#pathogenicity — Public Fediverse posts on home.social

🛡️Understanding #plant-#pathogen interactions helps protect crucial #food #crops.
This #MAPK signaling cascade contributes to #wheat stripe rust resistance, providing insights into crop immunity and #fungal #pathogenicity.
https://doi.org/10.1111/jipb.13888
@wileyplantsci
#PlantSci #JIPB #botany

#plant #pathogen #food #crops #mapk #wheat

JIPB @[email protected] · 2025-08-08 · 15:04 UTC

🛡️Understanding #plant-#pathogen interactions helps protect crucial #food #crops.
This #MAPK signaling cascade contributes to #wheat stripe rust resistance, providing insights into crop immunity and #fungal #pathogenicity.
https://doi.org/10.1111/jipb.13888
@wileyplantsci
#PlantSci #JIPB #botany

#plant #pathogen #food #crops #mapk #wheat

JIPB @[email protected] · 2025-08-08 · 15:04 UTC

🛡️Understanding #plant-#pathogen interactions helps protect crucial #food #crops.
This #MAPK signaling cascade contributes to #wheat stripe rust resistance, providing insights into crop immunity and #fungal #pathogenicity.
https://doi.org/10.1111/jipb.13888
@wileyplantsci
#PlantSci #JIPB #botany

#botany #jipb #plantsci #pathogenicity #fungal #wheat

Giuseppe Michieli @[email protected] · 2025-05-24 · 08:07 UTC

A G219A #hemagglutinin #substitution increases #pathogenicity and viral #replication of Eurasian avian-like #H1N1 swine #influenza viruses, https://etidiohnew.blogspot.com/2025/05/a-g219a-hemagglutinin-substitution.html

#hemagglutinin #substitution #pathogenicity #replication #h1n1 #influenza

Giuseppe Michieli @[email protected] · 2025-05-22 · 19:18 UTC

Comparative #pathogenicity of three A(#H5N1) clade 2.3.4.4b HPAI viruses in blue-winged #teal and #transmission to domestic #poultry, https://etidiohnew.blogspot.com/2025/05/comparative-pathogenicity-of-three.html

#pathogenicity #h5n1 #teal #transmission #poultry

Giuseppe Michieli @[email protected] · 2025-05-21 · 17:00 UTC

#Pathogenicity and #transmissibility of bovine-derived HPAI #H5N1 B3.13 virus in #pigs, https://etidiohnew.blogspot.com/2025/05/pathogenicity-and-transmissibility-of.html

#pathogenicity #transmissibility #h5n1 #pigs

JIPB @[email protected] · 2025-04-09 · 14:21 UTC

🛡️Understanding #plant-#pathogen interactions will help us protect crucial #food #crops

🌾Shu et al. characterize a #MAPK signaling cascade that contributes to #wheat stripe rust resistance, providing new insights into crop immunity and the #pathogenicity of an obligate biotrophic #fungus.

https://doi.org/10.1111/jipb.13888
@wileyplantsci
#PlantSci #JIPB #botany

#plant #pathogen #food #crops #mapk #wheat

JIPB @[email protected] · 2025-04-09 · 14:21 UTC

🛡️Understanding #plant-#pathogen interactions will help us protect crucial #food #crops

🌾Shu et al. characterize a #MAPK signaling cascade that contributes to #wheat stripe rust resistance, providing new insights into crop immunity and the #pathogenicity of an obligate biotrophic #fungus.

https://doi.org/10.1111/jipb.13888
@wileyplantsci
#PlantSci #JIPB #botany

#botany #jipb #plantsci #fungus #pathogenicity #wheat

Giuseppe Michieli @[email protected] · 2024-07-07 · 08:05 UTC

#Aminoacid #mutations #PB1-V719M and #PA-N444D combined with #PB2-627K contribute to the #pathogenicity of #H7N9 in #mice, Vet Res.: https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6

Overall, this study revealed that #virulence in H7N9 is a #polygenic trait and identified novel virulence-related residues (PB2-627K combined with PB1-719M and/or PA-444D) in viral ribonucleoprotein (vRNP) complexes.

