#mousemodel — Public Fediverse posts

Genetic survey exposes flaws in widely used #mouse models: A survey of more than 300 mouse strains (such as in C57BL/6) has found widespread discrepancies between how mutant mice are reported and their actual #genetic make-up.

🌍 https://www.nature.com/articles/d41586-026-01534-4

#Neuroscience #MouseModel

Genetic survey exposes flaws in widely used #mouse models: A survey of more than 300 mouse strains (such as in C57BL/6) has found widespread discrepancies between how mutant mice are reported and their actual #genetic make-up.

🌍 https://www.nature.com/articles/d41586-026-01534-4

#Neuroscience #MouseModel

Genetic survey exposes flaws in widely used #mouse models: A survey of more than 300 mouse strains (such as in C57BL/6) has found widespread discrepancies between how mutant mice are reported and their actual #genetic make-up.

🌍 https://www.nature.com/articles/d41586-026-01534-4

#Neuroscience #MouseModel

Genetic survey exposes flaws in widely used #mouse models: A survey of more than 300 mouse strains (such as in C57BL/6) has found widespread discrepancies between how mutant mice are reported and their actual #genetic make-up.

🌍 https://www.nature.com/articles/d41586-026-01534-4

#Neuroscience #MouseModel

Genetic survey exposes flaws in widely used #mouse models: A survey of more than 300 mouse strains (such as in C57BL/6) has found widespread discrepancies between how mutant mice are reported and their actual #genetic make-up.

🌍 https://www.nature.com/articles/d41586-026-01534-4

#Neuroscience #MouseModel

Base editing approach repairs deadly Dravet syndrome mutation in mice

Gene editing can repair a DNA error in mice that causes Dravet syndrome, a rare, incurable, and potentially…
#NewsBeep #News #Health #Adenine #AU #Australia #Brain #Children #dna #DravetSyndrome #Epilepsy #food #Gene #Genetic #Hospital #Laboratory #MedicalSchool #medicine #MouseModel #Mutation #Neurons #Preclinical #raredisease #research #Syndrome
https://www.newsbeep.com/au/669882/

Base editing approach repairs deadly Dravet syndrome mutation in mice

Gene editing can repair a DNA error in mice that causes Dravet syndrome, a rare, incurable, and potentially…
#NewsBeep #News #Health #Adenine #AU #Australia #Brain #Children #dna #DravetSyndrome #Epilepsy #food #Gene #Genetic #Hospital #Laboratory #MedicalSchool #medicine #MouseModel #Mutation #Neurons #Preclinical #raredisease #research #Syndrome
https://www.newsbeep.com/au/669882/

https://www.europesays.com/ie/452625/ Scientists identify STING switch driving inflammation in Alzheimer’s disease #Aging #Alzheimer'sDisease #Brain #Cell #Chronic #Cysteine #Éire #Health #IE #ImmuneSystem #inflammation #Ireland #Molecule #MouseModel #Nerve #Preclinical #Protein #Research

https://www.europesays.com/ie/447562/ Calcium signals in microglia drive anxiety and compulsive behaviors #anxiety #Brain #Calcium #Chronic #Éire #Genetic #Genetics #IE #Ireland #medicine #microglia #Microscope #MouseModel #Neurons #Physiology #Psychiatry #Research #Science

https://www.europesays.com/ie/416573/ Celiac disease weakens gut microbes that digest fiber #Autoantibodies #AutoimmuneDisease #CeliacDisease #diet #DietaryFiber #Éire #Genetic #gluten #Health #Hyperplasia #IE #inflammation #Ireland #Metabolism #MouseModel #SmallIntestine #wheat

Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of…
#NewsBeep #News #Health #Assay #AU #Australia #Cancer #Cell #Chromatin #Chronic #Colon #Colorectal #dna #Inflammation #InflammatoryBowelDisease #inflammatorydisease #MouseModel #Mutation #protein #StemCells #Transcription #Tumor
https://www.newsbeep.com/au/573305/

Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of…
#NewsBeep #News #Health #Assay #AU #Australia #Cancer #Cell #Chromatin #Chronic #Colon #Colorectal #dna #Inflammation #InflammatoryBowelDisease #inflammatorydisease #MouseModel #Mutation #protein #StemCells #Transcription #Tumor
https://www.newsbeep.com/au/573305/

