#synthesis — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #synthesis, aggregated by home.social.
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I’ve been playing and really enjoying this new release Resilience by Daniel M Karlsson ( @t36s) on @EVEL a lot over the last day or so.
It's a swooping, swirling, swooning 91 minute continuous piece of utterly sublime computer music, full of sweeping drama and intense emotional resonance. Very highly recommended!
#ExperimentalMusic #ComputerMusic #Synthesis #DeterministicMusic #DroneMusic #ElectronicMusic https://social.ordinal.garden/@t36s/116623783188222602
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In the charged dark, endless listening fueled our quiet exchange of truth. By dawn, we had catalyzed into an unbroken whole. 🌌🌅 #Dialogue #Synthesis
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🔴 LIVE NOW ON VORTEX
📻 Vortex Abyss 🕳️ (Dark ambient, neofolk, shoegaze, immersive)
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🎵 Angelzoom - Fairyland▶️ Écouter / Listen : VorteX [Radio]
https://lesonduvortex.net💬 Join us on Discord:
https://discord.gg/d82hJZBeDE -
I'm in this picture and I don't like it
#shitpost #MusicShitpost #MusicProduction #Synthesis #FMSynthesis
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I'm in this picture and I don't like it
#shitpost #MusicShitpost #MusicProduction #Synthesis #FMSynthesis
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I'm in this picture and I don't like it
#shitpost #MusicShitpost #MusicProduction #Synthesis #FMSynthesis
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I'm in this picture and I don't like it
#shitpost #MusicShitpost #MusicProduction #Synthesis #FMSynthesis
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I'm in this picture and I don't like it
#shitpost #MusicShitpost #MusicProduction #Synthesis #FMSynthesis
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Research Unveils Novel Light-Triggered Copper Catalysts for Chemical Reactions
Scientists made new light-activated copper catalysts for easier chemical reactions. This could change how medicines and materials are made.
#CopperCatalyst, #ChemicalReactions, #LightActivated, #ChemistryNews, #Synthesis
https://newsletter.tf/light-triggered-copper-catalysts-for-chemical-reactions/
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This new method uses light to make chemical reactions happen more easily than before. It's a big step for making chemicals for medicines and materials.
#CopperCatalyst, #ChemicalReactions, #LightActivated, #ChemistryNews, #Synthesis
https://newsletter.tf/light-triggered-copper-catalysts-for-chemical-reactions/ -
https://www.evshift.com/449006/peugeot-lions-portrait-l-julie-sardin-l-vehicle-synthesis-manager-2/ Peugeot Lions Portrait l Julie Sardin l Vehicle Synthesis Manager #Allure #automobile #Belchamp #CARS #Design #ElectricCars #ElectricVehicles #engineering #EV #French #Julie #JulieSardin #Lions #LionsPortrait #manager #peugeot #PeugeotEngineers #portrait #Sardin #Stellantis #synthesis #vehicle #VehicleSynthesisManager
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https://www.evshift.com/448820/peugeot-lions-portrait-l-julie-sardin-l-vehicle-synthesis-manager/ Peugeot Lions Portrait l Julie Sardin l Vehicle Synthesis Manager #ElectricCars #ElectricVehicles #EV #Julie #Lions #manager #peugeot #portrait #Sardin #synthesis #vehicle
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Cantai (US) want good choral singers for 2 hr recording session with royalties.
" singers with a straight-tone technique — minimal-to-no vibrato, clean blending, the kind of voice you'd hear in a chamber choir or an early music ensemble. Not operatic, not pop. All voice parts welcome, soprano through bass.If that's you, or someone you know, head to https://cantai.app and tap the green chat bubble in the bottom-right corner to start a conversation. "
#AI #choral #synthesis -
Cantai (US) want good choral singers for 2 hr recording session with royalties.
" singers with a straight-tone technique — minimal-to-no vibrato, clean blending, the kind of voice you'd hear in a chamber choir or an early music ensemble. Not operatic, not pop. All voice parts welcome, soprano through bass.If that's you, or someone you know, head to https://cantai.app and tap the green chat bubble in the bottom-right corner to start a conversation. "
#AI #choral #synthesis -
Cantai (US) want good choral singers for 2 hr recording session with royalties.
" singers with a straight-tone technique — minimal-to-no vibrato, clean blending, the kind of voice you'd hear in a chamber choir or an early music ensemble. Not operatic, not pop. All voice parts welcome, soprano through bass.If that's you, or someone you know, head to https://cantai.app and tap the green chat bubble in the bottom-right corner to start a conversation. "
#AI #choral #synthesis -
Cantai (US) want good choral singers for 2 hr recording session with royalties.
