#postcovid — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #postcovid, aggregated by home.social.
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Understanding neuroinflammation in post-COVID-19 syndrome: biological mechanisms, diagnostic biomarkers, and therapeutic prospects
https://www.nature.com/articles/s41398-026-04286-x
Screenshot from Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome @longcovid
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Understanding neuroinflammation in post-COVID-19 syndrome: biological mechanisms, diagnostic biomarkers, and therapeutic prospects
https://www.nature.com/articles/s41398-026-04286-x
Screenshot from Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome @longcovid
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#Losartan and #prednisolone for #postCOVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial, https://etidiohnew.blogspot.com/2026/07/losartan-and-prednisolone-for-postcovid.html
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#Losartan and #prednisolone for #postCOVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial, https://etidiohnew.blogspot.com/2026/07/losartan-and-prednisolone-for-postcovid.html
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From the US 🇺🇸
Small extracellular vesicles proteome reveals persistent inflammatory and coagulopathic dysregulation in long-COVID
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1805159/full
Screenshot from Science for ME weekly update
#LongCovid #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome #Covidlonghaulers @longcovid
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From the US 🇺🇸
Small extracellular vesicles proteome reveals persistent inflammatory and coagulopathic dysregulation in long-COVID
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1805159/full
Screenshot from Science for ME weekly update
#LongCovid #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome #Covidlonghaulers @longcovid
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2/
Alternative link that is only in English for the press release: "New research: muscle problems in post-COVID and ME/CFS cannot be explained by prolonged inactivity"
https://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind2607E&L=CO-CURE&P=R2
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2/
Alternative link that is only in English for the press release: "New research: muscle problems in post-COVID and ME/CFS cannot be explained by prolonged inactivity"
https://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind2607E&L=CO-CURE&P=R2
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Sehr hörenswerte und gut recherchierte Sendung vom #Deutschlandfunk über den Forschungsstand und die Versorgung bei #MECFS und #LongCOVID:
"Wann heilen wir #MECFS"
Teil 1:
https://www.deutschlandfunk.de/me-cfs-heilen-1-2-therapie-und-irrtum-100.htmlTeil 2:
https://www.deutschlandfunk.de/me-cfs-heilen-2-2-forschung-nimmt-fahrt-auf-100.html -
From Denmark
Persistent neuromuscular dysfunction in long COVID: A quantitative and single fiber EMG follow-up study
https://www.sciencedirect.com/science/article/pii/S0987705326000511
Screenshot from Science for ME weekly update
#LongCovid #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers
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From Denmark
Persistent neuromuscular dysfunction in long COVID: A quantitative and single fiber EMG follow-up study
https://www.sciencedirect.com/science/article/pii/S0987705326000511
Screenshot from Science for ME weekly update
#LongCovid #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers
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(Victoria, Australia)
Long Covid study that is recruitingScreenshot from latest Emerge Australia email bulletin
#LongCovid #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome #auscovid19 @longcovid
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(Victoria, Australia)
Long Covid study that is recruitingScreenshot from latest Emerge Australia email bulletin
#LongCovid #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome #auscovid19 @longcovid
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DATE: July 28, 2026 at 04:00PM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: Overactive immune cells might drive nerve pain in long COVID
URL: https://www.psypost.org/how-overactive-immune-cells-might-drive-nerve-pain-in-long-covid/
Millions of people who recover from the initial stages of COVID-19 continue to suffer from lingering nerve pain, fatigue, and cognitive issues. A new academic review proposes that a specific type of overactive immune cell might be responsible for driving this persistent nerve damage. These findings were published in the Journal of Neuropathology & Experimental Neurology.
Long COVID, officially termed post-acute sequelae of SARS-CoV-2 infection, remains a widespread public health issue. Global estimates suggest the condition affects over 60 million individuals. One meta-analysis reviewing a massive sample of over two million confirmed COVID-19 cases estimated a global prevalence of nearly 36 percent. A different review of a massive sample of over 480,000 individuals found that over half of survivors experienced at least one lingering symptom for more than a year.
Despite these high numbers, the underlying biology of Long COVID is not fully understood. Patients report a wide array of symptoms across multiple organ systems. These frequently include extreme fatigue, brain fog, and shortness of breath.
A prominent feature of Long COVID is neuropathy, a general term for damage or dysfunction of the peripheral nervous system. Peripheral nerves connect the brain and spinal cord to the rest of the body. Data from several observational studies indicates that up to 59 percent of Long COVID patients show signs of small-fiber neuropathy.
