#aducanumab — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #aducanumab, aggregated by home.social.
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@Lupposofi A couple of years ago, I coauthored a paper trying to measure the applicability of the #aducanumab (#Aduhelm)'s results applied to the real world practice of a #geriatric outpatient clinic (with special focus on older persons with #cognitive impairment). Less than 1% of patients were potentially eligible. And this on the top of the unclear/arguable effects...
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A long-awaited AlzForum's take on the news that ApoE4 homozygotism means in fact an AD pathology (though not necessarily dementia before death), https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers
The comments-section gives a glimpse of some of the trenchlines regarding the treatment of dementia, but I guess the prevention-camp has only just been strirred up from their Sleeping Beauty's slumber.
I, as an example, still have only a 1 % measured risk of acquiring AD, according to some widely used screens, and no "preventable risk factors" except maybe age. Too bad, my genetic inheritance seems to have been enough to skew the Amyloid-Beta balance early on. Luckily, I was recruited to the aducanumab-study for four years (a precursor of lecanemab with more severe side-effects), and probably got some more years to be able to think things like these.
#alzheimer #research #medical #APOE4 #alzForum #dementia #ad #alzheimers #amyloid #lecanemab #aducanumab #prevention #cure
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An expected news from Alzheimer therapies, https://www.alzforum.org/news/community-news/adieu-aduhelm-biogen-stops-marketing-antibody
A bit nostalgic, though, because I was one of the few whose cognition improved (relatively, i.e. compared to the control-group) during the years I got the antibody 10 mg / kg, enough for Biogen to apply for license.
It was a marvellous box-seat to observe pharmaceutical research with all it's intricacies, and live neurological expertise within an arm's reach was invaluable.
Here is the history of aducanumab, rest in pieces, https://www.alzforum.org/therapeutics/aduhelm
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"I think one of the reasons Leqembi was approved (and Lilly's donanemab is likely to be, this year) is that aducanumab was approved. I remain skeptical that these drugs will provide any real-world benefit, but I am not skeptical at all of the sales potentials for both of them."
#Alzheimer
#Leqembi
#aducanumabhttps://www.science.org/content/blog-post/goodbye-aduhelm?s=09
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Biogen dumps dubious Alzheimer’s drug after profit-killing FDA scandal - Enlarge / The exterior of the headquarters of biotechnology company Bio... - https://arstechnica.com/?p=2000435 #clinicaltrial #aducanumab #alzheimers #science #aduhelm #health #biogen #fda
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Diese Innovation bringt ein Alzheimer-Medikament durch die Blut-Hirn-Schranke | heise online
https://heise.de/-9600712 #Alzheimer #Ultraschall #Aducanumab #BlutHirnSchranke -
Update on #aducanumab fiasco:
Congressional investigation into regulatory capture of the FDA is damning:
FDA's approval process was "rife with irregularities"