#medmastodon — Public Fediverse posts

Healthcare workers of various types are in short supply in Canada. It’s a key reason why we have backlogs in care. Lots of jobs. The province of BC on the west coast has made it much easier for healthcare workers from the US to move there. Other provinces are working on shortening the process too.
Heard about this source helping Americans learn more about moving to Vancouver Island. There was a great show on CBC Radio’s programme White Coat, Black Art hosted by Dr. Brian Goldman on this topic, interviewing the Maffins who created helpful info and sources.
There is also a group on Discord with discussions and where questions can be answered, also started by the Maffins.
#Canada #Healthcare #MedMastodon

https://engageq.notion.site/islandinfusion

As a GP in Germany, I struggle with the claim that “people don’t want to work.” In daily practice, I see the opposite: many patients push themselves to keep working, even when they should rest. They worry about burdening colleagues, unfinished tasks, or upcoming deadlines.

If we want to understand rising sick leave, we need to look at real factors: increasing workload, constant pressure, lack of recovery time, social isolation, and overall exhaustion. Reducing this to a question of “motivation” ignores both evidence and lived experience.

In my experience, people who genuinely try to avoid work are a tiny minority. Framing the issue this way feels similar to old narratives about unemployment—oversimplified, misleading, and disconnected from reality.

#MedMastodon #GeneralPractice #PrimaryCare #WorkStress #MentalHealth #SickLeave #HealthPolicy #Germany #Arbeitswelt #Burnout #PublicHealth #Reform #AU #Arbeitsunfähigkeit #Gesundheitsreform #gesundheitspolitik #gesundheitssystem

Another study using the "date of birth" for risk stratification in clinical #care

High risk of #ageism

Waiting for recommendations using #capacity and #function in the decision-making process for older people

#RoadToAgeism #Geriatrics #Cancer #Medicine #Prevention #MedMastodon

https://jamanetwork.com/journals/jama/article-abstract/2847311

Like, Share & Follow to spread Awareness! 👨‍⚕️ #MedMastodon #MeningitisAwareness #PublicHealth #unitedkingdom #kent #healthcare #doctor

Music credit: Sound of Salaar

I need translation for an easier ecosia search.
How do allistic people describe "nauseous above knee"?
It's like the 2 or 3 inches above the top of my right kneecap.
I'm literally only getting separate results for "feeling sick" and "knee / joint pain".
The area above my kneecap feels nausea. How tf do I research that?

#medicine #MedMastodon #health #healthCare #language #term #HowTo #help #tips #idea #ideas #autism #autistic #allism #allistic #neuroDiverse #neuroDivergent #neuroTypical #neuroType #neuroExpected #NeuroDefault #NeuroSupport #NeuroSupported #NeuroAccommodation #NeuroAccommodated #word #words #comms #Communication #Communicate

1. https://www.mkuh.nhs.uk/wp-content/uploads/2022/10/Women-with-Disabilities-and-Special-Needs-Guideline.pdf
2. https://bmjopen.bmj.com/content/7/7/e016757
3. https://rcm.org.uk/blog/2025/06/improving-maternity-care-and-support-for-pregnant-women-with-disabilities/
4. https://birthrights.org.uk/factsheets/disability-and-long-term-health-conditions-and-maternity-care/
5. https://criplife.co.uk/pregnancy-and-disability-ensuring-inclusive-maternity-care-for-prospective-disabled-mothers/
6. https://www.ableize.com/health-and-fitness/pregnancy-and-parenthood/

I guess obstretics is My New Thing.