Small-fiber neuropathy specifically affects the tiny, unmyelinated nerve endings in the skin and organs. These fibers transmit pain and temperature sensations. When damaged, they often cause burning pain, numbness, and tingling in the extremities.
Conventional nerve conduction studies often fail to detect this specific type of damage. Standard medical tests primarily assess large, myelinated nerve fibers responsible for major muscle movements and gross sensation. Because standard diagnostic tools easily miss damage to small nerve fibers, the prevalence of Long COVID neuropathy likely went underreported in the early stages of the pandemic.
These small nerves also help control the autonomic nervous system, which manages involuntary body functions like heart rate and digestion. Autonomic dysfunction is frequently observed in Long COVID patients. Many develop postural orthostatic tachycardia syndrome, a condition where the heart races uncontrollably upon standing.
Zachary L. Morcos and Theoharis C. Theoharides, researchers affiliated with Nova Southeastern University and Tufts University, sought to explore potential cellular mechanisms connecting these varied symptoms. They noticed that many Long COVID complaints closely mirror an immune condition called mast cell activation syndrome. This prompted them to investigate whether mast cells might serve as the biological bridge between a past viral infection and ongoing nerve pain.
Mast cells are specialized immune cells that act as sentinels throughout the body. They are heavily concentrated in tissues that interface with the external environment, such as the skin, lungs, and gut. They also cluster heavily around blood vessels and nerve fibers.
Normally, mast cells help defend against pathogens and play a central role in allergic reactions. When triggered by a virus, an allergen, or physiological stress, they undergo a process called degranulation. During degranulation, the cells split open and dump an arsenal of chemical mediators into the surrounding tissue.
These inflammatory chemicals include histamine, tryptase, and various signaling proteins. While these mediators help orchestrate a defense against immediate threats, chronic release can damage surrounding tissues. Because mast cells are positioned directly next to nerve fibers, their chemical output can easily irritate pain receptors.
Mast cells are well known for their role in asthma and skin hives. However, researchers are increasingly recognizing their ability to modulate both neurovascular and neuroimmune responses. Because they sit at the biological crossroads of the blood supply and the nervous system, any prolonged mast cell hyperactivity can easily disrupt both systems simultaneously.
To evaluate this hypothesis, the researchers conducted a narrative literature review. They gathered and synthesized data from cell cultures, animal models, clinical case reports, and human observational studies. The goal was to build a comprehensive picture of how mast cells interact with the pandemic virus and the human nervous system.
The collected research suggests that the spike protein of the SARS-CoV-2 virus directly binds to specific receptors on the surface of mast cells. These docking points include the angiotensin-converting enzyme 2 and toll-like receptor 4 proteins. This cellular interaction triggers the mast cells to release their inflammatory payload without requiring a traditional allergic trigger. Once released, these harsh chemicals bathe nearby nerve endings, making them overly sensitive to pain.
The prolonged presence of these mediators initiates a localized chain reaction of inflammation. The chemicals degrade the structural integrity of small nerve fibers, leading to the numbness and burning characteristic of neuropathy. In the autonomic nervous system, this localized damage disrupts the normal transmission of signals required to regulate blood pressure and heart rate.
The researchers note that the collateral damage is not limited to peripheral limbs. Inflammatory mediators released by mast cells can travel through the bloodstream and compromise the blood-brain barrier. This barrier is a highly selective membrane designed to keep circulating toxins out of the central nervous system.
When the blood-brain barrier weakens, general immune cells and inflammatory molecules can slip into the brain. Once inside, they may aggravate microglia, the brain’s resident immune cell population. This localized brain inflammation is suspected to be a primary driver of the cognitive dysfunction and extreme fatigue often reported by patients.
Past clinical observations provide associative evidence that mast cells contribute to Long COVID. The review highlights a small study of 21 patients with severe COVID-19 where resting immune markers were abnormally elevated. Autopsy data from deceased patients has also revealed heavy accumulations of mast cells in the lungs and near blocked blood vessels.
In addition to causing direct nerve damage, overactive mast cells might intersect with other theorized Long COVID mechanisms. The chemicals they release can disrupt normal blood clotting, potentially contributing to the microscopic blood clots found in some patients. Their constant signaling might also skew the broader immune system, inducing the autoimmune responses seen long after the virus clears.
If hyperactive mast cells are causing neurological symptoms, targeting them directly might offer symptom relief. The review evaluated several potential therapeutic strategies reported in recent clinical literature. Standard antihistamines, which block the cellular receptors for one of the main chemicals released by mast cells, have provided mixed outcomes.
Some case reports describe patients achieving remission from autonomic nervous system issues after starting antihistamine therapy. However, human mast cells can release up to 390 different inflammatory mediators depending on the trigger. Blocking histamine alone might not be sufficient to completely halt the widespread nerve damage.