#aminoacid #mutations #pb1 #pa #pb2 #pathogenicity

Giuseppe Michieli @[email protected] · 2024-11-09 · 09:03 UTC

#SARS-CoV-2 #JN1 reveals attenuated #pathogenicity and #airborne #transmission

Source: BioRxIV, AbstractJN.1 is a subvariant of SARS-CoV-2 Omicron BA.2.86 lineage that was predominant worldwide in early 2024, of which the in vivo characteristics are largely unknown. Our results demonstrated that the replication of JN.1 was more efficient than that of the parental BA.2 in Vero cells, which demonstrated low dependence on TMPRSS2. Compared to Omicron variants BA.2 and XBB…

https://etidioh.wordpress.com/2024/11/09/sars-cov-2-jn1-reveals-attenuated-pathogenicity-and-airborne-transmission/

#sars #jn1 #pathogenicity #airborne #transmission

Giuseppe Michieli @[email protected] · 2024-10-09 · 08:26 UTC

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#lineage #pathogenicity #evasion #features #sars #ba286

Giuseppe Michieli @[email protected] · 2024-05-31 · 15:28 UTC

#Outbreaks of #H5N1 High Pathogenicity Avian #Influenza in #SouthAfrica in 2023 Were Caused by Two Distinct Sub-#Genotypes of Clade 2.3.4.4b Viruses, Viruses: https://www.mdpi.com/1999-4915/16/6/896

South African clade 2.3.4.4b H5N1 viruses had comparatively fewer #markers of #virulence and #pathogenicity compared to European strains, a possible reason why no #spillover to #mammals has occurred here yet.

#outbreaks #h5n1 #influenza #southafrica #genotypes #markers

Samuel Alizon @[email protected] · 2023-12-20 · 08:55 UTC

I agree with all the discussion and think this misunderstanding about evolution to #avirulence comes from a confusion between #virulence (an evolutionary concept involving host fitness), #lethality (related to the host), #mortality (measured at the population level), and #pathogenicity (at the cellular level).

We tried to clarify this with @mtsofonea in our review on the evolution of #SarsCoV2 virulence.

https://onlinelibrary.wiley.com/doi/10.1111/jeb.13896

@david_crispin @memerman @gpollara @foaylward @b_longdon

#avirulence #virulence #lethality #mortality #pathogenicity #sarscov2

Giuseppe Michieli @[email protected] · 2024-06-12 · 08:27 UTC

Increased #pathogenicity {in animal models} and #transmission of #SarsCoV2 #Omicron #XBB19 #sublineage, including #HK3 and #EG51, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.10.598324v1?rss=1

HK.3 and EG.5.1 exhibited greater pathogenicity than XBB.1.9.1 and BA.2 in H11-K18-hACE2 #hamsters. Our studies provide insight into the newly emerging #pathogens HK.3 and EG.5.1.

#pathogenicity #transmission #sarscov2 #omicron #xbb19 #sublineage

Giuseppe Michieli @[email protected] · 2024-10-30 · 09:30 UTC

#Replication #Kinetics, #Pathogenicity and Virus-induced Cellular Responses of #Cattle-origin #Influenza A(#H5N1) Isolates from #Texas, United States

Source: BioRxIV, AbstractThe host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States. Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the cattle-origin influenza…

https://etidioh.wordpress.com/2024/10/30/replication-kinetics-pathogenicity-and-virus-induced-cellular-responses-of-cattle-origin-influenza-ah5n1-isolates-from-texas-united-states/

#replication #kinetics #pathogenicity #cattle #influenza #h5n1

Giuseppe Michieli @[email protected] · 2024-08-29 · 15:55 UTC

#Molecular basis of #pathogenicity of recently emerged #FCoV23 #coronavirus, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.25.607996v1

FCoV-23 is a recently emerged, highly pathogenic #recombinant coronavirus responsible for a widespread #outbreak of #feline infectious #peritonitis (FIP) likely linked to in-host viral evolution. Here, we report cryoEM structures of two FCoV-23 spike (S) isoforms explaining that the in-host loss of domain 0 observed in clinical samples enhances entry into cells ...