#maternity #pregnancy #ObGyn #Obstetrics #pregnant #nativity #disabled #DisabledJoy #DisabledFedi #disability #MedMastodon #med #meds #medicine #medical

https://www.mkuh.nhs.uk/wp-content/uploads/2022/10/Women-with-Disabilities-and-Special-Needs-Guideline.pdf "Appendix 1: MOTHERS WITH LEARNING DISABILITIES GUIDANCE TOOL
V
Value family – Involve individuals who best know the woman with learning disabilities as they can provide additional information that may be helpful to the decision-making process.
A
Avoid making assumptions – Do not assume that because someone has a diagnosis of a learning disability that they cannot be good enough parents
L
Look for support – Professionals should not work in isolation and should involve learning disability services for further support and guidance.
U
Understand emotions – Take into consideration that many mothers with learning disabilities have their own anxieties and worries about motherhood and fear of judgment. Do not assume they are being difficult.
E
Establish reasonable adjustments – Professionals should put reasonable adjustments into place to ensure women with learning disabilities can comprehend and understand information to give informed consent. I.E. easy read, pictorials, large font, visual and hearing aids.

M
Mental Capacity – Do not assume capacity. In liaison with the Mental Capacity Act 2005, professionals should consider completing a Mental Capacity Assessment (MCA) to establish whether the women can give informed consent. Professionals should also consider best interest, Deprivation of Liberty Safeguards (DoLS) and involving an Independent Mental Capacity Advocate (IMCA).
E
Efficient discharge – Professionals should consider possible support that can be put into place to ensure a person-centered discharge is consolidated. Consider, access to health and additional services, transport, financial support and accommodation.

THINK... VALUE ME"

#maternity #pregnancy #ObGyn #Obstetrics #pregnant #nativity #disabled #DisabledJoy #DisabledFedi #disability #MedMastodon #med #meds #medicine #medical

Omfg. Read section 3.4 "Learning Disabilities support" on page 5. Literally everyone will be helped by these suggestions, not just diagnosed disabled people.
https://www.mkuh.nhs.uk/wp-content/uploads/2022/10/Women-with-Disabilities-and-Special-Needs-Guideline.pdf
"3.4 Learning Disabilities support
Although 7% of people with learning disabilities become parents ( Best Beginnings) the Equality Act 2010 obligates responsibility to service providers to ensure that reasonable adjustments are put into place to ensure the holistic needs of people with learning disabilities are met to the highest standards.
Remember to think VALUE ME! (Appendix 1)

1. Early intervention strategies should be considered. Ensure that the community midwife is involved and if they are under 20 consider discussion with the specialist teenage pregnancy midwife for additional support.
2. Professionals should ensure that adequate time is provided for consultations, appointments and formal discussions. Taking time to allow the woman to understand the information in
order to make an informed decision.
3. Professionals should ensure that reasonable adjustments are put into place to aid with understanding. Including: easy read, pictorials, large font, visual and hearing aids.
4. Abilities led practice rather than inabilities led practice. Professionals should avoid making assumptions based on a diagnosis of a learning disability as often mothers will have their own anxieties, fears and worries regarding motherhood.
5. Avoid assuming that mothers are being difficult. Consider other possible reasons such as the environment, loud noises, bright lights (especially if they have a dual diagnosis of learning disability and ASD), sensory needs, stress and anxiety. Provide a side room if possible."

#maternity #pregnancy #ObGyn #Obstetrics #pregnant #nativity #disabled #DisabledJoy #DisabledFedi #disability #MedMastodon #med #meds #medicine #medical

Oh, and yeah, we published that a few weeks ago: https://academic.oup.com/ckj/article/18/4/sfaf028/8024413

#ADPKD #kidney #epidemiology #statistics #rstats #MedMastodon #medicine

Oh, and yeah, we published that a few weeks ago: https://academic.oup.com/ckj/article/18/4/sfaf028/8024413

#ADPKD #kidney #epidemiology #statistics #rstats #MedMastodon #medicine

Oh, and yeah, we published that a few weeks ago: https://academic.oup.com/ckj/article/18/4/sfaf028/8024413

#ADPKD #kidney #epidemiology #statistics #rstats #MedMastodon #medicine

Oh, and yeah, we published that a few weeks ago: https://academic.oup.com/ckj/article/18/4/sfaf028/8024413

#ADPKD #kidney #epidemiology #statistics #rstats #MedMastodon #medicine

In case it was missed in the post above, this is my updated article:

👉 https://www.thecanary.co/global/world-analysis/2025/04/01/anna-severe-me-cfs/

My doctor predicts I will die if I don’t leave soon.

