#medchem — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #medchem, aggregated by home.social.
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Congratulations to Daniel Merk from the LMU München on being award the EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Academia.
Great to see Benjamin Schumann from Technische Universität Dresden and Luca Laraia from Technical University of Denmark listed as the most meritorious runners-ups. Very well deserved!
#Award #Congratulations #Academia #MedChem #ChemBio #Glycotime
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Another thought-provoking #MedChem #SciComm story by Stan Van Boeckel.
On the example of Sitagliptin, he explains the power of minimizing molecules and looking for the highest ligand efficiency in #DrugDiscovery.
#Chemistry #ChemBio #StoryTelling #SmallMolecules #LigandEfficiency #Science #Medicines
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The final stage of my #conference tour is today in Amsterdam at the spring meeting of the #MedChem and #ChemBio division of #KNCV in Amsterdam #KNCVMCCB2026.
Looking forward to a full day of exciting Medicinal Chemistry and Chemical Biology #research
The meeting was just opened by Iwan de Esch and the president of the KNCV MCCB division, Ingrid Dijkgraaf.
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Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.
https://www.fodranlab.com/
#Chemistry #ChemBio #DrugDiscovery #Synthesis -
A very good read about computational chemistry and how it helps in drug discovery, and more importantly, what should be done so that it would be even more efficient.
https://medium.com/@dapscience/ai-drug-discovery-grand-challenges-benchmarks-be495dfb5ce4
#compchem #academicChatter #chemistry #medchem #drugDiscovery #drugDevelopment
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We’re excited to invite you to Computational and Medicinal Chemistry by the Lake 2026, happening June 2–4 in beautiful Kuopio, Finland.
This three-day symposium brings together researchers from academia and industry to explore the latest in drug discovery — from PROTACs to AI-driven screening, molecular dynamics, and more.
We’d love to see you too there — let’s talk science by the lake!
https://sites.uef.fi/cmcl-2026/
#medchem #compchem #science #kuopio #AcademicChatter #drugdiscovery #chemistry
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Neue Episode im Wirkstoffradio!
WSR085 Lipidsenker: Statine, Ezetimib und Fibrate mit Hans-Dieter Höltje und Bernd Rupp (@Rupi42ai).https://www.wirkstoffradio.de/2025/05/04/wsr085-lipidsenker-statine-ezetimib-und-fibrate/
#Lipidsenker #Cholesterol #Statine #Fibrate #Wirkstoffentwicklung #Pharmazie #Biochemie #MedChem -
Researchers from #Germany have isolated a novel #antibiotic named saarvienin A. The glycopeptide was obtained from an Amycolatopsis strain by Rolf Müller and his team and was described in the journal Angewandte Chemie. With a completely novel structure, it exhibits excellent antibiotic activity against Gram-positive bacteria and can overcome vancomycin resistance. However, cytotoxicity against eukaryotic cells has also been observed.
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To treat diseases, proteins are often targeted for inhibition. Recently, PROTACs emerged as an alternative approach, degrading proteins by recruiting a ubiquitinase followed by a protease.
In J Med Chem, Darci Trader (UC California) and colleagues demonstrated that the protease can be engaged without ubiquitinase recruitment. Though early-stage and less active than PROTACs, this offers a promising new direction.
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Efficient Synthesis of ProTide antivirals: A team from from #Fudan University and #Shanghai Jiao Tong University reporting a copper-catalyzed method for synthesizing chiral phosphates in #JACS.
This research represents a new tool for the synthesis of ProTide nucleoside analogues, providing an efficient route that can enhance the development of antiviral drugs in future studies.
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Today is day 4 of the #EFMC International symposium on medical chemistry in #Rome. Had some interesting talks about my research on #antivirals. #MedChem #Chemistry
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The synthesis of #drug libraries is key in drug discovery but can be inefficient, especially in small labs. Jiang Weng and colleagues at Sun Yat-Sen University (#Guangzhou #China) propose a reagent-free sulfamide coupling strategy to form bifunctional molecules. This method allows the coupling of acid and amine on a 96-well plate without additives published in the journal Angewandte Chemie.
