#drugdevelopment — Public Fediverse posts

https://www.europesays.com/dk/79980/ Novo Nordisk hands a Parkinson’s cell therapy to Cellular Intelligence, a startup trying to design cell behavior #ArtificialIntelligence #Biotechnology #CellTherapy #CellularIntelligence #ClinicalTrials #DopaminergicNeurons #DrugDevelopment #MichaBreakstone #neurology #NovoNordisk #Parkinson'sDisease #SomiteAI #StemCellResearch #STEMPD #VentureCapital

Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)

#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success

Most clinical trials don't fail because the science was wrong.
They fail because:
→ Sites weren't activated on time
→ Enrollment targets were optimistic, not evidence-based
→ Data issues were caught late
→ No one owned the full picture
That's a project management problem — not a scientific one.
We wrote about how structured clinical project management prevents exactly this.

#clinicalresearch #clinicaltrials #projectmanagement #CRO #pharma #drugdevelopment
https://genelifecr.blogspot.com/2026/05/clinical-project-management-in-clinical.html

In our latest article, we explore how Clinical Project Managementserves as the backbone of successful clinical trials — ensuring efficiency, quality, and compliance from study design to completion.
If you're involved in clinical development, this provides a comprehensive view of how integrated project management drives better outcomes.
#ClinicalResearch #CRO #ClinicalTrials #ProjectManagement #Pharma #DrugDevelopment #genelife

https://genelifecr.blogspot.com/2026/05/clinical-project-management-in-clinical.html

https://www.europesays.com/britain/25193/ AstraZeneca to inject £300 million into UK in surprise U-turn #AstraZeneca #Cambridge #DrugDevelopment #INVESTMENT #KeirStarmer #Macclesfield #PascalSoriot #SirKeir #UK #UnitedKingdom

New Machines for Medicine: AI Crafts Drug Candidates

AI diffusion models created new drug candidates in 2025, speeding up medicine creation. This helps patients get new treatments sooner.

#AIDrugDiscovery, #FutureOfMedicine, #DrugDevelopment, #AIinHealthcare, #MedicalInnovation

https://newsletter.tf/ai-designs-new-drug-molecules-faster-2025/

Axplora Expands Manufacturing Facilities at Its Italian Farmabios Site

Axplora, which develops and manufactures highly potent active pharmaceutical in…
#dining #cooking #diet #food #Italianingredient #axplora #biomanufacturing #biopharmaceuticals #bioprocessing #drugdevelopment(researchanddevelopment) #IndustryNews #ingredient #Italia #Italian #italiano #italy #news #QualityControl
https://www.diningandcooking.com/2586519/axplora-expands-manufacturing-facilities-at-its-italian-farmabios-site-2/

Axplora Expands Manufacturing Facilities at Its Italian Farmabios Site https://www.diningandcooking.com/2586519/axplora-expands-manufacturing-facilities-at-its-italian-farmabios-site-2/ #axplora #biomanufacturing #biopharmaceuticals #bioprocessing #DrugDevelopment(researchAndDevelopment) #IndustryNews #ingredient #Italia #Italian #ItalianIngredient #italiano #italy #news #QualityControl

Axplora Expands Manufacturing Facilities at Its Italian Farmabios Site https://www.diningandcooking.com/2563031/axplora-expands-manufacturing-facilities-at-its-italian-farmabios-site/ #axplora #biomanufacturing #biopharmaceuticals #bioprocessing #DrugDevelopment(researchAndDevelopment) #IndustryNews #ingredient #Italia #Italian #ItalianIngredient #italiano #italy #news #QualityControl

#KNCVMCCB2026 comes to an end with an interesting talk by Danielle Vugts. She talked about the importance of #imaging during #DrugDevelopment on the example of PET imaging of #biologics.

https://link.springer.com/article/10.1186/s41181-024-00258-y
#DrugDiscovery #PETImaging #Radiolabeling #Antibodies #Nanoparticles #Chemistry

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

A very good read about computational chemistry and how it helps in drug discovery, and more importantly, what should be done so that it would be even more efficient.

https://medium.com/@dapscience/ai-drug-discovery-grand-challenges-benchmarks-be495dfb5ce4

#compchem #academicChatter #chemistry #medchem #drugDiscovery #drugDevelopment

SuppCo launches certification to verify actives in dietary supplements https://www.diningandcooking.com/2538917/suppco-launches-certification-to-verify-actives-in-dietary-supplements/ #America #approval #Building #Certification #ClinicalTrials #Drug #DrugDevelopment #exterior #fda #FdaApproval #FdaApproved #federal #FoodAdditives #health #HealthAndHumanServices #HealthCare #hhs #Landmark #Maryland #medication #NavalOrdnanceLaboratory #nutrition #outdoor #Park #Policy #regulation #RestrictedArea #trees #urban #vaccine #VaccineDevelopment

