#amyloid — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #amyloid, aggregated by home.social.
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Nicht #Amyloid, nicht Cholinesterase – GRK2. Ursula Quitterer und ihr Team von der ETH Zürich setzen bei der Attacke auf #Alzheimer auf ein zelluläres Enzym, das bisher übersehen wurde. Die Mausdaten sind vielversprechend … 👉
https://www.laborjournal.de/editorials/3532.php -
Nicht #Amyloid, nicht Cholinesterase – GRK2. Ursula Quitterer und ihr Team von der ETH Zürich setzen bei der Attacke auf #Alzheimer auf ein zelluläres Enzym, das bisher übersehen wurde. Die Mausdaten sind vielversprechend … 👉
https://www.laborjournal.de/editorials/3532.php -
Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade
My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".
I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗
#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness
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Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade
My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".
I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗
#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness
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I Must admit that I didn‘t know this type of #amyloid existed.
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I Must admit that I didn‘t know this type of #amyloid existed.
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HAI2026 konferenssin uutisia kootusti, https://www.alzforum.org/news/conference-coverage/human-amyloid-imaging-conference-hai2026
Vastaavasti 2025 lopun CTAD:ista https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2025, ja kesän AAIC:ista https://www.alzforum.org/news/conference-coverage/alzheimers-association-international-conference-aaic-2025
#alzheimer #dementia #memory #muisti #tutkimus #research #clinical_trials #news #alzForum #amyloid #sairaus #imaging #tau #medical
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HAI2026 konferenssin uutisia kootusti, https://www.alzforum.org/news/conference-coverage/human-amyloid-imaging-conference-hai2026
Vastaavasti 2025 lopun CTAD:ista https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2025, ja kesän AAIC:ista https://www.alzforum.org/news/conference-coverage/alzheimers-association-international-conference-aaic-2025
#alzheimer #dementia #memory #muisti #tutkimus #research #clinical_trials #news #alzForum #amyloid #sairaus #imaging #tau #medical
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阿茲海默症有害蛋白質 新療法可在數小時內清除 實驗成功逆轉小鼠腦退化
由西班牙卡塔隆尼亞生物工學研究所 (IBEC) 與中國四川大學華西醫院組成的國際研究團隊，開發出創新阿茲海默症 […]
#健康 #生活科技 #Alzheimer #Amyloid beta
https://unwire.hk/2025/10/17/alzheimers-nanoparticle-clears-amyloid-beta-hours/life-tech/health/?utm_source=rss&utm_medium=rss&utm_campaign=alzheimers-nanoparticle-clears-amyloid-beta-hours -
New nanotherapy clears amyloid-β reversing Alzheimer's in mice
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New nanotherapy clears amyloid-β reversing Alzheimer's in mice
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News in #Alzheimer's diagnosis!
#FDA cleared the Lumipulse G pTau217/ß-Amyloid 1-42 Plasma Ratio, a blood test that aids in detecting #amyloid plaques associated with Alzheimer's.
➡️ Less invasive & reduces reliance on PET scans and increases accessibility.
The test measures two proteins in blood plasma and calculates their ratio, correlating to the presence or absence of amyloid plaques.
