#biomarker — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #biomarker, aggregated by home.social.
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DATE: August 11, 2026 at 02:00PM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: A surprising shift in sniffing and odor perception could be a key sign of Parkinson’s disease
A new test that measures both how people describe odors and how they physically sniff them provides a way to distinguish Parkinson’s disease from other causes of smell loss. The findings suggest that people with Parkinson’s do not just lose their sense of smell, but experience a shift in how they perceive odors. This research was published in the journal npj Parkinson’s Disease.
A reduced ability to detect and identify odors often appears years or even decades before the motor symptoms of Parkinson’s disease emerge. Because of this connection, standard smell tests are sometimes used to support a diagnosis. However, these traditional tests measure overall performance, such as whether a person can detect or name a scent.
This creates a diagnostic challenge because general smell loss is common. People often lose their sense of smell due to healthy aging, viral infections, or sinus issues, making it difficult to know if poor test results point to Parkinson’s or something else entirely. Michal Andelman-Gur, a medical doctor and researcher who conducted the study while working with Noam Sobel’s Weizmann Olfaction Research Group at the Weizmann Institute of Science, wanted to address this diagnostic gap.
“As a medical doctor, I have always been interested in neurological diseases,” Andelman-Gur said. “Before joining the lab, I worked in the Neurology Department at Tel Aviv Medical Center, where I saw firsthand the impact these diseases can have on patients and their families.”
“When I joined the lab, I became especially interested in early detection, because I truly believe that detecting a disease as early as possible is key to developing better treatments and improving patients’ lives,” Andelman-Gur added.
“Smell loss may seem like a minor, common symptom, but in some cases it can be an early warning sign of Parkinson’s disease years before motor symptoms begin,” Andelman-Gur noted. “Today, smell tests can tell us that someone’s sense of smell is impaired, but not why.”
“Our test aims to fill this gap by identifying a specific pattern of smell changes associated with Parkinson’s disease,” she explained. “We hope it could eventually help detect Parkinson’s disease earlier and lead to earlier intervention and better treatment.”
Recent studies in vision and hearing suggest that Parkinson’s disease alters how sensory information is processed, rather than just dulling the senses. For instance, individuals might see colors differently or perceive rhythms in an altered way. The authors of the new study reasoned that a similar perceptual shift might happen with smell.
Andelman-Gur and her colleagues recruited 94 participants to test this idea. The sample included 33 individuals diagnosed with Parkinson’s disease, 33 healthy control participants matched for age and sex, and 28 participants experiencing smell loss from causes unrelated to Parkinson’s. The average age across the groups ranged from about 58 to 66 years old.
First, all participants completed a standard clinical smell test that measures the ability to detect, discriminate, and identify odors on a 48-point scale. The standard test successfully identified smell loss but failed to specify the cause. Both the Parkinson’s group and the non-Parkinson’s smell loss group performed poorly compared to healthy controls.
Out of a possible 48 points, healthy controls scored a median of 30.5. The Parkinson’s group scored a median of 16.5, and the group with other types of smell loss scored a median of 12.4. When controlling for variables like age, sex, and Parkinson’s medication, the test still could not tell the two groups with smell loss apart.
Next, the researchers asked the participants to smell jars containing either a pleasant lemon scent, an unpleasant fecal scent, or no odor at all. Participants rated the intensity and pleasantness of these jars on a scale from 1 to 100. People with non-Parkinson’s smell loss rated the intensity of the pleasant odor at a median of just 16, showing a steep drop compared to healthy controls, who gave it a 78.
Interestingly, individuals with Parkinson’s rated the intensity of the pleasant odor at a 78 as well, matching the healthy controls. When it came to pleasantness, however, the Parkinson’s group matched the group with other types of smell loss. Healthy controls rated the pleasant scent at a median of 81.5 out of 100.
In contrast, both the Parkinson’s group and the other smell loss group rated it at a median of 50. This separation in ratings indicates that people with Parkinson’s do not experience a generalized dulling of the senses, but rather a specific change in how they assign pleasantness to smells.
To build a more detailed profile, the researchers asked participants to rate 10 different chemical odors across 11 descriptive categories, such as sweet, spicy, and burnt, on a 100-point scale. This process created a mathematical representation of how similar or different various smells are to each individual.
When the researchers analyzed these profiles, they found that people with Parkinson’s shared a specific pattern of odor perception. Their ratings correlated more closely with other individuals who have Parkinson’s than with healthy controls or people with different types of smell loss.
The study also measured involuntary physical reactions to smells using a miniature nasal flow sensor. “One thing I find especially exciting is that this approach uses a very simple, natural behavior how we sniff to reveal information about the brain,” Andelman-Gur told PsyPost. “I hope this can eventually help us identify disease much earlier than we can today.”
