#jacs — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #jacs, aggregated by home.social.
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Fantastic paper from Brooks Able at Berkeley using an organic catalyst to achieve high molecular weight for poly(THF) via cationic ring-opening polymerization. The low ceiling temperatures of these polymers make them attractive targets for reversible polymerizations, but it has previously been really hard to get to the molecular weights required for good mechanical properties. #chemistry #polymers #JACS https://pubs.acs.org/doi/10.1021/jacs.5c18359
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Efficient Synthesis of ProTide antivirals: A team from from #Fudan University and #Shanghai Jiao Tong University reporting a copper-catalyzed method for synthesizing chiral phosphates in #JACS.
This research represents a new tool for the synthesis of ProTide nucleoside analogues, providing an efficient route that can enhance the development of antiviral drugs in future studies.
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Excited to share my very first paper which was just published in #JACS:
https://pubs.acs.org/doi/10.1021/jacs.2c10673
In this work carried out during my PhD together with Jamie Klein, Tomasz Kaminski, and Pierre-Yves Colin in the Hollfelder Lab at #UniversityofCambridge we evolve a #phosphotriesterase with a new, metal-independent mechanism by using droplet #microfluidics.
Comments and feedback welcome! A thread: (1/6)
#EnzymeEngineering #ProteinEngineering #EnzymeMechanism #DirectedEvolution #Bioremediation
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