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  1. A great talk by Kim Bonger at the #qBioLeiden kick-off meeting. She talked about "Chemical tools to study biological immune processes" and gave exciting insights into the power of chemical tools to study biology on the example of NETosis.

    nature.com/articles/s42004-024
    #Chemistry #ChemBio

  2. A great talk by Kim Bonger at the #qBioLeiden kick-off meeting. She talked about "Chemical tools to study biological immune processes" and gave exciting insights into the power of chemical tools to study biology on the example of NETosis.

    nature.com/articles/s42004-024
    #Chemistry #ChemBio

  3. A great talk by Kim Bonger at the #qBioLeiden kick-off meeting. She talked about "Chemical tools to study biological immune processes" and gave exciting insights into the power of chemical tools to study biology on the example of NETosis.

    nature.com/articles/s42004-024
    #Chemistry #ChemBio

  4. A great talk by Kim Bonger at the #qBioLeiden kick-off meeting. She talked about "Chemical tools to study biological immune processes" and gave exciting insights into the power of chemical tools to study biology on the example of NETosis.

    nature.com/articles/s42004-024
    #Chemistry #ChemBio

  5. A great talk by Kim Bonger at the #qBioLeiden kick-off meeting. She talked about "Chemical tools to study biological immune processes" and gave exciting insights into the power of chemical tools to study biology on the example of NETosis.

    nature.com/articles/s42004-024
    #Chemistry #ChemBio

  6. Interesting paper by the groups of Hilal Lashuel and Muhammad Jbara in JACS.

    Using organometallic chemistry, they arylate cysteines to site-specifically introduce "native-like" phosphotyrosine mimics on the example of α-synuclein.

    doi.org/10.1021/jacs.6c12345
    #Chemistry #ChemBio #Peptides #Proteins #Aggregation

  7. Interesting paper by the groups of Hilal Lashuel and Muhammad Jbara in JACS.

    Using organometallic chemistry, they arylate cysteines to site-specifically introduce "native-like" phosphotyrosine mimics on the example of α-synuclein.

    doi.org/10.1021/jacs.6c12345
    #Chemistry #ChemBio #Peptides #Proteins #Aggregation

  8. Interesting paper by the groups of Hilal Lashuel and Muhammad Jbara in JACS.

    Using organometallic chemistry, they arylate cysteines to site-specifically introduce "native-like" phosphotyrosine mimics on the example of α-synuclein.

    doi.org/10.1021/jacs.6c12345
    #Chemistry #ChemBio #Peptides #Proteins #Aggregation

  9. Interesting paper by the groups of Hilal Lashuel and Muhammad Jbara in JACS.

    Using organometallic chemistry, they arylate cysteines to site-specifically introduce "native-like" phosphotyrosine mimics on the example of α-synuclein.

    doi.org/10.1021/jacs.6c12345
    #Chemistry #ChemBio #Peptides #Proteins #Aggregation

  10. Interesting paper by the groups of Hilal Lashuel and Muhammad Jbara in JACS.

    Using organometallic chemistry, they arylate cysteines to site-specifically introduce "native-like" phosphotyrosine mimics on the example of α-synuclein.

    doi.org/10.1021/jacs.6c12345
    #Chemistry #ChemBio #Peptides #Proteins #Aggregation

  11. 𝐇𝐨𝐰 𝐜𝐚𝐧 𝐲𝐨𝐮 𝐛𝐞𝐬𝐭 𝐚𝐬𝐬𝐞𝐬𝐬 𝐭𝐡𝐞 𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 𝐟𝐨𝐫 𝐟𝐮𝐫𝐭𝐡𝐞𝐫 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭?

    An interesting paper by the group of Jeffrey Keillor in the Journal of Medicinal Chemistry addresses this important question. (1/4)

    doi.org/10.1021/acs.jmedchem.6
    #Chemistry #ChemBio #DrugDiscovery #CovalentDrugs #Electrophiles

  12. 𝐇𝐨𝐰 𝐜𝐚𝐧 𝐲𝐨𝐮 𝐛𝐞𝐬𝐭 𝐚𝐬𝐬𝐞𝐬𝐬 𝐭𝐡𝐞 𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 𝐟𝐨𝐫 𝐟𝐮𝐫𝐭𝐡𝐞𝐫 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭?