Typically, humans take longer, deeper sniffs of pleasant odors and shorter sniffs of unpleasant ones. The researchers measured sniff duration for the pleasant and unpleasant scents in normalized units of time. Healthy controls inhaled the pleasant odor for 1.12 units and the unpleasant odor for 0.98 units, demonstrating the expected behavior.
Participants with non-Parkinson’s smell loss showed a similar pattern, sniffing the pleasant odor for 1.32 units and the unpleasant one for 1.17 units.
People with Parkinson’s disease behaved differently. They inhaled the pleasant odor for 1.18 units of time and the unpleasant odor for 1.20 units. This means they did not adjust their sniffing behavior based on how pleasant the odor was, and frequently took longer sniffs of the foul-smelling scent.
“At first, I was mainly interested in characterizing sniffing patterns and the natural tendency to reduce or briefly hold your breath in response to unpleasant odors,” Andelman-Gur said. “I did not expect patients with Parkinson’s disease to take longer sniffs when smelling unpleasant odors.”
“It was completely counterintuitive,” she added. “That was the moment I realized we might be seeing something really interesting, something that could reveal meaningful information about the disease itself.”
This abnormal sniffing pattern provided another independent marker of the disease. Finally, the researchers combined the subjective odor ratings with the physical sniff measurements to create a combined statistical model. This model analyzed the data and attempted to categorize each participant based solely on their perceptual and physical responses to smell.
The combined approach identified Parkinson’s disease from healthy controls with 89 percent accuracy, correctly categorizing 83 percent of actual Parkinson’s cases and 94 percent of the healthy cases. When distinguishing Parkinson’s from other types of smell loss, the model achieved 88 percent accuracy. After researchers analyzed a smaller, tightly matched group of 16 participants per condition to completely eliminate any slight age or sex differences, the accuracy rose to 94 percent.
The current model tested people who already had a confirmed diagnosis of Parkinson’s disease. Because smell loss usually begins long before motor symptoms appear, future studies need to evaluate if this type of test can identify the disease in its earliest, pre-symptomatic stages. Evaluating this tool as a predictive screening measure will require tracking healthy individuals over many years.
“The main limitation is that our cohorts are still relatively small, so the findings will need to be replicated in larger and more diverse groups,” Andelman-Gur noted.
The researchers plan to expand this work by testing individuals who possess specific genetic traits associated with the condition. Some people carry a mutation in a gene called LRRK2, which substantially increases their chances of developing Parkinson’s.
“Our next step is to test the method in groups at higher risk of developing Parkinson’s disease, such as LRRK2 mutation carriers,” Andelman-Gur said. “Ultimately, we hope to develop it into a simple screening tool that could be used more broadly in the general population.”
The study sample also included substantially more men than women. Men generally develop Parkinson’s disease at higher rates than women, but testing this specific odor profiling method in a more balanced demographic sample would help ensure the results apply evenly across the population. Finally, the researchers suggest exploring the relationship between altered breathing patterns and brain changes, raising the question of whether unusual sniffing behavior might contribute to sensory decline over time.
The study, “The World Smells Different in Parkinson’s Disease,” was authored by Michal M. Andelman-Gur, Sagit Shushan, Kobi Snitz, Gal Pinchasof, Danielle Honigstein, Lior Gorodisky, Aharon Ravia, Adi Ezra, Neomi Hezi, Tanya Gurevich, and Noam Sobel.
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #ParkinsonsDisease #OlfactoryTest #SmellLoss #EarlyDetection #NeurologyResearch #OdorPerception #SniffingPatterns #Biomarker #LRRK2 #Neuroscience
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Sleep Spindles at One Electrode Site Flag Schizophrenia With Near-Perfect Accuracy in Small Pilot Study
Share if you found this interesting.
