#synthesis — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #synthesis, aggregated by home.social.
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Cantai (US) want good choral singers for 2 hr recording session with royalties.
" singers with a straight-tone technique — minimal-to-no vibrato, clean blending, the kind of voice you'd hear in a chamber choir or an early music ensemble. Not operatic, not pop. All voice parts welcome, soprano through bass.If that's you, or someone you know, head to https://cantai.app and tap the green chat bubble in the bottom-right corner to start a conversation. "
#AI #choral #synthesis -
By the way, and for the avoidance of doubt/suspicion: none of the "audio etymology" sequences that I've created and am posting here involve any use of AI, LLM's, neural nets, none of that. All are made from original audio recordings of real people speaking words in their various languages, which are then subjected to good old-fashioned signal processing (speech coding and synthesis). The continua of change are made using straightforward linear interpolation over the space of cepstrograms, which are 2 dimensional matrices encoding the acoustics of the original recordings. Using scripts that I wrote, by hand.
#acoustics #phonetics #speech #synthesis #audio #maths #linear_algebra
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Fa temps que no jugo amb harmònics. M'ha fet voler tornar-hi a fer una ullada a #clam
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Fa temps que no jugo amb harmònics. M'ha fet voler tornar-hi a fer una ullada a #clam
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Fa temps que no jugo amb harmònics. M'ha fet voler tornar-hi a fer una ullada a #clam
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He also hinted at a new class of synthetic antibiotics that is in current development at Roche. Hopefully there are many more new antibiotics in the future. (7/7)
#Antibiotics #DrugDiscovery #DrugDevelopment #ChemBio #Chemistry #cryoEM #AMR #Resistance #Bacteria #SAR #Synthesis #Zosurabalpin
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Hypothesis, Antithesis, Synthesis
https://antithesis.com/blog/2026/hegel/
#HackerNews #Hypothesis #Antithesis #Synthesis #Hegel #Philosophy #Debate
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Excited to share our paper in Journal of Medicinal #Chemistry exploring carbobicyclic nucleoside analogues as potential #antivirals!
We swapped the ribose oxygen for a carbon in nucleoside analogues and explored this novel scaffold.
From our library, several compounds showed activity against #HCV, #HSV, #influenza, and #RSV. One uracil-based analogue stood out by inhibiting multiple viruses like #flu and HCV. Modeling suggests it “locks” the viral active site instead of being incorporated into RNA.
What really surprised us: nucleobases with known antiviral effects (like NHC from molnupiravir) didn’t work in our scaffold—but unmodified uracil did. The scaffold itself changes how these molecules behave.
Encouragingly, these compounds phosphorylate efficiently in cells without needing prodrugs, don't inhibit human polymerases, and our #synthesis is efficient: 28 pyrimidine and 35 purine analogues from just two intermediates in under 10 steps.
Huge thanks to all collaborators and colleagues who made this work possible!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02584
J. Med. Chem. 2026, 69, 5, 5501–5539.
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As an organic chemist, should you specialize in synthesis method development or total synthesis?
In his inspiring talk at #Lunteren2026, Alois Fürstner from the Max-Planck-Institut für Kohlenforschung shows how his group is excelling at both and makes the point that there is important cross-fertilization between the two research directions in his group.
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Interesting talk by Géraldine Masson at #Lunteren2026. She gave a presentation with the title "Chiral Brønsted Acid–Driven Enantio- and Regioselective Transformations of Polyunsaturated Systems toward Complex Molecular Architectures".
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Interesting talk by Antonio Echavarren at #Lunteren2026. He talked about the use of gold-carbene catalysis to perform complex and enantioselective transformations in organic synthesis.
https://pubs.acs.org/doi/10.1021/jacsau.3c00159
#Synthesis #OrganicChemistry #Chemistry #Catalysis -
Interesting talk by Antonio Echavarren at #Lunteren2026. He talked about the use of gold-carbene catalysis to perform complex and enantioselective transformations in organic synthesis. pubs.acs.org/doi/10.1021/... #Synthesis #OrganicChemistry #ChemSky #Catalysis
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Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)
#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL
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Insightful talk by Varinder Aggarwal from the University of Bristol at #Lunteren2026. He talked about efficient synthesis procedures through Iterative chemistry enabled by boron. He presented e.g. the synthesis and structural annotation of baulamycins A.
https://www.nature.com/articles/nature23265
#Chemistry #Synthesis #boron #iteromics -
Insightful talk by Varinder Aggarwal from the University of Bristol at #Lunteren2026. He talked about efficient synthesis procedures through Iterative chemistry enabled by boron. He presented e.g. the synthesis and structural annotation of baulamycins A.
https://www.nature.com/articles/nature23265
#Chemistry #Synthesis #boron #iteromics -
Insightful talk by Varinder Aggarwal from the University of Bristol at #Lunteren2026. He talked about efficient synthesis procedures through Iterative chemistry enabled by boron. He presented e.g. the synthesis and structural annotation of baulamycins A.
