune dynamics & nirmatrelvir #pharmacokinetics and suggest that early treatment preserves susceptible cells & blunts innate immune response without fully eliminating infection. They project that treatment extension for 10 days may overcome this effect.

There are no laws

There are no laws. You have to be in the moment. You have to understand the circumstances you’re in. Learning to adapt to each new circumstance means seeing events through your own eyes, and often ignoring the advice that people constantly peddle your way. It means that ultimately you must throw out the laws that others preach, and the books they write to tell you what to do, and the sage advice of the elder.

~ Robert Greene

slip:4a1028.

What happens now

Do not bother about what will happen someday, somewhere, in the far away distance, in a future time; think and be very attentive to what happens now, here, in this place.

~ John Ruskin

slip:4a1008.

Speak more

If you want to stop a person from action, ask him to speak more on the topic. The more people speak, the less desire they have to act.

~ Thomas Carlyle

slip:4a973.

Discontent

This is discontent, but it is not the discontent of pessimism. It is noble discontent which is the secret of progress. Only the pusillanimous are content. Heart’s desires are divine discontents. Only the unsatisfied do things. The satisfied do nothing. Unsatisfaction is the stimulus to achievement. Satisfaction is destruction and leads down to the chamber of death.

~ Jack London

slip:4a928.

Thought and action

Please remember I am talking about the world as it is. The men who act without thinking, and the men who both think and act, are the ones who mould the world. The man who thinks and does not act never moulds the world. He may think that he does—but that, too, is only a thought, the thought of a deedless, actionless thinker.

~ Jack London

slip:4a923.

Effectiveness

Focus on effectiveness—what your actions will actually accomplish—and not self-actualization or other ways of trying to feel good about yourself.

~ Steven Pinker

slip:4a798.

Motivation versus validation

A great number of bits are dedicated to discussing motivation. In particular, it’s well-covered that my motivation should spring from within. I should do whatever-it-is because I value the work or the self-transformation. Far too many people are externally motivated and so those bits are well-deployed.

But validation? I don’t hear about that so much.

Engineering, (think bridges and airplanes,) we all agree should be validated. Implicitly we know that means externally validated. We know that engineering done in a filter-bubble is not truly validated, and that ends badly.

But eveyone seems to toss the baby with the bath water: “I’m not doing engineering or hard science, therefore, as a principle, I don’t need external validation.“

But, that’s right only as a corrective term in our lives. “Holy shit our society is too externally motivated, so let’s stop with the external motivation.” Yes, please.

But once you figure out how to do your work from a place of kindness and internal motivation, you next need to put it out there. Put a price tag on it… Ask for feedback… Does the book sell… Do the people who follow your advice go on to do nicer or better things… In short, are you efficacious?

Yes yes yes art for arts’ sake is not what I’m talking about. Paint just for yourself and die an undiscovered master—that’s internal motivation for the win. (not sarcasm)

But if, you know, what you’re doing is supposed to be True, (however that’s defined for whatever it is you’re doing,) then you better put yourself out there and get some external validation. Yes, you’re going to need thick skin, and certainly don’t go alone, but go you must.

ɕ