Live and recent posts from across the Fediverse tagged #lunteren2026, aggregated by home.social.
How do you pick the right target molecule for a total synthesis program?
At #Lunteren2026, Dirk Trauner gave an inspiring lecture with a lot of thought-provoking potential reasons to select a target molecule in combination with many insights into fascinating completed total syntheses.
https://pubs.acs.org/doi/abs/10.1021/jacs.8b01918
#Chemistry #Synthesis
Interesting talk by Danny Broere of the University of Utrecht at #Lunteren2026. He gave exciting insights into equipping metal complexes with new functions by exploiting metal-ligand cooperativity.
https://pubs.acs.org/doi/abs/10.1021/jacs.5c15308
#Chemistry #Catalysis #MetalComplexes
How can we improve peptide- and protein-based drugs and equip them with new functions?
In #Lunteren2026, Jeffrey Bode talked about the synthesis of challenging, chemically modified proteins using a combination of solid-phase peptide synthesis, recombinant expression and ligation strategies like the KAHA ligation.
https://pubs.acs.org/doi/abs/10.1021/acs.accounts.7b00277
He also talked about the synthesis of defined ubiquitin multimers using a chemoenzymatic strategy.
https://chemrxiv.org/doi/10.26434/chemrxiv-2025-943j7
How can peptide-based drugs be modified at a late stage for further biological evaluation?
At #Lunteren2026, Eva Meeus told us about her amazing work on modifying the skeleton of tryptophan in peptides through nitrogen atom insertion.
https://pubs.acs.org/doi/abs/10.1021/jacs.5c16498
#Chemistry #ChemBio #Peptide
Congratulations to @robpollice on being awarded the “EurJOC Best Research Article by Early Career Researcher” award at #Lunteren2026.
He gave an exciting Award Lecture on a generalizable framework for analyzing chemical reaction networks.
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202400949
#Chemistry #Networks #Data #Award
Activating prodrugs with an external stimulus is an exciting strategy in #DrugDiscovery to obtain a localized effect, while avoiding systemic toxicity. Nevertheless, commonly used light-activation strategies can have an issue with penetrating deeply enough into tissues.
Rienk Eelkema told us at #Lunteren2026 about the alternative strategy of using ionizing radiation as a trigger for prodrug activation that can overcome this issue.
https://pubs.rsc.org/en/content/articlelanding/2026/sc/d5sc03191e
Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.
https://www.fodranlab.com/
#Chemistry #ChemBio #DrugDiscovery #Synthesis
Great talk by Phillip Yesley from the group of Wim Velema at #Lunteren2026.
He discussed the use of mutational profiling to find covalent ligands for structured #RNA using acyl imidazoles as the reactive group.
https://onlinelibrary.wiley.com/doi/10.1002/ange.202517243
#Chemistry #ChemBio #Covalent #CovalentInhibitor
Predicting the stereochemical outcome of glycosylation reactions is a complex problem.
In his talk at #Lunteren2026, Daan Hoogers from the group of Jeroen Codee of our @LED3hub presented his research into the systematic exploration of this question with various methods.
https://pubs.rsc.org/en/content/articlelanding/2026/sc/d5sc07201h
#Chemistry #ChemBio #Glycotime
As an organic chemist, should you specialize in synthesis method development or total synthesis?
In his inspiring talk at #Lunteren2026, Alois Fürstner from the Max-Planck-Institut für Kohlenforschung shows how his group is excelling at both and makes the point that there is important cross-fertilization between the two research directions in his group.
Interesting talk by Géraldine Masson at #Lunteren2026. She gave a presentation with the title "Chiral Brønsted Acid–Driven Enantio- and Regioselective Transformations of Polyunsaturated Systems toward Complex Molecular Architectures".
Great talk by Mathijs Mabesoone at #Lunteren2026. He talked about the use of automated synthesis and characterization of peptides as a basis for data-driven discovery of peptides with new properties on the example of general design-rules for peptide surfactants.
#Chemistry #Surfactants #Robotics
Interesting talk by Antonio Echavarren at #Lunteren2026. He talked about the use of gold-carbene catalysis to perform complex and enantioselective transformations in organic synthesis.
https://pubs.acs.org/doi/10.1021/jacsau.3c00159
#Synthesis #OrganicChemistry #Chemistry #Catalysis
Interesting talk by Antonio Echavarren at #Lunteren2026. He talked about the use of gold-carbene catalysis to perform complex and enantioselective transformations in organic synthesis. pubs.acs.org/doi/10.1021/... #Synthesis #OrganicChemistry #ChemSky #Catalysis
Great talk by Dmitrii Nagornîi from the group of Timothy Noël at #Lunteren2026. He talked about the late-stage modification of aryl compounds with NCF3 and SCF3 groups using flow chemistry.
https://chemrxiv.org/doi/full/10.26434/chemrxiv.15000577/v2
#Chemistry #FlowChemistry
How can LDL-cholesterol ("bad" cholesterol) be lowered in patients? Danila Branca gave an exciting talk at #Lunteren2026 on the development of orally bioavailable, macrocyclic peptide-based inhibitors of PCSK9 that were initially discovered by mRNA display and investigated by Merck in a clinical phase 3 study as enlicitide.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01084
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01599
How does Mycobacterium tuberculosis manage to survive in human macrophages? The virulence factor 1-TbAd plays a key role in this process, but its exact molecular mechanism is so far poorly understood.
Interesting talk by Paul Wienecke from the group of Adriaan Minnaard at #Lunteren2026. He talked about his exciting project "SAR and Target Identification Studies on 1-TbAd - a Nucleosidic Virulence Factor of Mycobacterium tuberculosis". (1/2)
Insightful talk by Varinder Aggarwal from the University of Bristol at #Lunteren2026. He talked about efficient synthesis procedures through Iterative chemistry enabled by boron. He presented e.g. the synthesis and structural annotation of baulamycins A.
https://www.nature.com/articles/nature23265
#Chemistry #Synthesis #boron #iteromics
Excellent #OrganicSynthesis is the basis of many #ChemBio projects. Nevertheless, we often do not present much of our synthesis. I am excited to be at the Dutch Symposium on Organic Chemistry #Lunteren2026, where synthesis will take the center stage. #ChemSky #OrganicChemistry #Science #Conference
Excellent #OrganicSynthesis is the basis of so many exciting #ChemBio projects. Nevertheless, we often do not present much of the synthesis that we do.
Therefore, I am very happy to be at the Dutch Symposium on Organic Chemistry #Lunteren2026, where organic synthesis will take the center stage for the next 2 days.
Getting started with a full week of #Science #conferences. I will be at #Lunteren2026 and #KNCVMCCB2026 by the #KNCV and at #Biochemistry2026 by @GDCh_BioChem. Looking forward to learning about exciting science and (re-)connecting with many scientists.
#ChemBio #Biochemistry #Chemistry
Getting started with a full week of #Science #conferences. I will be at #Lunteren2026 and #KNCVMCCB2026 by the #KNCV and at #Biochemistry2026 by @[email protected]. Looking forward to learning about exciting science and (re-)connecting with many scientists. #ChemBio #Biochemistry #ChemSky