" singers with a straight-tone technique — minimal-to-no vibrato, clean blending, the kind of voice you'd hear in a chamber choir or an early music ensemble. Not operatic, not pop. All voice parts welcome, soprano through bass.If that's you, or someone you know, head to https://cantai.app and tap the green chat bubble in the bottom-right corner to start a conversation. "
#AI #choral #synthesis -
Cantai (US) want good choral singers for 2 hr recording session with royalties.
" singers with a straight-tone technique — minimal-to-no vibrato, clean blending, the kind of voice you'd hear in a chamber choir or an early music ensemble. Not operatic, not pop. All voice parts welcome, soprano through bass.If that's you, or someone you know, head to https://cantai.app and tap the green chat bubble in the bottom-right corner to start a conversation. "
#AI #choral #synthesis -
By the way, and for the avoidance of doubt/suspicion: none of the "audio etymology" sequences that I've created and am posting here involve any use of AI, LLM's, neural nets, none of that. All are made from original audio recordings of real people speaking words in their various languages, which are then subjected to good old-fashioned signal processing (speech coding and synthesis). The continua of change are made using straightforward linear interpolation over the space of cepstrograms, which are 2 dimensional matrices encoding the acoustics of the original recordings. Using scripts that I wrote, by hand.
#acoustics #phonetics #speech #synthesis #audio #maths #linear_algebra
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By the way, and for the avoidance of doubt/suspicion: none of the "audio etymology" sequences that I've created and am posting here involve any use of AI, LLM's, neural nets, none of that. All are made from original audio recordings of real people speaking words in their various languages, which are then subjected to good old-fashioned signal processing (speech coding and synthesis). The continua of change are made using straightforward linear interpolation over the space of cepstrograms, which are 2 dimensional matrices encoding the acoustics of the original recordings. Using scripts that I wrote, by hand.
#acoustics #phonetics #speech #synthesis #audio #maths #linear_algebra
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Fa temps que no jugo amb harmònics. M'ha fet voler tornar-hi a fer una ullada a #clam
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Fa temps que no jugo amb harmònics. M'ha fet voler tornar-hi a fer una ullada a #clam
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Fa temps que no jugo amb harmònics. M'ha fet voler tornar-hi a fer una ullada a #clam
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He also hinted at a new class of synthetic antibiotics that is in current development at Roche. Hopefully there are many more new antibiotics in the future. (7/7)
#Antibiotics #DrugDiscovery #DrugDevelopment #ChemBio #Chemistry #cryoEM #AMR #Resistance #Bacteria #SAR #Synthesis #Zosurabalpin
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Hypothesis, Antithesis, Synthesis
https://antithesis.com/blog/2026/hegel/
#HackerNews #Hypothesis #Antithesis #Synthesis #Hegel #Philosophy #Debate
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Excited to share our paper in Journal of Medicinal #Chemistry exploring carbobicyclic nucleoside analogues as potential #antivirals!
We swapped the ribose oxygen for a carbon in nucleoside analogues and explored this novel scaffold.
From our library, several compounds showed activity against #HCV, #HSV, #influenza, and #RSV. One uracil-based analogue stood out by inhibiting multiple viruses like #flu and HCV. Modeling suggests it “locks” the viral active site instead of being incorporated into RNA.
What really surprised us: nucleobases with known antiviral effects (like NHC from molnupiravir) didn’t work in our scaffold—but unmodified uracil did. The scaffold itself changes how these molecules behave.
Encouragingly, these compounds phosphorylate efficiently in cells without needing prodrugs, don't inhibit human polymerases, and our #synthesis is efficient: 28 pyrimidine and 35 purine analogues from just two intermediates in under 10 steps.
Huge thanks to all collaborators and colleagues who made this work possible!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02584
J. Med. Chem. 2026, 69, 5, 5501–5539.
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Excited to share our paper in Journal of Medicinal #Chemistry exploring carbobicyclic nucleoside analogues as potential #antivirals!
We swapped the ribose oxygen for a carbon in nucleoside analogues and explored this novel scaffold.
From our library, several compounds showed activity against #HCV, #HSV, #influenza, and #RSV. One uracil-based analogue stood out by inhibiting multiple viruses like #flu and HCV. Modeling suggests it “locks” the viral active site instead of being incorporated into RNA.
