#kinase — Public Fediverse posts

#HAYZE #PERHAM allgraph.ro?lang=en&q=HA... #TYROSINE #KINASE #INHIBITOR aepiot.com?lang=en&q=TY... #HWANG IN #BEOM allgraph.ro?lang=en&q=HW... aepiot.ro

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https://www.europesays.com/ie/498457/ Pim1 identified as promising therapeutic target for inflammatory arthritis treatment #AnkylosingSpondylitis #Arthritis #Bone #Calcium #Cartilage #CD4 #Cell #Chronic #Éire #IE #InflammatoryArthritis #Ireland #Kinase #Metabolism #Protein #Research #RheumatoidArthritis #Spondylitis #Technology

Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which…
#NewsBeep #News #Technology #Ankylosingspondylitis #Arthritis #AU #Australia #Bone #Calcium #cartilage #CD4 #Cell #Chronic #inflammatoryarthritis #Kinase #Metabolism #protein #research #rheumatoidarthritis #Spondylitis
https://www.newsbeep.com/au/688640/

Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which…
#NewsBeep #News #Technology #Ankylosingspondylitis #Arthritis #AU #Australia #Bone #Calcium #cartilage #CD4 #Cell #Chronic #inflammatoryarthritis #Kinase #Metabolism #protein #research #rheumatoidarthritis #Spondylitis
https://www.newsbeep.com/au/688640/

Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @PLOSBiology plos.io/4tjuKgI

Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @PLOSBiology plos.io/4tjuKgI

How could bisphenol A raise depression risk? Study identifies six key molecular targets

Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mous…
#NewsBeep #News #Health #AU #Australia #Blood #Cell #Chemicals #depression #depressivedisorder #ELISA #Endocrine #epidemiology #estrogen #Gene #GeneExpression #Genetic #Kinase #majordepressivedisorder #Mentalhealth #protein #psychiatry #publichealth #Receptor #research #Transcriptomics
https://www.newsbeep.com/au/577535/

How could bisphenol A raise depression risk? Study identifies six key molecular targets

Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mous…
#NewsBeep #News #Health #AU #Australia #Blood #Cell #Chemicals #depression #depressivedisorder #ELISA #Endocrine #epidemiology #estrogen #Gene #GeneExpression #Genetic #Kinase #majordepressivedisorder #Mentalhealth #protein #psychiatry #publichealth #Receptor #research #Transcriptomics
https://www.newsbeep.com/au/577535/

https://www.europesays.com/ie/414176/ How could bisphenol A raise depression risk? Study identifies six key molecular targets #blood #Cell #chemicals #Depression #DepressiveDisorder #Éire #ELISA #Endocrine #Epidemiology #estrogen #Gene #GeneExpression #Genetic #Health #IE #Ireland #Kinase #MajorDepressiveDisorder #MentalHealth #Protein #Psychiatry #PublicHealth #Receptor #Research #Transcriptomics

New server, new #introduction

Hi, I'm Dave. I'm a Research #Scientist at a Research Institute in #London, #UK

I'm a #StructuralBiologist by training. I help run a group that studies #Kinase #signalling in human #health and #disease.

In my spare time I take photos, play #bass and walk #dogs.

I do #Crystallography #CryoEM #Biophysics #DrugDesign and #Glycobiology. #Science #Research

New server, new #introduction

Hi, I'm Dave. I'm a Research #Scientist at a Research Institute in #London, #UK

I'm a #StructuralBiologist by training. I help run a group that studies #Kinase #signalling in human #health and #disease.

In my spare time I take photos, play #bass and walk #dogs.

I do #Crystallography #CryoEM #Biophysics #DrugDesign and #Glycobiology. #Science #Research

The 5th Virtual #ChemBioTalks continue with an insightful talk by Kelly Chibale. He talked about his group's research into new treatments for #malaria. Great insights into the repurposing of anti #cancer #kinase inhibitors to treat P. falciparum. https://onlinelibrary.wiley.com/doi/10.1002/anie.202425206

Very much looking forward to the talk by Kelly Chibale at the 5th Virtual @ChemBioTalks and to learn more about the repurposing of #anticancer #kinase inhibitors to treat #malaria.

#ChemBio #Chemistry #DrugDiscovery

3 projects by the LED3 researchers Nathaniel Martin, Anthe Janssen and Mirjam Huizenga have been awarded NWO Take-off funding to explore commercial development of compounds and technologies with applications in #oncology, #NeuropathicPain treatment and #kinase research!
https://www.nwo.nl/en/news/49-take-off-projects-awarded-in-spring-round-2025

SciTech Chronicles. . . . . .May 6th, 2025

https://bit.ly/stc050625

#EphB1/2 #tyrosine #kinase #inhibitors #carbene #thiamine #Breslow #B1 #3D-printable #electroencephalogram #continuously #bioadhesive #AMT #mesothelioma #"low-carbon metal oxides" #CO2 #"digital twin" #"3D digital model" #sonar #Magellan