Sustained high progesterone during pregnancy can improve menstrual cyclicity in PCOS patients

Polycystic ovary syndrome (PCOS) affects 6%−20% of reproductive-aged women, and is commonly accompanied by irregular menstrual cycles and…
#NewsBeep #News #Health #Apoptosis #AU #Australia #Cell #Hormone #Infertility #menstrualcycle #Metabolism #MouseModel #polycysticovarysyndrome #pregnancy #Progesterone #Syndrome
https://www.newsbeep.com/au/473361/

Our new #preprint on #ThreePhoton in vivo #imaging of #neurons and #glia 🔬 in the medial prefrontal cortex (#mPFC) 🧠 with sub-cellular resolution 🔍 is out! Check it out on #biorxiv:

🌍 https://www.biorxiv.org/content/10.1101/2024.08.28.610026v1

#Neuroscience #multiphoton #3p vs. #2p #twophoton #hippocampus #drosophila #MouseModel #DeepImaging #preprintalert #DZNE @dzne

Our new #preprint on #ThreePhoton in vivo #imaging of #neurons and #glia 🔬 in the medial prefrontal cortex (#mPFC) 🧠 with sub-cellular resolution 🔍 is out! Check it out on #biorxiv:

🌍 https://www.biorxiv.org/content/10.1101/2024.08.28.610026v1

#Neuroscience #multiphoton #3p vs. #2p #twophoton #hippocampus #drosophila #MouseModel #DeepImaging #preprintalert #DZNE @dzne

Our new #preprint on #ThreePhoton in vivo #imaging of #neurons and #glia 🔬 in the medial prefrontal cortex (#mPFC) 🧠 with sub-cellular resolution 🔍 is out! Check it out on #biorxiv:

🌍 https://www.biorxiv.org/content/10.1101/2024.08.28.610026v1

#Neuroscience #multiphoton #3p vs. #2p #twophoton #hippocampus #drosophila #MouseModel #DeepImaging #preprintalert #DZNE @dzne

Our new #preprint on #ThreePhoton in vivo #imaging of #neurons and #glia 🔬 in the medial prefrontal cortex (#mPFC) 🧠 with sub-cellular resolution 🔍 is out! Check it out on #biorxiv:

🌍 https://www.biorxiv.org/content/10.1101/2024.08.28.610026v1

#Neuroscience #multiphoton #3p vs. #2p #twophoton #hippocampus #drosophila #MouseModel #DeepImaging #preprintalert #DZNE @dzne

Our new #preprint on #ThreePhoton in vivo #imaging of #neurons and #glia 🔬 in the medial prefrontal cortex (#mPFC) 🧠 with sub-cellular resolution 🔍 is out! Check it out on #biorxiv:

🌍 https://www.biorxiv.org/content/10.1101/2024.08.28.610026v1

#Neuroscience #multiphoton #3p vs. #2p #twophoton #hippocampus #drosophila #MouseModel #DeepImaging #preprintalert #DZNE @dzne

Macrophages are essential immune cells that reside in all tissues. Some macrophages arise from monocytes in the blood, but during fetal development they also come from a unique pathway!

We still have a lot to learn, but here I'll describe how Zhao et al. (2023) used mouse models to uncover hints about which progenitor cells create tissue-macrophages.

https://doi.org/10.1016/j.celrep.2023.113364

#Macrophages #MouseModel #Immunology #Immunity #scRNAseq #FlowCytometry #Research #JournalArticle #JournalClub

1/9🧵

Really cool application of Infinity Flow to #MouseModel #Tcells, which allows readout/prediction of >200 surface epitopes on single cells via #FlowCytometry.

https://doi.org/10.1016/j.immuni.2023.06.005

By @maxevrard
#Immunology #TissueImmunity

Oleic acid from olive oil reduces infection-related bone loss with age

New re…
#dining #cooking #diet #food #MediterraneanOliveOil #OliveOil ##inflammation #aging #Antibiotic #Bacterial #Bone #cardiovasculardisease #Diabetes #ImmuneResponse #Mediterranean #MediterraneanDiet #Microbiome #MouseModel #Olive #Osteoclast #osteoporosis #Periodontitis #Research #saturatedfats #stress #teeth
https://www.diningandcooking.com/2154139/oleic-acid-from-olive-oil-reduces-infection-related-bone-loss-with-age/

