#lecanemab — Public Fediverse posts

https://www.europesays.com/ie/484075/ Price reductions needed to make groundbreaking Alzheimer’s drugs available – study #Alzheimer'sDisease #dementia #donanemab #Éire #Health #IE #Ireland #Lecanemab

Less than 20% of people in Japan who showed interest in new medications for Alzheimer's disease went on to receive one, mainly because they were not medically eligible or they decided against it for fear of side effects. https://www.japantimes.co.jp/news/2026/04/08/japan/science-health/dementia-drugs-research/?utm_medium=Social&utm_source=mastodon #japan #sciencehealth #alzheimers #lecanemab #donanemab #health #medicine #dementia #brain

Lees tip -> Zorginstituut: lecanemab geen meerwaarde bij Alzheimer | Lecanemab vertraagt Alzheimer nauwelijks, kent risico’s en wordt daarom niet geadviseerd voor vergoeding. | #Alzheimer #basispakket #lecanemab #Leqembi #ZorginstituutNederland |

https://hbpmedia.nl/zorginstituut-lecanemab-geen-meerwaarde-bij-alzheimer/

🧠 Gehirn fit halten: Steht die Alzheimerforschung an einem Wendepunkt? 🤔
Neue #Medikamente wecken Hoffnung, aber es bleiben viele Fragezeichen. Der individuelle Lebensstil hat einen großen Einfluss auf die Entstehung und Genese der Krankheit. Darüber sprechen Professor Dr. Frank Jessen und Professor Dr. Alfredo Ramírez im aktuellen Unimagazin ▶️ https://uni.koeln/NYVVR

#uniköln #unicologne #uniklinikkoeln #Alzheimerforschung #Alzheimer #Gehirn #Lebensstil #Lecanemab #Donanemab

In fast-aging Japan, struggles with dementia are a common story. But researchers hope that future breakthroughs will help them rewrite the ending. https://www.japantimes.co.jp/news/2025/09/17/japan/science-health/dementia-research/?utm_medium=Social&utm_source=mastodon #japan #sciencehealth #aging #elderly #mentalhealth #alzheimer039s #medicine #pharmaceuticals #dementia #lecanemab #donanemab

Schwellungen und Blutungen des Gehirns sind unerwünschte Wirkungen der Antikörper gegen #Alzheimer-#Demenz – und das bei eher geringem Nutzen. Dabei scheint die Bilanz für #Donanemab schlechter zu sein als bei #Lecanemab. (€)
https://gutepillen-schlechtepillen.de/antikoerper-gegen-alzheimer-wenig-nutzen-schwere-risiken/

Will this be the death knell for Alzheimer’s monoclonal antibody treatments 🤔

Preprint on #Alzheimers drug deaths ignites dispute among authors

“Infighting among a group of prominent Alzheimer’s disease researchers has led to the withdrawal of a preprint they co-authored, which suggested a new Alzheimer’s drug markedly increases the risk of death. One scientist involved in the work charges the senior author failed to seek the go-ahead from his co-authors before posting an edited version of the article to a preprint server.”

#Lecanemab #Donanemab #Kisunla #amyloid #dementia
https://www.science.org/content/article/preprint-alzheimer-s-drug-deaths-ignites-dispute-among-authors

Will Klotho Prevent or Slow Dementia?

Klotho: Hope For Increased Longevity And Reduced Neurodegenerative Disease

“Renewed interest in a protein called klotho is pervading the scientific world. Klotho is a known anti-inflammatory protein that also contains anti-aging properties. In this two-part series, we will explore what klotho is, how it might impact inflammatory brain diseases, and how it ultimately prevents aging.”

#alzheimers #dementia #longevity #klotho #lecanemab #donanemab #aging
https://www.forbes.com/sites/williamhaseltine/2023/02/20/klotho-hope-for-increased-longevity-and-reduced-neurodegenerative-disease-part-1/

A long-awaited AlzForum's take on the news that ApoE4 homozygotism means in fact an AD pathology (though not necessarily dementia before death), https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers

The comments-section gives a glimpse of some of the trenchlines regarding the treatment of dementia, but I guess the prevention-camp has only just been strirred up from their Sleeping Beauty's slumber.