I need a solid, safe, home I can go to and recover to at least a stable baseline. It’s not full recovery, but it’s better than a slow death.

Help please 🙏

#PwME #LongCovid #MECFS #Hypothyroidism #ChronicIllness #Neisvoid #Abuse #Housing #Dysautonomia #SocialWork #MedMastodon #PWLC #MutualAid
#HumanRights #Press #Housing #Journalism #MECFS #SevereME #Abuse #Neglect #MutualAid #Narcissist #Psychopath #MCAS #MCAD #Endometriosis #ChronicPain #CostOfLivingCrisis #Melbourne #Australia #DomesticAbuse #DV

@chronicillness @longcovid @neisvoid
@disabilityjustice
@disability @socialwork
@dysautonomia @mutualaid
@mecfs
@chronicpain
@mcas
@australia
@melbourne

I'm still surprised at the lack of use of #MedMastodon for conference posting.

#ASCOQLTY24 ~ 1000 delegates - ZERO posts here.

What am I missing?

#OncoPharm - do you want #BOPA2024 content here or not?

Happiness with Circumcision Status, Not Status Itself, Predicts Genital Self-Image in a Geographically Diverse Sample
Selino & Krawczyk, 2023 Archives of Sexual Behavior

"Participants who were circumcised tended to have less happiness with their circumcision status than non-circumcised participants regardless of region of birth."

https://link.springer.com/article/10.1007/s10508-023-02543-4

#MedMastodon #Autonomy #BodilyAutonomy #GenitalAutonomy #Feminism

Great resource on primary #hyperaldosteronism

#hypertension #conn #MedMastodon #nephrology

https://ajkdblog.org/2023/10/04/primary-aldosteronism-an-interview/

Oh good, cos this is exactly what we do.

In #Clostridiumdifficile diarrhoea, we treat NAAT+ve, / toxin - ve if they have #diarrhea and no obvious reason for it.

#IDMastodon #MedMastodon #medicine #infectiousdiseases

Clinical Outcomes and Management of NAAT-Positive/Toxin-Negative Clostridioides difficile Infection: A Systematic Review and Meta-Analysis | Clinical Infectious Diseases | Oxford Academic

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad523/7256092

Urinary Schistosomiasis

https://www.nejm.org/doi/full/10.1056/NEJMicm2300207

> Images in Clinical Medicine from The New England Journal of Medicine
#IDMastodon #MedMastodon #medicine #infectiousdiseases #tropical #bladder #schistosomiasis

There's no #BigTech #VC bottom here… and no vulnerable population they won't exploit:

"Alcohol recovery startups Monument and Tempest shared patients’ private data with advertisers” https://techcrunch.com/2023/04/04/monument-tempest-alcohol-data-breach/

#Surveillace
#BioSurveillance
#SurveiilanceCapitalsim
#PersonalData
#Privacy
#Health
#MentalHealth
#DigitalMentalHealth
#Addiction
#Psychology
#Recovery
#MedMastodon

Any transplantation carries a risk of infection transmission. Concern that faecal transplantation may 👉 H pylori transmission.

Not from this (small) case series. Also needs saying that faeces were screened for antigen, which ≭ live organism.

#IDMastodon #MedMastodon #transplant #feces #Clostridiumdifficile

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00081-2/fulltext?dgcid=raven_jbs_aip_email

#Articular #cartilage, which is a type of #tissue found in #joints, allows for nearly frictionless motion and can absorb large loads. Unfortunately, when it is damaged, it cannot repair itself. #Tissueengineering is a promising approach to repair the damage, but it falls short of creating functional tissue. This is because the tissue-engineered constructs do not have the same mechanical properties as native articular cartilage, which is due to the insufficient accumulation of #extracellular matrix components. To address this, researchers have been exploring the use of adenosine triphosphate (#ATP) to directly harness the underlying mechanotransduction pathways responsible. ATP is a molecule that is released as a result of mechanical stimulation and acts as an autocrine/paracrine signaling #molecule. It acts on P2 receptors on the #plasma #membrane to promote extracellular matrix #synthesis. However, high doses of ATP can lead to an increase in matrix #metalloproteinase 13 (MMP-13) activity and extracellular inorganic pyrophosphate (ePPi) accumulation, which can lead to undesirable effects such as #mineralization of articular cartilage. Therefore, the purpose of this study is to identify the mechanism of ATP-mediated #catabolism and to determine a therapeutic dose range to maximize the #anabolic effect.