The researchers point to other chemical interventions, such as naturally occurring plant compounds called flavonoids. Specifically, natural molecules like luteolin and quercetin appear to stabilize the outer membrane of mast cells. Laboratory studies suggest these compounds prevent the cells from releasing their contents in the first place, rather than just blocking single mediators after they are loose in the tissue.
Another proposed treatment is alpha-lipoic acid, a natural antioxidant involved in cellular energy production. Previous research indicates this compound helps neutralize oxidative stress in biological tissues. It has also shown promise in promoting nerve regeneration and suppressing pain signals traveling along damaged nerve fibers.
While the biological mechanism appears plausible, the researchers outline several caveats to their conclusions. Narrative reviews synthesize existing evidence but do not act as standalone experiments to confirm a hypothesis. Much of the underlying data comes from isolated test tube studies, animal models, and individual patient case reports.
Additionally, blood tests designed to measure mast cell activation are not consistently elevated in all Long COVID patients. Because the results of these tests were not statistically significant across all cohorts, the authors suggest this might be because mast cell activity fluctuates. The inflammation might also be localized inside specific organ tissues rather than circulating through the whole body in high concentrations.
The wide variation in patient responses to immune-modulating treatments indicates that Long COVID is likely an umbrella term for several distinct biological problems. Mast cell dysfunction might be a primary driver for some individuals, while persistent viral fragments or blood clotting issues might dominate in others. These distinct but overlapping biological pathways make diagnosing and treating the condition exceptionally difficult.
The exact sequence of events leading from an initial respiratory infection to chronic nerve pain remains partially theoretical. Addressing this knowledge gap will require prospective clinical trials specifically designed to track mast cell activity over time. Until then, understanding this specific immune response offers a rational foundation for developing targeted therapies to help those suffering from chronic post-viral illness.
The study, “Long COVID neuropathy: The role of mast cells,” was authored by Zachary L. Morcos and Theoharis C. Theoharides.
URL: https://www.psypost.org/how-overactive-immune-cells-might-drive-nerve-pain-in-long-covid/
-------------------------------------------------
Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #LongCOVID #MastCells #Neuropathy #SmallFiberNeuropathy #Neuroinflammation #AutonomicDysfunction #BrainFog #PostCovid #InflammationMedicine #PainManagement
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DATE: July 28, 2026 at 04:00PM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: Overactive immune cells might drive nerve pain in long COVID
URL: https://www.psypost.org/how-overactive-immune-cells-might-drive-nerve-pain-in-long-covid/
Millions of people who recover from the initial stages of COVID-19 continue to suffer from lingering nerve pain, fatigue, and cognitive issues. A new academic review proposes that a specific type of overactive immune cell might be responsible for driving this persistent nerve damage. These findings were published in the Journal of Neuropathology & Experimental Neurology.
Long COVID, officially termed post-acute sequelae of SARS-CoV-2 infection, remains a widespread public health issue. Global estimates suggest the condition affects over 60 million individuals. One meta-analysis reviewing a massive sample of over two million confirmed COVID-19 cases estimated a global prevalence of nearly 36 percent. A different review of a massive sample of over 480,000 individuals found that over half of survivors experienced at least one lingering symptom for more than a year.
Despite these high numbers, the underlying biology of Long COVID is not fully understood. Patients report a wide array of symptoms across multiple organ systems. These frequently include extreme fatigue, brain fog, and shortness of breath.
A prominent feature of Long COVID is neuropathy, a general term for damage or dysfunction of the peripheral nervous system. Peripheral nerves connect the brain and spinal cord to the rest of the body. Data from several observational studies indicates that up to 59 percent of Long COVID patients show signs of small-fiber neuropathy.
Small-fiber neuropathy specifically affects the tiny, unmyelinated nerve endings in the skin and organs. These fibers transmit pain and temperature sensations. When damaged, they often cause burning pain, numbness, and tingling in the extremities.
Conventional nerve conduction studies often fail to detect this specific type of damage. Standard medical tests primarily assess large, myelinated nerve fibers responsible for major muscle movements and gross sensation. Because standard diagnostic tools easily miss damage to small nerve fibers, the prevalence of Long COVID neuropathy likely went underreported in the early stages of the pandemic.
These small nerves also help control the autonomic nervous system, which manages involuntary body functions like heart rate and digestion. Autonomic dysfunction is frequently observed in Long COVID patients. Many develop postural orthostatic tachycardia syndrome, a condition where the heart races uncontrollably upon standing.
