#kinase — Public Fediverse posts

#HAYZE #PERHAM allgraph.ro?lang=en&q=HA... #TYROSINE #KINASE #INHIBITOR aepiot.com?lang=en&q=TY... #HWANG IN #BEOM allgraph.ro?lang=en&q=HW... aepiot.ro

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https://www.europesays.com/ie/521185/ Bee-derived propolis shows potent antiviral activity against varicella-zoster virus #Acyclovir #chickenpox #children #Cytotoxicity #Depression #Éire #Gene #GeneExpression #Genes #Health #Herpes #HerpesZoster #IE #Ireland #Kinase #Luciferase #Pain #RNA #shingles #skin #virus

Bee-derived propolis shows potent antiviral activity against varicella-zoster virus

Announcing a new article publication for Zoonoses journal. Varicella-zoster virus (VZV) is a clinically important human neurotropic herpesvirus…
#NewsBeep #News #Health #Acyclovir #AU #Australia #chickenpox #Children #Cytotoxicity #depression #Gene #GeneExpression #Genes #herpes #HerpesZoster #Kinase #Luciferase #Pain #RNA #shingles #Skin #virus
https://www.newsbeep.com/au/718248/

Bee-derived propolis shows potent antiviral activity against varicella-zoster virus

Announcing a new article publication for Zoonoses journal. Varicella-zoster virus (VZV) is a clinically important human neurotropic herpesvirus…
#NewsBeep #News #Health #Acyclovir #AU #Australia #chickenpox #Children #Cytotoxicity #depression #Gene #GeneExpression #Genes #herpes #HerpesZoster #Kinase #Luciferase #Pain #RNA #shingles #Skin #virus
https://www.newsbeep.com/au/718248/

https://www.europesays.com/ie/498457/ Pim1 identified as promising therapeutic target for inflammatory arthritis treatment #AnkylosingSpondylitis #Arthritis #Bone #Calcium #Cartilage #CD4 #Cell #Chronic #Éire #IE #InflammatoryArthritis #Ireland #Kinase #Metabolism #Protein #Research #RheumatoidArthritis #Spondylitis #Technology

Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which…
#NewsBeep #News #Technology #Ankylosingspondylitis #Arthritis #AU #Australia #Bone #Calcium #cartilage #CD4 #Cell #Chronic #inflammatoryarthritis #Kinase #Metabolism #protein #research #rheumatoidarthritis #Spondylitis
https://www.newsbeep.com/au/688640/

Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which…
#NewsBeep #News #Technology #Ankylosingspondylitis #Arthritis #AU #Australia #Bone #Calcium #cartilage #CD4 #Cell #Chronic #inflammatoryarthritis #Kinase #Metabolism #protein #research #rheumatoidarthritis #Spondylitis
https://www.newsbeep.com/au/688640/

https://www.europesays.com/ie/452010/ Fred Hutch study dramatically expands therapeutic range of approved kinase drugs #BrainCancer #DnaMutation #DrugResistance #Éire #Glioblastoma #HumanBiology #IE #Ireland #Kinase #LungCancer #RareCancers #TaranGujral #Technology

Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @PLOSBiology plos.io/4tjuKgI

Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @PLOSBiology plos.io/4tjuKgI

How could bisphenol A raise depression risk? Study identifies six key molecular targets

Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mous…
#NewsBeep #News #Health #AU #Australia #Blood #Cell #Chemicals #depression #depressivedisorder #ELISA #Endocrine #epidemiology #estrogen #Gene #GeneExpression #Genetic #Kinase #majordepressivedisorder #Mentalhealth #protein #psychiatry #publichealth #Receptor #research #Transcriptomics
https://www.newsbeep.com/au/577535/

How could bisphenol A raise depression risk? Study identifies six key molecular targets

Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mous…
#NewsBeep #News #Health #AU #Australia #Blood #Cell #Chemicals #depression #depressivedisorder #ELISA #Endocrine #epidemiology #estrogen #Gene #GeneExpression #Genetic #Kinase #majordepressivedisorder #Mentalhealth #protein #psychiatry #publichealth #Receptor #research #Transcriptomics
https://www.newsbeep.com/au/577535/

https://www.europesays.com/ie/414176/ How could bisphenol A raise depression risk? Study identifies six key molecular targets #blood #Cell #chemicals #Depression #DepressiveDisorder #Éire #ELISA #Endocrine #Epidemiology #estrogen #Gene #GeneExpression #Genetic #Health #IE #Ireland #Kinase #MajorDepressiveDisorder #MentalHealth #Protein #Psychiatry #PublicHealth #Receptor #Research #Transcriptomics

Loss of metabolic control mechanisms promotes uncontrolled cancer cell proliferation

Researchers from the University of Seville have participated in research to identify the molecular details of the regulation…
#NewsBeep #News #Health #Acetylation #AU #Australia #Cancer #Cell #CellProliferation #Enzyme #Fruit #Kinase #Metabolism #Proliferation #research
https://www.newsbeep.com/au/432382/

New server, new #introduction

Hi, I'm Dave. I'm a Research #Scientist at a Research Institute in #London, #UK

I'm a #StructuralBiologist by training. I help run a group that studies #Kinase #signalling in human #health and #disease.