Prasad overruled FDA staff to reject Moderna flu vaccine application

WASHINGTON — Top Food and Drug Administration official Vinay Prasad overruled the agency’s reviewers when he refused to accept…
#NewsBeep #News #Topstories #Biotechnology #drugdevelopment #FDA #Headlines #Pharmaceuticals #Policy #Publichealth #STAT+ #TopStories #vaccines
https://www.newsbeep.com/392794/

#Amgen’s Dark Blue deal (up to $840m) is less about one preclinical asset and more about a trend: pharma is paying to remove proteins, not just block them. Feature: https://biotech.industryexaminer.com/amgen-dark-blue-protein-degrader-aml/ #Hematology #AML #Oncology #Biotech #Pharma #DrugDevelopment #ProteinDegradation #TechNews

#Amgen’s Dark Blue deal (up to $840m) is less about one preclinical asset and more about a trend: pharma is paying to remove proteins, not just block them. Feature: https://biotech.industryexaminer.com/amgen-dark-blue-protein-degrader-aml/ #Hematology #AML #Oncology #Biotech #Pharma #DrugDevelopment #ProteinDegradation #TechNews

#Amgen’s Dark Blue deal (up to $840m) is less about one preclinical asset and more about a trend: pharma is paying to remove proteins, not just block them. Feature: https://biotech.industryexaminer.com/amgen-dark-blue-protein-degrader-aml/ #Hematology #AML #Oncology #Biotech #Pharma #DrugDevelopment #ProteinDegradation #TechNews

#Amgen’s Dark Blue deal (up to $840m) is less about one preclinical asset and more about a trend: pharma is paying to remove proteins, not just block them. Feature: https://biotech.industryexaminer.com/amgen-dark-blue-protein-degrader-aml/ #Hematology #AML #Oncology #Biotech #Pharma #DrugDevelopment #ProteinDegradation #TechNews

#Amgen’s Dark Blue deal (up to $840m) is less about one preclinical asset and more about a trend: pharma is paying to remove proteins, not just block them. Feature: https://biotech.industryexaminer.com/amgen-dark-blue-protein-degrader-aml/ #Hematology #AML #Oncology #Biotech #Pharma #DrugDevelopment #ProteinDegradation #TechNews

In joint work with #EMA and #FDA colleagues we wrote down 10 guiding principles of good #AI practices in #drugdevelopment that are now finally published.

The principles are quite general and hopefully quite universally agreed upon, more detailed guidance will follow.

An of course we're yet to see what is actually used and submitted in regulatory proceedings.

https://www.fda.gov/media/189581/download

#pharma #regulatory

🤖 Can AI help us predict and prevent off-target effects in PROTAC drug design?

🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028

📚 CSBJ: https://www.csbj.org/

#DrugDevelopment #StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery #Cheminformatics #Bioinformatics #PrecisionMedicine #TargetedProteinDegradation

Thermo Fisher and OpenAI team up to accelerate drug development through AI

https://web.brid.gy/r/https://nerds.xyz/2025/10/thermo-fisher-openai-drug-development/

GCCL and Medirama sign MOU for clinical trial services collaboration, aiming to enhance drug development processes and strengthen market competitiveness
#YonhapInfomax #GCCL #Medirama #ClinicalTrialServices #DrugDevelopment #MOU #Economics #FinancialMarkets #Banking #Securities #Bonds #StockMarket
https://en.infomaxai.com/news/articleView.html?idxno=62941

PhD Student Position: Drug Development for Parkinson's Disease

Ben-Gurion University of the Negev

#PhDStudentPosition: #DrugDevelopment for #Parkinson'sDisease using #ProteinDesign, #ComputerAidedDrugDesign, #GeneTherapy, #iPSCs

See the full job description on jobRxiv: https://jobrxiv.org/job/ben-gurion-university-of-the-negev-27778-phd-student-posit...
https://jobrxiv.org/job/ben-gurion-university-of-the-negev-27778-phd-student-position-drug-development-for-parkinsons-disease/?feed_id=92530

PhD Student Position: Drug Development for Parkinson's Disease

Ben-Gurion University of the Negev

#PhDStudentPosition: #DrugDevelopment for #Parkinson'sDisease using #ProteinDesign, #ComputerAidedDrugDesign, #GeneTherapy, #iPSCs

