#medchem — Public Fediverse posts

Another thought-provoking #MedChem #SciComm story by Stan Van Boeckel.

On the example of Sitagliptin, he explains the power of minimizing molecules and looking for the highest ligand efficiency in #DrugDiscovery.

https://www.linkedin.com/posts/stan-van-boeckel-a0089b15_part-29-sometimes-smaller-is-elegant-share-7453453246150430720-uYYw?utm_source=share&utm_medium=member_desktop&rcm=ACoAACVzmDsB7J_8sWXEOBYlnnAs1T4cVcDlrxQ

#Chemistry #ChemBio #StoryTelling #SmallMolecules #LigandEfficiency #Science #Medicines

⚗️ For everyone interested in the synthesis of #antiviral #drugs:

I collected 7 synthesis routes for #entecavir, a marketed #HBV antiviral. At first sight, this carbocyclic nucleoside analogue looks quite simple, however, its synthesis requires a multi-step total synthesis.

Check the article for further information and share it with your audience:

https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-strategies-for-entecavir

#Chemistry #Synthesis #Virus #MedChem #Science #Research