Live and recent posts from across the Fediverse tagged #chembio, aggregated by home.social.
Great talk by Douglas Mitchell at #ICBS2026.
He gave exciting insights into ribosomally synthesized and post-translationally modified peptides (RiPPs) that fold into lasso peptides and their potential to treat cancer.
#Cancer #RiPP #LassoPeptide #Peptide #DrugDiscovery #ChemBio #Chemistry #Science
Interesting talk by Ziyang Zhang at #ICBS2026.
He presented his group's exciting work on small molecules that enhance GTP hydrolysis by KRAS with important implications in switching off signaling by KRAS Q61 mutants in cancer cell lines.
Inspiring ICBS Global Lectureship Award lecture by Peng Chen at #ICBS2026.
He gave exciting insights into the power of genetic code expansion to better understand PTMs and to enable new chemistry in living cells.
Congratulations to Yilong Zou on being one of the 2026 ICBS Young Chemical Biologist Awardees #ICBS2026.
He gave a great award lecture: "Chemical basis and intervention of ferroptosis in cancer and tissue injury"
Congratulations to Angad Mehta on being one of the 2026 ICBS Young Chemical Biologist Awardees.
He gave a great award lecture: "In vitro immune-like systems for continuous directed evolution of biologics"
Interesting talk by Elena Reckzeh at #ICBS2026.
She gave a broad overview of the many different applications of organoids in Drug Discovery that her group is developing.
#Organoids #DrugDiscovery #ChemBio #Chemistry #DrugDevelopment
Thank you to the International Chemical Biology Society for inviting me to present some of our latest research today in San Francisco.
#ICBS2026 is truly an amazing conference. Thank you to Michelle Arkin and her team for the great organization.
#ChemBio #Chemistry #ChemicalProteomics #Science
Photo credit: Billy Ng
O-GlcNAcylation is a posttranslational modification of proteins with important implications in health and disease.
In his talk at #ICBS2026, Billy Ng gave an exciting overview, how they use proximity-inducing OGTACs to specifically introduce this modification on target proteins.
https://www.cell.com/cell-chemical-biology/abstract/S2451-9456(26)00318-1
Amazing talk by Brian Paegel at #ICBS2026.
He talked about his group's exciting work on using DNA-encoded libraries for phenotypic screening for effectors of human signaling and for #antibiotics.
https://pubs.acs.org/acscii/article/9/8/1603/1282515/Hydrogel-Encapsulated-Beads-Enable-Proximity
Great talk by Jason Gestwicki at #ICBS2026.
He talked about the many different structures that Tau fibrils can adopt and how this relates to different neurodegenerative disorders. He also gave great insights into their dynamics.
https://pubs.acs.org/jacsat/article/148/33/35386/5254992/Cofactor-Free-Tau-Filaments-Are-Dynamic-and
Great talk by Chimno Nnadi at #ICBS2026.
"Deep Learning Guided Phenotypic Drug Screen Uncovers Structure-Activity-Relationships of Pyrazoloquinolinones"
Exciting talk by Evan Miller at #ICBS2026.
He talked about his group's work on novel NIR fluorophores based on bis(trifluoromethyl)carborhodamine and their application for live cell microscopy and activity-based sensing.
Can the properties of psychedelics be optimized into safe, non-cardiotoxic and non-hallucinogenic antipsychotic drugs?
Great talk by David Olson at #ICBS2026 on their work in this field in the context of lysergic acid diethylamide analogs.
Interesting talk by Jie Liu from the group of Kevan Shokat at #ICBS2026.
He talked about the development of BisRoc, a bivalent rocaglamide, that functions as a molecular glue to form higher-order eIF4A-RNA complexes for cancer cell-specific translation suppression
#RNA #ProximityInduction #Glue #MolecularGlue #ChemBio #Chemistry #Science
How can the targeted degradation of #RNA be exploited to treat diseases?
Peng Wu gave an insightfull talk at #ICBS2026 on his group's work on RNA-degrading RIBOTACs e.g. on the example of an NRAS mRNA degrader with implications in #cancer.
#Degradation #Degrader #mRNA #DrugDiscovery #ChemBio #Chemistry #Science
How can we specifically address RNA with small molecules?
Amanda Garner gave an exciting talk at #ICBS2026, in which she discussed her group's work on developing tools for studying small molecule-RNA interactions in cells and disrupting RNA-protein interactions.
Gianluca Sbardella opened the third day of #ICBS2026 and introduced the EFMC - European Federation for Medicinal Chemistry and Chemical Biology and the EFMC Young Scientists Network.
It was great to visit UCLA and get a chance to present our work to an amazing audience of scientists.
Special thanks to Keriann Backus for inviting me and to Stuart Conway for showing me around the campus.
It was great to hear about the exciting science of Keriann Backus and her group, Stuart Conway, Mehdi Bouhaddou, Antonio Tinoco Valencia and Joseph Loo.
Thank you to everyone for having me.