#medmastodon — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #medmastodon, aggregated by home.social.
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We often describe the epidemiological transition as a shift from infectious diseases to #NCDs. This analysis suggests a more useful framing: increasing returns to preventing, delaying and managing ageing-related #diseases
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We often describe the epidemiological transition as a shift from infectious diseases to #NCDs. This analysis suggests a more useful framing: increasing returns to preventing, delaying and managing ageing-related #diseases
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We often describe the epidemiological transition as a shift from infectious diseases to #NCDs. This analysis suggests a more useful framing: increasing returns to preventing, delaying and managing ageing-related #diseases
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We often describe the epidemiological transition as a shift from infectious diseases to #NCDs. This analysis suggests a more useful framing: increasing returns to preventing, delaying and managing ageing-related #diseases
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We often describe the epidemiological transition as a shift from infectious diseases to #NCDs. This analysis suggests a more useful framing: increasing returns to preventing, delaying and managing ageing-related #diseases
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Warmer weather is enjoyable for many, but it can also mean an increased risk of getting insect bites & stings #summer #heat #insect #insectbite #healthtips #healthcare #MedMastodon
Song Credit: Another One Bites The Dust (Glee Cast Version)
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Warmer weather is enjoyable for many, but it can also mean an increased risk of getting insect bites & stings #summer #heat #insect #insectbite #healthtips #healthcare #MedMastodon
Song Credit: Another One Bites The Dust (Glee Cast Version)
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Warmer weather is enjoyable for many, but it can also mean an increased risk of getting insect bites & stings #summer #heat #insect #insectbite #healthtips #healthcare #MedMastodon
Song Credit: Another One Bites The Dust (Glee Cast Version)
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Warmer weather is enjoyable for many, but it can also mean an increased risk of getting insect bites & stings #summer #heat #insect #insectbite #healthtips #healthcare #MedMastodon
Song Credit: Another One Bites The Dust (Glee Cast Version)
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Warmer weather is enjoyable for many, but it can also mean an increased risk of getting insect bites & stings #summer #heat #insect #insectbite #healthtips #healthcare #MedMastodon
Song Credit: Another One Bites The Dust (Glee Cast Version)
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NIH (USA): New curriculum empowers future healthcare providers to recognize and treat Long COVID
A new online curriculum provides free #LongCOVID education for healthcare providers.
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Highlight from this week's news:
The WE&ME Foundation has launched a new call for ME/CFS research (WE&ME Projects) in collaboration with the Science for ME forum.
They aim to fund 7 projects, each with a budget of €120,000 - 180,000. Researchers from all over the world can apply. The deadline for the first stage is 25 August 2026.
https://www.weandmecfs.org/weme-projects/
They explicitly welcome applications from researchers new to the ME/CFS field
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Hello 👋
Welcome to the new Mastodon account for the Science for ME forum. Migration to the new server appears to have succeeded and most followers have been transferred.
Our forum is an independent, patient-led, international forum for people with ME/CFS or Long Covid and the carers, clinicians, scientists and advocates who support us.
Anyone can read the public posts on the forum but to join the discussion you must become a forum member.
You can learn more about our forum here:
https://www.s4me.info/threads/welcome.38181/
If you have any questions, just ask! 😁
But please note that this account is run by volunteers who have ME/CFS so replies may be delayed.
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Message for our followers:
This Mastodon account will migrate to a new server tomorrow (Saturday). We're making this change because the med-mastodon.com server is expected to shut down by the end of the month.
https://mastodonapp.uk/@wild1145/116156385290604411
The migration process should automatically transfer all of our followers to the new account. But in case of errors our new account can be found here:
https://universeodon.com/@s4me
Thanks! ❤️
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Metformin reduces risk of Long Covid. https://thesicktimes.org/2025/10/28/metformin-has-been-shown-to-reduce-the-risk-of-long-covid-why-isnt-it-more-widely-used/?mc_cid=01de0f1b88&mc_eid=4b751fcf19
#TheSickTimes #LongCovid #ProlongedPandemic #pandemic #disease #illness #sick #chronic #MedMastodon #medicine #medical #Metformin #Rapamycin #diagnose #prognosis #wellness #digestion #diabetes #hba1c #doctor #doctors #clinic #GP #physicians
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🦠 #Pneumokokken – die Hauptverursacher von #Lungenentzündungen – schädigen die Lunge anders als gedacht. Wie ein Forschungsteam der #CharitéBerlin jetzt zeigt, säuern sie ihre Umgebung an und zerstören so die Gewebebarriere. Das eröffnet möglicherweise neue Therapieansätze.
#Medizin #Forschung #Wissenschaft #ScienceMastodon #MedMastodon #CharitéMikrobio #CharitéPaper
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FYI - These are the kind of emails I send out to #medical facilities that I have to go to. I don't fucking play around!