Zachary L. Morcos and Theoharis C. Theoharides, researchers affiliated with Nova Southeastern University and Tufts University, sought to explore potential cellular mechanisms connecting these varied symptoms. They noticed that many Long COVID complaints closely mirror an immune condition called mast cell activation syndrome. This prompted them to investigate whether mast cells might serve as the biological bridge between a past viral infection and ongoing nerve pain.
Mast cells are specialized immune cells that act as sentinels throughout the body. They are heavily concentrated in tissues that interface with the external environment, such as the skin, lungs, and gut. They also cluster heavily around blood vessels and nerve fibers.
Normally, mast cells help defend against pathogens and play a central role in allergic reactions. When triggered by a virus, an allergen, or physiological stress, they undergo a process called degranulation. During degranulation, the cells split open and dump an arsenal of chemical mediators into the surrounding tissue.
These inflammatory chemicals include histamine, tryptase, and various signaling proteins. While these mediators help orchestrate a defense against immediate threats, chronic release can damage surrounding tissues. Because mast cells are positioned directly next to nerve fibers, their chemical output can easily irritate pain receptors.
Mast cells are well known for their role in asthma and skin hives. However, researchers are increasingly recognizing their ability to modulate both neurovascular and neuroimmune responses. Because they sit at the biological crossroads of the blood supply and the nervous system, any prolonged mast cell hyperactivity can easily disrupt both systems simultaneously.
To evaluate this hypothesis, the researchers conducted a narrative literature review. They gathered and synthesized data from cell cultures, animal models, clinical case reports, and human observational studies. The goal was to build a comprehensive picture of how mast cells interact with the pandemic virus and the human nervous system.
The collected research suggests that the spike protein of the SARS-CoV-2 virus directly binds to specific receptors on the surface of mast cells. These docking points include the angiotensin-converting enzyme 2 and toll-like receptor 4 proteins. This cellular interaction triggers the mast cells to release their inflammatory payload without requiring a traditional allergic trigger. Once released, these harsh chemicals bathe nearby nerve endings, making them overly sensitive to pain.
The prolonged presence of these mediators initiates a localized chain reaction of inflammation. The chemicals degrade the structural integrity of small nerve fibers, leading to the numbness and burning characteristic of neuropathy. In the autonomic nervous system, this localized damage disrupts the normal transmission of signals required to regulate blood pressure and heart rate.
The researchers note that the collateral damage is not limited to peripheral limbs. Inflammatory mediators released by mast cells can travel through the bloodstream and compromise the blood-brain barrier. This barrier is a highly selective membrane designed to keep circulating toxins out of the central nervous system.
When the blood-brain barrier weakens, general immune cells and inflammatory molecules can slip into the brain. Once inside, they may aggravate microglia, the brain’s resident immune cell population. This localized brain inflammation is suspected to be a primary driver of the cognitive dysfunction and extreme fatigue often reported by patients.
Past clinical observations provide associative evidence that mast cells contribute to Long COVID. The review highlights a small study of 21 patients with severe COVID-19 where resting immune markers were abnormally elevated. Autopsy data from deceased patients has also revealed heavy accumulations of mast cells in the lungs and near blocked blood vessels.
In addition to causing direct nerve damage, overactive mast cells might intersect with other theorized Long COVID mechanisms. The chemicals they release can disrupt normal blood clotting, potentially contributing to the microscopic blood clots found in some patients. Their constant signaling might also skew the broader immune system, inducing the autoimmune responses seen long after the virus clears.
If hyperactive mast cells are causing neurological symptoms, targeting them directly might offer symptom relief. The review evaluated several potential therapeutic strategies reported in recent clinical literature. Standard antihistamines, which block the cellular receptors for one of the main chemicals released by mast cells, have provided mixed outcomes.
Some case reports describe patients achieving remission from autonomic nervous system issues after starting antihistamine therapy. However, human mast cells can release up to 390 different inflammatory mediators depending on the trigger. Blocking histamine alone might not be sufficient to completely halt the widespread nerve damage.
The researchers point to other chemical interventions, such as naturally occurring plant compounds called flavonoids. Specifically, natural molecules like luteolin and quercetin appear to stabilize the outer membrane of mast cells. Laboratory studies suggest these compounds prevent the cells from releasing their contents in the first place, rather than just blocking single mediators after they are loose in the tissue.
Another proposed treatment is alpha-lipoic acid, a natural antioxidant involved in cellular energy production. Previous research indicates this compound helps neutralize oxidative stress in biological tissues. It has also shown promise in promoting nerve regeneration and suppressing pain signals traveling along damaged nerve fibers.