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

🌐💡 We suggest which protein kinases (like CK1 and CK2) are involved (see bonus post 👇!).
These are key enzymes ensuring everything runs in sync in humans too, making O. tauri an intriguing example of efficient biological timing.
#Kinase #Phosphorylation 5/7

🌐💡 We suggest which protein kinases (like CK1 and CK2) are involved (see bonus post 👇!).
These are key enzymes ensuring everything runs in sync in humans too, making O. tauri an intriguing example of efficient biological timing.
#Kinase #Phosphorylation 5/7

🌟eLife Special Issue 🌟

A specially curated collection of articles untangles the bewildering complexity of #kinase enzymes.
https://elifesciences.org/collections/eb7614d5/special-issue-allosteric-regulation-of-kinase-activity?utm_source=mastodon&utm_medium=social&utm_campaign=organic

🌟eLife Special Issue 🌟

A specially curated collection of articles untangles the bewildering complexity of #kinase enzymes.
https://elifesciences.org/collections/eb7614d5/special-issue-allosteric-regulation-of-kinase-activity?utm_source=mastodon&utm_medium=social&utm_campaign=organic

The Raf #kinase #inhibitors #Dabrafenib and #Regorafenib impair #Zika virus #replication via distinct mechanisms, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00618-24?af=R

This study provides further insight into ZIKV-host interactions and has implications for the development of novel #antivirals against ZIKV and possibly other #flaviviruses.

The Raf #kinase #inhibitors #Dabrafenib and #Regorafenib impair #Zika virus #replication via distinct mechanisms, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00618-24?af=R

This study provides further insight into ZIKV-host interactions and has implications for the development of novel #antivirals against ZIKV and possibly other #flaviviruses.

Study reveals how a #sugar_sensing #protein acts as a 'machine' to switch #plant #growth—and #oil production—on and off

#kinase #KIN10 #trehalose_6_phosphate

https://phys.org/news/2024-05-reveals-sugar-protein-machine-growth.html

Study reveals how a #sugar_sensing #protein acts as a 'machine' to switch #plant #growth—and #oil production—on and off

#kinase #KIN10 #trehalose_6_phosphate

https://phys.org/news/2024-05-reveals-sugar-protein-machine-growth.html

Researchers uncover natural variation in wild #emmer #wheat for broad-spectrum #disease resistance.

#immunity #agriculture #powdery_mildew #transmembrane #kinase #WTK7_TM #Pm36

https://phys.org/news/2024-04-uncover-natural-variation-wild-emmer.html

Location, location, location: Protein #kinase nanoclustering for optimised signalling output. https://elifesciences.org/articles/93902?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Location, location, location: Protein #kinase nanoclustering for optimised signalling output. https://elifesciences.org/articles/93902?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Postdoc - Kinase biology and signalling

Barts Cancer Institute

Join @DrTanyaSoliman 's team @QMBCI #postdoc #kinase

See the full job description on jobRxiv: https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

#cell_biology #kinases #mass_spectrometry #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

Postdoc - Kinase biology and signalling

Barts Cancer Institute

Join @DrTanyaSoliman 's team @QMBCI #postdoc #kinase

See the full job description on jobRxiv: https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

#cell_biology #kinases #mass_spectrometry #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

Death by a thousand cuts through #kinase inhibitor combinations that can more selectively inhibit individual or multiple protein #kinases than single inhibitors. https://elifesciences.org/articles/86189?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Death by a thousand cuts through #kinase inhibitor combinations that can more selectively inhibit individual or multiple protein #kinases than single inhibitors. https://elifesciences.org/articles/86189?utm_source=mastodon&utm_medium=social&utm_campaign=organic

This “highly interesting” study adds a new layer to our mechanistic understanding of the complex #Parkinson’s disease-linked LRRK2 #kinase. https://elifesciences.org/articles/87098?utm_source=mastodon&utm_medium=social&utm_campaign=organic

This “highly interesting” study adds a new layer to our mechanistic understanding of the complex #Parkinson’s disease-linked LRRK2 #kinase. https://elifesciences.org/articles/87098?utm_source=mastodon&utm_medium=social&utm_campaign=organic

pYtags enable spatiotemporal measurements of receptor tyrosine #kinase signalling in living cells, with enzymes shown here rapidly moving from the cytosol to the cell membranes. #12DaysOfeLife https://elifesciences.org/articles/82863?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days

pYtags enable spatiotemporal measurements of receptor tyrosine #kinase signalling in living cells, with enzymes shown here rapidly moving from the cytosol to the cell membranes. #12DaysOfeLife https://elifesciences.org/articles/82863?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days

In developing #presynapses, the #ActiveZone structure assembles via liquid-liquid #PhaseSeparation (#LLPS). This study shows that the #kinase SAD-1 phosphorylates the scaffold protein SYD-2/Liprin-α, relieving autoinhibition & triggering LLPS #PLOSBiology https://plos.io/3Ne6OZg

