#talin — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #talin, aggregated by home.social.
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SciTech Chronicles. . . . . . . . .Feb 2nd, 2025
#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage
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"Single-molecule magnetic tweezers to capture over a million individual transitions as a single talin protein unfolds and refolds under force in equilibrium. When observed at classically probed timescales, talin folds in an apparently uncomplicated two-state manner. As the sampling time extends from minutes to days, the underlying energy landscape exhibits gradually larger signatures of complexity, involving a finite number of well-defined rare conformations.[...]The physiological relevance of each distinct conformation can be connected to the binding of the cytoskeletal protein vinculin, suggesting an extra layer of complexity in talin-mediated mechanotransduction."
https://www.nature.com/articles/s41567-022-01808-4
#StructuralBiology #Talin #Vinculin #MechanoTransduction #MechanoBiology #Cytoskeleton