#amyloid — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #amyloid, aggregated by home.social.
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Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade
My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".
I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗
#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness
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Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade
My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".
I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗
#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness
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Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade
My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".
I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗
#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness
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Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade
My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".
I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗
#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness
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Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade
My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".
I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗
#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness
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I Must admit that I didn‘t know this type of #amyloid existed.
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HAI2026 konferenssin uutisia kootusti, https://www.alzforum.org/news/conference-coverage/human-amyloid-imaging-conference-hai2026
Vastaavasti 2025 lopun CTAD:ista https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2025, ja kesän AAIC:ista https://www.alzforum.org/news/conference-coverage/alzheimers-association-international-conference-aaic-2025
#alzheimer #dementia #memory #muisti #tutkimus #research #clinical_trials #news #alzForum #amyloid #sairaus #imaging #tau #medical
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HAI2026 konferenssin uutisia kootusti, https://www.alzforum.org/news/conference-coverage/human-amyloid-imaging-conference-hai2026
Vastaavasti 2025 lopun CTAD:ista https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2025, ja kesän AAIC:ista https://www.alzforum.org/news/conference-coverage/alzheimers-association-international-conference-aaic-2025
#alzheimer #dementia #memory #muisti #tutkimus #research #clinical_trials #news #alzForum #amyloid #sairaus #imaging #tau #medical
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HAI2026 konferenssin uutisia kootusti, https://www.alzforum.org/news/conference-coverage/human-amyloid-imaging-conference-hai2026
Vastaavasti 2025 lopun CTAD:ista https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2025, ja kesän AAIC:ista https://www.alzforum.org/news/conference-coverage/alzheimers-association-international-conference-aaic-2025
#alzheimer #dementia #memory #muisti #tutkimus #research #clinical_trials #news #alzForum #amyloid #sairaus #imaging #tau #medical
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HAI2026 konferenssin uutisia kootusti, https://www.alzforum.org/news/conference-coverage/human-amyloid-imaging-conference-hai2026
Vastaavasti 2025 lopun CTAD:ista https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2025, ja kesän AAIC:ista https://www.alzforum.org/news/conference-coverage/alzheimers-association-international-conference-aaic-2025
#alzheimer #dementia #memory #muisti #tutkimus #research #clinical_trials #news #alzForum #amyloid #sairaus #imaging #tau #medical
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HAI2026 konferenssin uutisia kootusti, https://www.alzforum.org/news/conference-coverage/human-amyloid-imaging-conference-hai2026
Vastaavasti 2025 lopun CTAD:ista https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2025, ja kesän AAIC:ista https://www.alzforum.org/news/conference-coverage/alzheimers-association-international-conference-aaic-2025
#alzheimer #dementia #memory #muisti #tutkimus #research #clinical_trials #news #alzForum #amyloid #sairaus #imaging #tau #medical
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In Jan 2026 we will organize the 3rd Dutch protein aggregation network (DPAN) symposium in Amsterdam: we invite Dutch researchers interested in (disease-related) protein aggregation to join the meeting! Registration and other info: dpan-nl.org/3rd-dpan-sym... #amyloid #proteinaggregation
3rd DPAN symposium 2026 – DPAN -
New nanotherapy clears amyloid-β reversing Alzheimer's in mice
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🧠✨🧠
Alzheimer’s steals memories, but knowledge is our best defense!
🧠✨🧠Dive into my latest podcast with the Medical Society of Delaware, with an update on groundbreaking research which is flipping the script on dementia.
Hit play, tag someone who needs this must-hear update and let’s turn awareness into action.
Who in your circle should tune in?
#dementia #alzheimers #amyloid #DementiaDecoded #ShareKnowledge
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Two new articles from our lab:
Calcium-Dependent S100A8 Amyloid Fibril Formation via S100A1-Mediated Transient Interaction https://pubs.acs.org/doi/10.1021/acschemneuro.5c00086
Heterotypic Droplet Formation by Pro-Inflammatory S100A9 and Neurodegenerative Disease-Related α-Synuclein https://pubs.acs.org/doi/10.1021/acs.biomac.5c00130
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News in #Alzheimer's diagnosis!
#FDA cleared the Lumipulse G pTau217/ß-Amyloid 1-42 Plasma Ratio, a blood test that aids in detecting #amyloid plaques associated with Alzheimer's.
➡️ Less invasive & reduces reliance on PET scans and increases accessibility.
The test measures two proteins in blood plasma and calculates their ratio, correlating to the presence or absence of amyloid plaques.
Has a high accuracy rate ➡️ offers hope for earlier and easier diagnosis. -
Researchers developed synthetic mini-#proteins that inhibit both #amyloid formation in #Parkinsons and harmful protein interactions between #Alzheimers, Parkinsons and #type2diabetes in experimental models: http://go.tum.de/819859
📷A.Eckert
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Experimenting with #ThT stain on #spider webs to see if it successfully bonds to the beta chain #fibrin / #amyloid like components. I've applied the stain and naturally under 460nm webs fluoresce the expected green. I'm waiting for the sample to completely dry before differentiating with alcohol and then using a water based mount to finally disassociate the unbounded stain from the webs and other artefacts. All being so, we might be left with ThT stained #spidroins #science #biology #microscopy
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#3goodthings
Another sunny day
Lunch with some of my cousins to meet the cousin who lives in Thailand and has a Thai wife and daughter
Watched a documentary about #Alzheimers and #amyloid research presented by Sally Magusson. -
Did a new Alzheimer's drug keep this patient's brain healthier for longer?