In developing #presynapses, the #ActiveZone structure assembles via liquid-liquid #PhaseSeparation (#LLPS). This study shows that the #kinase SAD-1 phosphorylates the scaffold protein SYD-2/Liprin-α, relieving autoinhibition & triggering LLPS #PLOSBiology https://plos.io/3Ne6OZg

"Here, we demonstrate that damaged #lysosomal #membranes are repaired by #microautophagy (a process termed “microlysophagy”) and identify key regulators of the first and last steps. We reveal the AGC #kinase STK38 as a novel microlysophagy regulator...microlysophagy is regulated by STK38 and GABARAPs and could be essential for maintaining lysosomal integrity and preventing #aging."

https://www.embopress.org/doi/full/10.15252/embr.202357300

#autophagy

"Here, we demonstrate that damaged #lysosomal #membranes are repaired by #microautophagy (a process termed “microlysophagy”) and identify key regulators of the first and last steps. We reveal the AGC #kinase STK38 as a novel microlysophagy regulator...microlysophagy is regulated by STK38 and GABARAPs and could be essential for maintaining lysosomal integrity and preventing #aging."

https://www.embopress.org/doi/full/10.15252/embr.202357300

#autophagy

Are you interested in #Calmodulin (CaM) and its interaction with CaMKII? We had a look at this interaction with #photocrosslinking. Covalent attachment of CaM did not break apart the CaMKII holoenzyme but did promote ongoing #kinase activity. The CaM binding segment is also more mobile than expected from previous reports.

This is the accepted pdf, a long time in the making as you might detect.
https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.4798

#Biophysics #Biochemistry #Neuroscience #MassPhotometry

Are you interested in #Calmodulin (CaM) and its interaction with CaMKII? We had a look at this interaction with #photocrosslinking. Covalent attachment of CaM did not break apart the CaMKII holoenzyme but did promote ongoing #kinase activity. The CaM binding segment is also more mobile than expected from previous reports.

This is the accepted pdf, a long time in the making as you might detect.
https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.4798

#Biophysics #Biochemistry #Neuroscience #MassPhotometry

#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics

#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al

https://www.embopress.org/doi/full/10.15252/embj.2022112630

#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics

#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al

https://www.embopress.org/doi/full/10.15252/embj.2022112630

Our latest work is out now in @Circ_Gen! 🎉

❗️Genetic variants in #TNNI3K are associated with dilated cardiomyopathy and supraventricular arrhythmias

#DCM #Arrhythmia #Genetics #Kinase #cardiology Big big thanks to all co-authors! @_CarolinePham Karolina Andrzejczyck, @JurgensSean, @steven_lubitz, @patrick_ellinor, @Jael_Copier, @ArthurWilde5, @cbezzina1, @eml314 and others ✨
https://www.ahajournals.org/doi/abs/10.1161/CIRCGEN.122.003975

https://www.science.org/doi/10.1126/sciadv.adf2331

"The ectopic activation of ERK in scar-prone injuries induced a pro-regenerative response, including cell proliferation, extracellular matrix remodeling, and hair follicle neogenesis. Our data detail an important distinction in ERK activity between regenerating and poorly regenerating adult mammals and open avenues to redirect fibrotic repair toward regenerative healing"

#healing #fibrosis #scarTissue #enzyme #kinase #phosphorylation #mammalianBiology #mammal #scar

Researchers decode targets for hundreds of #signaling #enzymes.

#kinase

https://phys.org/news/2023-02-decode-hundreds-enzymes.html

Researchers decode targets for hundreds of #signaling #enzymes.

#kinase

https://phys.org/news/2023-02-decode-hundreds-enzymes.html

What is the role of #DNAdamage #kinase #DNAPKcs in the cellular response to #oxidative stress?

Benjamin Chen at UT Southwestern, Hsinyu Lee at National Taiwan University, and coworkers implicate it as part of a #checkpoint that modulates #ANT2-#VDAC2-mediated ADP-ATP exchange over #mitochondrial membranes to limit #OXPHOS-derived ROS

https://www.embopress.org/doi/10.15252/embj.2022112094

What is the role of #DNAdamage #kinase #DNAPKcs in the cellular response to #oxidative stress?

Benjamin Chen at UT Southwestern, Hsinyu Lee at National Taiwan University, and coworkers implicate it as part of a #checkpoint that modulates #ANT2-#VDAC2-mediated ADP-ATP exchange over #mitochondrial membranes to limit #OXPHOS-derived ROS

https://www.embopress.org/doi/10.15252/embj.2022112094

#DNAdamage #DNArepair #kinase #DNAPK and #cGAS synergize to induce cancer-related #inflammation in #glioblastoma
Clara Taffoni, Johanna Marines, Nadine Laguette et al at IGH Montpellier
https://www.embopress.org/doi/10.15252/embj.2022111961