https://1ban.news/sleep-spindles-c3-schizophrenia-biomarker-pilot-mizuki-2026/
#1ban #sleep #spindles #schizophrenia #biomarker #neuroscience
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🔥 TRENDING
📢 Firefly Neuroscience identifiziert mittels KI einen Biomarker für PTBS - Investing.com Deutsch
#Firefly #Neuroscience #Biomarker #Ptbs #GlobalFeed #News #DE
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#Endometriose trifft jede zehnte Frau – aber die #Diagnose dauert oft Jahre. Marlene Rezk-Füreder und ihr Team vom #Startup Diamens in Linz nutzen Menstruationsblut als #Biomarker -Quelle. Bettina Dupont hat mit ihr gesprochen:
laborjournal.de/editorials/3492.php #biotech #lifescience -
#askfedi any useful biomedical angel investor resources or links floating around these parts? our focus is novel biomarkers of epilepsy & neurodegenation #investing #startup #startups #biomedical #neuromedical #medicine #biotech #biomed #neuroscience #epilepsy #neurodegeneration #biomarker
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Moderate wine intake tied to slower biological aging in men
A large Italian cohort study suggests that moderate wine intake, as defined within a traditional Mediterranean diet, may be associated with slightly slower biological aging in men, whereas total alcohol intake showed a differe…
#dining #cooking #diet #food #MediterraneanDiet #aging #alcohol #Biomarker #Mediterranean #publichealth #Wine
https://www.diningandcooking.com/2582710/moderate-wine-intake-tied-to-slower-biological-aging-in-men/ -
Moderate wine intake tied to slower biological aging in men
A large Italian cohort study suggests that moderate wine intake, as defined within a traditional Mediterranean diet, may be associated with slightly slower biological aging in men, whereas tot…
#dining #cooking #diet #food #mediterranean #MediterraneanDiet #MediterraneanFood #aging #alcohol #Biomarker #Mediterranean #publichealth #Wine
https://www.diningandcooking.com/2582710/moderate-wine-intake-tied-to-slower-biological-aging-in-men/ -
„Gehirnwäsche“ im #Schlaf – das #glymphatische System als neues #Therapie-Ziel? #parkinson #biomarker
https://nachrichten.idw-online.de/2026/03/26/gehirnwaesche-im-schlaf-das-glymphatische-system-als-neues-therapie-ziel-welt-parkinson-tag-2026 -
Schizophrenia study finds new biomarker, drug candidate to treat symptoms
#HackerNews #Schizophrenia #Biomarker #DrugResearch #MentalHealth #Neuroscience
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Study reveals coffee triggers distinct cytokine responses compared with pure caffeine
A controlled human study reveals that coffee’s complex chemical matrix may shape immune responses differently than pure caffeine,…
#NewsBeep #News #Health #AU #Australia #Biomarker #Caffeine #Coffee #Cytokine #Cytokines #Interferon #Metabolism #Nutrition #Pharmacokinetics #Physiology #publichealth #research
https://www.newsbeep.com/au/489828/ -
`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1
#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain
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Another great session of #PosterPitches at #NWOCHAINS. We learned about a huge diversity of topics including #SupramoecularAssemblies, #biomarker #sensing, #Ion-selective #membranes, radical #polymerization and #MassSpectrometry.
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😅 Don't sweat it: New device detects sweat biomarker at minimal perspiration rate
https://medicalxpress.com/news/2025-09-dont-device-biomarker-minimal-perspiration.html
#sweat #sensors #wearables #biomarker #stress #diagnostics #research
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NASA-Rover Perseverance entdeckt mögliche Hinweise auf uraltes Leben auf dem Mars
Die NASA meldet neue Funde vom Mars: Der Perseverance-Rover hat Anzeichen von möglichen Überresten urzeitlichen Lebens entdeckt. Hier
https://www.apfeltalk.de/magazin/news/nasa-rover-perseverance-entdeckt-moegliche-hinweise-auf-uraltes-leben-auf-dem-mars/
#News #Tellerrand #Biomarker #Forschung #Gesteinsproben #Leben #Mars #Mikroben #Mineralien #Nasa #OrganischesMaterial #Perseverance #Rover #Wissenschaft -
DATE: August 25, 2025 at 04:10PM
SOURCE: BioWorld MedTechDirect article link at end of text block below.
Aivis’ Qanti IHC uses AI to visualize biomarkers in cancer care
#medtech #cancer #HER2 #biomarker #deal #AI
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It's primitive... but it works... mostly...
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-------------------------------------------------#healthcare #healthtech #healthcaretech #healthtechnology #medgadget #medicine #doctor #hospital #medtech
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DATE: July 30, 2025 at 06:30PM
SOURCE: BioWorld MedTechDirect article link at end of text block below.
AI-based video #biomarker developed for #aorticstenosis
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Articles can be found by scrolling down the page at https://www.bioworld.com/topics/85-bioworld-medtech .
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NYU Information for Practice puts out 400-500 good quality health-related research posts per week but its too much for many people, so that bot is limited to just subscribers. You can read it or subscribe at @PsychResearchBot
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Since 1991 The National Psychologist has focused on keeping practicing psychologists current with news, information and items of interest. Check them out for more free articles, resources, and subscription information: https://www.nationalpsychologist.com
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It's primitive... but it works... mostly...
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-------------------------------------------------#healthcare #healthtech #healthcaretech #healthtechnology #medgadget #medicine #doctor #hospital #medtech
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DATE: July 28, 2025 at 05:00PM
SOURCE: BioWorld MedTechDirect article link at end of text block below.