New drugs Leqembi and Kisunla may have a modest benefit, don't cure #Alzheimer's, have a host of side effects (including brain bleeds), are troublesome to use (require IV infusion or injection) and multiple brain scans and cost 10's of thousands to administer.
"I think it helped," says her husband, Ken Bell. "But I'm not sure."
That sort of uncertainty is common when it comes to #Leqembi and #Kisunla…
Both drugs clear the brain of a substance called beta-#amyloid, which forms the sticky plaques associated with #Alzheimers.
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SciTech Chronicles. . . . . . . . .Feb 2nd, 2025
#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage
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SciTech Chronicles. . . . . . . . .Feb 2nd, 2025
#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage
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SciTech Chronicles. . . . . . . . .Feb 2nd, 2025
#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage
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SciTech Chronicles. . . . . . . . .Feb 2nd, 2025
#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage
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SciTech Chronicles. . . . . . . . .Feb 2nd, 2025
#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage
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SciTech Chronicles. . . . . . . . . . . . . . . . . Jan 16, 2025
#Antiaging #longevity #LCA #bile #AMPK #liver #AMOC #WHOI #climate #fluxes #proxy-based #British #DNA #Durotriges #Dorset #U5b1 #mitochondrial #Alzheimer’s #Parkinson’s #amyloid #Tau #dopamine #Iceland #Bárðarbunga #eqrthquake #swarm #Holuhraun
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SciTech Chronicles. . . . . . . . . . . . . . . . . Jan 16, 2025
#Antiaging #longevity #LCA #bile #AMPK #liver #AMOC #WHOI #climate #fluxes #proxy-based #British #DNA #Durotriges #Dorset #U5b1 #mitochondrial #Alzheimer’s #Parkinson’s #amyloid #Tau #dopamine #Iceland #Bárðarbunga #eqrthquake #swarm #Holuhraun
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SciTech Chronicles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Jan 12, 2025
#TBI #injury-related #2021 #brain #function #proton #irradiation #molecules #polymers #Linux #OS #Distribution #kernel #Torvalds #security #CLI #Ultrasound #amyloid-β #Alzheimer’s #Plaques #Polar #Vortex #southern #lobe #blocking
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SciTech Chronicles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Jan 9, 2025
#Mediterranean #DASH #cognitive #neuroprotective #joy #anticipation #neuroplasticity #Straub #carnitine #acetyl-L-carnitine #amyloid #tau #dementia #glymphatic #norepinephrine #cerebrospinal #zolpidem #fortresses #communities #herders #nomads #Dmanisi
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SciTech Chronicles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Jan 9, 2025
#Mediterranean #DASH #cognitive #neuroprotective #joy #anticipation #neuroplasticity #Straub #carnitine #acetyl-L-carnitine #amyloid #tau #dementia #glymphatic #norepinephrine #cerebrospinal #zolpidem #fortresses #communities #herders #nomads #Dmanisi
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... and counting. 14 comments thus far, one even from a fellow-guinea-pig with awful experiences. I may have benefited from my own participation (EMERGE, high dose) with few adverse effects, and in any case the general discussion is exciting.
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An interesting open expert question regarding the approval of Alzheimer immuno-therapies on the basis of amyloid-removal alone, https://www.alzforum.org/news/research-news/it-time-approve-drugs-based-amyloid-removal
The question is framed with Aisen et.al's open-access article in A & D Perspectives, https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14342
The answers may turn out to be the most interesting part, at least with respect to staunch "trenchlines", though both articles contain lots of concise up-to-date information.
My own interest stems in part from first-hand experience as a guinea-pig in one of those therapies during 2017-22.