Oleic acid from olive oil reduces infection-related bone loss with age https://www.diningandcooking.com/2154139/oleic-acid-from-olive-oil-reduces-infection-related-bone-loss-with-age/ ##inflammation #aging #Antibiotic #Bacterial #Bone #CardiovascularDisease #Diabetes #diet #ImmuneResponse #Mediterranean #MediterraneanDiet #MediterraneanOliveOil #Microbiome #MouseModel #Olive #OliveOil #Osteoclast #osteoporosis #Periodontitis #Research #SaturatedFats #stress #teeth

New NIH grants fuel research in oral cancer treatment and pain relief

Researchers at the School of Denti…
#NewsBeep #News #Health #addiction #AU #Australia #Calcium #Cancer #CancerTreatment #carcinoma #Cell #DentalSchool #Dentistry #Drugs #Endodontics #Inflammasome #Inflammation #Ion #IonChannel #MouseModel #Mucositis #Neck #Nursing #oral #oralcancer #Pain #painmanagement #Radiotherapy #Receptor #research #SquamousCellCarcinoma #Therapeutics #Tumor #Xenograft
https://www.newsbeep.com/au/269995/

https://www.europesays.com/ie/168909/ New NIH grants fuel research in oral cancer treatment and pain relief #Addiction #Calcium #cancer #CancerTreatment #carcinoma #Cell #DentalSchool #Dentistry #Drugs #Éire #Endodontics #Health #IE #Inflammasome #inflammation #Ion #IonChannel #Ireland #MouseModel #Mucositis #Neck #Nursing #oral #OralCancer #Pain #PainManagement #radiotherapy #Receptor #Research #SquamousCellCarcinoma #Therapeutics #Tumor #Xenograft

https://www.europesays.com/ie/226528/ Dietary restriction boosts antitumour immunity by rewiring T cell metabolism #Antigen #blood #cancer #CancerImmunotherapy #Cell #CellMetabolism #Chronic #diet #Éire #Exhaustion #Glucose #Health #IE #ImmuneSystem #immunity #immunotherapy #Ireland #Metabolism #Metabolite #MouseModel #Preclinical #Proliferation #Tumor

Meet Dr Emily Warren, 1st author of new #OpenAccess paper from Dr Eric Morrow's lab at #BrownUniversity

They developed the 1st lab model of 17q12 deletion syndrome, a copy number variant disorder associated with #neurodevelopmental disorders and #RenalCysts and #diabetes syndrome. The #MouseModel recapitulated many features of the human disorder & will be used to guide #clinical & #mechanistic studies

Interview & research article:
👩🏻‍🔬https://journals.biologists.com/dmm/article/15/12/dmm050017/285934/
📰https://journals.biologists.com/dmm/article/15/12/dmm049752/285935/

DAMM, Detect Any #MouseModel 🐭, has just been released 👌 It’s a robustly validated mouse detector that excels in generalization, tracking mice in complex social and experimental settings with zero to minimal setup-specific training

🌍 http://web.eecs.umich.edu/gkaul/DAMM
🌍 GitHub: http://github.com/backprop64/DAMM
📒 Kaul et al. (2024) http://biorxiv.org/content/10.1101/2024.01.18.576153v1

#BehavioralScience #behavioralanalysis #neuroscience #machinelearning

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

https://doi.org/10.1177/0960327119877460

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

A novel orthotopic mouse model replicates human lung cancer cachexia. https://doi.org/10.1002/jcsm.13222 #CancerCachexia #LungCancer #MuscleWasting #MouseModel #OrthotopicMouseModel

New results in a mouse model "demonstrate the rapid and potent effects of [artificial light at night] on cerebrovascular networks, highlighting the importance of ALAN mitigation in the context of health and cerebrovascular disease."

