#nwochains — Public Fediverse posts

#NWOCHAINS comes to an end with the closing ceremony led by Ioana Ilie.

I had two days of exciting science and learned a lot. Thank you to everyone, who was involved in organizing and who contributed to the program. Congratulations to all winners of the poster prizes!

#Chemistry #ChemBio #Networking

Interesting talk by Florian Ort from the group of Floris Rutjes at #NWOCHAINS. He talked about the use of #mechanochemistry for solvent-free, racemization-free #peptide #ligation. Exciting applications for #NativeChemicalLigation of insoluble peptides.

#Chemistry #ChemBio #GreenChemistry

Very happy that Marnix Roseboom represented our group of the @LED3hub with a very well-attended talk at #NWOCHAINS. He reported on his #PhD work on developing #ChemoProteomics technologies to study #CovalentInhibitor target engagement at arginines.

#Chemistry #ChemBio #ProudPI

Interesting talk by Foteini Skoulikopoulou of the group of Zach Armstrong of the @LED3hub at #NWOCHAINS. She talked about her research into the synthesis of stable 9-O-acetylated sialic acid mimics with potential applications as #antivirals.

#glycotime #Chemistry #ChemBio

Interesting talk by Friedrich Förster at #NWOCHAINS. He talked about his group's exciting research into visualizing protein biogenesis at the ER membrane using cryo-electron microscopy and cryo-electron tomography.

https://www.nature.com/articles/s41586-022-05638-5
#cryoEM #proteins #structure

Another great session of #PosterPitches at #NWOCHAINS. We learned about a huge diversity of topics including #SupramoecularAssemblies, #biomarker #sensing, #Ion-selective #membranes, radical #polymerization and #MassSpectrometry.

Sean McKenna represented the group of Sebastian Pomplun and the @LED3hub with an exciting talk at #NWOCHAINS. He talked about using a combination of in silico screening and semi-automated synthesis to accelerate #DrugDiscovery.
#Chemistry #ChemBio

Excited that Yorick van Aalst represented the group of Anthe Janssen and our group of the @LED3hub with a talk at #NWOCHAINS. He talked about mining #AlphaFold structures of the entire proteome for pockets and using this information to prioritize hits from #Chemoproteomic screens.
#Chemistry #ChemBio #ProudPI

Exciting talk by Charalampos Ntallis from the group of Markus Weingarth at #NWOCHAINS. He talked about his exciting research into using solid-state #NMR to understand the interaction between the last resort #antibiotic #polymyxin and #LPS on the molecular level.

Insightful talk by Bob van Puffelen from the groups of Jeroen Codee and Dima Filippov of the @LED3hub at #NWOCHAINS. He talked about a glycan modification of the bacterial flagellum and how they use synthetic tools to study its biosynthesis.
#Chemistry #ChemBio #bacteria

Great talk by Cristina Lopez Gallego from the group of Marcellus Ubbink of our @LED3hub at #NWOCHAINS. She talked about the study of second sphere residues and their effect on the structure, dynamics and function of beta-lactamases.

#Biochemistry #Evolution

"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

Insightful talk by Anthe Janssen at #NWOCHAINS. He talked about his research with Dompé Farmaceutica in the framework of #ChemistryNL on using #docking and #MachineLearning-assisted re-scoring to better predict compound binding affinity to #kinases.
https://pubs.acs.org/doi/10.1021/acs.jcim.4c01260
#Chemistry #ChemBio #DrugDiscovery
CC: @LED3hub

Amazing talk by Sander Woutersen at #NWOCHAINS. He gave an entertaining talk on his Ig Nobel Prize winning research on using (drunk) worms as a model for active polymers to better understand their exciting properties.
https://iop.uva.nl/content/news/2024/09/ig-nobel-prize-for-drunk-worms.html
https://www.science.org/doi/10.1126/sciadv.abj7918
#Chemistry #Polymers

Great talk by Bianca van Tol at #NWOCHAINS. She talked about the development of neutron-encoded ubiquitins and diubiquitins to study the linkage selectivity of E2 enzymes, E3 ligases and deubiquitinating enzymes.

https://www.nature.com/articles/s41467-023-37363-6
#Chemistry #ChemBio #Ubiquitin

Great talk by Floor Stevens from the group of Mario van der Stelt of our @LED3hub at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime

Insightful talk by Dieuwertje Streefkerk at #NWOCHAINS. She talked about their synthetic work on stereochemically defined sulfur(VI) electrophiles and their use as #CovalentInhibitors on the example of chymotrypsin inhibition.

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202415873
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915519
#Chemistry #ChemBio #Electrophiles

Exciting talk by Kevin Neumann at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.

https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3548
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ceur.202500273
#Chemistry #ChemBio #DrugDiscovery

Great talk by Marta Artola at #NWOCHAINS. She talked about the use of modified sugars as inhibitors and molecular #chaperones in #DrugDiscovery. Exciting insights into the use of cyclic sulfamates and sulfamidates as reactive groups for #CovalentInhibitors.
https://pubs.acs.org/doi/10.1021/acscentsci.7b00214
#Chemistry #ChemBio

"Novel Covalent Inhibitors and Where to Find Them"

I was very excited that together with Madeline Kavanagh, Marc Baggelaar and Rita Petracca we were awarded a focus session at #NWOCHAINS under this topic. We had an amazing program with talks by Marta Artola, Kevin Neumann and Dieuwertje Streefkerk as well as a panel discussion on the topic. (1/2)

The poster pitches at #NWOCHAINS were an absolute firework of great science. We learned about #antivirals, #organocatalysis, #MolecularMotors, #EnzymeEngineering, #photocontrol, #odor detection, sensing of #bacteria, #recycling, #batteries, #QuantumDots, #vitrimers, #BoneRegeneration, native #MassSpectrometry and #biomaterials. Always one of my highlights of the conference.

#Chemistry #ChemBio #ECR #PosterPitch

Interesting talk by Tobias Erb at #NWOCHAINS. He talked about his group's research into building complex, artificial enzyme networks that can fix CO2 and produce high value molecules driven e.g. by light or electricity as energy source.
https://www.science.org/doi/10.1126/science.aah5237
https://www.cell.com/joule/fulltext/S2542-4351(23)00310-0
#Chemistry #ChemBio #Energy

The scientific program of #NWOCHAINS starts with the opening words by Sandra de Keijzer, head of NWO Chemistry and Physics, and Ioana Ilie, chair of the programme committee of CHAINS.

#Chemistry #ChemBio #Conferencing

Two days of connecting the Dutch Academic Community are coming up at #NWOCHAINS. Yesterday, we already had the New PI meeting and the PI meeting with a lot of great content. (1/8) #ECR #PI #Chemistry #ChemBio #Connections #NewPI

Two days of connecting the Dutch Academic Community are coming up at #NWOCHAINS.

Yesterday, we already had the New PI meeting and the PI meeting with a lot of great content. (1/8)

#ECR #PI #Chemistry #ChemBio #Connections #NewPI