#medchem — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #medchem, aggregated by home.social.
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Another thought-provoking #MedChem #SciComm story by Stan Van Boeckel.
On the example of Sitagliptin, he explains the power of minimizing molecules and looking for the highest ligand efficiency in #DrugDiscovery.
#Chemistry #ChemBio #StoryTelling #SmallMolecules #LigandEfficiency #Science #Medicines
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The final stage of my #conference tour is today in Amsterdam at the spring meeting of the #MedChem and #ChemBio division of #KNCV in Amsterdam #KNCVMCCB2026.
Looking forward to a full day of exciting Medicinal Chemistry and Chemical Biology #research
The meeting was just opened by Iwan de Esch and the president of the KNCV MCCB division, Ingrid Dijkgraaf.
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The final stage of my #conference tour is today in Amsterdam at the spring meeting of the #MedChem and #ChemBio division of #KNCV in Amsterdam #KNCVMCCB2026.
Looking forward to a full day of exciting Medicinal Chemistry and Chemical Biology #research
The meeting was just opened by Iwan de Esch and the president of the KNCV MCCB division, Ingrid Dijkgraaf.
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The final stage of my #conference tour is today in Amsterdam at the spring meeting of the #MedChem and #ChemBio division of #KNCV in Amsterdam #KNCVMCCB2026.
Looking forward to a full day of exciting Medicinal Chemistry and Chemical Biology #research
The meeting was just opened by Iwan de Esch and the president of the KNCV MCCB division, Ingrid Dijkgraaf.
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The final stage of my #conference tour is today in Amsterdam at the spring meeting of the #MedChem and #ChemBio division of #KNCV in Amsterdam #KNCVMCCB2026.
Looking forward to a full day of exciting Medicinal Chemistry and Chemical Biology #research
The meeting was just opened by Iwan de Esch and the president of the KNCV MCCB division, Ingrid Dijkgraaf.
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A very good read about computational chemistry and how it helps in drug discovery, and more importantly, what should be done so that it would be even more efficient.
https://medium.com/@dapscience/ai-drug-discovery-grand-challenges-benchmarks-be495dfb5ce4
#compchem #academicChatter #chemistry #medchem #drugDiscovery #drugDevelopment
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Neue Episode im Wirkstoffradio!
WSR085 Lipidsenker: Statine, Ezetimib und Fibrate mit Hans-Dieter Höltje und Bernd Rupp (@Rupi42ai).https://www.wirkstoffradio.de/2025/05/04/wsr085-lipidsenker-statine-ezetimib-und-fibrate/
#Lipidsenker #Cholesterol #Statine #Fibrate #Wirkstoffentwicklung #Pharmazie #Biochemie #MedChem -
Neue Episode im Wirkstoffradio!
WSR085 Lipidsenker: Statine, Ezetimib und Fibrate mit Hans-Dieter Höltje und Bernd Rupp (@Rupi42ai).https://www.wirkstoffradio.de/2025/05/04/wsr085-lipidsenker-statine-ezetimib-und-fibrate/
#Lipidsenker #Cholesterol #Statine #Fibrate #Wirkstoffentwicklung #Pharmazie #Biochemie #MedChem -
Efficient Synthesis of ProTide antivirals: A team from from #Fudan University and #Shanghai Jiao Tong University reporting a copper-catalyzed method for synthesizing chiral phosphates in #JACS.
This research represents a new tool for the synthesis of ProTide nucleoside analogues, providing an efficient route that can enhance the development of antiviral drugs in future studies.
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Today is day 4 of the #EFMC International symposium on medical chemistry in #Rome. Had some interesting talks about my research on #antivirals. #MedChem #Chemistry
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⚗️ For everyone interested in the synthesis of #antiviral #drugs:
I collected 7 synthesis routes for #entecavir, a marketed #HBV antiviral. At first sight, this carbocyclic nucleoside analogue looks quite simple, however, its synthesis requires a multi-step total synthesis.
Check the article for further information and share it with your audience:
https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-strategies-for-entecavir
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⚗️ For everyone interested in the synthesis of #antiviral #drugs:
I collected 7 synthesis routes for #entecavir, a marketed #HBV antiviral. At first sight, this carbocyclic nucleoside analogue looks quite simple, however, its synthesis requires a multi-step total synthesis.
Check the article for further information and share it with your audience:
https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-strategies-for-entecavir
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⚗️ For everyone interested in the synthesis of #antiviral #drugs:
I collected 7 synthesis routes for #entecavir, a marketed #HBV antiviral. At first sight, this carbocyclic nucleoside analogue looks quite simple, however, its synthesis requires a multi-step total synthesis.
Check the article for further information and share it with your audience:
https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-strategies-for-entecavir
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⚗️ For everyone interested in the synthesis of #antiviral #drugs:
I collected 7 synthesis routes for #entecavir, a marketed #HBV antiviral. At first sight, this carbocyclic nucleoside analogue looks quite simple, however, its synthesis requires a multi-step total synthesis.
Check the article for further information and share it with your audience:
https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-strategies-for-entecavir
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⚗️ For everyone interested in the synthesis of #antiviral #drugs:
I collected 7 synthesis routes for #entecavir, a marketed #HBV antiviral. At first sight, this carbocyclic nucleoside analogue looks quite simple, however, its synthesis requires a multi-step total synthesis.
Check the article for further information and share it with your audience:
https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-strategies-for-entecavir
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I am happy to share my recent publication in #OrgLett 📰
⚗️ We synthesized carbobicyclic nucleoside analogues which appear to be potent #antivirals against #RSV Despite their novel bicyclic structure, they adopt a ribose-like structure. This may be a new template for novel nucleoside analogues.
https://pubs.acs.org/doi/10.1021/acs.orglett.3c03590
➡️ Next step: Explore the mechanism of action.
#chemistry #medchem #virus #science #research #CUHK #HongKong
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#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200 -
Our chemical tool #BCL6 #degrader is now available for free from the SGC as part of their donated chemical probes programme. We are very pleased to support this initiative which enables researchers to access quality tool compounds for their research. Remarkably, this is the first approved degrader on their list, with no doubt many more to follow! https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/CCT369260 #chemicalprobes #medchem #DrugDiscovery #tpd
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Carbasugar #nucleoside analogues often lack biological activity, which is attributed to an unfavorable conformation. Locked nucleoside analogues, however, can mantain the ribose-like conformation. Another synthetic access is published in #OrgLett by Lak Shin Joeng and colleagues from Seoul National University (S. #Korea)
They were able to report the synthesis of the conformationally locked cytidine nucleoside analogue in 19 steps.
#chemistry #MedChem @chemistry
https://pubs.acs.org/doi/10.1021/acs.orglett.2c03853 -
A nice overview on #PCSK9 #inhibitors and related #medchem opportunities.
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c01290