#apoe — Public Fediverse posts

"El gen APOE y el sueño roto de la inmortalidad".
https://precisionmed.eu/el-gen-apoe-y-el-sueno-roto-de-la-inmortalidad/
#genética #MedicinaIntegrativa #exposoma #APOE

Study: High meat intake linked to lower dementia risk in older adults with APOE genetic risk; a lower share of processed meat and more unprocessed meat also tied to reduced dementia risk and all‑cause mortality—though observational, trials are needed. Read: https://news.ki.se/high-meat-consumption-linked-to-lower-dementia-risk-in-genetic-risk-group 🧠🥩 #Alzheimers #Nutrition #APOE

research article from 2005:

Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender

https://pubmed.ncbi.nlm.nih.gov/15650186

#HSV1 #hormones #herpesvirus #ApoE

APOE expression and secretion are modulated by mitochondrial dysfunction

This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.

#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction

https://elifesciences.org/articles/85779

La actividad física ayuda a contrarrestar el riesgo genético del alzhéimer

#Neurociencia #Cerebro #Neurología #EnfermedadesNeurológicas #EnfermedadesNeurodegenerativas #Neurodegeneración #Demencia #Alzheimer #Neurogenética #ApoE #EjercicioFísico #ActividadFísica #Deporte
#Biomedicina

https://www.agenciasinc.es/Noticias/La-actividad-fisica-ayuda-a-contrarrestar-el-riesgo-genetico-del-alzheimer

Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man

The male remained cognitively intact until 67 years of age despite carrying a PSEN1-E280A mutation. He had extremely elevated amyloid plaque burden and limited entorhinal Tau tangle burden.
He was heterozygous for a rare variant in RELN showing stronger ability to reduce human Tau phosphorylation in a knockin mouse.

#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #Tau #Reelin #ApoE #Dementia #Neurogenetics

https://www.nature.com/articles/s41591-023-02318-3

New video!

A scientific review of #Limitless, #DisneyPlus and @NatGeo’s epic new series on longevity.

What’s the best thing #chrishemsworth could do for his health? Watch and find out: https://www.youtube.com/watch?v=AfFqxSwEaWs

#aging #ageing #agingbiology #biology #science #apoe #dementia #fasting

Effects of APOE alleles ɛ2 & ɛ4 in @uk_biobank participants shows that the protective effect of #APOE ɛ2 on #AlzheimersDisease risk is sex-specific & linked to distinct #hippocampus-#DefaultNetwork co-variations @ChloeSavignac @danilobzdok &co #PLOSBiology https://plos.io/3WbmTB0

'Our structural, genetic, and phenotypic analyses in this large epidemiological cohort reinvigorate the often-neglected interplay between APOE ɛ2 dosage and sex and link APOE alleles to inter-individual brain structural differences indicative of ADRD familial risk.'

#Alzheimer #ApoE

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001863

Effects of APOE alleles ɛ2 & ɛ4 in @uk_biobank participants shows that the protective effect of #APOE ɛ2 on #AlzheimersDisease risk is sex-specific & linked to distinct #hippocampus-#DefaultNetwork co-variations @ChloeSavignac @danilobzdok &co #PLOSBiology https://plos.io/3WbmTB0

Effects of APOE alleles ɛ2 & ɛ4 in @uk_biobank participants shows that the protective effect of #APOE ɛ2 on #AlzheimersDisease risk is sex-specific & linked to distinct #hippocampus-#DefaultNetwork co-variations @ChloeSavignac @danilobzdok &co #PLOSBiology https://plos.io/3WbmTB0

¿Por qué ciertas áreas del #cerebro son más vulnerables en la enfermedad de #Alzheimer ?
Algunos estudios sugieren que las partes del cerebro en las que el gen APOE (un importante factor de riesgo genético en la enfermedad de Alzheimer) es más activo son las zonas que sufren más daños.
#Neurología #Neurociencia #EnfermedadesNeurodegenerativas #APOE #Tau

https://www.infosalus.com/salud-investigacion/noticia-alzheimer-dana-ciertas-partes-cerebro-20221121163354.html