#BCpoli #BCPublicHealth #FireBonnieHenry #OathbreakerBonnie #Eugenics #MaskUp #C19 #CovidIsNotOver #CovidSafety #BCNDP #BCNewDeathParty #BCNDPLegacyoOfDeath #ConfrontAntimaskers #PublicHealthAdvocacy #FAFO #PlagueSpreaders #health #MedMastodon #Covid #ZeroCovid
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A review of data from 51 countries finds that adolescent girls and young women using hormonal contraception had lower odds of being anemic. https://pubmed.ncbi.nlm.nih.gov/37978956/
#FPRH #ReproductiveHealth #Health #Healthcare #PublicHealth #MedMastodon @medmastodon @pediatrics
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👀 New data out from Centers for Disease Control and Prevention show a worrying trend: prenatal care rates dropped substantially in 2022—a smaller share of births got 1st trimester prenatal care and a larger share didn't got late or no care compared with 2021 and 2020.
https://www.cdc.gov/nchs/data/nvsr/nvsr73/nvsr73-02.pdf
#Health #PublicHealth #InfantHealth #Pediatrics #Obstetrics #FamilyPlanning #MedMastodon #ReproductiveHealth #Epidemiology @publichealth @medmastodon @pediatrics
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❤️ Preeclampsia and gestational diabetes can affect the heart health of both mother and child, suggests a new study led by The Ohio State University Wexner Medical Center.
The study, which included 3,317 mother-child pairs, examined the childrens' BMI, blood pressure, cholesterol, and glucose at ages 10 to 14 using data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study.
“This presents an opportunity for us to intervene early in childhood and recommend healthy changes for the family to help improve their child’s health later in life,” said lead researcher Kartik Venkatesh. https://bit.ly/43CRRHo
#Health #PublicHealth #MaternalHealth #InfantHealth #ChildHealth #Children #MedMastodon @medmastodon @pediatrics
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Funding opportunity:
The California Dept of Social Services Office of Child Abuse Prevention is accepting Request for Applications for its Road to Resilience program.
This RFA will award competitive grant funds to partnerships that, through interagency collaboration & integration of services, identify & serve pregnant individuals w known histories of substance use, pregnant individuals w current substance use, & parents/caregivers of substance-exposed infants.
Details:
https://www.cdss.ca.gov/inforesources/ocap/grants#PublicHealth #MedMastodon #MentalHealth #MaternalHealth #InfantHealth #Health #Healthcare @publichealth @medmastodon
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#FactOfTheDay: In 2020, 72.9% of California's Native Hawaiian/Pacific Islander births received prenatal care in the first trimester, compared to 49.6% nationwide. https://www.kidsdata.org/topic/313/prenatal-care-race/bar#fmt=95&loc=2,1&tf=110&pdist=73&ch=7,11,70,507,72,9,73&sort=loc
#PrenatalCare #MaternalHealth #InfantHealth #Healthcare #SDoH #MedMastodon @medmastodon -
There's no #BigTech #VC bottom here… and no vulnerable population they won't exploit:
"Alcohol recovery startups Monument and Tempest shared patients’ private data with advertisers” https://techcrunch.com/2023/04/04/monument-tempest-alcohol-data-breach/
#Surveillace
#BioSurveillance
#SurveiilanceCapitalsim
#PersonalData
#Privacy
#Health
#MentalHealth
#DigitalMentalHealth
#Addiction
#Psychology
#Recovery
#MedMastodon -
Are you struggling to find medications due to the recent #DrugShortages?
Here's all the tips I've come up with.
Any others? @tootiatricians
#shortages #MedMastodon #pharm #pharmacists #tootiatricians #tootiatricians #MedicationShortages #Adderall #TylenolShortage #pandemic
https://drkristenstuppy.substack.com/p/managing-medication-shortages
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I've had to have the conversation about #DrugShortages a lot lately. Here's all the tips I've come up with.
Any others? @tootiatricians
#shortages #MedMastodon #pharm #pharmacists #tootiatricians #tootiatricians #MedicationShortages #Adderall #TylenolShortage #pandemic #Consequences
https://drkristenstuppy.substack.com/p/managing-medication-shortages
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If you're #scicurious but aren't in a scientific field, feel free to reach out and ask about peer reviewed studies and trusted references.
Remember: Toot responsibly!
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#Articular #cartilage, which is a type of #tissue found in #joints, allows for nearly frictionless motion and can absorb large loads. Unfortunately, when it is damaged, it cannot repair itself. #Tissueengineering is a promising approach to repair the damage, but it falls short of creating functional tissue. This is because the tissue-engineered constructs do not have the same mechanical properties as native articular cartilage, which is due to the insufficient accumulation of #extracellular matrix components. To address this, researchers have been exploring the use of adenosine triphosphate (#ATP) to directly harness the underlying mechanotransduction pathways responsible. ATP is a molecule that is released as a result of mechanical stimulation and acts as an autocrine/paracrine signaling #molecule. It acts on P2 receptors on the #plasma #membrane to promote extracellular matrix #synthesis. However, high doses of ATP can lead to an increase in matrix #metalloproteinase 13 (MMP-13) activity and extracellular inorganic pyrophosphate (ePPi) accumulation, which can lead to undesirable effects such as #mineralization of articular cartilage. Therefore, the purpose of this study is to identify the mechanism of ATP-mediated #catabolism and to determine a therapeutic dose range to maximize the #anabolic effect.