What really surprised us: nucleobases with known antiviral effects (like NHC from molnupiravir) didn’t work in our scaffold—but unmodified uracil did. The scaffold itself changes how these molecules behave.
Encouragingly, these compounds phosphorylate efficiently in cells without needing prodrugs, don't inhibit human polymerases, and our #synthesis is efficient: 28 pyrimidine and 35 purine analogues from just two intermediates in under 10 steps.
Huge thanks to all collaborators and colleagues who made this work possible!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02584
J. Med. Chem. 2026, 69, 5, 5501–5539.
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Excited to share our paper in Journal of Medicinal #Chemistry exploring carbobicyclic nucleoside analogues as potential #antivirals!
We swapped the ribose oxygen for a carbon in nucleoside analogues and explored this novel scaffold.
From our library, several compounds showed activity against #HCV, #HSV, #influenza, and #RSV. One uracil-based analogue stood out by inhibiting multiple viruses like #flu and HCV. Modeling suggests it “locks” the viral active site instead of being incorporated into RNA.
What really surprised us: nucleobases with known antiviral effects (like NHC from molnupiravir) didn’t work in our scaffold—but unmodified uracil did. The scaffold itself changes how these molecules behave.
Encouragingly, these compounds phosphorylate efficiently in cells without needing prodrugs, don't inhibit human polymerases, and our #synthesis is efficient: 28 pyrimidine and 35 purine analogues from just two intermediates in under 10 steps.
Huge thanks to all collaborators and colleagues who made this work possible!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02584
J. Med. Chem. 2026, 69, 5, 5501–5539.
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Excited to share our paper in Journal of Medicinal #Chemistry exploring carbobicyclic nucleoside analogues as potential #antivirals!
We swapped the ribose oxygen for a carbon in nucleoside analogues and explored this novel scaffold.
From our library, several compounds showed activity against #HCV, #HSV, #influenza, and #RSV. One uracil-based analogue stood out by inhibiting multiple viruses like #flu and HCV. Modeling suggests it “locks” the viral active site instead of being incorporated into RNA.
What really surprised us: nucleobases with known antiviral effects (like NHC from molnupiravir) didn’t work in our scaffold—but unmodified uracil did. The scaffold itself changes how these molecules behave.
Encouragingly, these compounds phosphorylate efficiently in cells without needing prodrugs, don't inhibit human polymerases, and our #synthesis is efficient: 28 pyrimidine and 35 purine analogues from just two intermediates in under 10 steps.
Huge thanks to all collaborators and colleagues who made this work possible!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02584
J. Med. Chem. 2026, 69, 5, 5501–5539.
-
Excited to share our paper in Journal of Medicinal #Chemistry exploring carbobicyclic nucleoside analogues as potential #antivirals!
We swapped the ribose oxygen for a carbon in nucleoside analogues and explored this novel scaffold.
From our library, several compounds showed activity against #HCV, #HSV, #influenza, and #RSV. One uracil-based analogue stood out by inhibiting multiple viruses like #flu and HCV. Modeling suggests it “locks” the viral active site instead of being incorporated into RNA.
What really surprised us: nucleobases with known antiviral effects (like NHC from molnupiravir) didn’t work in our scaffold—but unmodified uracil did. The scaffold itself changes how these molecules behave.
Encouragingly, these compounds phosphorylate efficiently in cells without needing prodrugs, don't inhibit human polymerases, and our #synthesis is efficient: 28 pyrimidine and 35 purine analogues from just two intermediates in under 10 steps.
Huge thanks to all collaborators and colleagues who made this work possible!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02584
J. Med. Chem. 2026, 69, 5, 5501–5539.
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How do you pick the right target molecule for a total synthesis program?
At #Lunteren2026, Dirk Trauner gave an inspiring lecture with a lot of thought-provoking potential reasons to select a target molecule in combination with many insights into fascinating completed total syntheses.
https://pubs.acs.org/doi/abs/10.1021/jacs.8b01918
#Chemistry #Synthesis -
How do you pick the right target molecule for a total synthesis program?
At #Lunteren2026, Dirk Trauner gave an inspiring lecture with a lot of thought-provoking potential reasons to select a target molecule in combination with many insights into fascinating completed total syntheses.
https://pubs.acs.org/doi/abs/10.1021/jacs.8b01918
#Chemistry #Synthesis -
How do you pick the right target molecule for a total synthesis program?