https://www.nature.com/articles/nature23265
#Chemistry #Synthesis #boron #iteromics -
Insightful talk by Varinder Aggarwal from the University of Bristol at #Lunteren2026. He talked about efficient synthesis procedures through Iterative chemistry enabled by boron. He presented e.g. the synthesis and structural annotation of baulamycins A.
https://www.nature.com/articles/nature23265
#Chemistry #Synthesis #boron #iteromics -
Insightful talk by Varinder Aggarwal from the University of Bristol at #Lunteren2026. He talked about efficient synthesis procedures through Iterative chemistry enabled by boron. He presented e.g. the synthesis and structural annotation of baulamycins A.
https://www.nature.com/articles/nature23265
#Chemistry #Synthesis #boron #iteromics -
19-Feb-2026
New method for housane #synthesis
Chemists synthesise high-tensile ring #molecules through #photocatalysis / Components for #drugDevelopmenthttps://www.eurekalert.org/news-releases/1117117 #science #chemistry
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“Marvel has remarked that more money has been wasted in polymer research by the use of impure monomers than in any other manner.” pp. 12 of Polymer Chemistry 2e by Hiemenz & Lodge. #polymers #synthesis #chemistry #research #purity
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SHORTCIRCUIT XT: Monstrous Open Source Sample & VA Synthesis Engine Goes Beta
https://social.trom.tf/display/dbc8dc44-9669-7f8a-07d3-dde156919970
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YM2149-rs - Chiptune Sound Synthesis in Pure Rust
https://ym2149-rs.org/
https://github.com/slippyex/ym2149-rs#sound #audio #chiptune #rust #synthesis #ay38910 #ym2149 #opensource #foss #yamaha #demoscene #gamedev
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Music & A.I. (Advanced Idiots)
https://social.trom.tf/display/dbc8dc44-9769-7e20-274f-419851762853
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"#TheWeb: Everything Is Shifting at Once
What makes this moment disorienting to some, but also exciting, is that multiple systems are changing simultaneously. It’s not just consumption models or discovery mechanisms or economics of the internet. It’s all of them, at the same time, and they’re interconnected.
The #consumption model used to be straightforward. A user goes to a surface, consumes content directly, and synthesizes the information themselves.
Now an AI intermediary does the #synthesis across dozens of surfaces and delivers the answer directly. The user can get what they need (achieve that conversion) without directly visiting the source anymore."
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Further context with PHOTOSENSITIVITY WARNING: A fresh snippet with this incinerator, from my track "Freakbox Raver” from my fresh EP Hypnopomp. Both Freakbox and this chimney guy have been mascots of my new EP with freaky contributing to sounds, chimneyiyiy supporting visuals 🙃 When you walk to this club that they’ll sadly knock down to build some expensive development, you see this chimney from different angles. It looks eerie but also funny. Full track here https://hazalelif.bandcamp.com/album/elif-yalvac-hypnopomp-ep
#hardcore #speedcore #experimental #audiovisual #maxmsp #synthesis
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Wavetable Creator by Ocean Swift Synthesis 🎛️
Create complex wavetables, Serum/Vital/Waldorf compatible, batch processing, crossfade blending💻 Win/Mac/Linux
🎁 FREE (reg. $42) for a limited time only!
🔗 Link in bio! -
My #MutableInstruments ... adventure. Although I've been focusing on pi pico, we have some examples running on other mcus https://github.com/poetaster/arduinoMI/tree/main/PlaitsEngines1.2-ESP32-S3 where https://github.com/ledlaux tests the esp32 chips. #tonetoys #DIY #synthesis
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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A new effect is added in @mercury . It is a Karplus-Strong effect, based on a lowpass feedback combfilter, that can be tuned to the notes of your scale. The feedback can be positive (odd+even harmonics) or negative (odd harmonics, for a flute-like sound).
#audioworkletprocessor #mercurylivecoding #synthesis #karplusstrong #stringsynthesis #browserbased #webaudio
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🎉 Ah, the riveting world of Windows clipboard text format synthesis—truly the Shakespeare of tech blogs! 🎭 Dive into this catalogue of mismatched locales and thrill at how a clipboard can be so delightfully mundane. 🤦♂️ Because nothing screams innovation like a dozen different ways to paste text wrong! 😜
https://devblogs.microsoft.com/oldnewthing/20251211-37/?p=111858 #WindowsClipboard #TechInnovation #ClipboardHumor #TextFormat #Synthesis #HackerNews #ngated -
Various locale mismatch scenarios in Windows clipboard text format synthesis
https://devblogs.microsoft.com/oldnewthing/20251211-37/?p=111858
#HackerNews #locale #mismatch #clipboard #Windows #textformat #synthesis
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Please give 12 minutes to this mind altering TED talk. Discover more about what is going on, think outside the box, and reach for a new dimension.