#ad #alzheimers #amyloid #immunothreapy #drugs #dementia #query #alzForum #clinical #neurology #geriatrics #medicine
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started a #wikipedia article on biochemist Lawreen Connors (1954-2024), director of the Amyloidosis Center at Boston University: https://en.wikipedia.org/wiki/Lawreen_Connors @wikiwomeninred #WomeninSTEM #BostonUniversity @bostoncollege @tuftsuniversity #WoburnMA #OgdensburgNY #amyloid #amyloidosis #Diedin2024
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started a #wikipedia article on biochemist Lawreen Connors (1954-2024), director of the Amyloidosis Center at Boston University: https://en.wikipedia.org/wiki/Lawreen_Connors @wikiwomeninred #WomeninSTEM #BostonUniversity @bostoncollege @tuftsuniversity #WoburnMA #OgdensburgNY #amyloid #amyloidosis #Diedin2024
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started a #wikipedia article on biochemist Lawreen Connors (1954-2024), director of the Amyloidosis Center at Boston University: https://en.wikipedia.org/wiki/Lawreen_Connors @wikiwomeninred #WomeninSTEM #BostonUniversity @bostoncollege @tuftsuniversity #WoburnMA #OgdensburgNY #amyloid #amyloidosis #Diedin2024
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started a #wikipedia article on biochemist Lawreen Connors (1954-2024), director of the Amyloidosis Center at Boston University: https://en.wikipedia.org/wiki/Lawreen_Connors @wikiwomeninred #WomeninSTEM #BostonUniversity @bostoncollege @tuftsuniversity #WoburnMA #OgdensburgNY #amyloid #amyloidosis #Diedin2024
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started a #wikipedia article on biochemist Lawreen Connors (1954-2024), director of the Amyloidosis Center at Boston University: https://en.wikipedia.org/wiki/Lawreen_Connors @wikiwomeninred #WomeninSTEM #BostonUniversity @bostoncollege @tuftsuniversity #WoburnMA #OgdensburgNY #amyloid #amyloidosis #Diedin2024
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Will this be the death knell for Alzheimer’s monoclonal antibody treatments 🤔
Preprint on #Alzheimers drug deaths ignites dispute among authors
“Infighting among a group of prominent Alzheimer’s disease researchers has led to the withdrawal of a preprint they co-authored, which suggested a new Alzheimer’s drug markedly increases the risk of death. One scientist involved in the work charges the senior author failed to seek the go-ahead from his co-authors before posting an edited version of the article to a preprint server.”
#Lecanemab #Donanemab #Kisunla #amyloid #dementia
https://www.science.org/content/article/preprint-alzheimer-s-drug-deaths-ignites-dispute-among-authors -
Secondary nucleation is increasing recognized as a dominant process in protein aggregation, and in particular also for pathogenic (disease causing) proteins. Still, many questions remain about how this process works, and what implications it has for pathogenic mechanisms. Here we show the unique power of HS-AFM to actually visualize this process directly. Check it out!
#amyloid #AFM #huntingtonsdisease (2/2)
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related, from 2012:
Serum albumin prevents protein aggregation and amyloid formation and retains chaperone-like activity in the presence of physiological ligands
https://pubmed.ncbi.nlm.nih.gov/22549788/"Although serum albumin has an established function as a transport protein, evidence is emerging that serum albumin may also have a role as a molecular chaperone. Using established techniques to characterize chaperone interactions, this study demonstrates that bovine serum albumin: 1) preferentially binds stressed over unstressed client proteins; 2) forms stable, soluble, high molecular weight complexes with stressed client proteins; 3) reduces the aggregation of client proteins when it is present at physiological levels; and 4) inhibits amyloid formation by both WT and L55P transthyretin. Although the antiaggregatory effect of serum albumin is maintained in the presence of physiological levels of Ca(2+) and Cu(2+), the presence of free fatty acids significantly alters this activity: stabilizing serum albumin at normal levels but diminishing chaperone-like activity at high concentrations. Moreover, here it is shown that depletion of albumin from human plasma leads to a significant increase in aggregation under physiologically relevant heat and shear stresses. This study demonstrates that serum albumin possesses chaperone-like properties and that this activity is maintained under a number of physiologically relevant conditions."
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Alzheimer's Gets a New Definition
“In the revised criteria, the committee outlined three broad categories of biomarkers: those specific to #Alzheimer's changes like #amyloid and tau, referred to as "core" biomarkers; those important to #Alzheimers but not specific to the disease, like neurodegeneration and inflammation; and those that reflect conditions that commonly co-exist with Alzheimer's, like vascular pathology and alpha-synuclein.”
https://www.medpagetoday.com/neurology/alzheimersdisease/110912
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@CStamp @DemocracyMattersALot This will be important for many people already dealing with memory issues or with family members showing possible signs of #dementia, however it is still limited by lack of any real treatment options. The closing paragraph says, “For people without memory loss who are worried about genetic or familial #Alzheimers risk, blood tests are not yet recommended. #Amyloid buildup can begin decades before symptoms appear, and no preventive treatments are currently available apart from general guidelines about healthy eating and living.”
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Do we have #Alzheimer’s disease all wrong?
“As Science noted in its story on the retracted paper, scientists are still debating whether the #amyloid theory is viable. The skeptics cite the fraudulent research and lack of a genuine breakthrough; supporters can point to this new class of drugs including #donanemab that have led to some improvement in some patients.”
https://www.vox.com/future-perfect/355108/alzheimers-disease-drug-approval-research-retraction
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Two Is Better Than One in the Alzheimer’s Market
“Last week, a panel of independent advisers to the FDA unanimously voted in support of Eli Lilly’s #donanemab, a competitor in the same class of drugs that target #amyloid plaques in the brain. The #FDA is expected to decide on whether to approve the drug by the end of the year.
Life expectancies around the world have surged in recent decades, increasingly putting people at risk of #dementia. About one in nine seniors has #Alzheimer’s disease, the most common cause of the condition, which works out to some seven million Americans.”
https://finance.yahoo.com/news/two-better-one-alzheimer-market-110000384.html
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Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock -
Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock -
Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock -
Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock -
Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock -
Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock