#orgchem — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #orgchem, aggregated by home.social.
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#RobSelects preprint of the week #ChemRxiv: Addition of hydroxylamines across cyclooctynes to form nitrones. #orgchem https://doi.org/10.26434/chemrxiv.15002347/v1
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#RobSelects preprint of the week #ChemRxiv: Addition of hydroxylamines across cyclooctynes to form nitrones. #orgchem https://doi.org/10.26434/chemrxiv.15002347/v1
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#RobSelects preprint of the week #ChemRxiv: Addition of hydroxylamines across cyclooctynes to form nitrones. #orgchem https://doi.org/10.26434/chemrxiv.15002347/v1
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#RobSelects preprint of the week #ChemRxiv: Addition of hydroxylamines across cyclooctynes to form nitrones. #orgchem https://doi.org/10.26434/chemrxiv.15002347/v1
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#RobSelects paper of the week #J_A_C_S: Excited-state nucleophilic aromatic substitution of nitroarenes. #orgchem https://doi.org/10.1021/jacs.5c21841
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#RobSelects paper of the week #J_A_C_S: Excited-state nucleophilic aromatic substitution of nitroarenes. #orgchem https://doi.org/10.1021/jacs.5c21841
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#RobSelects paper of the week #J_A_C_S: Excited-state nucleophilic aromatic substitution of nitroarenes. #orgchem https://doi.org/10.1021/jacs.5c21841
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#RobSelects paper of the week #J_A_C_S: Excited-state nucleophilic aromatic substitution of nitroarenes. #orgchem https://doi.org/10.1021/jacs.5c21841
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#RobSelects paper of the week #ACSCentSci: Systematic statistical analysis of 66,000 organic reactions from high-throughput experiments representative of pharmaceutical drug discovery. #orgchem https://doi.org/10.1021/acscentsci.5c02031
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#RobSelects preprint of the week #ChemRxiv: Photochemical conversion of aryl azides into pyridines via triplet aryl nitrenes. #orgchem https://doi.org/10.26434/chemrxiv-2026-jn9zb
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#RobSelects preprint of the week #ChemRxiv: Photochemical isomerization of N-substituted pyrazoles to imidazoles. #orgchem https://doi.org/10.26434/chemrxiv-2026-68vcj
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#RobSelects preprint of the week #ChemRxiv: Intermolecular alkene hydroamination promoted by single electron reduction. #orgchem https://doi.org/10.26434/chemrxiv-2025-fblsl
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#RobSelects preprint of the week #ChemRxiv: E-Selective hydrazine-mediated cross carbonyl-olefine metathesis. #orgchem https://doi.org/10.26434/chemrxiv-2025-hb5l1
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#RobSelects preprint of the week #ChemRxiv: Comprehensive mechanistic study of the oxidative aminative cleavage of alkenes with a hypervalent iodine oxidant and ammonium carbamate. #orgchem https://doi.org/10.26434/chemrxiv-2025-6cdgb
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Check out the latest Synthesis Workshop video with a presentation from Ann-Sophie Paschke and Stefanie Schiele on their latest work with Bill Morandi group that has been published in Chemical Science.
https://www.youtube.com/watch?v=D513hX1gOTg
The video covers skeletal editing, and the advances made in the latest Chem Sci publication, which involves chemodivergent C-to-N atom swapping reactions.
You can read the full paper (for free) here: https://doi.org/10.1039/D5SC02032H
If you are interested in related developments, do check out our new Editor's Choice collection from Associate Editor Professor Ning Jiao (https://rsc.li/4owdnHw including other work from the Morandi group) and our collection of most popular works in organic chemistry (https://rsc.li/4opmslv.
Thank you too to Matthew Horwitz for the ongoing Synthesis Workshop initiative and Karim Abd El-Latef for hosting this episode!
Visit their YouTube channel at https://lnkd.in/e9wsZPzQ
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#RobSelects paper of the week #J_A_C_S: Reversible carbon-hydrogen activation of benzene and unactivated arenes with a nickel(0)-silylene complex. #orgchem https://doi.org/10.1021/jacs.5c10922
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#RobSelects paper of the week #J_A_C_S: Leveraging a [1,3]-hydride shift in alpha-fluoro-diborylalkanes to synthesize cyclopropyl boronic esters. #orgchem https://doi.org/10.1021/jacs.5c08276
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A team led by Yong-Qiang Tu (Lanzhou University, #China) has developed a highly enantioselective approach to synthesize α-ethynylated 3-substituted oxindoles using a hypervalent iodine alkynyl donor and a triazolium bromide catalyst. This method delivers excellent yields and enantioselectivity, providing key intermediates for alkaloid synthesis — demonstrated in their recent publication in Angewandte Chemie.
