#polygenic — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #polygenic, aggregated by home.social.
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La structure des réseaux de régulation explique l'évolution et l'héritabilité des phénotypes complexes
De nombreux phénotypes humains sont polygéniques, déterminés par plusieurs gènes et éléments régulateurs : la taille à l’âge adulte, le métabolisme, l’immunité, la prédisposition génétique à de nombreuses maladies, y compris des cancers et des maladies auto-immunes, des troubles psychiatriques et des maladies neurodégénératives. Ces gènes sont souvent pléiotropes, déterminant simultanément différents phénotypes. Cela s’explique par le grand nombre d’interactions au niveau moléculaire dans chaque cellule, où des réseaux complexes régulent finement l’expression des gènes. Étant donné l’intrication des bases génétiques des différents phénotypes complexes, nous nous sommes demandé comment un phénotype complexe peut évoluer en réponse aux contraintes environnementales, sans altérer les autres phénotypes.
#ideev #gqelemoulon #maudfagny @hal_fr @officialSMBE #mbe #phenotype #regulation #polygenic @inrae_france
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https://www.europesays.com/uk/321935/ At-home DNA tests — what can they tell you? #23andme #advice #Alzheimer's #ancestry #apoe4 #AtHome #brca #Cancer #CardiovascularDisease #commercial #diet #DirectToConsumer #Disease #DNA #exercise #Food #Genetic #Genetics #Heath #kit #Lifestyle #mental #NormanSwan #physical #Podcast #polygenic #Product #race #Rash #risk #Science #score #Sleep #swab #TeganTaylor #test #Testing #that #UK #UnitedKingdom #Vitamins #Wellness #what’s
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At-home DNA tests — what can they tell you?
Norman Swa…
#NewsBeep #News #Genetics #23andMe #advice #Alzheimer's #ancestry #apoe4 #at-home #brca #cancer #cardiovasculardisease #commercial #Diet #directtoconsumer #disease #dna #exercise #food #Genetic #heath #kit #Lifestyle #Mental #normanswan #Physical #Podcast #polygenic #product #Race #rash #risk #Science #score #Sleep #swab #tegantaylor #test #Testing #that #UK #UnitedKingdom #Vitamins #wellness #what's
https://www.newsbeep.com/uk/47340/ -
At-home DNA tests — what can they tell you?
Norman Swan: So…
#NewsBeep #News #Genetics #23andMe #advice #Alzheimer's #Ancestry #apoe4 #at-home #AU #Australia #brca #Cancer #CardiovascularDisease #Commercial #diet #directtoconsumer #disease #dna #Exercise #food #Genetic #heath #kit #Lifestyle #mental #normanswan #physical #podcast #polygenic #product #race #rash #risk #Science #score #Sleep #swab #tegantaylor #test #Testing #that #Vitamins #wellness #whats
https://www.newsbeep.com/au/46425/ -
#Aminoacid #mutations #PB1-V719M and #PA-N444D combined with #PB2-627K contribute to the #pathogenicity of #H7N9 in #mice, Vet Res.: https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6
Overall, this study revealed that #virulence in H7N9 is a #polygenic trait and identified novel virulence-related residues (PB2-627K combined with PB1-719M and/or PA-444D) in viral ribonucleoprotein (vRNP) complexes.
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STATGEN 2024 talk
Polygenic risk score analysis for multiethnic populations
Chris AmosPolygenic Risk Scores (PRS)
* Inform re biological processes
* Identify some at higher risk
* Might motivate behavioral changePRS could inform when to start screening.
"measles plot instead of a manhattan plot" - has excessive false positives all over the genome.
Lung cancer risk snp also is related to response to smoking cessation
1/
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STATGEN 2024 talk
Polygenic risk score analysis for multiethnic populations
Chris AmosPolygenic Risk Scores (PRS)
* Inform re biological processes
* Identify some at higher risk
* Might motivate behavioral changePRS could inform when to start screening.
"measles plot instead of a manhattan plot" - has excessive false positives all over the genome.
Lung cancer risk snp also is related to response to smoking cessation
1/
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STATGEN 2024 talk
Polygenic risk score analysis for multiethnic populations
Chris AmosPolygenic Risk Scores (PRS)
* Inform re biological processes
* Identify some at higher risk
* Might motivate behavioral changePRS could inform when to start screening.
"measles plot instead of a manhattan plot" - has excessive false positives all over the genome.
Lung cancer risk snp also is related to response to smoking cessation
1/
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STATGEN 2024 talk
Polygenic risk score analysis for multiethnic populations
Chris AmosPolygenic Risk Scores (PRS)
* Inform re biological processes
* Identify some at higher risk
* Might motivate behavioral changePRS could inform when to start screening.
"measles plot instead of a manhattan plot" - has excessive false positives all over the genome.
Lung cancer risk snp also is related to response to smoking cessation
1/
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#Beethoven's #musicality put to the test: An international #research team incl. @mpi_nl and @MPI_ae set out to analyze the composer’s #genetic predisposition by calculating his #polygenic score for #beat synchronization ability. Out now in @CurrentBiology: https://doi.org/10.1016/j.cub.2024.01.025
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Researchers have developed statistical tools called #polygenic risk scores (PRSs) that can estimate individuals’ risk for certain diseases with strong #genetic components, such as #heart disease or #diabetes.
#Genetics #sflorg
https://www.sflorg.com/2024/03/gen03192401.html -
This festive season 🎄 give the gift 🎁 of a #Bayesian model to a friend still trying to run a frequentist linkage mapping approach looking for significant associations 🧬🖥️
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"Polygenic risk scores performed poorly in population screening, individual risk prediction, and population risk stratification. Strong claims about the effect of polygenic risk scores on healthcare seem to be disproportionate to their performance."
Hingorani et al. Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog. BMJ Medicine. 2023 Oct 1;2(1). DOI: https://doi.org/10.1136/bmjmed-2023-000554
#genetics #polygenic -
A polygenic explanation for Haldane’s rule in butterflies
Xiong et al. (Jim Mallet's team)
#PopGen #Hybridization #Polygenic"numerous small-effect factors on a single chromosome can appear as spurious large-effect loci. This mapping artifact persists even for large samples and dense markers and may cause underreporting of polygenicity from genetic crosses."
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Cryptic #sexChromosome was found after removing a master sex-determining #chromosome. This result suggests that #polygenic #sexDetermination system may be more prevalent than previously thought.
Open access article by Kitano et al. now available ahead of print!
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Cryptic #sexChromosome was found after removing a master sex-determining #chromosome. This result suggests that #polygenic #sexDetermination system may be more prevalent than previously thought.
Open access article by Kitano et al. now available ahead of print!
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Cryptic #sexChromosome was found after removing a master sex-determining #chromosome. This result suggests that #polygenic #sexDetermination system may be more prevalent than previously thought.
Open access article by Kitano et al. now available ahead of print!
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Cryptic #sexChromosome was found after removing a master sex-determining #chromosome. This result suggests that #polygenic #sexDetermination system may be more prevalent than previously thought.
Open access article by Kitano et al. now available ahead of print!
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Cryptic #sexChromosome was found after removing a master sex-determining #chromosome. This result suggests that #polygenic #sexDetermination system may be more prevalent than previously thought.
Open access article by Kitano et al. now available ahead of print!
