#apoe4 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #apoe4, aggregated by home.social.
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DATE: May 26, 2026 at 12:56AM
SOURCE: SCIENCE DAILY MIND-BRAIN FEEDTITLE: USC scientists discover a hidden Alzheimer’s trigger and a possible way to shut it down
URL: https://www.sciencedaily.com/releases/2026/05/260525000504.htm
USC researchers have identified potential new drug compounds that may reduce the brain inflammation linked to Alzheimer’s disease, especially in people with the high-risk APOE4 gene. The compounds target cPLA2, an enzyme that seems to fuel harmful inflammation while also being important for normal brain activity.
URL: https://www.sciencedaily.com/releases/2026/05/260525000504.htm
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #AlzheimersResearch #APOE4 #cPLA2 #BrainInflammation #Neurodegeneration #DrugDiscovery # USC #AlzheimersPrevention #Neurology #ScientificBreakthrough
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https://www.europesays.com/es/508739/ Qué se sabe del gen de riesgo que podría provocar Alzheimer, según un reciente estudio #alzheimer #APOE4 #cerebro #Ciencia #demencia #EnfermedadDeAlzheimer #Enfermedades #ES #España #Health #LaTercera #memoria #Salud #SaludCerebral #Spain
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https://www.europesays.com/si/59775/ Švedski znanstveniki ugotovili povezavo med uživanjem mesa in demenco, mnoge bo presenetila #APOE4 #demenca #meso #raziskava #Slovene #Slovenščina #študija #Svet #World #zdravje
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MIND OVER MATTER? OR BRAIN FUEL? NEW INSIGHTS ON DEMENTIA'S ADVANCE
Learn how positive beliefs about aging, certain personality traits, and the MIND diet can lower dementia risk, even for those with genetic predispositions.
#DementiaRisk, #AgingWell, #MindDiet, #CognitiveHealth, #APOE4
https://newsletter.tf/positive-age-beliefs-cut-dementia-risk-gene-carriers/
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https://www.europesays.com/uk/321935/ At-home DNA tests — what can they tell you? #23andme #advice #Alzheimer's #ancestry #apoe4 #AtHome #brca #Cancer #CardiovascularDisease #commercial #diet #DirectToConsumer #Disease #DNA #exercise #Food #Genetic #Genetics #Heath #kit #Lifestyle #mental #NormanSwan #physical #Podcast #polygenic #Product #race #Rash #risk #Science #score #Sleep #swab #TeganTaylor #test #Testing #that #UK #UnitedKingdom #Vitamins #Wellness #what’s
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At-home DNA tests — what can they tell you?
Norman Swa…
#NewsBeep #News #Genetics #23andMe #advice #Alzheimer's #ancestry #apoe4 #at-home #brca #cancer #cardiovasculardisease #commercial #Diet #directtoconsumer #disease #dna #exercise #food #Genetic #heath #kit #Lifestyle #Mental #normanswan #Physical #Podcast #polygenic #product #Race #rash #risk #Science #score #Sleep #swab #tegantaylor #test #Testing #that #UK #UnitedKingdom #Vitamins #wellness #what's
https://www.newsbeep.com/uk/47340/ -
At-home DNA tests — what can they tell you?
Norman Swan: So…
#NewsBeep #News #Genetics #23andMe #advice #Alzheimer's #Ancestry #apoe4 #at-home #AU #Australia #brca #Cancer #CardiovascularDisease #Commercial #diet #directtoconsumer #disease #dna #Exercise #food #Genetic #heath #kit #Lifestyle #mental #normanswan #physical #podcast #polygenic #product #race #rash #risk #Science #score #Sleep #swab #tegantaylor #test #Testing #that #Vitamins #wellness #whats
https://www.newsbeep.com/au/46425/ -
Genetics can raise dementia risks. But the Mediterranean diet may counter them, study finds https://www.diningandcooking.com/2251233/genetics-can-raise-dementia-risks-but-the-mediterranean-diet-may-counter-them-study-finds/ #Alzheimer'sDisease #APOE4 #CognitiveDecline #dementia #EnvironmentalFactors #GeneticData #GeneticRisk #GeneticRisks #GeneticVariant #Mediterranean #MediterraneanCuisine #MediterraneanDiet #YuxiLiu
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Thirty years on, our research linking viral infections with Alzheimer’s is finally getting the attention it deserves
#Health #Alzheimers #ColdSoreVirus #HerpesSimplex #Vaccines #DementiaResearch #Neuroscience #Brain #APOE4 #VirusLink #Dementia #Shingles
https://the-14.com/thirty-years-on-our-research-linking-viral-infections-with-alzheimers-is-finally-getting-the-attention-it-deserves/ -
A HS student emailed me out of the blue to do an interview as part of her capstone project on #Alzheimer's. I spoke w/her about #brain science & #caregiving. She's 18, her family has the #APOE4 gene - a risk factor for the disease - & she will study neuroscience to find a cure for Alzheimer's. She's smart, determined, & I had chills listening to her story and her passion. The senseless, fascistic #NIH cuts are imperiling the potential, the future of people like her, & our own.