At #Lunteren2026, Dirk Trauner gave an inspiring lecture with a lot of thought-provoking potential reasons to select a target molecule in combination with many insights into fascinating completed total syntheses.
https://pubs.acs.org/doi/abs/10.1021/jacs.8b01918
#Chemistry #Synthesis -
How do you pick the right target molecule for a total synthesis program?
At #Lunteren2026, Dirk Trauner gave an inspiring lecture with a lot of thought-provoking potential reasons to select a target molecule in combination with many insights into fascinating completed total syntheses.
https://pubs.acs.org/doi/abs/10.1021/jacs.8b01918
#Chemistry #Synthesis -
How do you pick the right target molecule for a total synthesis program?
At #Lunteren2026, Dirk Trauner gave an inspiring lecture with a lot of thought-provoking potential reasons to select a target molecule in combination with many insights into fascinating completed total syntheses.
https://pubs.acs.org/doi/abs/10.1021/jacs.8b01918
#Chemistry #Synthesis -
Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.
https://www.fodranlab.com/
#Chemistry #ChemBio #DrugDiscovery #Synthesis -
Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.
https://www.fodranlab.com/
#Chemistry #ChemBio #DrugDiscovery #Synthesis -
Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.
https://www.fodranlab.com/
#Chemistry #ChemBio #DrugDiscovery #Synthesis -
Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.
https://www.fodranlab.com/
#Chemistry #ChemBio #DrugDiscovery #Synthesis -
Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.
https://www.fodranlab.com/
#Chemistry #ChemBio #DrugDiscovery #Synthesis -
As an organic chemist, should you specialize in synthesis method development or total synthesis?
In his inspiring talk at #Lunteren2026, Alois Fürstner from the Max-Planck-Institut für Kohlenforschung shows how his group is excelling at both and makes the point that there is important cross-fertilization between the two research directions in his group.
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As an organic chemist, should you specialize in synthesis method development or total synthesis?
In his inspiring talk at #Lunteren2026, Alois Fürstner from the Max-Planck-Institut für Kohlenforschung shows how his group is excelling at both and makes the point that there is important cross-fertilization between the two research directions in his group.
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As an organic chemist, should you specialize in synthesis method development or total synthesis?
In his inspiring talk at #Lunteren2026, Alois Fürstner from the Max-Planck-Institut für Kohlenforschung shows how his group is excelling at both and makes the point that there is important cross-fertilization between the two research directions in his group.
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As an organic chemist, should you specialize in synthesis method development or total synthesis?
In his inspiring talk at #Lunteren2026, Alois Fürstner from the Max-Planck-Institut für Kohlenforschung shows how his group is excelling at both and makes the point that there is important cross-fertilization between the two research directions in his group.
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As an organic chemist, should you specialize in synthesis method development or total synthesis?
In his inspiring talk at #Lunteren2026, Alois Fürstner from the Max-Planck-Institut für Kohlenforschung shows how his group is excelling at both and makes the point that there is important cross-fertilization between the two research directions in his group.
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Interesting talk by Géraldine Masson at #Lunteren2026. She gave a presentation with the title "Chiral Brønsted Acid–Driven Enantio- and Regioselective Transformations of Polyunsaturated Systems toward Complex Molecular Architectures".
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Interesting talk by Géraldine Masson at #Lunteren2026. She gave a presentation with the title "Chiral Brønsted Acid–Driven Enantio- and Regioselective Transformations of Polyunsaturated Systems toward Complex Molecular Architectures".
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Interesting talk by Géraldine Masson at #Lunteren2026. She gave a presentation with the title "Chiral Brønsted Acid–Driven Enantio- and Regioselective Transformations of Polyunsaturated Systems toward Complex Molecular Architectures".
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Interesting talk by Géraldine Masson at #Lunteren2026. She gave a presentation with the title "Chiral Brønsted Acid–Driven Enantio- and Regioselective Transformations of Polyunsaturated Systems toward Complex Molecular Architectures".
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Interesting talk by Géraldine Masson at #Lunteren2026. She gave a presentation with the title "Chiral Brønsted Acid–Driven Enantio- and Regioselective Transformations of Polyunsaturated Systems toward Complex Molecular Architectures".
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Interesting talk by Antonio Echavarren at #Lunteren2026. He talked about the use of gold-carbene catalysis to perform complex and enantioselective transformations in organic synthesis.
https://pubs.acs.org/doi/10.1021/jacsau.3c00159
#Synthesis #OrganicChemistry #Chemistry #Catalysis