While the biological mechanism appears plausible, the researchers outline several caveats to their conclusions. Narrative reviews synthesize existing evidence but do not act as standalone experiments to confirm a hypothesis. Much of the underlying data comes from isolated test tube studies, animal models, and individual patient case reports.
Additionally, blood tests designed to measure mast cell activation are not consistently elevated in all Long COVID patients. Because the results of these tests were not statistically significant across all cohorts, the authors suggest this might be because mast cell activity fluctuates. The inflammation might also be localized inside specific organ tissues rather than circulating through the whole body in high concentrations.
The wide variation in patient responses to immune-modulating treatments indicates that Long COVID is likely an umbrella term for several distinct biological problems. Mast cell dysfunction might be a primary driver for some individuals, while persistent viral fragments or blood clotting issues might dominate in others. These distinct but overlapping biological pathways make diagnosing and treating the condition exceptionally difficult.
The exact sequence of events leading from an initial respiratory infection to chronic nerve pain remains partially theoretical. Addressing this knowledge gap will require prospective clinical trials specifically designed to track mast cell activity over time. Until then, understanding this specific immune response offers a rational foundation for developing targeted therapies to help those suffering from chronic post-viral illness.
The study, “Long COVID neuropathy: The role of mast cells,” was authored by Zachary L. Morcos and Theoharis C. Theoharides.
URL: https://www.psypost.org/how-overactive-immune-cells-might-drive-nerve-pain-in-long-covid/
-------------------------------------------------
Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot
-------------------------------------------------
#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #LongCOVID #MastCells #Neuropathy #SmallFiberNeuropathy #Neuroinflammation #AutonomicDysfunction #BrainFog #PostCovid #InflammationMedicine #PainManagement
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Thema #ME #PostCovid
Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest | Nature Communications
https://www.nature.com/articles/s41467-026-75725-y -
Hello Fedi! My employer went through my #PostCovid time with me. Now that I'm back to work full time, they suddenly decided to let me go. 🤷♀️ I'm a #pentester with 5 years of experience in the field, before that 3 years of software dev in the #infosec field as well. Got a Bsc. in Computer Sience with emphasis on infosec and networke systems. In my #homelab I'm selfhosting on #proxmox and #k8s. I've been daily driving #linux for the past 20 years, first #gentoo, then #fedora. I'm pretty good with it, but no certs. I'm looking to continue in #offensivesecurity, but would be happy to pivot into infra/network or any other adventure given it's interessting or a good cause. Happy to invest in my skillset. Hybrid in north-eastern #Switzerland fully remote anywhere else.
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Hello Fedi! My employer went through my #PostCovid time with me. Now that I'm back to work full time, they suddenly decided to let me go. 🤷♀️ I'm a #pentester with 5 years of experience in the field, before that 3 years of software dev in the #infosec field as well. Got a Bsc. in Computer Sience with emphasis on infosec and networke systems. In my #homelab I'm selfhosting on #proxmox and #k8s. I've been daily driving #linux for the past 20 years, first #gentoo, then #fedora. I'm pretty good with it, but no certs. I'm looking to continue in #offensivesecurity, but would be happy to pivot into infra/network or any other adventure given it's interessting or a good cause. Happy to invest in my skillset. Hybrid in north-eastern #Switzerland fully remote anywhere else.
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Agreement & reliability between the 2-day 6-minute incremental step test & 2-day cardiopulmonary exercise test in post COVID-19 condition for assessing post-exertional malaise:The REVEAL-study
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0353132
Screenshot from Science for ME update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
Agreement & reliability between the 2-day 6-minute incremental step test & 2-day cardiopulmonary exercise test in post COVID-19 condition for assessing post-exertional malaise:The REVEAL-study
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0353132
Screenshot from Science for ME update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
From Brazil 🇧🇷
CD4+ T cell signature in long COVID: insights from an unvaccinated cohort
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1823850/full
Screenshot from Science for ME weekly update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
From Brazil 🇧🇷
CD4+ T cell signature in long COVID: insights from an unvaccinated cohort
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1823850/full
Screenshot from Science for ME weekly update
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
From the US
Recent SARS-CoV-2 infections and increased antibody responses to viral antigens are associated with greater autoantibody reactivity