    An interesting paper by the group of Jeffrey Keillor in the Journal of Medicinal Chemistry addresses this important question. (1/4)

    doi.org/10.1021/acs.jmedchem.6
    #Chemistry #ChemBio #DrugDiscovery #CovalentDrugs #Electrophiles

  13. 𝐇𝐨𝐰 𝐜𝐚𝐧 𝐲𝐨𝐮 𝐛𝐞𝐬𝐭 𝐚𝐬𝐬𝐞𝐬𝐬 𝐭𝐡𝐞 𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 𝐟𝐨𝐫 𝐟𝐮𝐫𝐭𝐡𝐞𝐫 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭?

    An interesting paper by the group of Jeffrey Keillor in the Journal of Medicinal Chemistry addresses this important question. (1/4)

    doi.org/10.1021/acs.jmedchem.6
    #Chemistry #ChemBio #DrugDiscovery #CovalentDrugs #Electrophiles

  14. 𝐇𝐨𝐰 𝐜𝐚𝐧 𝐲𝐨𝐮 𝐛𝐞𝐬𝐭 𝐚𝐬𝐬𝐞𝐬𝐬 𝐭𝐡𝐞 𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 𝐟𝐨𝐫 𝐟𝐮𝐫𝐭𝐡𝐞𝐫 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭?

    An interesting paper by the group of Jeffrey Keillor in the Journal of Medicinal Chemistry addresses this important question. (1/4)

    doi.org/10.1021/acs.jmedchem.6
    #Chemistry #ChemBio #DrugDiscovery #CovalentDrugs #Electrophiles

  15. 𝐇𝐨𝐰 𝐜𝐚𝐧 𝐲𝐨𝐮 𝐛𝐞𝐬𝐭 𝐚𝐬𝐬𝐞𝐬𝐬 𝐭𝐡𝐞 𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 𝐟𝐨𝐫 𝐟𝐮𝐫𝐭𝐡𝐞𝐫 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭?

    An interesting paper by the group of Jeffrey Keillor in the Journal of Medicinal Chemistry addresses this important question. (1/4)

    doi.org/10.1021/acs.jmedchem.6
    #Chemistry #ChemBio #DrugDiscovery #CovalentDrugs #Electrophiles

  16. What is the effect of stereochemistry on protein binding?

    In their newest tour-de-force study, the groups of Herman Overkleeft, Hans Aerts and Marta Artola of our @LED3hub comprehensively evaluate this question on the example of 8 variants of all 16 isomers of 1-deoxynojirimycin and their evaluation towards binding to glucosylceramide synthase (GCS), lysosomal glucosylceramidase (GBA1), and nonlysosomal glucosylceramidase (GBA2).

    pubs.acs.org/jmcmar/article/do

    #Chemistry #ChemBio #glycotime

  17. What is the effect of stereochemistry on protein binding?

    In their newest tour-de-force study, the groups of Herman Overkleeft, Hans Aerts and Marta Artola of our @LED3hub comprehensively evaluate this question on the example of 8 variants of all 16 isomers of 1-deoxynojirimycin and their evaluation towards binding to glucosylceramide synthase (GCS), lysosomal glucosylceramidase (GBA1), and nonlysosomal glucosylceramidase (GBA2).

    pubs.acs.org/jmcmar/article/do

    #Chemistry #ChemBio #glycotime

  18. What is the effect of stereochemistry on protein binding?

    In their newest tour-de-force study, the groups of Herman Overkleeft, Hans Aerts and Marta Artola of our @LED3hub comprehensively evaluate this question on the example of 8 variants of all 16 isomers of 1-deoxynojirimycin and their evaluation towards binding to glucosylceramide synthase (GCS), lysosomal glucosylceramidase (GBA1), and nonlysosomal glucosylceramidase (GBA2).

    pubs.acs.org/jmcmar/article/do

    #Chemistry #ChemBio #glycotime

  19. What is the effect of stereochemistry on protein binding?

    In their newest tour-de-force study, the groups of Herman Overkleeft, Hans Aerts and Marta Artola of our @LED3hub comprehensively evaluate this question on the example of 8 variants of all 16 isomers of 1-deoxynojirimycin and their evaluation towards binding to glucosylceramide synthase (GCS), lysosomal glucosylceramidase (GBA1), and nonlysosomal glucosylceramidase (GBA2).

