#nwochains — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #nwochains, aggregated by home.social.
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"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"
Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.
#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B
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Insightful talk by Dieuwertje Streefkerk at #NWOCHAINS. She talked about their synthetic work on stereochemically defined sulfur(VI) electrophiles and their use as #CovalentInhibitors on the example of chymotrypsin inhibition.
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202415873
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915519
#Chemistry #ChemBio #Electrophiles -
Exciting talk by Kevin Neumann at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.
https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3548
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ceur.202500273
#Chemistry #ChemBio #DrugDiscovery -
Great talk by Marta Artola at #NWOCHAINS. She talked about the use of modified sugars as inhibitors and molecular #chaperones in #DrugDiscovery. Exciting insights into the use of cyclic sulfamates and sulfamidates as reactive groups for #CovalentInhibitors.
https://pubs.acs.org/doi/10.1021/acscentsci.7b00214
#Chemistry #ChemBio -
The poster pitches at #NWOCHAINS were an absolute firework of great science. We learned about #antivirals, #organocatalysis, #MolecularMotors, #EnzymeEngineering, #photocontrol, #odor detection, sensing of #bacteria, #recycling, #batteries, #QuantumDots, #vitrimers, #BoneRegeneration, native #MassSpectrometry and #biomaterials. Always one of my highlights of the conference.