I, as an example, still have only a 1 % measured risk of acquiring AD, according to some widely used screens, and no "preventable risk factors" except maybe age. Too bad, my genetic inheritance seems to have been enough to skew the Amyloid-Beta balance early on. Luckily, I was recruited to the aducanumab-study for four years (a precursor of lecanemab with more severe side-effects), and probably got some more years to be able to think things like these.

#alzheimer #research #medical #APOE4 #alzForum #dementia #ad #alzheimers #amyloid #lecanemab #aducanumab #prevention #cure

#Dementia
'#Alzheimer’s ‘breakthrough’ stalls: why a much-hyped drug is facing approval delays

The benefits of drugs such as #donanemab, £aducanumab and #lecanemab are proving harder to quantify than potential harms, experts say'
https://www.theguardian.com/society/2024/mar/24/alzheimers-breakthrough-drugs-medicine-donanemab-aducanumab-lecanemab
#Health

Alzheimer’s breakthrough as blood tests could be offered on NHS | The Independent
https://www.independent.co.uk/news/health/alzheimers-blood-tests-nhs-cure-b2444022.html

#Alzheimers
#AlzheimersDiagnosis
#Dementia
#BloodTest
#NHS
#BloodBiomarkerChallenge
#AlzheimersResearchUK
#AlzheimersSociety
#NationalInstituteForHealthAndCareResearch
#Rochester
#EliLilly
#HongKong
#US
#Donanemab
#Lecanemab
#DementiaTreatments

Können neue #Medikamente die #Demenz besiegen?
Therapeutische #Antikörper, die sich gegen #Proteinablagerungen im #Gehirn von Menschen mit #Alzheimer richten, stehen in #Europa kurz vor der Zulassung. Bei wie vielen Betroffenen ihre positiven Effekte die Nachteile der Behandlung aufwiegen, ist noch unklar.

Zwei neue Wirkstoffe – #Lecanemab und #Donanemab – sollen #Alzheimerpatienten vor geistigem Abbau schützen.

(...)

https://www.spektrum.de/news/alzheimer-wie-wirksam-sind-lecanemab-und-donanemab/2184111 #Wissenschaft #Medizin

quote :
厚生勞動省（相當於衛生福利部）專家小組8月21日審核通過 #日本 #衛采製藥 （ #Eisai ）與 #美國 藥廠 #百健（ #Biogen ）合作開發的 #阿茲海默症 新藥 #Lecanemab （又稱為 #Leqembi ）。日本厚生勞動大臣武見敬三今天正式批准這種新藥。

https://www.cna.com.tw/news/aopl/202309250285.aspx

A health ministry panel reviewing the new Alzheimer’s drug lecanemab greenlighted its approval in Japan on Monday. https://www.japantimes.co.jp/news/2023/08/21/japan/science-health/lecanemab-alzheimers-drug-approval/?utm_content=buffer356e4&utm_medium=social&utm_source=mastodon&utm_campaign=bffmstdn #japan #sciencehealth #lecanemab #eisai #alzheimer039s #pharmaceuticals #health

Disease Modifying Therapy for #Alzheimer's #Dementia

"The long-awaited era of disease-modifying therapy for Alzheimer’s disease has finally arrived and will substantially impact how the disease is perceived and managed. The drugs closest to widespread clinical implementation are #lecanemab and #donanemab—intravenous #MonoclonalAntibodies that remove β #amyloid plaques from the #brain and can slow cognitive and functional decline."
#leqembi
https://cnmri.com/2023/07/21/disease-modifying-therapy-for-alzheimers/

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #CognitiveDecline #CognitiveDysfunction #MemoryLoss #BetaAmyloid #AmyloidFibrils #Aβ #AβFibrils #Immunotherapy #Lecanemab

https://www.cell.com/neuron/fulltext/S0896-6273(23)00269-6

Alzheimer’s Drug Lecanemab Shields Brain from Free-Roaming Amyloid Fibrils

Amyloid beta protein forms small aggregates that disrupt brain function in Alzheimer’s disease.
Lecanemab, a recently FDA-approved Alzheimer’s treatment, can neutralize these disruptive aggregates, hinting at its potential to slow down the disease’s cognitive decline.

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #CognitiveDecline #CognitiveDysfunction #MemoryLoss #BetaAmyloid #AmyloidFibrils #Immunotherapy #Lecanemab

https://neurosciencenews.com/amyloid-fibril-neuropharmacology-23207/