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When you think of a reaction between an acid and an alcohol, you think of an ester as the product. MacMillan and co-workers from Princeton have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. Read more about this in JACS:
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When you think of a reaction between an acid and an alcohol, you think of an ester as the product. MacMillan and co-workers from Princeton have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. Read more about this in JACS:
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When you think of a reaction between an acid and an alcohol, you think of an ester as the product. MacMillan and co-workers from Princeton have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. Read more about this in JACS:
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When you think of a reaction between an acid and an alcohol, you think of an ester as the product. MacMillan and co-workers from Princeton have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. Read more about this in JACS:
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When you think of a reaction between an acid and an alcohol, you think of an ester as the product. MacMillan and co-workers from Princeton have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. Read more about this in JACS:
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Radical Fluorosulfonylation of Allyl Bromides:
Catalyst-free protocol under electroreductive conditions
https://www.chemistryviews.org/radical-fluorosulfonylation-of-allyl-bromides/#orgchem #fluorosulfonylation #chemistry #chemistryviews #chemviews
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Site-Selective C–H Functionalization Used to Prepare Atropisomers:
Organic photoredox catalysis provides a general approach to the coupling of biaryls with a range of nucleophiles
https://www.chemistryviews.org/site-selective-c-h-functionalization-used-to-prepare-atropisomers/#orgchem #biaryls #organocatalysis #chemistry #chemistryviews #chemviews
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Enantioselective Heteroarylalkylation Combines Photoredox and Chromium Catalysis:
Radical-polar crossover three-component transformation for the functionalization of 1,3-dienes
https://www.chemistryviews.org/enantioselective-heteroarylalkylation-combines-photoredox-and-chromium-catalysis/#orgchem #dualcatalysis #chemistry #chemistryviews #chemviews
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#RobSelects paper of the week #angew_chem: Generation and characterization of a triphenylphosphine-stabilized monovalent carbon atom with a triplet ground state. #orgchem https://doi.org/10.1002/anie.202424166
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Rh(III)-Catalyzed Formal Cycloaddition Provides a Path to Furanones:
Formal [3+2] cycloaddition reaction between cyclopropenones and aldehydes
https://www.chemistryviews.org/rhiii-catalyzed-formal-cycloaddition-provides-a-path-to-furanones/#orgchem #rhodiumcatalysis #chemistry #chemistryviews #chemviews
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Rh(III)-Catalyzed Formal Cycloaddition Provides a Path to Furanones:
Formal [3+2] cycloaddition reaction between cyclopropenones and aldehydes
https://www.chemistryviews.org/rhiii-catalyzed-formal-cycloaddition-provides-a-path-to-furanones/#orgchem #rhodiumcatalysis #chemistry #chemistryviews #chemviews
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Rh(III)-Catalyzed Formal Cycloaddition Provides a Path to Furanones:
Formal [3+2] cycloaddition reaction between cyclopropenones and aldehydes
https://www.chemistryviews.org/rhiii-catalyzed-formal-cycloaddition-provides-a-path-to-furanones/#orgchem #rhodiumcatalysis #chemistry #chemistryviews #chemviews
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Rh(III)-Catalyzed Formal Cycloaddition Provides a Path to Furanones:
Formal [3+2] cycloaddition reaction between cyclopropenones and aldehydes
https://www.chemistryviews.org/rhiii-catalyzed-formal-cycloaddition-provides-a-path-to-furanones/#orgchem #rhodiumcatalysis #chemistry #chemistryviews #chemviews
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Rh(III)-Catalyzed Formal Cycloaddition Provides a Path to Furanones:
Formal [3+2] cycloaddition reaction between cyclopropenones and aldehydes
https://www.chemistryviews.org/rhiii-catalyzed-formal-cycloaddition-provides-a-path-to-furanones/#orgchem #rhodiumcatalysis #chemistry #chemistryviews #chemviews
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Luo et al. from Tsinghua University (#China) report in #JACS a novel method to create enantioenriched α-amino aldehydes using a chiral amine catalyst and iridium photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised and subsequently stabilised via analogues formation (e.g. through Wittig reaction).