https://www.sciencedirect.com/science/article/abs/pii/S0165247826000854
Screenshot from latest Science for ME weekly update
#LongCovid #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers @longcovid
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From the US
Recent SARS-CoV-2 infections and increased antibody responses to viral antigens are associated with greater autoantibody reactivity
https://www.sciencedirect.com/science/article/abs/pii/S0165247826000854
Screenshot from latest Science for ME weekly update
#LongCovid #postcovid #PASC #PwLC #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers @longcovid
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Longitudinal assessment of SARS-CoV-2 Spike and Nucleocapsid antigenemia in the ORCHESTRA Post-COVID cohort
https://www.clinicalmicrobiologyandinfection.org/article/S1198-743X(26)00379-4/abstract
Screenshot from latest Science for ME weekly update
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome @longcovid
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Longitudinal assessment of SARS-CoV-2 Spike and Nucleocapsid antigenemia in the ORCHESTRA Post-COVID cohort
https://www.clinicalmicrobiologyandinfection.org/article/S1198-743X(26)00379-4/abstract
Screenshot from latest Science for ME weekly update
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome @longcovid
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Fatigue after COVID-19 infection is associated with peripheral immunometabolic alterations affecting neuroimmune responses in the hippocampus
https://www.nature.com/articles/s41398-026-04250-9
Screenshot from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC #PASC #PwLC #postcovid #postcovid19 @longcovid
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Fatigue after COVID-19 infection is associated with peripheral immunometabolic alterations affecting neuroimmune responses in the hippocampus
https://www.nature.com/articles/s41398-026-04250-9
Screenshot from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC #PASC #PwLC #postcovid #postcovid19 @longcovid
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From the US
Signatures Across Multiple Sclerosis, Neuromyelitis Optica, and Neurological Post-Acute Sequelae of COVID-19
https://www.mdpi.com/2077-0383/15/13/4968
Screenshot from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome @longcovid
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From the US
Signatures Across Multiple Sclerosis, Neuromyelitis Optica, and Neurological Post-Acute Sequelae of COVID-19
https://www.mdpi.com/2077-0383/15/13/4968
Screenshot from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome @longcovid
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@herrstoeckchen Nur zu gut, leider - my daily business - leider ... :(
#mecfs #PostCovid -
Eindelijk een keer wat positiever nieuws.
"Geld over, dus blijven expertisecentra voor postcovid jaar langer open"
https://nos.nl/artikel/2623420-geld-over-dus-blijven-expertisecentra-voor-postcovid-jaar-langer-open
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'‘Geweldig nieuws’ voor postcovidpatiënten: expertisecentra blijven toch jaar langer open'
"Sluiting van de centra dreigde, maar het kabinet heeft toch nog geld gevonden om ze in ieder geval een jaar langer open te houden."
"Hoewel Hermans schrijft dat het ‘voortbestaan van de centra’ voor 2027 ‘geborgd’ is, is er volgens een woordvoerder van de minister geen garantie dat alle zes centra volgend jaar open zullen blijven."
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'‘Geweldig nieuws’ voor postcovidpatiënten: expertisecentra blijven toch jaar langer open'
"Sluiting van de centra dreigde, maar het kabinet heeft toch nog geld gevonden om ze in ieder geval een jaar langer open te houden."
"Hoewel Hermans schrijft dat het ‘voortbestaan van de centra’ voor 2027 ‘geborgd’ is, is er volgens een woordvoerder van de minister geen garantie dat alle zes centra volgend jaar open zullen blijven."
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Lees tip -> Kabinet werkt aan duurzame zorg voor post-COVID en PAIS-patiënten | Stichting Q- en C-support stopt eind volgend jaar, waarna de opgebouwde kennis overgaat naar het reguliere zorgdomein. | #PAIS #Qsupport #zorg #Gezondheidsraad #ministerievanVWS #postCOVID |
https://hbpmedia.nl/kabinet-werkt-aan-duurzame-zorg-voor-post-covid-en-pais-patienten/
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RE: https://mastodon.social/@Frieke72/116925323522344106
"Geld is niet de kern van het probleem. Of in elk geval: dat zou het niet moeten zijn. Een Duitse risico-analysefirma becijferde in opdracht van de Duitse ME/CVS-vereniging dat long covid en ME/CVS in 2024 Duitsland 63 miljard kostte – omgerekend zeventien miljard euro voor Nederland. Die kosten maakt de samenleving al, door onder meer verloren arbeidsjaren, uitkeringen en extra zorgkosten."
17 miljard. Even los van het persoonlijke leed van Post-Covid, 17 miljard... 🤐
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RE: https://mastodon.social/@Frieke72/116925323522344106
"Geld is niet de kern van het probleem. Of in elk geval: dat zou het niet moeten zijn. Een Duitse risico-analysefirma becijferde in opdracht van de Duitse ME/CVS-vereniging dat long covid en ME/CVS in 2024 Duitsland 63 miljard kostte – omgerekend zeventien miljard euro voor Nederland. Die kosten maakt de samenleving al, door onder meer verloren arbeidsjaren, uitkeringen en extra zorgkosten."