https://www.cell.com/iscience/fulltext/S2589-0042(23)01073-8

#Neuroscience #Chronobiology #MouseModel #ModelOrganism #Cerebrovascular #ALAN

https://www.europesays.com/ie/226485/ Optogenetic tool helps decipher mechanisms of brain dysfunction in Huntington’s disease #Brain #BrainCell #camp #Cell #Éire #Health #Huntington'sDisease #IE #Ireland #medicine #MouseModel #NeurodegenerativeDisease #NeurodegenerativeDiseases #Neurons #Optogenetics #Protein #Research

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

https://doi.org/10.1177/0960327119877460

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

https://doi.org/10.1177/0960327119877460

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

https://doi.org/10.1177/0960327119877460

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

https://www.europesays.com/ie/351431/ Researchers show red blood cells drive better glucose tolerance at high altitude #blood #BloodSugar #Cell #CellMetabolism #Chronic #Cytometry #diabetes #Éire #Fasting #FlowCytometry #Glucose #GlucoseMetabolism #Glycemia #Health #Hemoglobin #Hypoglycemia #Hypoxia #IE #imaging #Insulin #Intracellular #Ireland #Metabolism #MouseModel #Oxygen #Phlebotomy #Protein #RedBloodCells #Research #shunt #Tomography #Type2Diabetes

Alzheimer’s research uncovers a new therapeutic pathway for the memory-robbing malady

The gut contains the largest collection of immu…
#NewsBeep #News #Health #Aging #Alzheimer'sDisease #Antibody #AU #Australia #Bacteria #Brain #Cell #Chemokine #Chemokines #diet #ImmuneSystem #Inflammation #Metabolite #Microbiome #MouseModel #multiplesclerosis #NeurodegenerativeDisease #NeurologicalDisease #Pathology #Physiology #research #Sclerosis #Therapeutics #Tremor
https://www.newsbeep.com/au/105133/

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Globally recognized figures like Muhammad Ali and Michael J. Fox have long suffered from Parkinson’s disease. The diseas…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Artificialintelligence #AI #Animalmodel #ArtificialIntelligence #Bradykinesia #Brain #Diagnostic #drugs #MouseModel #Optogenetics #Parkinson'sdisease #Preclinical #Research #Technology
https://www.newsbeep.com/us/183154/

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Globally recognized figures like Muhammad Ali and Michael J. Fox have long suffered from Parkinson’s disease. The diseas…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Artificialintelligence #AI #Animalmodel #ArtificialIntelligence #Bradykinesia #Brain #Diagnostic #drugs #MouseModel #Optogenetics #Parkinson'sdisease #Preclinical #Research #Technology
https://www.newsbeep.com/us/183154/

https://www.europesays.com/ie/285674/ A safer gene-editing tool shows promise for transthyretin amyloidosis treatment #Amyloidosis #bacteria #Biotechnology #Cas9 #CRISPR #DNA #Drugs #Efficacy #Éire #Gene #GeneEditing #Genetic #Genetics #Genome #GenomeEditing #Genomic #Heart #HeartFailure #IE #Ireland #Laboratory #LifeScience #MedicalResearch #medicine #MouseModel #Neuropathy #PalindromicRepeats #Protein #Q #Research #RibonucleicAcid #RNA #Science #Technology #Transgenic

DAMM, Detect Any #MouseModel 🐭, has just been released 👌 It’s a robustly validated mouse detector that excels in generalization, tracking mice in complex social and experimental settings with zero to minimal setup-specific training

🌍 http://web.eecs.umich.edu/gkaul/DAMM
🌍 GitHub: http://github.com/backprop64/DAMM
📒 Kaul et al. (2024) http://biorxiv.org/content/10.1101/2024.01.18.576153v1

#BehavioralScience #behavioralanalysis #neuroscience #machinelearning

DAMM, Detect Any #MouseModel 🐭, has just been released 👌 It’s a robustly validated mouse detector that excels in generalization, tracking mice in complex social and experimental settings with zero to minimal setup-specific training

🌍 http://web.eecs.umich.edu/gkaul/DAMM
🌍 GitHub: http://github.com/backprop64/DAMM
📒 Kaul et al. (2024) http://biorxiv.org/content/10.1101/2024.01.18.576153v1

