#ba286 — Public Fediverse posts

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

Structural basis for #receptor-binding domain mobility of the #spike in #SARS-CoV-2 #BA286 and #JN1

Source: Nature Communications, AbstractSince 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD in the down-conformation to…

https://etidioh.wordpress.com/2024/10/07/structural-basis-for-receptor-binding-domain-mobility-of-the-spike-in-sars-cov-2-ba286-and-jn1/

Structural basis for #receptor-binding domain mobility of the #spike in #SARS-CoV-2 #BA286 and #JN1

Source: Nature Communications, AbstractSince 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD in the down-conformation to…

https://etidioh.wordpress.com/2024/10/07/structural-basis-for-receptor-binding-domain-mobility-of-the-spike-in-sars-cov-2-ba286-and-jn1/

Structural basis for #receptor-binding domain mobility of the #spike in #SARS-CoV-2 #BA286 and #JN1

Source: Nature Communications, AbstractSince 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD in the down-conformation to…

https://etidioh.wordpress.com/2024/10/07/structural-basis-for-receptor-binding-domain-mobility-of-the-spike-in-sars-cov-2-ba286-and-jn1/

Structural basis for #receptor-binding domain mobility of the #spike in #SARS-CoV-2 #BA286 and #JN1

Source: Nature Communications, AbstractSince 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD in the down-conformation to…

https://etidioh.wordpress.com/2024/10/07/structural-basis-for-receptor-binding-domain-mobility-of-the-spike-in-sars-cov-2-ba286-and-jn1/

Structural basis for #receptor-binding domain mobility of the #spike in #SARS-CoV-2 #BA286 and #JN1

Source: Nature Communications, AbstractSince 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD in the down-conformation to…

https://etidioh.wordpress.com/2024/10/07/structural-basis-for-receptor-binding-domain-mobility-of-the-spike-in-sars-cov-2-ba286-and-jn1/

Immune #escape and attenuated #severity associated with the #SARS-CoV-2 #BA286 / #JN1 #lineage

Source: Nature Communications, AbstractThe SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023–24. However, this surge in infections was not accompanied by COVID-19 hospitalizations and mortality commensurate with prior waves. To understand shifts in COVID-19 epidemiology associated with JN.1…

https://etidioh.wordpress.com/2024/10/03/immune-escape-and-attenuated-severity-associated-with-the-sars-cov-2-ba286-jn1-lineage/

Immune #escape and attenuated #severity associated with the #SARS-CoV-2 #BA286 / #JN1 #lineage

Source: Nature Communications, AbstractThe SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023–24. However, this surge in infections was not accompanied by COVID-19 hospitalizations and mortality commensurate with prior waves. To understand shifts in COVID-19 epidemiology associated with JN.1…

https://etidioh.wordpress.com/2024/10/03/immune-escape-and-attenuated-severity-associated-with-the-sars-cov-2-ba286-jn1-lineage/

Immune #escape and attenuated #severity associated with the #SARS-CoV-2 #BA286 / #JN1 #lineage

Source: Nature Communications, AbstractThe SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023–24. However, this surge in infections was not accompanied by COVID-19 hospitalizations and mortality commensurate with prior waves. To understand shifts in COVID-19 epidemiology associated with JN.1…

https://etidioh.wordpress.com/2024/10/03/immune-escape-and-attenuated-severity-associated-with-the-sars-cov-2-ba286-jn1-lineage/

Immune #escape and attenuated #severity associated with the #SARS-CoV-2 #BA286 / #JN1 #lineage

Source: Nature Communications, AbstractThe SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023–24. However, this surge in infections was not accompanied by COVID-19 hospitalizations and mortality commensurate with prior waves. To understand shifts in COVID-19 epidemiology associated with JN.1…

https://etidioh.wordpress.com/2024/10/03/immune-escape-and-attenuated-severity-associated-with-the-sars-cov-2-ba286-jn1-lineage/

Immune #escape and attenuated #severity associated with the #SARS-CoV-2 #BA286 / #JN1 #lineage