17 miljard. Even los van het persoonlijke leed van Post-Covid, 17 miljard... 🤐
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Selbststudie: Ich habe bisher 4 "Wirkmenchanismen" ausgemacht, wie mein #PAIS Schmerzen verursacht.
1. Systemschwäche
Immunsystem, Kreislauf, etc. - alle Systeme sind geschwächt und kleine Wewehchen werden zu schweren chronischen Schmerzen. So ähnlich muss sich alt sein anfühlen.2. Fehlende Fitness
Die ständige Erschöpfung schränkt die Aktivität ein und dadurch wird jede kleine Belastung zu einer außergewöhnlichen Belastung. Ein paar Stunden am Tag aufrecht Stehen oder Gehen führt zu Nackenverspannungen und Kopfschmerzen, dazwischen auf der Couch Knozen und Gamen führt zu Tennisarm und das viele Liegen setzt den restlichen Gelenken zu.3. Tollpatschertheit
Brainfog macht mich ungeschickt. Das führt nicht nur dazu, dass ich literweise Wasser verschütte und verschlucke, statt es zu trinken, sondern auch dazu, dass ich mir alles, was ich mir anhauen kann, anhaue. Heute hab ich mir eine Türklinke in die Hüfte gerammt beim Versuch vorbeizugehen.4. Heilungsverzögerung
Egal ob blaue Flecken, Hauteinrisse oder sonstwas - so viel wie sich da anhäuft kann ich mir das nicht nur durchs Ungeschicktsein erklären. Ich glaube es braucht auch alles länger abzuheilen.5. - x. hab ich vergessen.
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Selbststudie: Ich habe bisher 4 "Wirkmenchanismen" ausgemacht, wie mein #PAIS Schmerzen verursacht.
1. Systemschwäche
Immunsystem, Kreislauf, etc. - alle Systeme sind geschwächt und kleine Wewehchen werden zu schweren chronischen Schmerzen. So ähnlich muss sich alt sein anfühlen.2. Fehlende Fitness
Die ständige Erschöpfung schränkt die Aktivität ein und dadurch wird jede kleine Belastung zu einer außergewöhnlichen Belastung. Ein paar Stunden am Tag aufrecht Stehen oder Gehen führt zu Nackenverspannungen und Kopfschmerzen, dazwischen auf der Couch Knozen und Gamen führt zu Tennisarm und das viele Liegen setzt den restlichen Gelenken zu.3. Tollpatschertheit
Brainfog macht mich ungeschickt. Das führt nicht nur dazu, dass ich literweise Wasser verschütte und verschlucke, statt es zu trinken, sondern auch dazu, dass ich mir alles, was ich mir anhauen kann, anhaue. Heute hab ich mir eine Türklinke in die Hüfte gerammt beim Versuch vorbeizugehen.4. Heilungsverzögerung
Egal ob blaue Flecken, Hauteinrisse oder sonstwas - so viel wie sich da anhäuft kann ich mir das nicht nur durchs Ungeschicktsein erklären. Ich glaube es braucht auch alles länger abzuheilen.5. - x. hab ich vergessen.
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'Nieuw model spoort verborgen oogschade na COVID op'
"De studie laat zien dat bestaande oogonderzoeken deze afwijkingen vaak niet detecteren, waardoor veel patiënten jarenlang zonder diagnose of passende behandeling blijven. De onderzoekers identificeren bovendien een mogelijk nieuw post-COVID-oogsyndroom, gekenmerkt door aanhoudende ontsteking en beschadiging van zenuwen die de oogfunctie aansturen."
"lichtgevoeligheid, ernstige oogpijn, moeite met lezen, problemen met scherpstellen en extreme vermoeidheid van de ogen."
https://www.icthealth.nl/nieuws/nieuw-model-spoort-verborgen-oogschade-na-covid-op
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'Nieuw model spoort verborgen oogschade na COVID op'
"De studie laat zien dat bestaande oogonderzoeken deze afwijkingen vaak niet detecteren, waardoor veel patiënten jarenlang zonder diagnose of passende behandeling blijven. De onderzoekers identificeren bovendien een mogelijk nieuw post-COVID-oogsyndroom, gekenmerkt door aanhoudende ontsteking en beschadiging van zenuwen die de oogfunctie aansturen."