#BehavioralScience #behavioralanalysis #neuroscience #machinelearning

DAMM, Detect Any #MouseModel 🐭, has just been released 👌 It’s a robustly validated mouse detector that excels in generalization, tracking mice in complex social and experimental settings with zero to minimal setup-specific training

🌍 http://web.eecs.umich.edu/gkaul/DAMM
🌍 GitHub: http://github.com/backprop64/DAMM
📒 Kaul et al. (2024) http://biorxiv.org/content/10.1101/2024.01.18.576153v1

#BehavioralScience #behavioralanalysis #neuroscience #machinelearning

DAMM, Detect Any #MouseModel 🐭, has just been released 👌 It’s a robustly validated mouse detector that excels in generalization, tracking mice in complex social and experimental settings with zero to minimal setup-specific training

🌍 http://web.eecs.umich.edu/gkaul/DAMM
🌍 GitHub: http://github.com/backprop64/DAMM
📒 Kaul et al. (2024) http://biorxiv.org/content/10.1101/2024.01.18.576153v1

#BehavioralScience #behavioralanalysis #neuroscience #machinelearning

https://www.europesays.com/ie/243524/ Blocking platelet-activating factor reduces liver damage in cirrhosis #Biomedicine #Biotechnology #Cirrhosis #Éire #Gene #Health #IE #inflammation #Ireland #Liver #medicine #MouseModel #Receptor #Research #Vascular

Blocking platelet-activating factor reduces liver damage in cirrhosis

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural…
#NewsBeep #News #Health #AU #Australia #Biomedicine #Biotechnology #Cirrhosis #Gene #Inflammation #Liver #medicine #MouseModel #Receptor #research #Vascular
https://www.newsbeep.com/au/361241/

https://www.europesays.com/ie/198283/ Autoimmune thyroiditis promotes breast cancer progression: exploratory role of thyroid hormone receptor beta signaling disruption | Breast Cancer Research #AutoimmuneThyroiditis #BreastCancer #CancerResearch #Éire #Health #IE #Ireland #MouseModel #oncology #SurgicalOncology #THRβReactiveAntibody #TumorMicroenvironment

A murine distal femoral epiphysis ischemia model reveals spatiotemporal stratification of necrotic bone marrow clearance and associated inflammatory responses | Journal of Orthopaedic Surgery and Research

Kim HK. Pathophysi…
#NewsBeep #News #Health #AU #Australia #Damage-associatedmolecularpatterns(DAMPs) #Epiphysealischemia #Macrophagepolarization #MouseModel #Myeloperoxidase #Neutrophil #Orthopedics #Revascularization #Secondarynecrosis #SurgicalOrthopedics
https://www.newsbeep.com/au/303151/

Muscle-driven gene therapy shows promise for protecting memory in Alzheimer’s

Alzheimer’s disease (AD) is a devastating cause of memor…
#NewsBeep #News #Health #Aging #Alzheimer'sDisease #AU #Australia #Blood #Brain #Cancer #Cell #cognitivefunction #Education #Exercise #Gene #genetherapy #Genetic #Hippocampus #medicine #Molecule #MouseModel #Muscle #Neuron #Pathology #pH #physicalactivity #protein #research #students #Surgery #therapy #ViralVector #virus
https://www.newsbeep.com/au/292887/

https://www.europesays.com/ie/185846/ Dysfunctional mitochondria shown to initiate the onset of Parkinson’s #Brain #CLARITY #Dopamine #Éire #IE #Ireland #Mitochondria #MouseModel #Mutation #OxidativeStress #Oxygen #Parkinson'sDisease #Protein #Research #Science #Stress

https://www.europesays.com/ie/178119/ Innovative research reveals FGD3 as a key player in breast cancer cell death #Biochemistry #BreastCancer #cancer #Cell #CellDeath #chemotherapy #Doxorubicin #Drugs #Efficacy #Éire #estrogen #Gene #Health #IE #immunotherapy #Ireland #medicine #MouseModel #NaturalKillerCells #oncology #Organoids #Preclinical #Protein #Receptor #Research #Stress #Tumor