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A HS student emailed me out of the blue to do an interview as part of her capstone project on #Alzheimer's. I spoke w/her about #brain science & #caregiving. She's 18, her family has the #APOE4 gene - a risk factor for the disease - & she will study neuroscience to find a cure for Alzheimer's. She's smart, determined, & I had chills listening to her story and her passion. The senseless, fascistic #NIH cuts are imperiling the potential, the future of people like her, & our own.
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APOE4 gene may influence brain barrier function in early stages of Alzheimer’s disease https://www.psypost.org/apoe4-gene-may-influence-brain-barrier-function-in-early-stages-of-alzheimers-disease/?utm_source=dlvr.it&utm_medium=mastodon #AlzheimersDisease #APOE4 #brainbarrier #neurodegeneration #Alzheimersrisk
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Study Suggests #Genetics as a Cause, Not Just a Risk, for Some #Alzheimer’s
People with two copies of the #gene variant #APOE4 are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such #patients could be diagnosed years before symptoms.
https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html
https://archive.ph/yTtsM -
A long-awaited AlzForum's take on the news that ApoE4 homozygotism means in fact an AD pathology (though not necessarily dementia before death), https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers
The comments-section gives a glimpse of some of the trenchlines regarding the treatment of dementia, but I guess the prevention-camp has only just been strirred up from their Sleeping Beauty's slumber.
I, as an example, still have only a 1 % measured risk of acquiring AD, according to some widely used screens, and no "preventable risk factors" except maybe age. Too bad, my genetic inheritance seems to have been enough to skew the Amyloid-Beta balance early on. Luckily, I was recruited to the aducanumab-study for four years (a precursor of lecanemab with more severe side-effects), and probably got some more years to be able to think things like these.
#alzheimer #research #medical #APOE4 #alzForum #dementia #ad #alzheimers #amyloid #lecanemab #aducanumab #prevention #cure
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Alzheimer’s disease seen in near 100% APOE4 homozygotes
“Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to #APOE3 homozygotes.
By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive #amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in #APOE4 homozygotes”
#Alzheimers #Dementia
https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg -
New Genetic Form of Alzheimer's Identified in People With Common Risk Factor : ScienceAlert
https://www.sciencealert.com/new-genetic-form-of-alzheimers-identified-in-people-with-common-risk-factor#Alzheimers
#Genetics
#GeneticFormOfAlzheimers
#ApolipoproteinE4
#APOE4
#AutosomalDominantAlzheimersDisease
#ADAD
#APP
#DownSyndrome -
People with 2 copies of APOE4 were known to have a high risk of #Alzheimers.
📍Today that changed to nearly 100% full penetrance
-
Predictors of longitudinal cognitive ageing from age 70 to 82 including #APOEe4 status, early-life and #lifestyle factors: the Lothian Birth Cohort 1936
APOE4 status explains the majority of variance in cognitive aging (but not much in a verbal domain) when early-life and lifestyle factors are included in the same model.
(Open Access)
https://www.nature.com/articles/s41380-022-01900-4 -
@philshapiro NIH Study reveals how APOE4 gene may increase risk for dementia - women are at higher risk of inheriting this gene from each parent thus increasing the risk by 8 to 10 times. https://www.nih.gov/news-events/nih-research-matters/study-reveals-how-apoe4-gene-may-increase-risk-dementia #Dementia #APOE4 #gene Take #Cholinesupplements
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This is really intriguing - but it's VERY early in development. And if this tx is dangerous and/or staggeringly expensive, determing benefit of reducing lifetine risk from say 30-55% to 20% is going to be complicated. #Alzheimers #APOE4
Alzheimer’s APOE4 Genetic Risk Targeted in Promising Trial.
https://www.nytimes.com/2022/12/02/health/alzheimers-apoe4-gene-therapy.html -
It’s well-known that carrying one copy of the #APOE4 gene variant increases one’s risk for #Alzheimer’s disease threefold and two copies about tenfold, but the fundamental reasons why, and what can be done to help patients, remain largely unknown
#Neuroscience #sflorg
https://www.sflorg.com/2022/11/ns11222202.html -
The #APOE4 gene variant is the strongest genetic risk factor for #Alzheimer disease. However, the effects of APOE4 on the human brain are not fully understood. A new study suggests that this risk gene may undermine insulation of the brain's wiring, opening opportunities to develop targeted therapies.