In my spare time I take photos, play #bass and walk #dogs.

I do #Crystallography #CryoEM #Biophysics #DrugDesign and #Glycobiology. #Science #Research

New server, new #introduction

Hi, I'm Dave. I'm a Research #Scientist at a Research Institute in #London, #UK

I'm a #StructuralBiologist by training. I help run a group that studies #Kinase #signalling in human #health and #disease.

In my spare time I take photos, play #bass and walk #dogs.

I do #Crystallography #CryoEM #Biophysics #DrugDesign and #Glycobiology. #Science #Research

The 5th Virtual #ChemBioTalks continue with an insightful talk by Kelly Chibale. He talked about his group's research into new treatments for #malaria. Great insights into the repurposing of anti #cancer #kinase inhibitors to treat P. falciparum. https://onlinelibrary.wiley.com/doi/10.1002/anie.202425206

Very much looking forward to the talk by Kelly Chibale at the 5th Virtual @ChemBioTalks and to learn more about the repurposing of #anticancer #kinase inhibitors to treat #malaria.

#ChemBio #Chemistry #DrugDiscovery

3 projects by the LED3 researchers Nathaniel Martin, Anthe Janssen and Mirjam Huizenga have been awarded NWO Take-off funding to explore commercial development of compounds and technologies with applications in #oncology, #NeuropathicPain treatment and #kinase research!
https://www.nwo.nl/en/news/49-take-off-projects-awarded-in-spring-round-2025

SciTech Chronicles. . . . . .May 6th, 2025

https://bit.ly/stc050625

#EphB1/2 #tyrosine #kinase #inhibitors #carbene #thiamine #Breslow #B1 #3D-printable #electroencephalogram #continuously #bioadhesive #AMT #mesothelioma #"low-carbon metal oxides" #CO2 #"digital twin" #"3D digital model" #sonar #Magellan

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

🌐💡 We suggest which protein kinases (like CK1 and CK2) are involved (see bonus post 👇!).
These are key enzymes ensuring everything runs in sync in humans too, making O. tauri an intriguing example of efficient biological timing.
#Kinase #Phosphorylation 5/7

🌐💡 We suggest which protein kinases (like CK1 and CK2) are involved (see bonus post 👇!).
These are key enzymes ensuring everything runs in sync in humans too, making O. tauri an intriguing example of efficient biological timing.
#Kinase #Phosphorylation 5/7

🌟eLife Special Issue 🌟

A specially curated collection of articles untangles the bewildering complexity of #kinase enzymes.
https://elifesciences.org/collections/eb7614d5/special-issue-allosteric-regulation-of-kinase-activity?utm_source=mastodon&utm_medium=social&utm_campaign=organic

🌟eLife Special Issue 🌟

A specially curated collection of articles untangles the bewildering complexity of #kinase enzymes.
https://elifesciences.org/collections/eb7614d5/special-issue-allosteric-regulation-of-kinase-activity?utm_source=mastodon&utm_medium=social&utm_campaign=organic

The Raf #kinase #inhibitors #Dabrafenib and #Regorafenib impair #Zika virus #replication via distinct mechanisms, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00618-24?af=R

This study provides further insight into ZIKV-host interactions and has implications for the development of novel #antivirals against ZIKV and possibly other #flaviviruses.

The Raf #kinase #inhibitors #Dabrafenib and #Regorafenib impair #Zika virus #replication via distinct mechanisms, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00618-24?af=R

This study provides further insight into ZIKV-host interactions and has implications for the development of novel #antivirals against ZIKV and possibly other #flaviviruses.

Study reveals how a #sugar_sensing #protein acts as a 'machine' to switch #plant #growth—and #oil production—on and off

#kinase #KIN10 #trehalose_6_phosphate

https://phys.org/news/2024-05-reveals-sugar-protein-machine-growth.html

Study reveals how a #sugar_sensing #protein acts as a 'machine' to switch #plant #growth—and #oil production—on and off

#kinase #KIN10 #trehalose_6_phosphate

https://phys.org/news/2024-05-reveals-sugar-protein-machine-growth.html

Study reveals how a #sugar_sensing #protein acts as a 'machine' to switch #plant #growth—and #oil production—on and off

#kinase #KIN10 #trehalose_6_phosphate

https://phys.org/news/2024-05-reveals-sugar-protein-machine-growth.html

Study reveals how a #sugar_sensing #protein acts as a 'machine' to switch #plant #growth—and #oil production—on and off

#kinase #KIN10 #trehalose_6_phosphate

https://phys.org/news/2024-05-reveals-sugar-protein-machine-growth.html

Study reveals how a #sugar_sensing #protein acts as a 'machine' to switch #plant #growth—and #oil production—on and off

#kinase #KIN10 #trehalose_6_phosphate

https://phys.org/news/2024-05-reveals-sugar-protein-machine-growth.html

Researchers uncover natural variation in wild #emmer #wheat for broad-spectrum #disease resistance.