"lichtgevoeligheid, ernstige oogpijn, moeite met lezen, problemen met scherpstellen en extreme vermoeidheid van de ogen."
https://www.icthealth.nl/nieuws/nieuw-model-spoort-verborgen-oogschade-na-covid-op
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#ATP #covid #postcovid #longcovid #MRS
Weber-Fahr et al. 2026 Jan 10, Biol Psychiatry (ahead of print)
Reduced Adenosine Triphosphate-to-Phosphocreatine Ratios in Neuropsychiatric Post-COVID Condition: Evidence From 31P Magnetic Resonance Spectroscopy
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#ATP #covid #postcovid #longcovid #MRS
Weber-Fahr et al. 2026 Jan 10, Biol Psychiatry (ahead of print)
Reduced Adenosine Triphosphate-to-Phosphocreatine Ratios in Neuropsychiatric Post-COVID Condition: Evidence From 31P Magnetic Resonance Spectroscopy
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Implications of RNA virus persistence for post-acute sequelae and chronic inflammatory syndromes
https://www.nature.com/articles/s41590-026-02577-5
Screenshot from latest Science for ME weekly update
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
Implications of RNA virus persistence for post-acute sequelae and chronic inflammatory syndromes
https://www.nature.com/articles/s41590-026-02577-5
Screenshot from latest Science for ME weekly update
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
From Italy 🇮🇹
Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19: in vivo evidence of structural autonomic dysfunction
https://www.ijidonline.com/article/S1201-9712(26)00608-9/abstract
Screenshot from latest Science for ME weekly update
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
From Italy 🇮🇹
Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19: in vivo evidence of structural autonomic dysfunction
https://www.ijidonline.com/article/S1201-9712(26)00608-9/abstract
Screenshot from latest Science for ME weekly update
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
From Germany 🇩🇪
Persistent impairments in muscle function and symptom burden in post-COVID syndrome: a prospective longitudinal study
https://link.springer.com/article/10.1186/s12967-026-08579-z
Screenshot from latest Science for ME weekly update
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
From Germany 🇩🇪
Persistent impairments in muscle function and symptom burden in post-COVID syndrome: a prospective longitudinal study
https://link.springer.com/article/10.1186/s12967-026-08579-z
Screenshot from latest Science for ME weekly update
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers -
Temelimab versus placebo in patients with post-COVID condition
https://www.sciencedirect.com/science/article/pii/S0889159126006409
"In this trial involving 203 patients with post-COVID condition, there was no improvement in fatigue in the group of individuals who received Temelimab compared to placebo."
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Temelimab versus placebo in patients with post-COVID condition
https://www.sciencedirect.com/science/article/pii/S0889159126006409
"In this trial involving 203 patients with post-COVID condition, there was no improvement in fatigue in the group of individuals who received Temelimab compared to placebo."
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3/
"[Symptoms] lead to significant vision disability and are linked to clinical findings not detectable in routine exams but only with specialized tests."”
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3/
"[Symptoms] lead to significant vision disability and are linked to clinical findings not detectable in routine exams but only with specialized tests."”
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Long COVID patients are told symptoms are in their head – here’s how to change the narrative
#Health #LongCOVID #MECFS #ChronicIllness #COVID19 #PostCOVID #LongHaulers #BrainHealth #NervousSystem #PatientCare #InvisibleIllness #ChronicPain #Rehabilitation
https://the-14.com/long-covid-patients-are-told-symptoms-are-in-their-head-heres-how-to-change-the-narrative/ -
Long COVID patients are told symptoms are in their head – here’s how to change the narrative
#Health #LongCOVID #MECFS #ChronicIllness #COVID19 #PostCOVID #LongHaulers #BrainHealth #NervousSystem #PatientCare #InvisibleIllness #ChronicPain #Rehabilitation
https://the-14.com/long-covid-patients-are-told-symptoms-are-in-their-head-heres-how-to-change-the-narrative/ -
News Release 8-Jul-2026
Commonly used drugs show small benefit for long Covid fatiguehttps://www.eurekalert.org/news-releases/1135110
Objective measures would have been more revealing for an open-label trial particularly with "usual care" which they all received.
Open access paper:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00242-2/fulltext@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers #COVIDBrain #NeuroPASC -
"Listening for the Long Haul" launch video now available.
Links from image:
https://longcovidjustice.org/listening-for-the-long-haul/?link_id=4&can_id=9315143877d75187a007747f1ffe508a#lflh-launchhttps://form.jotform.com/261245082706050
https://www.listeningforthelonghaul.org/
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers #COVIDBrain #NeuroPASC -
News Release 8-Jul-2026
Eye problems after COVID-19 can now be explained
https://www.eurekalert.org/news-releases/1134768"The impaired pupil function was furthermore linked to headaches, difficulty reading text & in focusing the eyes"
It would be interesting to know how many had general fatigue, PEM, etc. People with ME/CFS can suffer from eye problems.
Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers #COVIDBrain #NeuroPASC