https://www.nature.com/articles/s41586-022-05439-w
News and views:
https://twitter.com/DrLiHueiTsai/status/1593082131449716736?s=20&t=Ec-nCdyjXknQ3WtWj24zYw -
CW: APOE in #Alzheimer's
This is what #EPAD and other studies are showing. #APOE4 is such a huge risk factor for #Alzheimer's (akin to a decade of ageing) that it's basically a different, #amyloid-heavy disease. There are other routes to #Tauopathy in those with e.g. E3/E3. Paper from the great and good here https://www.nature.com/articles/s41583-021-00533-w
But if Amyloid++ 4/4 genotypes predict best response AND worse SE to anti-Amyloid therapies, shouldn't we start to TEST for it and learn how best to communicate results? -
New research shows positive age beliefs can make individuals with a high genetic risk for dementia nearly 50% less likely to develop it.
#DementiaRisk, #AgingWell, #MindDiet, #CognitiveHealth, #APOE4
https://newsletter.tf/positive-age-beliefs-cut-dementia-risk-gene-carriers/ -
https://www.europesays.com/at/81231/ Fleisch schützt APOE4-Gene vor Demenz #ApoE4 #APOE4Gene #AT #Austria #Demenz #Demenzrisiko #Fleisch #Gens #Gesundheit #Health #KarolinskaInstituts #Konsum #Langzeitstudie #Österreich #Träger
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Thirty years on, our research linking viral infections with Alzheimer’s is finally getting the attention it deserves
#Health #Alzheimers #ColdSoreVirus #HerpesSimplex #Vaccines #DementiaResearch #Neuroscience #Brain #APOE4 #VirusLink #Dementia #Shingles
https://the-14.com/thirty-years-on-our-research-linking-viral-infections-with-alzheimers-is-finally-getting-the-attention-it-deserves/ -
Thirty years on, our research linking viral infections with Alzheimer’s is finally getting the attention it deserves
#Health #Alzheimers #ColdSoreVirus #HerpesSimplex #Vaccines #DementiaResearch #Neuroscience #Brain #APOE4 #VirusLink #Dementia #Shingles
https://the-14.com/thirty-years-on-our-research-linking-viral-infections-with-alzheimers-is-finally-getting-the-attention-it-deserves/ -
Thirty years on, our research linking viral infections with Alzheimer’s is finally getting the attention it deserves
#Health #Alzheimers #ColdSoreVirus #HerpesSimplex #Vaccines #DementiaResearch #Neuroscience #Brain #APOE4 #VirusLink #Dementia #Shingles
https://the-14.com/thirty-years-on-our-research-linking-viral-infections-with-alzheimers-is-finally-getting-the-attention-it-deserves/ -
Thirty years on, our research linking viral infections with Alzheimer’s is finally getting the attention it deserves
#Health #Alzheimers #ColdSoreVirus #HerpesSimplex #Vaccines #DementiaResearch #Neuroscience #Brain #APOE4 #VirusLink #Dementia #Shingles
https://the-14.com/thirty-years-on-our-research-linking-viral-infections-with-alzheimers-is-finally-getting-the-attention-it-deserves/ -
https://www.europesays.com/at/43717/ Eisai präsentiert neue Langzeitdaten zu Alzheimer-Mittel Leqembi #AlzheimerForschung #AlzheimerMittel #ApoE4 #AT #Austria #Eisai #Gesundheit #Health #Langzeitdaten #Leqembi #Österreich #patienten #Risikogen #Studienergebnisse #Therapien
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New Genetic Form of Alzheimer's Identified in People With Common Risk Factor : ScienceAlert
https://www.sciencealert.com/new-genetic-form-of-alzheimers-identified-in-people-with-common-risk-factor#Alzheimers
#Genetics
#GeneticFormOfAlzheimers
#ApolipoproteinE4
#APOE4
#AutosomalDominantAlzheimersDisease
#ADAD
#APP
#DownSyndrome -
New Genetic Form of Alzheimer's Identified in People With Common Risk Factor : ScienceAlert
https://www.sciencealert.com/new-genetic-form-of-alzheimers-identified-in-people-with-common-risk-factor#Alzheimers
#Genetics
#GeneticFormOfAlzheimers
#ApolipoproteinE4
#APOE4
#AutosomalDominantAlzheimersDisease
#ADAD
#APP
#DownSyndrome -
New Genetic Form of Alzheimer's Identified in People With Common Risk Factor : ScienceAlert
https://www.sciencealert.com/new-genetic-form-of-alzheimers-identified-in-people-with-common-risk-factor#Alzheimers
#Genetics
#GeneticFormOfAlzheimers
#ApolipoproteinE4
#APOE4
#AutosomalDominantAlzheimersDisease
#ADAD
#APP
#DownSyndrome -
New Genetic Form of Alzheimer's Identified in People With Common Risk Factor : ScienceAlert
https://www.sciencealert.com/new-genetic-form-of-alzheimers-identified-in-people-with-common-risk-factor#Alzheimers
#Genetics
#GeneticFormOfAlzheimers
#ApolipoproteinE4
#APOE4
#AutosomalDominantAlzheimersDisease
#ADAD
#APP
#DownSyndrome -
https://www.europesays.com/ch/34192/ Roche secures CE mark for blood test to identify ApoE4 carriers #Alzheimer'sDisease #ApoE4 #BioWorld #dementia #diagnostics #Elecsys #ElecsysApolipoproteinE4 #Europe #MedicalTechnology #Neurology/psychiatric #Regulatory #Roche #RocheHoldingAG
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Alzheimer’s disease seen in near 100% APOE4 homozygotes
“Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to #APOE3 homozygotes.