(1/2)
#integration #equilibrium #thesis #antithesis #synthesis #perspective #coexist #culturewars #awakening #conscious #awareness #wisdom #intelligence
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We explored the question, from which different areas of chemistry, including glycochemistry, peptide chemistry, materials chemistry and synthetic method development new electrophiles for covalent inhibitors can originate in order to keep expanding the druggable space. (2/2)
#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #Glycotime #Peptides #Materials #Synthesis #Undruggable #CovalentInhibitors
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Spent the evening working on visualizing #EchoThief impulse responses for the up coming "Spaces" reverb module for Sonic Fauna! Good times :)
#indiedev #python #matplotlib #librosa #daw #music #reverb #effects #synthesis #electronic #coding
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Oh joy, another way for tech nerds to overcomplicate a children's block game with a #Verilog #synthesis flow for #redstone #circuits. 🤓🔧 Because who doesn't want to explain hardware description languages to kids building pixel art sheep? 🎨🐑
https://github.com/itsfrank/MinecraftHDL #technerds #pixelart #hardwareeducation #HackerNews #ngated -
💠 Can a crystal have different magnetic properties in alternating domains?
👉 Check out in our latest work, how close we can get to such scenario. A "topotactic jump" into a miscibility gap allows #synthesis of metastable crystalline spinel nanoflakes with alternating ferri- and antiferromagnetic domains.
🔗 https://doi.org/10.1002/anie.202504171
🤝 Many thanks for the fruitful collaboration with wonderful groups at @fhi_mpg_de, #UDE, @TU, @ruhr-uni-bochum.de and #RWTH. We have learned a lot about #magnetism and #TEM.
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Zero ASIC releases Wildebeest, the highest performance FPGA synthesis tool
https://www.zeroasic.com/blog/wildebeest-launch
#HackerNews #ZeroASIC #Wildebeest #FPGA #Synthesis #Tool #HighPerformance #ASICs #TechNews
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Meet me at the intersection
of Love and AffectionThis prospective relationship
will be a dynamic #synthesis
of all our strengths and weaknesses
we are destined to shareWhen we connect
the whole of us
will exceed
than the sum of our parts -
A ball of fire illuminates Autumn's fiery hues.
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#DailyPictureTheme #fire
#vss365 #synthesis
#BlueSkyRelay #arrival / #starcrossed
#FindThePrompt
DailyHaikuPrompt (tho no haiku) lotus / subtle
#WritingCommunity #poetry #nonet
#KBFPhotography #MobilePhonePhotography #Photography -
Silverberg's invention of "Helix Parlours" was more far-fetched than @GreatDismal William Gibson's branded "Under the Knife" plastic surgery shops. Then.
This is interesting https://www.theguardian.com/science/2025/aug/15/scientists-capture-first-footage-of-human-embryo-implanting-in-a-uterus
"In synthetic endometrium" might be a better description, albeit less exciting. Or is it more exciting. Are we heading for Aldous Huxley's Brave New World, with growth of cloned embryos in jars, and decanting?
And various interstellar epic dashes.
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Popular this week:
#music #synthesis #1980 #doomgaze #trashy #distopian #bleeps #cartoons #berlinschool #postrock #indiepop #80s #electroacoustic #minimalism #postpunk #leftfield #blackgaze #janglepop #diy #ebm
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welkom @sebastiaanfranken op mijn #TL met
Crushed Stratocaster uit 2015 een experimenteel sound-design Jimmy ThePeach✞
het experiment Crushed #Stratocaster met het gitaarspel van Jimmy ThePeach✞ is een poging om van een herkenbaar geluid een totaal niet meer te herleiden nieuw geluid te maken met behulp van technieken zoals #Granular #Synthesis – het leek me maar het beste om dit experiment naar een fijngestampte gitaar te noemen - luister op https://ferrie.audio/b/1A3
volg Seb 🙏🏻
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Designers don’t just solve problems—they shape how we see them. Learn how #synthesis, #sensemaking, and #problemframing turn complexity into clarity and insight into strategic action.
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Llasa: Llama-Based Speech Synthesis
https://llasatts.github.io/llasatts/
#HackerNews #Llasa #Llama-Based #Speech #Synthesis #SpeechTechnology #AIInnovation #VoiceSynthesis
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Coqui TTS: Free Text-to-Speech
#HackerNews #Coqui #TTS #Free #Text-to-Speech #AI #Speech #Synthesis #OpenSource
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📘 New #DynaTrait synthesis paper online, led by Ellen van Velzen: "Flexibility in Aquatic Food Web Interactions: Linking Scales and Approaches"
Read it here: https://link.springer.com/article/10.1007/s10021-025-00968-7
#ecology #evolution #traits #limnology #aquatic #freshwater #science #synthesis #foodweb #interactions
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Novel enantioselective #synthesis of rubriflordilactone B by Gui and colleagues from the Chinese Academy of Science published in #JACS
This is already the second total synthesis of this group, with an interesting reaction cascade as the key reaction in this process.