See the full job description on jobRxiv: https://jobrxiv.org/job/ben-gurion-university-of-the-negev-27778-phd-student-posit...
https://jobrxiv.org/job/ben-gurion-university-of-the-negev-27778-phd-student-position-drug-development-for-parkinsons-disease/?feed_id=92033

PhD Student Position: Drug Development for Parkinson's Disease

Ben-Gurion University of the Negev

#PhDStudentPosition: #DrugDevelopment for #Parkinson'sDisease using #ProteinDesign, #ComputerAidedDrugDesign, #GeneTherapy, #iPSCs

See the full job description on jobRxiv: https://jobrxiv.org/job/ben-gurion-university-of-the-negev-27778-phd-student-posit...
https://jobrxiv.org/job/ben-gurion-university-of-the-negev-27778-phd-student-position-drug-development-for-parkinsons-disease/?feed_id=91788

PhD Student Position: Drug Development for Parkinson's Disease

Ben-Gurion University of the Negev

#PhDStudentPosition: #DrugDevelopment for #Parkinson'sDisease using #ProteinDesign, #ComputerAidedDrugDesign, #GeneTherapy, #iPSCs

See the full job description on jobRxiv: https://jobrxiv.org/job/ben-gurion-university-of-the-negev-27778-phd-student-posit...
https://jobrxiv.org/job/ben-gurion-university-of-the-negev-27778-phd-student-position-drug-development-for-parkinsons-disease/?feed_id=86419

Synthetic Miniproteins Inhibit “Undruggable” Cancer Drug Target

“DuoMYC” binds to the target DNA of the transcription factor MYC, which plays a role in over 50 % of all human cancers

https://www.chemistryviews.org/synthetic-miniproteins-inhibit-undruggable-cancer-drug-target/

#drugdevelopment #anticancer #ebox #myc #transcription factor #chemistry #chemistryviews #chemviews

Synthetic Miniproteins Inhibit “Undruggable” Cancer Drug Target

“DuoMYC” binds to the target DNA of the transcription factor MYC, which plays a role in over 50 % of all human cancers

https://www.chemistryviews.org/synthetic-miniproteins-inhibit-undruggable-cancer-drug-target/

#drugdevelopment #anticancer #ebox #myc #transcription factor #chemistry #chemistryviews #chemviews

Keytruda strikes out again in endometrial cancer with phase III flop—Novo inks $600M deal with Metaphore to develop next-gen obesity drugs —Takeda Pharma to restructure after annual profit slump --http://bit.ly/w28kSd #merck #keytruda #endometrialcancer #clinicaltrials #novonordisk #obesity #drugdevelopment #takeda #restructuring #pharma #pharmanews #biotech #biopharma #biotechnology #cafepharma

@inkican

Interesting, but the article is frustratingly vague about the mechanism of action.

The drug/MoA is probably the same as in this article⬇️
"PnPP-19 potentiates erection, in vivo and ex vivo, via NO/cGMP pathway, does not affect sodium channels or rat heart, and shows no toxicity and low immunogenicity, what makes it a very promising candidate as a novel drug in the therapy of erectile dysfunction."

http://dx.doi.org/10.1016/j.juro.2015.06.081

~
NO is antimicrobial and it's possible this drug could be used for other purposes.

#NitricOxide #cGMP #vasodilators #DrugDevelopment #NaturalProducts #BZ371A

Lilly walks away from Nektar's PEG conjugate of rhIL-2, rezpeg - aka rezpegaldesleukin, aka NKTR-358 - after disappointing phase II results in lupus.

#Immunology #immunotherapy #RegulatoryTCell #Lupus #Treg #drugdevelopment

https://www.fiercebiotech.com/biotech/after-gathering-enough-nektar-lilly-hands-backs-rights-immunology-med-post-lupus-fail

'Two US congressional committees have accused the Food and Drug Administration of inappropriately collaborating with Biogen before approving the company’s Alzheimer’s drug.'

#FDA #Alzheimer #Biogen #DrugDevelopment

https://www.ft.com/content/5389750b-71b0-4fe6-9793-feb6f64712e1

Medable raises $91 million for its clinical trial management software - The clinical trial management software developer Medable has raised $91 million in a new round of fi... - http://feedproxy.google.com/~r/Techcrunch/~3/D_Hr3zzwT-E/ #streamlinedventures #sapphireventures #drugdevelopment #telemedicine #gsrventures #telehealth #alivecor #articles #medable #health #tc