Has a high accuracy rate ➡️ offers hope for earlier and easier diagnosis. -
Researchers developed synthetic mini-#proteins that inhibit both #amyloid formation in #Parkinsons and harmful protein interactions between #Alzheimers, Parkinsons and #type2diabetes in experimental models: http://go.tum.de/819859
📷A.Eckert
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Researchers developed synthetic mini-#proteins that inhibit both #amyloid formation in #Parkinsons and harmful protein interactions between #Alzheimers, Parkinsons and #type2diabetes in experimental models: http://go.tum.de/819859
📷A.Eckert
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Experimenting with #ThT stain on #spider webs to see if it successfully bonds to the beta chain #fibrin / #amyloid like components. I've applied the stain and naturally under 460nm webs fluoresce the expected green. I'm waiting for the sample to completely dry before differentiating with alcohol and then using a water based mount to finally disassociate the unbounded stain from the webs and other artefacts. All being so, we might be left with ThT stained #spidroins #science #biology #microscopy
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Experimenting with #ThT stain on #spider webs to see if it successfully bonds to the beta chain #fibrin / #amyloid like components. I've applied the stain and naturally under 460nm webs fluoresce the expected green. I'm waiting for the sample to completely dry before differentiating with alcohol and then using a water based mount to finally disassociate the unbounded stain from the webs and other artefacts. All being so, we might be left with ThT stained #spidroins #science #biology #microscopy
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#3goodthings
Another sunny day
Lunch with some of my cousins to meet the cousin who lives in Thailand and has a Thai wife and daughter
Watched a documentary about #Alzheimers and #amyloid research presented by Sally Magusson. -
#3goodthings
Another sunny day
Lunch with some of my cousins to meet the cousin who lives in Thailand and has a Thai wife and daughter
Watched a documentary about #Alzheimers and #amyloid research presented by Sally Magusson. -
SciTech Chronicles. . . . . . . . .Feb 2nd, 2025
#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage
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SciTech Chronicles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Jan 12, 2025
#TBI #injury-related #2021 #brain #function #proton #irradiation #molecules #polymers #Linux #OS #Distribution #kernel #Torvalds #security #CLI #Ultrasound #amyloid-β #Alzheimer’s #Plaques #Polar #Vortex #southern #lobe #blocking
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... and counting. 14 comments thus far, one even from a fellow-guinea-pig with awful experiences. I may have benefited from my own participation (EMERGE, high dose) with few adverse effects, and in any case the general discussion is exciting.
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An interesting open expert question regarding the approval of Alzheimer immuno-therapies on the basis of amyloid-removal alone, https://www.alzforum.org/news/research-news/it-time-approve-drugs-based-amyloid-removal
The question is framed with Aisen et.al's open-access article in A & D Perspectives, https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14342
The answers may turn out to be the most interesting part, at least with respect to staunch "trenchlines", though both articles contain lots of concise up-to-date information.
My own interest stems in part from first-hand experience as a guinea-pig in one of those therapies during 2017-22.
#ad #alzheimers #amyloid #immunothreapy #drugs #dementia #query #alzForum #clinical #neurology #geriatrics #medicine
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started a #wikipedia article on biochemist Lawreen Connors (1954-2024), director of the Amyloidosis Center at Boston University: https://en.wikipedia.org/wiki/Lawreen_Connors @wikiwomeninred #WomeninSTEM #BostonUniversity @bostoncollege @tuftsuniversity #WoburnMA #OgdensburgNY #amyloid #amyloidosis #Diedin2024
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started a #wikipedia article on biochemist Lawreen Connors (1954-2024), director of the Amyloidosis Center at Boston University: https://en.wikipedia.org/wiki/Lawreen_Connors @wikiwomeninred #WomeninSTEM #BostonUniversity @bostoncollege @tuftsuniversity #WoburnMA #OgdensburgNY #amyloid #amyloidosis #Diedin2024
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Secondary nucleation is increasing recognized as a dominant process in protein aggregation, and in particular also for pathogenic (disease causing) proteins. Still, many questions remain about how this process works, and what implications it has for pathogenic mechanisms. Here we show the unique power of HS-AFM to actually visualize this process directly. Check it out!
#amyloid #AFM #huntingtonsdisease (2/2)
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Secondary nucleation is increasing recognized as a dominant process in protein aggregation, and in particular also for pathogenic (disease causing) proteins. Still, many questions remain about how this process works, and what implications it has for pathogenic mechanisms. Here we show the unique power of HS-AFM to actually visualize this process directly. Check it out!