    pubs.acs.org/jmcmar/article/do

    #Chemistry #ChemBio #glycotime

  20. What is the effect of stereochemistry on protein binding?

    In their newest tour-de-force study, the groups of Herman Overkleeft, Hans Aerts and Marta Artola of our @LED3hub comprehensively evaluate this question on the example of 8 variants of all 16 isomers of 1-deoxynojirimycin and their evaluation towards binding to glucosylceramide synthase (GCS), lysosomal glucosylceramidase (GBA1), and nonlysosomal glucosylceramidase (GBA2).

    pubs.acs.org/jmcmar/article/do

    #Chemistry #ChemBio #glycotime

  21. Mark your calendars for the LED3 Lectures of the new academic year! We are expecting an excellent line-up of speakers.

    If you have already put them into your agenda, we had one change of date from October 29th to 28th.

    universiteitleiden.nl/en/scien
    #Chemistry #ChemBio #DrugDiscovery

  22. Mark your calendars for the LED3 Lectures of the new academic year! We are expecting an excellent line-up of speakers.

    If you have already put them into your agenda, we had one change of date from October 29th to 28th.

    universiteitleiden.nl/en/scien
    #Chemistry #ChemBio #DrugDiscovery

  23. Mark your calendars for the LED3 Lectures of the new academic year! We are expecting an excellent line-up of speakers.

    If you have already put them into your agenda, we had one change of date from October 29th to 28th.

    universiteitleiden.nl/en/scien
    #Chemistry #ChemBio #DrugDiscovery

  24. Mark your calendars for the LED3 Lectures of the new academic year! We are expecting an excellent line-up of speakers.

    If you have already put them into your agenda, we had one change of date from October 29th to 28th.

    universiteitleiden.nl/en/scien
    #Chemistry #ChemBio #DrugDiscovery

  25. Do you have experience in Organic Synthesis and an interest in Chemical Biology and are you looking for an exciting PhD position?

    A great opportunity in the lab of Steven Verhelst at KU Leuven in the context of the ANA-KIN consortium.

    kuleuven.be/personeel/jobsite/
    #Chemistry #ChemBio #Kinase

  26. Do you have experience in Organic Synthesis and an interest in Chemical Biology and are you looking for an exciting PhD position?

    A great opportunity in the lab of Steven Verhelst at KU Leuven in the context of the ANA-KIN consortium.

    kuleuven.be/personeel/jobsite/
    #Chemistry #ChemBio #Kinase

  27. Do you have experience in Organic Synthesis and an interest in Chemical Biology and are you looking for an exciting PhD position?

    A great opportunity in the lab of Steven Verhelst at KU Leuven in the context of the ANA-KIN consortium.

    kuleuven.be/personeel/jobsite/
    #Chemistry #ChemBio #Kinase

  28. Do you have experience in Organic Synthesis and an interest in Chemical Biology and are you looking for an exciting PhD position?

    A great opportunity in the lab of Steven Verhelst at KU Leuven in the context of the ANA-KIN consortium.

    kuleuven.be/personeel/jobsite/
    #Chemistry #ChemBio #Kinase

  29. Do you have experience in Organic Synthesis and an interest in Chemical Biology and are you looking for an exciting PhD position?

    A great opportunity in the lab of Steven Verhelst at KU Leuven in the context of the ANA-KIN consortium.

    kuleuven.be/personeel/jobsite/
    #Chemistry #ChemBio #Kinase

  30. Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.

    doi.org/10.64898/2026.08.13.74

    #Chemistry #ChemBio #ChemPro #ChemicalProteomics

  31. Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.

    doi.org/10.64898/2026.08.13.74

    #Chemistry #ChemBio #ChemPro #ChemicalProteomics

  32. Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.

    doi.org/10.64898/2026.08.13.74

    #Chemistry #ChemBio #ChemPro #ChemicalProteomics

  33. Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.

    doi.org/10.64898/2026.08.13.74

    #Chemistry #ChemBio #ChemPro #ChemicalProteomics

  34. Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.

    doi.org/10.64898/2026.08.13.74

    #Chemistry #ChemBio #ChemPro #ChemicalProteomics

  35. RE: mstdn.science/@ChemBioTalks/11

    Want to learn more about the latest exciting research in Chemical Biology?