https://me.organicchemistry.eu/post/deracemization-aldehyde-jacs-2025/
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Luo et al. from Tsinghua University (#China) report in #JACS a novel method to create enantioenriched α-amino aldehydes using a chiral amine catalyst and iridium photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised and subsequently stabilised via analogues formation (e.g. through Wittig reaction).
https://me.organicchemistry.eu/post/deracemization-aldehyde-jacs-2025/
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Luo et al. from Tsinghua University (#China) report in #JACS a novel method to create enantioenriched α-amino aldehydes using a chiral amine catalyst and iridium photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised and subsequently stabilised via analogues formation (e.g. through Wittig reaction).
https://me.organicchemistry.eu/post/deracemization-aldehyde-jacs-2025/
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Luo et al. from Tsinghua University (#China) report in #JACS a novel method to create enantioenriched α-amino aldehydes using a chiral amine catalyst and iridium photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised and subsequently stabilised via analogues formation (e.g. through Wittig reaction).
https://me.organicchemistry.eu/post/deracemization-aldehyde-jacs-2025/
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Luo et al. from Tsinghua University (#China) report in #JACS a novel method to create enantioenriched α-amino aldehydes using a chiral amine catalyst and iridium photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised and subsequently stabilised via analogues formation (e.g. through Wittig reaction).
https://me.organicchemistry.eu/post/deracemization-aldehyde-jacs-2025/
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Renewable Ethanol and Methanol Used for the Synthesis of 1,5-Diketones:
Nickel-catalyzed coupling of alcohols with ketones also allows for a one-pot aminomethylation
https://www.chemistryviews.org/renewable-ethanol-and-methanol-used-for-the-synthesis-of-15-diketones/#orgchem #diketones #sustainability #chemistry #chemistryviews #chemviews
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Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS
https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/
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Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS
https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/
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Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS
https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/
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Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS
https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/
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Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS
https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/
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Intense weekend working into this year's Merk #CompoundChallenge. Did we design the best route? Idk, but we sure had lots of laughs.
#OrganicChemistry #OrgChem #Synthesis #Chemistry #Challenge #Science
👩🔬🧑🔬: Pol Martínez-Balart, Eva Rivera-Chao, Akshay Nair, José L. Nova-Fernández, Saul Alberca, and me.
📷: Pol
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Intense weekend working into this year's Merk #CompoundChallenge. Did we design the best route? Idk, but we sure had lots of laughs.
#OrganicChemistry #OrgChem #Synthesis #Chemistry #Challenge #Science
👩🔬🧑🔬: Pol Martínez-Balart, Eva Rivera-Chao, Akshay Nair, José L. Nova-Fernández, Saul Alberca, and me.
📷: Pol
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Intense weekend working into this year's Merk #CompoundChallenge. Did we design the best route? Idk, but we sure had lots of laughs.
#OrganicChemistry #OrgChem #Synthesis #Chemistry #Challenge #Science
👩🔬🧑🔬: Pol Martínez-Balart, Eva Rivera-Chao, Akshay Nair, José L. Nova-Fernández, Saul Alberca, and me.
📷: Pol
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Intense weekend working into this year's Merk #CompoundChallenge. Did we design the best route? Idk, but we sure had lots of laughs.
#OrganicChemistry #OrgChem #Synthesis #Chemistry #Challenge #Science
👩🔬🧑🔬: Pol Martínez-Balart, Eva Rivera-Chao, Akshay Nair, José L. Nova-Fernández, Saul Alberca, and me.
📷: Pol
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Intense weekend working into this year's Merk #CompoundChallenge. Did we design the best route? Idk, but we sure had lots of laughs.
#OrganicChemistry #OrgChem #Synthesis #Chemistry #Challenge #Science
👩🔬🧑🔬: Pol Martínez-Balart, Eva Rivera-Chao, Akshay Nair, José L. Nova-Fernández, Saul Alberca, and me.
📷: Pol
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Novel method to prepare complex thioxanthones from relatively simple and accessible precursors
https://www.chemistryviews.org/faster-cheaper-smarter-thioxanthone-synthesis/
#chemistry #chemistryviews #chemviews #organicchemistry #orgchem #thioxanthones