#immunity #agriculture #powdery_mildew #transmembrane #kinase #WTK7_TM #Pm36

https://phys.org/news/2024-04-uncover-natural-variation-wild-emmer.html

Location, location, location: Protein #kinase nanoclustering for optimised signalling output. https://elifesciences.org/articles/93902?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Location, location, location: Protein #kinase nanoclustering for optimised signalling output. https://elifesciences.org/articles/93902?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Postdoc - Kinase biology and signalling

Barts Cancer Institute

Join @DrTanyaSoliman 's team @QMBCI #postdoc #kinase

See the full job description on jobRxiv: https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

#cell_biology #kinases #mass_spectrometry #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

Postdoc - Kinase biology and signalling

Barts Cancer Institute

Join @DrTanyaSoliman 's team @QMBCI #postdoc #kinase

See the full job description on jobRxiv: https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

#cell_biology #kinases #mass_spectrometry #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

Death by a thousand cuts through #kinase inhibitor combinations that can more selectively inhibit individual or multiple protein #kinases than single inhibitors. https://elifesciences.org/articles/86189?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Death by a thousand cuts through #kinase inhibitor combinations that can more selectively inhibit individual or multiple protein #kinases than single inhibitors. https://elifesciences.org/articles/86189?utm_source=mastodon&utm_medium=social&utm_campaign=organic

This “highly interesting” study adds a new layer to our mechanistic understanding of the complex #Parkinson’s disease-linked LRRK2 #kinase. https://elifesciences.org/articles/87098?utm_source=mastodon&utm_medium=social&utm_campaign=organic

This “highly interesting” study adds a new layer to our mechanistic understanding of the complex #Parkinson’s disease-linked LRRK2 #kinase. https://elifesciences.org/articles/87098?utm_source=mastodon&utm_medium=social&utm_campaign=organic

pYtags enable spatiotemporal measurements of receptor tyrosine #kinase signalling in living cells, with enzymes shown here rapidly moving from the cytosol to the cell membranes. #12DaysOfeLife https://elifesciences.org/articles/82863?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days

pYtags enable spatiotemporal measurements of receptor tyrosine #kinase signalling in living cells, with enzymes shown here rapidly moving from the cytosol to the cell membranes. #12DaysOfeLife https://elifesciences.org/articles/82863?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days

In developing #presynapses, the #ActiveZone structure assembles via liquid-liquid #PhaseSeparation (#LLPS). This study shows that the #kinase SAD-1 phosphorylates the scaffold protein SYD-2/Liprin-α, relieving autoinhibition & triggering LLPS #PLOSBiology https://plos.io/3Ne6OZg

In developing #presynapses, the #ActiveZone structure assembles via liquid-liquid #PhaseSeparation (#LLPS). This study shows that the #kinase SAD-1 phosphorylates the scaffold protein SYD-2/Liprin-α, relieving autoinhibition & triggering LLPS #PLOSBiology https://plos.io/3Ne6OZg

"Here, we demonstrate that damaged #lysosomal #membranes are repaired by #microautophagy (a process termed “microlysophagy”) and identify key regulators of the first and last steps. We reveal the AGC #kinase STK38 as a novel microlysophagy regulator...microlysophagy is regulated by STK38 and GABARAPs and could be essential for maintaining lysosomal integrity and preventing #aging."

https://www.embopress.org/doi/full/10.15252/embr.202357300

#autophagy

"Here, we demonstrate that damaged #lysosomal #membranes are repaired by #microautophagy (a process termed “microlysophagy”) and identify key regulators of the first and last steps. We reveal the AGC #kinase STK38 as a novel microlysophagy regulator...microlysophagy is regulated by STK38 and GABARAPs and could be essential for maintaining lysosomal integrity and preventing #aging."

https://www.embopress.org/doi/full/10.15252/embr.202357300

#autophagy

Are you interested in #Calmodulin (CaM) and its interaction with CaMKII? We had a look at this interaction with #photocrosslinking. Covalent attachment of CaM did not break apart the CaMKII holoenzyme but did promote ongoing #kinase activity. The CaM binding segment is also more mobile than expected from previous reports.

This is the accepted pdf, a long time in the making as you might detect.
https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.4798

#Biophysics #Biochemistry #Neuroscience #MassPhotometry

Are you interested in #Calmodulin (CaM) and its interaction with CaMKII? We had a look at this interaction with #photocrosslinking. Covalent attachment of CaM did not break apart the CaMKII holoenzyme but did promote ongoing #kinase activity. The CaM binding segment is also more mobile than expected from previous reports.

This is the accepted pdf, a long time in the making as you might detect.
https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.4798

#Biophysics #Biochemistry #Neuroscience #MassPhotometry

#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics

#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al

https://www.embopress.org/doi/full/10.15252/embj.2022112630