#amyloid #AFM #huntingtonsdisease (2/2)
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related, from 2012:
Serum albumin prevents protein aggregation and amyloid formation and retains chaperone-like activity in the presence of physiological ligands
https://pubmed.ncbi.nlm.nih.gov/22549788/"Although serum albumin has an established function as a transport protein, evidence is emerging that serum albumin may also have a role as a molecular chaperone. Using established techniques to characterize chaperone interactions, this study demonstrates that bovine serum albumin: 1) preferentially binds stressed over unstressed client proteins; 2) forms stable, soluble, high molecular weight complexes with stressed client proteins; 3) reduces the aggregation of client proteins when it is present at physiological levels; and 4) inhibits amyloid formation by both WT and L55P transthyretin. Although the antiaggregatory effect of serum albumin is maintained in the presence of physiological levels of Ca(2+) and Cu(2+), the presence of free fatty acids significantly alters this activity: stabilizing serum albumin at normal levels but diminishing chaperone-like activity at high concentrations. Moreover, here it is shown that depletion of albumin from human plasma leads to a significant increase in aggregation under physiologically relevant heat and shear stresses. This study demonstrates that serum albumin possesses chaperone-like properties and that this activity is maintained under a number of physiologically relevant conditions."
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@CStamp @DemocracyMattersALot This will be important for many people already dealing with memory issues or with family members showing possible signs of #dementia, however it is still limited by lack of any real treatment options. The closing paragraph says, “For people without memory loss who are worried about genetic or familial #Alzheimers risk, blood tests are not yet recommended. #Amyloid buildup can begin decades before symptoms appear, and no preventive treatments are currently available apart from general guidelines about healthy eating and living.”
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@CStamp @DemocracyMattersALot This will be important for many people already dealing with memory issues or with family members showing possible signs of #dementia, however it is still limited by lack of any real treatment options. The closing paragraph says, “For people without memory loss who are worried about genetic or familial #Alzheimers risk, blood tests are not yet recommended. #Amyloid buildup can begin decades before symptoms appear, and no preventive treatments are currently available apart from general guidelines about healthy eating and living.”
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Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock -
Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock -
A long-awaited AlzForum's take on the news that ApoE4 homozygotism means in fact an AD pathology (though not necessarily dementia before death), https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers
The comments-section gives a glimpse of some of the trenchlines regarding the treatment of dementia, but I guess the prevention-camp has only just been strirred up from their Sleeping Beauty's slumber.
I, as an example, still have only a 1 % measured risk of acquiring AD, according to some widely used screens, and no "preventable risk factors" except maybe age. Too bad, my genetic inheritance seems to have been enough to skew the Amyloid-Beta balance early on. Luckily, I was recruited to the aducanumab-study for four years (a precursor of lecanemab with more severe side-effects), and probably got some more years to be able to think things like these.
#alzheimer #research #medical #APOE4 #alzForum #dementia #ad #alzheimers #amyloid #lecanemab #aducanumab #prevention #cure
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Honored to keep company with #neurologist, #DanielGibbs's #book about his own experience of #dementia. The tattoo in the title is the #brain bleed (aka #ARIA) that occurred while in #clinicaltrials related to anti-#amyloid drugs. He has no regrets & would do it all over again if it might advance brain science & help in the effort to #ENDALZ.
If you have read either my #memoir or his, please consider reviewing them on #amazon. In different ways, we both aim to inform readers & undercut #stigma.
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Honored to keep company with #neurologist, #DanielGibbs's book about his own experience of #dementia. The tattoo in the title is the #brain bleed (aka #ARIA) that occurred while in #clinicaltrials related to anti-#amyloid drugs. He has no regrets & would do it all over again if it might advance brain science & help in the effort to #ENDALZ.
If you have read either my #memoir or his, please consider reviewing them on #amazon. In different ways, we both aim to inform readers & undercut #stigma.
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Honored to keep company with #neurologist, #DanielGibbs's book about his own experience of #dementia. The tattoo in the title is the #brain bleed (aka #ARIA) that occurred while in #clinicaltrials related to anti-#amyloid drugs. He has no regrets & would do it all over again if it might advance brain science & help in the effort to #ENDALZ.
If you have read either my #memoir or his, please consider reviewing them on #amazon. In different ways, we both aim to inform readers & undercut #stigma.
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University of Queensland researchers have found targeting #amyloid #plaque in the #brain is not essential for #ultrasound to deliver #cognitive improvement in #neurodegenerative disorders.
#Psychiatry #sflorg
https://www.sflorg.com/2024/04/pscy04022402.html -
University of Queensland researchers have found targeting #amyloid #plaque in the #brain is not essential for #ultrasound to deliver #cognitive improvement in #neurodegenerative disorders.