By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive #amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in #APOE4 homozygotes”
#Alzheimers #Dementia
https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg -
Alzheimer’s disease seen in near 100% APOE4 homozygotes
“Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to #APOE3 homozygotes.
By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive #amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in #APOE4 homozygotes”
#Alzheimers #Dementia
https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg -
Alzheimer’s disease seen in near 100% APOE4 homozygotes
“Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to #APOE3 homozygotes.
By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive #amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in #APOE4 homozygotes”
#Alzheimers #Dementia
https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg -
Alzheimer’s disease seen in near 100% APOE4 homozygotes
“Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to #APOE3 homozygotes.
By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive #amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in #APOE4 homozygotes”
#Alzheimers #Dementia
https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg -
Genetics can raise dementia risks. But the Mediterranean diet may counter them, study finds https://www.diningandcooking.com/2251233/genetics-can-raise-dementia-risks-but-the-mediterranean-diet-may-counter-them-study-finds/ #Alzheimer'sDisease #APOE4 #CognitiveDecline #dementia #EnvironmentalFactors #GeneticData #GeneticRisk #GeneticRisks #GeneticVariant #Mediterranean #MediterraneanCuisine #MediterraneanDiet #YuxiLiu
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Genetics can raise dementia risks. But the Mediterranean diet may counter them, study finds https://www.diningandcooking.com/2251233/genetics-can-raise-dementia-risks-but-the-mediterranean-diet-may-counter-them-study-finds/ #Alzheimer'sDisease #APOE4 #CognitiveDecline #dementia #EnvironmentalFactors #GeneticData #GeneticRisk #GeneticRisks #GeneticVariant #Mediterranean #MediterraneanCuisine #MediterraneanDiet #YuxiLiu
-
People with 2 copies of APOE4 were known to have a high risk of #Alzheimers.
📍Today that changed to nearly 100% full penetrance
-
People with 2 copies of APOE4 were known to have a high risk of #Alzheimers.
📍Today that changed to nearly 100% full penetrance
-
People with 2 copies of APOE4 were known to have a high risk of #Alzheimers.
📍Today that changed to nearly 100% full penetrance
-
People with 2 copies of APOE4 were known to have a high risk of #Alzheimers.
📍Today that changed to nearly 100% full penetrance
-
Predictors of longitudinal cognitive ageing from age 70 to 82 including #APOEe4 status, early-life and #lifestyle factors: the Lothian Birth Cohort 1936
APOE4 status explains the majority of variance in cognitive aging (but not much in a verbal domain) when early-life and lifestyle factors are included in the same model.
(Open Access)
https://www.nature.com/articles/s41380-022-01900-4 -
Predictors of longitudinal cognitive ageing from age 70 to 82 including #APOEe4 status, early-life and #lifestyle factors: the Lothian Birth Cohort 1936
APOE4 status explains the majority of variance in cognitive aging (but not much in a verbal domain) when early-life and lifestyle factors are included in the same model.
(Open Access)
https://www.nature.com/articles/s41380-022-01900-4 -
Predictors of longitudinal cognitive ageing from age 70 to 82 including #APOEe4 status, early-life and #lifestyle factors: the Lothian Birth Cohort 1936
APOE4 status explains the majority of variance in cognitive aging (but not much in a verbal domain) when early-life and lifestyle factors are included in the same model.
(Open Access)
https://www.nature.com/articles/s41380-022-01900-4 -
Predictors of longitudinal cognitive ageing from age 70 to 82 including #APOEe4 status, early-life and #lifestyle factors: the Lothian Birth Cohort 1936
APOE4 status explains the majority of variance in cognitive aging (but not much in a verbal domain) when early-life and lifestyle factors are included in the same model.
(Open Access)
https://www.nature.com/articles/s41380-022-01900-4 -
https://www.europesays.com/ch/33711/ Roche Advances in Alzheimer’s Diagnostics with New Blood Test Approval #Advances #Alzheimer’s #ApoE4 #Approval #Blood #diagnostics #new #Roche #test