COMP as a potential early #biomarker of thoracic aortic dissection
Here are any URLs found in the article text:
Articles can be found by scrolling down the page at https://www.bioworld.com/topics/85-bioworld-medtech .
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Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
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NYU Information for Practice puts out 400-500 good quality health-related research posts per week but its too much for many people, so that bot is limited to just subscribers. You can read it or subscribe at @PsychResearchBot
.
Since 1991 The National Psychologist has focused on keeping practicing psychologists current with news, information and items of interest. Check them out for more free articles, resources, and subscription information: https://www.nationalpsychologist.com
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It's primitive... but it works... mostly...
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-------------------------------------------------#healthcare #healthtech #healthcaretech #healthtechnology #medgadget #medicine #doctor #hospital #medtech
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Therapie: Hoffnung ja, Durchbruch nein:
Erste #OffLabel-Medikamente empfohlen – aber bislang keine heilende #Therapie.
Neue Studien (z. B. zur #Immunadsorption, HBOT) laufen – Ergebnisse bis 2026 erwartet.
Kinderambulanzen im Aufbau, 40 Mio. € Fördermittel vom BMG (#PEDNETLC).
Noch fehlt ein eindeutiger #Biomarker – aber: Die #Forschung rückt vor, das öffentliche Bewusstsein wächst.
Fazit: Jetzt braucht es mehr Mittel, mehr Forschung – und auch die Unterstützung der Pharmaindustrie.<
#MECFS
3/3 -
"#Brain #Age" is a neuroimaging-based #Biomarker that estimates an individual's brain health and "biological" age by analyzing structural features from MRI scans.
The difference between this predicted brain age and one's chronological age can indicate whether the brain is aging faster or slower than expected.
https://knowledgezone.co.in/posts/Age-vs-Brain-Age-6786117aa7e475eb5e304049
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Palaeontologists find #collagen #biomarker to identify ancient #Australian #megafauna, notable because it’s more durable than #DNA: https://www.sci.news/paleontology/megafauna-peptide-markers-13956.html #science #biology #palaeontology #paleontology #australia
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🧠 #Brain age proposed as a #biomarker to improve diagnosis and treatment for patients suffering from #neurodegenerative diseases using #DeepLearning & #BigData.
📃 Grant Proposal: https://doi.org/10.3897/rio.11.e156738
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Kernstück des Verfahrens ist eine #Datenbank, mit bislang 232 medizinisch besonders wichtige #Bakterien -Spezies & ihre Stoffwechselprodukte verzeichnet sind.Aus dieser werden #Biomarker hergeleitet, die zur direkten Detektion bestimmter Bakterien verwendet werden können... #med #research #diagnosis
RE: https://bsky.app/profile/did:plc:xqqgxgl6qzgwnwq2o6hpo6s6/post/3loicekmomu2n -
#AI Helps Unravel a Cause of #Alzheimers Disease and Identify a Therapeutic Candidate
"A new study found that a #gene recently recognized as a #biomarker for Alzheimer's disease is actually a cause of it," says UC San Diego, "due to its previously unknown secondary function."
"Researchers at UC San Diego used artificial intelligence to help both unravel this mystery of Alzheimer's disease and discover a potential treatment that obstructs the gene's moonlighting role."
https://today.ucsd.edu/story/ai-helps-unravel-a-cause-of-alzheimers-disease-and-identify-a-therapeutic-candidate -
Wenn ich das richtig verstanden habe, kommt dieser "Nachweis" auf "außerirdisches Leben" von Molekülen, die *auf der Erde* nur von Lebenwesen produziert werden.
Wie schließt man aus, dass es auf dem anderen Planeten nicht "geo"logische Prozesse gibt, die das auch ohne Leben hinkriegen? #aliens #science #biomarker
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Ein neuer #Bluttest könnte #Parkinson bereits erkennen, bevor erste Symptome auftreten.
Forschende analysieren dabei einfach, schnell und kostengünstig spezifische #RNA-Fragmente im Blut. Der Test zeigte eine hohe #Genauigkeit und könnte die #Früherkennung sowie gezielte Therapien deutlich verbessern.
#Neurologie #Früherkennung #Biomarker #Medizin #Diagnostik #ParkinsonForschung #Gesundheit
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Seit September 2024 werden fünf #Endometriose Forschungsverbünde vom #BMBF gefördert, um Ursachen, Diagnose und Therapie zu verbessern.
Der Forschungsverbund #StEPP-UPP erforscht die Mechanismen der #Schmerzen.
Unter der Leitung der Universität #Münster werden #Biomarker für Therapien identifiziert. Mithilfe von #KI und maschinellem Lernen sollen #Computermodelle entwickelt werden, die eine #Diagnose und individuelle Behandlung ermöglichen.