#h9n2 — Public Fediverse posts

Prior #immunity to seasonal #influenza #H3N2 virus confers varying levels of cross - #protection against challenge with clade 2.3.4.4b #H5N1, #H7N9, or #H9N2 virus in a #ferret model, https://etidiohnew.blogspot.com/2026/04/prior-immunity-to-seasonal-influenza.html

#Outbreak Reports: Epidemiological and Genetic Characterization of Three #H9N2 Viruses Causing #Human #Infections — Changsha City, #Hunan Province, #China, April 2025, https://etidiohnew.blogspot.com/2025/11/outbreak-reports-epidemiological-and.html

Dissecting the role of the HA1-226 #leucine #residue in the #fitness and #airborne #transmission of an A(#H9N2) avian #influenza virus

Source: Journal of Virology, ABSTRACTA better understanding of viral factors that contribute to influenza A virus (IAV) airborne transmission is crucial for pandemic preparedness. A limited capacity for airborne transmission was recently observed in a human A(H9N2) virus isolate (A/Anhui-Lujiang/39/2018, AL/39) that possesses a leucine…

https://etidioh.wordpress.com/2024/11/04/dissecting-the-role-of-the-ha1-226-leucine-residue-in-the-fitness-and-airborne-transmission-of-an-ah9n2-avian-influenza-virus/

#Genotypic & #phenotypic susceptibility of emerging avian #influenza A viruses to
#NAIs & cap-dependent endonuclease #inhibitors, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224001682?via%3Dihub

Frequencies of markers of resistance to antivirals were low among >20,000 avian influenza A viruses studied. #H5Nx, #H7Nx, & #H9N2 viruses were susceptible to sub-nanomolar concentrations of antivirals. NA-I222M, but not NA-S246N or NA-I222V, in H5N1 confers reduced inhibition by #oseltamivir.

#Diversity of #genotypes & #pathogenicity of #H9N2 avian #influenza virus derived from #wildbird and domestic #poultry, Front Microbiol.: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1402235/full

Genotype S H9N2 demonstrated oropharyngeal shedding, while genotype A H9N2 exhibited cloacal shedding & high viral loads in the duodenum. Both strains caused significant pathological injuries, with genotype S inducing more severe damage to the thymus and spleen, while genotype A caused duodenal muscle layer rupture.