#glycan — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #glycan, aggregated by home.social.
-
SciTech Chronicles. . . . . . . . .Feb 2nd, 2025
#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage
-
Structural and immunological characterization of the #H3 #influenza #hemagglutinin during #antigenic #drift, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.09.13.612776v1
In this study, we explore the influence of #glycan #evolution on H3 hemagglutinin from 1968 to present day and its impacts on antigenicity and immunogenicity.
-
#GlycoSHIELD: #OpenSource tool to graft #glycan #conformer arrays on a #protein #structure:
-speeds up #drug development
-#cryoEM consistentPaper: https://doi.org/10.1016/j.cell.2024.01.034
Web #app: https://dioscuri-biophysics.pages.mpcdf.de/glycoshield-md/
GitHub: https://github.com/GlycoSHIELD-MD/GlycoSHIELD-MD -
`We report a fluorinated azido-coumarin scaffold which enables #photolabeling under fast and mild activation, and which can leave a #fluorescent tag on crosslinked species. Coupling this scaffold to an α-fucoside, we demonstrate fluorogenic photolabeling of #glycan-#protein interactions over a wide range of affinities. We expect this strategy to be broadly applicable to other #chromophores and we envision that such “fluoro-crosslinkers” could become important tools`
-
An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.