Materials & Methods
Cell Isolation: This is the process of separating cells from a tissue sample. It is usually done using #enzymes to break down the tissue and then filtering the cells out.
3-Dimensional Culture: This is a type of #cellculture where the cells are grown in a three-dimensional environment, rather than in a flat layer. This allows the cells to interact with each other in a more natural way.
Exogenous ATP Supplementation: ATP (adenosine triphosphate) is a molecule that is important for energy production in cells. Exogenous ATP supplementation is the process of adding ATP to the cell culture from an outside source. This can help the cells to grow and function better.
MMP-13 Protein Activity is a type of protein that is found inside cells. It was extracted from 3-D cultured constructs and then frozen and pulverized. It was then homogenized in a buffer solution with a protease inhibitor. After that, it was centrifuged and stored at a low temperature. To measure the amount of active MMP-13, a FRET-based assay was used. This assay uses a fluorophore and quencher to measure the amount of MMP-13 that is present. To measure the amount of ECM synthesis, a range of exogenous ATP doses were used. To measure the effect of PPi on MMP-13 activity, chondrocyte monolayer cultures were established and PPi was added to the cultures. To investigate the underlying mechanisms, inhibitors were added to the cultures. Finally, Transmission Electron #Microscopy (TEM) was used to determine the presence of CPPD #crystal accumulation in the engineered tissue constructs. Statistical analyses were then used to analyze the collected data.
The researchers found that when they added ATP to the cultures, MMP-13 activity increased in a dose-dependent manner. This means that the more ATP they added, the more MMP-13 activity increased. They also found that the levels of PPi in the media increased significantly when they added a high dose of ATP, but the levels of PPi in the tissue did not appear to be affected. To determine the best dose of ATP to use, the researchers tested a range of doses and measured the effects on ECM synthesis (collagen and proteoglycans) and MMP-13 activity. They found that ECM synthesis and MMP-13 activity increased in response to intermediate doses of ATP, and further increased in response to higher doses of ATP.
In this study, the researchers wanted to see if they could use ATP to improve tissue growth and mechanical properties without the need for mechanical loading. They found that while high doses of ATP (250 μM) had a positive effect, it also caused a catabolic response, which is when the tissue breaks down. To find the optimal dose of ATP, the researchers tested different doses (31.25, 62.5, and 125 μM) to see which one had the best effect on tissue growth and mechanical properties without causing a catabolic response.
#Calcium is an important factor in the ATP-mediated catabolism process. The researchers found that when they added 10 μM PPi to #chondrocyte cultures, there was a 32% increase in MMP-13 activity compared to unstimulated controls. This effect appeared to require calcium and could be inhibited by the MEK1/2 inhibitor U0126. Additionally, TEM imaging was conducted on engineered cartilaginous tissues supplemented with 0, 62.5 and 250 μM ATP but no mineralization or CPPD crystals were observed which suggests that these doses of ATP did not cause any catabolic response due to crystal formation.
The text is discussing a method of improving tissue growth and mechanical properties of engineered cartilage constructs by applying mechanical loading. However, this approach has limitations when dealing with irregular geometry and high radii of curvature. An alternative approach is to use the known mechanotransduction pathways responsible to achieve the same effect without externally applied forces. In a recent study, it was demonstrated that direct stimulation of the ATP-purinergic receptor pathway through exogenous supplementation of ATP can elicit a comparable anabolic response and be used to improve both tissue growth and mechanical properties of the developed tissue. However, high doses of ATP (250 μM) resulted in a simultaneous catabolic response characterized by an increase in MMP-13 expression, potentially due to the accumulation of ePPi. The present study determined a therapeutic dose range of exogenous ATP to maximize the anabolic response and minimize the catabolic effect of exogenous ATP. It was found that the dose range of ATP between 62.5 and 125 μM was optimal for maximizing the anabolic effect and minimizing the catabolic effect of exogenous ATP. It was also found that calcium and pyrophosphate were key factors involved in the PPi-mediated catabolic response, and that CPPD crystals could potentially be endocytosed and elicit changes through a MAPK-dependent pathway.
#explainpaper #med #MedMastodon
The Therapeutic Potential of Exogenous Adenosine Triphosphate (ATP) for Cartilage Tissue Engineering
authors : Jenna Usprech , Gavin Chu , Renata Giardini-Rosa , Kathleen Martin , and Stephen D. Waldman
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#HCWvsHunger🍎 starts tomorrow so using #MyFirstToot to intro myself and @EShaughnessyMD as #KidVengers captains on #MedMastodon 🦸🏻♀️🦸♀️
No GIFs sadly, but will still keep it fun and try to out-raise all the better paid teams 😜