#pathogenicity — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #pathogenicity, aggregated by home.social.
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G4 #Eurasian avian-like #H1N1 swine #influenza viruses exhibit enhanced #pathogenicity potential in mice and #pigs, https://etidiohnew.blogspot.com/2026/05/g4-eurasian-avian-like-h1n1-swine.html
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A single PA-X #mutation in #bovine-origin #H5N1 #influenza virus reduces #pathogenicity in mice, https://etidiohnew.blogspot.com/2026/05/a-single-pa-x-mutation-in-bovine-origin.html
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Deciphering #HPAI #Influenza A Virus #H5N1: Molecular Basis of #Pathogenicity, Zoonotic Potential, and Advances in #Vaccination Strategies, https://etidiohnew.blogspot.com/2026/03/deciphering-hpai-influenza-virus-h5n1.html
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Emergence of #mammalian-adaptive #PB2 #mutations enhances #polymerase activity and #pathogenicity of #cattle-derived #H5N1 #influenza A virus, https://etidiohnew.blogspot.com/2025/12/emergence-of-mammalian-adaptive-pb2.html
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Increased #pathogenicity and #transmission of #SARS-CoV-2 #Omicron #XBB.1.9 subvariants, including HK.3 and EG.5.1, relative to BA.2, https://etidiohnew.blogspot.com/2025/11/increased-pathogenicity-and.html
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Continuous #evolution of #Eurasian #avian-like #H1N1 swine #influenza viruses with pdm/09-derived internal #genes enhances #pathogenicity in mice, https://etidiohnew.blogspot.com/2025/09/continuous-evolution-of-eurasian-avian.html
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#Pathogenicity of #SARS-CoV-2 #Omicron #Subvariants #JN.1, #KP.2, and #EG.5.1 in K18-hACE2 Transgenic #Mice, https://etidiohnew.blogspot.com/2025/08/pathogenicity-of-sars-cov-2-omicron.html
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The #pathogenicity and multi-organ proteomic profiles of #Mpox virus #infection in SIVmac239-infected rhesus #macaques, https://etidiohnew.blogspot.com/2025/08/the-pathogenicity-and-multi-organ.html
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🛡️Understanding #plant-#pathogen interactions will help us protect crucial #food #crops
🌾Shu et al. characterize a #MAPK signaling cascade that contributes to #wheat stripe rust resistance, providing new insights into crop immunity and the #pathogenicity of an obligate biotrophic #fungus.
https://doi.org/10.1111/jipb.13888
@wileyplantsci
#PlantSci #JIPB #botany -
🛡️Understanding #plant-#pathogen interactions will help us protect crucial #food #crops
🌾Shu et al. characterize a #MAPK signaling cascade that contributes to #wheat stripe rust resistance, providing new insights into crop immunity and the #pathogenicity of an obligate biotrophic #fungus.
https://doi.org/10.1111/jipb.13888
@wileyplantsci
#PlantSci #JIPB #botany -
#SARS-CoV-2 #JN1 reveals attenuated #pathogenicity and #airborne #transmission
Source: BioRxIV, AbstractJN.1 is a subvariant of SARS-CoV-2 Omicron BA.2.86 lineage that was predominant worldwide in early 2024, of which the in vivo characteristics are largely unknown. Our results demonstrated that the replication of JN.1 was more efficient than that of the parental BA.2 in Vero cells, which demonstrated low dependence on TMPRSS2. Compared to Omicron variants BA.2 and XBB…
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#Replication #Kinetics, #Pathogenicity and Virus-induced Cellular Responses of #Cattle-origin #Influenza A(#H5N1) Isolates from #Texas, United States
Source: BioRxIV, AbstractThe host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States. Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the cattle-origin influenza…
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#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3
Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…
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#Molecular basis of #pathogenicity of recently emerged #FCoV23 #coronavirus, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.25.607996v1
FCoV-23 is a recently emerged, highly pathogenic #recombinant coronavirus responsible for a widespread #outbreak of #feline infectious #peritonitis (FIP) likely linked to in-host viral evolution. Here, we report cryoEM structures of two FCoV-23 spike (S) isoforms explaining that the in-host loss of domain 0 observed in clinical samples enhances entry into cells ...
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#Aminoacid #mutations #PB1-V719M and #PA-N444D combined with #PB2-627K contribute to the #pathogenicity of #H7N9 in #mice, Vet Res.: https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6
Overall, this study revealed that #virulence in H7N9 is a #polygenic trait and identified novel virulence-related residues (PB2-627K combined with PB1-719M and/or PA-444D) in viral ribonucleoprotein (vRNP) complexes.
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Increased #pathogenicity {in animal models} and #transmission of #SarsCoV2 #Omicron #XBB19 #sublineage, including #HK3 and #EG51, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.10.598324v1?rss=1
HK.3 and EG.5.1 exhibited greater pathogenicity than XBB.1.9.1 and BA.2 in H11-K18-hACE2 #hamsters. Our studies provide insight into the newly emerging #pathogens HK.3 and EG.5.1.
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#Outbreaks of #H5N1 High Pathogenicity Avian #Influenza in #SouthAfrica in 2023 Were Caused by Two Distinct Sub-#Genotypes of Clade 2.3.4.4b Viruses, Viruses: https://www.mdpi.com/1999-4915/16/6/896
South African clade 2.3.4.4b H5N1 viruses had comparatively fewer #markers of #virulence and #pathogenicity compared to European strains, a possible reason why no #spillover to #mammals has occurred here yet.
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I agree with all the discussion and think this misunderstanding about evolution to #avirulence comes from a confusion between #virulence (an evolutionary concept involving host fitness), #lethality (related to the host), #mortality (measured at the population level), and #pathogenicity (at the cellular level).
We tried to clarify this with @mtsofonea in our review on the evolution of #SarsCoV2 virulence.