#Psychiatry #sflorg
https://www.sflorg.com/2024/04/pscy04022402.html -
Alzheimer's Might Not Actually Be a Brain Disease, Expert Reveals : ScienceAlert
https://www.sciencealert.com/alzheimers-might-not-actually-be-a-brain-disease-expert-reveals#Alzheimers
#Brain
#AutoImmune
#AutoimmuneDiseases
#BetaAmyloid
#Amyloid -
Alzheimer's Might Not Actually Be a Brain Disease, Expert Reveals : ScienceAlert
https://www.sciencealert.com/alzheimers-might-not-actually-be-a-brain-disease-expert-reveals#Alzheimers
#Brain
#AutoImmune
#AutoimmuneDiseases
#BetaAmyloid
#Amyloid -
New #research suggests that 40Hz audiovisual stimuli may help the #brain cleanse itself of #amyloid proteins, thereby helping mitigate symptoms of #Alzheimers disease.
https://spectrum.ieee.org/gamma-light-therapy-alzheimers #science #medicine #health #dementia #therapy
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What is known as the #prodromal phase, the years when #Alzheimer's is attacking the brain but the clinical presentations may not yet be apparent. "One early hallmark is that sticky protein called beta-amyloid, which over time builds up into brain-clogging #plaques. #Amyloid alone isn’t enough to damage memory — plenty of healthy people’s brains harbor a lot of plaque. An abnormal #tau protein that forms neuron-killing tangles is one of several co-conspirators."
https://www.yahoo.com/news/silent-brain-changes-precede-alzheimers-221628452.html
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Why diagnose someone with #Alzheimer's who has no memory issues but a build-up of #tau and/or #amyloid protein? Here's why. In a Nov, call with Wall St. analysts, Masoud Toloue, the chief executive at Quanterix, pointed out that the company’s blood test for tau — p-Tau 217 — had been recommended by the panel for diagnosing the disease. “We believe we’re in a strong position to capitalize on these opportunities,” Toloue said. "Opportunities"? Sickening.
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Inside the plan to diagnose Alzheimer’s in people with no memory problems — and who stands to benefit
#alzheimers #amyloid #biomarkers -
Prionen-ähnliche Ansteckung: Alzheimer kann in seltenen Fällen auch mit dem Blut übertragen werden, wie nun fünf Fälle bestätigen. #Alzheimer #Prionen #Amyloid #Demenz #Gehirn
https://www.scinexx.de/news/medizin/alzheimer-ist-auch-ueber-das-blut-uebertragbar/ -
Einige Menschen, die Wachstumshormone von Verstorbenen erhalten hatten, entwickelten Jahrzehnte später Demenzsymptome. Wie hängen die beiden Faktoren zusammen?#Alzheimer #Demenz #Prionen #Amyloide #Beta-Amyloid #Amyloid #Wachstumshormone #Alzheimererkrankung #Medizin
Weiterer Hinweis auf Übertragbarkeit von Alzheimer -
Einige Menschen, die Wachstumshormone von Verstorbenen erhalten hatten, entwickelten Jahrzehnte später Demenzsymptome. Wie hängen die beiden Faktoren zusammen?#Alzheimer #Demenz #Prionen #Amyloide #Beta-Amyloid #Amyloid #Wachstumshormone #Alzheimererkrankung #Medizin
Weiterer Hinweis auf Übertragbarkeit von Alzheimer -
Very glad to have this paper published - it is an idea from way back, and it is great to see these first experiments done and now also published. I hope this can be a start of much more cool science - looking into the mechanisms of amyloid formation, #amyloid toxicity and more.
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Yay! It is now online: our latest paper on the use #NMR spectroscopy to look at #amyloid formation by #polyQ peptides outfitted with a backbone modification, which allows photochemical control over beta-hairpin formation. Together with the groups of Szymanski and Feringa in #Groningen. A great new tool for studies of #amyloid formation mechanisms.
https://pubs.acs.org/doi/10.1021/jacs.3c11155
#photochemistry #NMR #huntingtonsdisease #amyloid