    Make sure to register for free for the 6th Virtual @ChemBioTalks on September 29th. We have an amazing program of speakers waiting for you!

    events.zoom.us/ev/Ag1AUcW3na5A

    #ChemBio #Chemistry #Symposium

  36. RE: mstdn.science/@ChemBioTalks/11

    Want to learn more about the latest exciting research in Chemical Biology?

    Make sure to register for free for the 6th Virtual @ChemBioTalks on September 29th. We have an amazing program of speakers waiting for you!

    events.zoom.us/ev/Ag1AUcW3na5A

    #ChemBio #Chemistry #Symposium

  37. RE: mstdn.science/@ChemBioTalks/11

    Want to learn more about the latest exciting research in Chemical Biology?

    Make sure to register for free for the 6th Virtual @ChemBioTalks on September 29th. We have an amazing program of speakers waiting for you!

    events.zoom.us/ev/Ag1AUcW3na5A

    #ChemBio #Chemistry #Symposium

  38. RE: mstdn.science/@ChemBioTalks/11

    Want to learn more about the latest exciting research in Chemical Biology?

    Make sure to register for free for the 6th Virtual @ChemBioTalks on September 29th. We have an amazing program of speakers waiting for you!

    events.zoom.us/ev/Ag1AUcW3na5A

    #ChemBio #Chemistry #Symposium

  39. RE: mstdn.science/@ChemBioTalks/11

    Want to learn more about the latest exciting research in Chemical Biology?

    Make sure to register for free for the 6th Virtual @ChemBioTalks on September 29th. We have an amazing program of speakers waiting for you!

    events.zoom.us/ev/Ag1AUcW3na5A

    #ChemBio #Chemistry #Symposium

  40. We are very excited that we have a program with seven world-leading scientists for the 6th Virtual ChemBioTalks on September 29th:

    Giulio Superti-Furga
    Hui (Vivian) Ye
    Gilles Gasser
    Nina Hartrampf
    Tomas Pluskal
    Luke Lavis
    Michelle Chang

    Make sure to register for free: events.zoom.us/ev/Ag1AUcW3na5A
    #ChemBio #Chemistry

  41. We are very excited that we have a program with seven world-leading scientists for the 6th Virtual ChemBioTalks on September 29th:

    Giulio Superti-Furga
    Hui (Vivian) Ye
    Gilles Gasser
    Nina Hartrampf
    Tomas Pluskal
    Luke Lavis
    Michelle Chang

    Make sure to register for free: events.zoom.us/ev/Ag1AUcW3na5A
    #ChemBio #Chemistry

  42. We are very excited that we have a program with seven world-leading scientists for the 6th Virtual ChemBioTalks on September 29th:

    Giulio Superti-Furga
    Hui (Vivian) Ye
    Gilles Gasser
    Nina Hartrampf
    Tomas Pluskal
    Luke Lavis
    Michelle Chang

    Make sure to register for free: events.zoom.us/ev/Ag1AUcW3na5A
    #ChemBio #Chemistry

  43. We are very excited that we have a program with seven world-leading scientists for the 6th Virtual ChemBioTalks on September 29th:

    Giulio Superti-Furga
    Hui (Vivian) Ye
    Gilles Gasser
    Nina Hartrampf
    Tomas Pluskal
    Luke Lavis
    Michelle Chang

    Make sure to register for free: events.zoom.us/ev/Ag1AUcW3na5A
    #ChemBio #Chemistry

  44. We are very excited that we have a program with seven world-leading scientists for the 6th Virtual ChemBioTalks on September 29th:

    Giulio Superti-Furga
    Hui (Vivian) Ye
    Gilles Gasser
    Nina Hartrampf
    Tomas Pluskal
    Luke Lavis
    Michelle Chang

    Make sure to register for free: events.zoom.us/ev/Ag1AUcW3na5A
    #ChemBio #Chemistry

  45. The final talk and second keynote lecture of the 6th Virtual ChemBioTalks will be given by Michelle Chang.

    She will talk about: "Discovery and engineering of new enzymes for biocatalysis"

    Register for free: events.zoom.us/ev/Ag1AUcW3na5A
    #ChemBio #Chemistry

  46. The final talk and second keynote lecture of the 6th Virtual ChemBioTalks will be given by Michelle Chang.

    She will talk about: "Discovery and engineering of new enzymes for biocatalysis"

    Register for free: events.zoom.us/ev/Ag1AUcW3na5A
    #ChemBio #Chemistry