#llps — Public Fediverse posts

The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation #LLPS to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @PLOSBiology https://plos.io/4o9onKQ

The type I regulatory subunit of #ProteinKinaseA undergoes #LiquidLiquidPhaseSeparation #LLPS to help compartmentalize cAMP. This study shows that this tunes Ca2+ & cAMP oscillations in pancreatic #BetaCells, controlling #insulin secretion & regulating proliferation @PLOSBiology https://plos.io/4o9onKQ

Please share …. 🙏
📣 Very soon, we’ll have an open PhD position starting in fall 2025 — this time not on cilia, but on YAP & TAZ in podocytes and their regulation via LLPS. Interested candidates are welcome to contact us directly.

Supervision by Inês Cabrita and me, embedded within PodoSigN!
Within this project, close collab. with Beate Vollenbröker‘s team.

#Podocyte #Trr422 #Fsgs #Nephrolab #PhdPosition #Biology #Genetics #LLPS #HippoSignaling #phd

@CECAD
@cilia

Liprin-α & RIM form presynaptic liquid phase-separated condensates #LLPS. This Primer explores a @PLOSBiology study of how these assemblies shape #synaptic fidelity and what their disruption might mean in #neurodevelopmental disease. Paper: https://plos.io/3Tj5CX7 Primer: https://plos.io/3HTacJ9

Liprin-α & RIM form presynaptic liquid phase-separated condensates #LLPS. This Primer explores a @PLOSBiology study of how these assemblies shape #synaptic fidelity and what their disruption might mean in #neurodevelopmental disease. Paper: https://plos.io/3Tj5CX7 Primer: https://plos.io/3HTacJ9

#Cellular structure without a #membrane: Researcher discusses how #synapses use #liquids to create functional separations.

#LLPS #membrane-less_organelles #neurotransmission

https://phys.org/news/2025-03-cellular-membrane-discusses-synapses-liquids.html

#Cellular structure without a #membrane: Researcher discusses how #synapses use #liquids to create functional separations.

#LLPS #membrane-less_organelles #neurotransmission

https://phys.org/news/2025-03-cellular-membrane-discusses-synapses-liquids.html

This allows condensate behaviour to respond to different inputs, such as lysine #acetylation in IDRs in other CBP domains. It can help to explain how #transcription factors binding to different regions of CBP differentially regulate CBP activity. #enhancers #generegulation #llps #chromatin #imaging #biochemistry #molecularbiology #CellBiology

Check out our new preprint titled "Diverse effects of fluorescent labels on alpha-synuclein condensate formation during liquid-liquid phase separation"

https://www.biorxiv.org/content/10.1101/2024.07.05.602219v1

#LLPS, #vilniusuniversity, #lifesciencescenter #Research

Hello Mastodon,

Our first post is about Liquid-liquid phase separation (LLPS) phenomena, during which proteins form liquid droplets, followed by amyloid aggregation. LLPS is observed in neurodegenerative disorders, cancers and certain cases is related to protein functions in the cell nucleus. Watch below as alpha-synuclein, a protein linked to Parkinson's disease, undergoes LLPS.

#LLPS #Science #LifeSciencesCenter #VilniusUniversity

Meta-analysis of postsynaptic proteomes reveals 97 poorly studied proteins; @TakeshiKaizuka @ToruTakumi &co find that FAM81A regulates condensation of #postsynaptic proteins via #LLPS to affect the size & function of #synapses #PLOSBiology https://plos.io/48KDPnO

Meta-analysis of postsynaptic proteomes reveals 97 poorly studied proteins; @TakeshiKaizuka @ToruTakumi &co find that FAM81A regulates condensation of #postsynaptic proteins via #LLPS to affect the size & function of #synapses #PLOSBiology https://plos.io/48KDPnO

Nuclear localization of #TDP43 is crucial for its function during #RNAprocessing & #neurodegeneration. @AyalaLab1 &co show that #RNAbinding & macromolecular assembly, including via #LLPS, play a central role in TDP-43 nuclear retention #PLOSBiology https://plos.io/3v372fT

Nuclear localization of #TDP43 is crucial for its function during #RNAprocessing & #neurodegeneration. @AyalaLab1 &co show that #RNAbinding & macromolecular assembly, including via #LLPS, play a central role in TDP-43 nuclear retention #PLOSBiology https://plos.io/3v372fT

In developing #presynapses, the #ActiveZone structure assembles via liquid-liquid #PhaseSeparation (#LLPS). This study shows that the #kinase SAD-1 phosphorylates the scaffold protein SYD-2/Liprin-α, relieving autoinhibition & triggering LLPS #PLOSBiology https://plos.io/3Ne6OZg

In developing #presynapses, the #ActiveZone structure assembles via liquid-liquid #PhaseSeparation (#LLPS). This study shows that the #kinase SAD-1 phosphorylates the scaffold protein SYD-2/Liprin-α, relieving autoinhibition & triggering LLPS #PLOSBiology https://plos.io/3Ne6OZg

Interesting paper from Tatjana Trcek lab.
She & her team looked at fly #GermGranules nucleation and, well... the title says it all:

"Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila "

#mRNA #mRNALocalization #Drosophila #LLPS

It is also her 1st paper as #NewPI so congrats are in order.

https://www.sciencedirect.com/science/article/pii/S2211124723007349

📣 I wrote a new post in my blog:
"Fixation of cells for imaging affects phase separation".
🔬 🍪

#imaging #microscopy #LLPS

https://greenfluorescentblog.wordpress.com/2023/02/25/fixation-of-cells-for-imaging-affects-phase-separation/

@fetzert

#tories cannot get their head round #keynsian exonomics - it cuts across too many of their prejudices.

The #rich buying yachts in tax havens using untaxed income held in #scottish #LLPs & the like are literally siphoning wealth out of the #uk - all the while claiming they are #wealthCreators ......

@fetzert

#tories cannot get their head round #keynsian exonomics - it cuts across too many of their prejudices.

The #rich buying yachts in tax havens using untaxed income held in #scottish #LLPs & the like are literally siphoning wealth out of the #uk - all the while claiming they are #wealthCreators ......

Unfortunately the CAG repeat GRC coincides with another great meeting: The FASEB Protein Aggregation Conference: Exploring Rugged Landscapes. #amyloid #llps and more! this year in Malahide, Ireland Jun 11-15 https://web.cvent.com/event/720adec4-52f0-4173-ba93-8681b42780eb/summary. #PACSRC