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⚗️ For everyone interested in the synthesis of #antiviral #drugs:
I collected 7 synthesis routes for #entecavir, a marketed #HBV antiviral. At first sight, this carbocyclic nucleoside analogue looks quite simple, however, its synthesis requires a multi-step total synthesis.
Check the article for further information and share it with your audience:
https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-strategies-for-entecavir
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I am happy to share my recent publication in #OrgLett 📰
⚗️ We synthesized carbobicyclic nucleoside analogues which appear to be potent #antivirals against #RSV Despite their novel bicyclic structure, they adopt a ribose-like structure. This may be a new template for novel nucleoside analogues.
https://pubs.acs.org/doi/10.1021/acs.orglett.3c03590
➡️ Next step: Explore the mechanism of action.
#chemistry #medchem #virus #science #research #CUHK #HongKong
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This enhances the efficacy of various classes of antibiotics by 32-512 fold, without inducing toxicity towards mammalian cells. The leading combination also disrupts mature multispecies biofilms composed of A. baumannii and methicillin-resistant Staphylococcus aureus (MRSA), which is typically resistant to most antibiotics.
#ChemSciPicks #medchem #AntibioticResistance #antibiotic -
Are there non-phosphorylated nucleoside analogs that act as inhibitors of viral polymerase?
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@Nature @SciReports
#CompChem #MedChem #ML #AI #MachineLearning
@unitartu @1Healthdrugs_ca @COSTprogramme @cnr_scitec @CSIR_IHBT #ArtificialInteligence #RealTimeChemhttps://www.nature.com/articles/s41598-023-44264-7
Drug repurposing: a nexus of innovation, science, and potential
Maria Cristina De Rosa, Rituraj Purohit & Alfonso T. García-Sosa
Scientific Reports volume 13, Article number: 17887 (2023) -
RT @conway_group: Our 'Mutate and Conjugate' paper is out now in ACS Chem Biol (@ACSBioMed)! We combine site-directed mutagenesis and electrophilic fragments to identify inhibitors the mutant protein with a view to helping target validation.
https://t.co/hN0oOHupVy
#chembiol #medchem https://t.co/lOn8k7F23C -
I always enjoy sharing Eline's work. She was a close collaborator during graduate school at UCSF.
With colleagues, Eline has extended the project we worked on together 5+ years ago and done the near-impossible: graft a covalent and non-covalent fragment into a PPI stabilizer.
Check it out!
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202308004
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#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200 -
Chung K. Chu and colleagues from #Georgia University (#Athens #USA) published in the Journal of Medical Chemistry the synthesis and biological evaluation of several prodrug strategies for l-BHDU against Varicella Zoster Virus. #antivirals #chemistry #medchem
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Our review on cannabinoid derivatives just got accepted at Org Biomol Chem, and you can read the preprint here.
This review discusses advanced derivatization strategies for the major cannabinoids, where the starting material is the pure phytocannabinoid itself, and the final product either a cannabinoid pro-drug, or a novel pharmacoactive material.
#cannabis #research #API #medchemhttps://chemrxiv.org/engage/chemrxiv/article-details/63bef4391f1258c73a9a22b5
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Small review about synthetic routes to #antiviral #drug remdesivir. Including first described synthesis by Gilead in #Nature, but also the approach from Benjamin List in Angewandte Chemie.
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I wrote a short excerpt about the #SARS-CoV-2 and #RSV #antiviral VV116 which was developed in #China. Structurally, it resembles #remdesivir but esterification led to much better bioavailability. Therefore, it can be administered orally.
Any opinions on this nucleoside analogue?
@chemistry #chemistry #medchem
https://www.organicchemistry.eu/books/nucleoside-analogues/page/sars-cov-2-antiviral-vv116