Materials & Methods

Cell Isolation: This is the process of separating cells from a tissue sample. It is usually done using #enzymes to break down the tissue and then filtering the cells out.

3-Dimensional Culture: This is a type of #cellculture where the cells are grown in a three-dimensional environment, rather than in a flat layer. This allows the cells to interact with each other in a more natural way.

Exogenous ATP Supplementation: ATP (adenosine triphosphate) is a molecule that is important for energy production in cells. Exogenous ATP supplementation is the process of adding ATP to the cell culture from an outside source. This can help the cells to grow and function better.

MMP-13 Protein Activity is a type of protein that is found inside cells. It was extracted from 3-D cultured constructs and then frozen and pulverized. It was then homogenized in a buffer solution with a protease inhibitor. After that, it was centrifuged and stored at a low temperature. To measure the amount of active MMP-13, a FRET-based assay was used. This assay uses a fluorophore and quencher to measure the amount of MMP-13 that is present. To measure the amount of ECM synthesis, a range of exogenous ATP doses were used. To measure the effect of PPi on MMP-13 activity, chondrocyte monolayer cultures were established and PPi was added to the cultures. To investigate the underlying mechanisms, inhibitors were added to the cultures. Finally, Transmission Electron #Microscopy (TEM) was used to determine the presence of CPPD #crystal accumulation in the engineered tissue constructs. Statistical analyses were then used to analyze the collected data.

The researchers found that when they added ATP to the cultures, MMP-13 activity increased in a dose-dependent manner. This means that the more ATP they added, the more MMP-13 activity increased. They also found that the levels of PPi in the media increased significantly when they added a high dose of ATP, but the levels of PPi in the tissue did not appear to be affected. To determine the best dose of ATP to use, the researchers tested a range of doses and measured the effects on ECM synthesis (collagen and proteoglycans) and MMP-13 activity. They found that ECM synthesis and MMP-13 activity increased in response to intermediate doses of ATP, and further increased in response to higher doses of ATP.

In this study, the researchers wanted to see if they could use ATP to improve tissue growth and mechanical properties without the need for mechanical loading. They found that while high doses of ATP (250 μM) had a positive effect, it also caused a catabolic response, which is when the tissue breaks down. To find the optimal dose of ATP, the researchers tested different doses (31.25, 62.5, and 125 μM) to see which one had the best effect on tissue growth and mechanical properties without causing a catabolic response.

#Calcium is an important factor in the ATP-mediated catabolism process. The researchers found that when they added 10 μM PPi to #chondrocyte cultures, there was a 32% increase in MMP-13 activity compared to unstimulated controls. This effect appeared to require calcium and could be inhibited by the MEK1/2 inhibitor U0126. Additionally, TEM imaging was conducted on engineered cartilaginous tissues supplemented with 0, 62.5 and 250 μM ATP but no mineralization or CPPD crystals were observed which suggests that these doses of ATP did not cause any catabolic response due to crystal formation.

The text is discussing a method of improving tissue growth and mechanical properties of engineered cartilage constructs by applying mechanical loading. However, this approach has limitations when dealing with irregular geometry and high radii of curvature. An alternative approach is to use the known mechanotransduction pathways responsible to achieve the same effect without externally applied forces. In a recent study, it was demonstrated that direct stimulation of the ATP-purinergic receptor pathway through exogenous supplementation of ATP can elicit a comparable anabolic response and be used to improve both tissue growth and mechanical properties of the developed tissue. However, high doses of ATP (250 μM) resulted in a simultaneous catabolic response characterized by an increase in MMP-13 expression, potentially due to the accumulation of ePPi. The present study determined a therapeutic dose range of exogenous ATP to maximize the anabolic response and minimize the catabolic effect of exogenous ATP. It was found that the dose range of ATP between 62.5 and 125 μM was optimal for maximizing the anabolic effect and minimizing the catabolic effect of exogenous ATP. It was also found that calcium and pyrophosphate were key factors involved in the PPi-mediated catabolic response, and that CPPD crystals could potentially be endocytosed and elicit changes through a MAPK-dependent pathway.

#explainpaper #med #MedMastodon

The Therapeutic Potential of Exogenous Adenosine Triphosphate (ATP) for Cartilage Tissue Engineering

authors : Jenna Usprech , Gavin Chu , Renata Giardini-Rosa , Kathleen Martin , and Stephen D. Waldman

RSV hospitalization rates for newborns are seven times higher than they were in 2018, the last full season before the pandemic struck.

Flu hospitalizations are the worst in a decade.

Rhinovirus, enterovirus, adenovirus, metapneumovirus and parainfluenza are also contributing to this wave of illness, and Covid cases are beginning to rise once again in the US.

My latest:
https://www.theguardian.com/us-news/2022/dec/01/us-surge-respiratory-virus-rsv-influenza-children-hospitalized
#rsv #flu #childhealth #emergency #respiratoryviruses #preemies #pediatrics #MedMastodon

Study in #JAMA Dermatology finds that various #guidelines for skin #cancer follow-up are inconsistent. "A call to action".
Canadian doctors & pharmacists can see my news report in The Medical Post/ Canadian Healthcare Network (Sorry, password protected to others).

Some highlights:
...A review of multiple clinical practice guidelines, from within Canada and beyond...

Researchers found “there is little consensus among clinical practice guidelines on the appropriate follow-up frequency after treatment of keratinocyte carcinoma. This is largely because there is limited data supporting one follow-up regimen over another,” said study coauthor Sara Mirali, a #medical and PhD student at the University of Toronto...

“Clinicians vary in how often they follow patients after treatment for keratinocyte #carcinoma ... Unfortunately, the optimal follow-up frequency is unclear, which has implications for patient outcomes and healthcare resources,” she told the Medical Post...(and more)

#dermatology #oncology #MedMastodon https://www.canadianhealthcarenetwork.ca/whats-doctor-do-various-guidelines-skin-cancer-follow-are-inconsistent

Which UK #Anaesthesia society will be the first on #MedMastodon ?

@dasairway @RAUK @SIVA @OAA @SOBA @vasgbi

#GasMastodon

@sethina @Anaes_Journal @LawtonTri @sajay @OBsleepmerchant @pjsouthall @propandkerosene @propofology @NaveenEipe @BobFunnekotter

Hepatocellular #carcinoma may develop in chronic #hepatitis B infections in the absence of #cirrhosis #MedMastodon #IDMastodon #Gastrodon #IMPearls

Migrated to #MedMastodon, so I should post my 1st toot (?!), right? 500 characters...so much freedom!

I'm a Clinical Microbiologist @MayoClinic. I direct the ID Serology Lab & am Program Director for the #ClinMicro ASM CPEP Fellowship. I also co-host the ASM #EditorsInConversation podcast for #JClinMicro.

Interests: #Virology, #VectorBorneDiseases, & #Mycology.

Originally from Bulgaria. LOVE to travel, history buff & busy w/ 2 kiddos 🥰

#ClinMicroMastadon #IDMastadon

#IDMastodon #MedMastodon

#Introduction

Adult ID Instructor at UNMC

Interested in
Antimicrobial Stewardship #Stewie
Infection Prevention
Digital Med Ed
Evidence-Based Medicine
Endocarditis & SAB
Podcasts
History of Science
KC Chiefs fan

Hope we can re-create our online community here if necessary. Social media has been so important to my early career development