Source: Nature Communications, AbstractThe SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023–24. However, this surge in infections was not accompanied by COVID-19 hospitalizations and mortality commensurate with prior waves. To understand shifts in COVID-19 epidemiology associated with JN.1…

https://etidioh.wordpress.com/2024/10/03/immune-escape-and-attenuated-severity-associated-with-the-sars-cov-2-ba286-jn1-lineage/

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Relative #vaccine #protection, #disease #severity, and #symptoms associated with the #SarsCoV2 #omicron #subvariant #BA286 and descendant #JN1 in #Denmark: a nationwide observational study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00220-2/fulltext?rss=yes

Although less effective against the new variants, XBB.1.5 vaccination remains protective and reduces the risk of infection and COVID-19 disease.

Relative #vaccine #protection, #disease #severity, and #symptoms associated with the #SarsCoV2 #omicron #subvariant #BA286 and descendant #JN1 in #Denmark: a nationwide observational study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00220-2/fulltext?rss=yes

Although less effective against the new variants, XBB.1.5 vaccination remains protective and reduces the risk of infection and COVID-19 disease.

Relative #vaccine #protection, #disease #severity, and #symptoms associated with the #SarsCoV2 #omicron #subvariant #BA286 and descendant #JN1 in #Denmark: a nationwide observational study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00220-2/fulltext?rss=yes

Although less effective against the new variants, XBB.1.5 vaccination remains protective and reduces the risk of infection and COVID-19 disease.

Relative #vaccine #protection, #disease #severity, and #symptoms associated with the #SarsCoV2 #omicron #subvariant #BA286 and descendant #JN1 in #Denmark: a nationwide observational study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00220-2/fulltext?rss=yes

Although less effective against the new variants, XBB.1.5 vaccination remains protective and reduces the risk of infection and COVID-19 disease.

Relative #vaccine #protection, #disease #severity, and #symptoms associated with the #SarsCoV2 #omicron #subvariant #BA286 and descendant #JN1 in #Denmark: a nationwide observational study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00220-2/fulltext?rss=yes

Although less effective against the new variants, XBB.1.5 vaccination remains protective and reduces the risk of infection and COVID-19 disease.

Molecular Evolution #MolEvol identified adaptive evolution of #ba286 lineage in August 2023 (reminder: 32 non-synonymous substitutions, including 22 in Spike, and only 11 synonyms) while still at very low frequency. #ba286 has now come to dominate globally 👇

https://ecoevo.social/@firefoxx66@mstdn.science/111964032240034358

Molecular Evolution #MolEvol identified adaptive evolution of #ba286 lineage in August 2023 (reminder: 32 non-synonymous substitutions, including 22 in Spike, and only 11 synonyms) while still at very low frequency. #ba286 has now come to dominate globally 👇

https://ecoevo.social/@firefoxx66@mstdn.science/111964032240034358

Molecular Evolution #MolEvol identified adaptive evolution of #ba286 lineage in August 2023 (reminder: 32 non-synonymous substitutions, including 22 in Spike, and only 11 synonyms) while still at very low frequency. #ba286 has now come to dominate globally 👇

https://ecoevo.social/@firefoxx66@mstdn.science/111964032240034358

Molecular Evolution #MolEvol identified adaptive evolution of #ba286 lineage in August 2023 (reminder: 32 non-synonymous substitutions, including 22 in Spike, and only 11 synonyms) while still at very low frequency. #ba286 has now come to dominate globally 👇

https://ecoevo.social/@firefoxx66@mstdn.science/111964032240034358

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

#Memory T #cells effectively recognize the #SARS-CoV-2 hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00505-X?rss=yes

• SARS-CoV-2 spike-specific T cells are profiled in healthy individuals and CLL patients
• T cell cross-recognition of mutated BA.2.86 spike epitopes is largely preserved
• BA.2.86-reactive T cells display features of high functional capacity

#Memory T #cells effectively recognize the #SARS-CoV-2 hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00505-X?rss=yes

• SARS-CoV-2 spike-specific T cells are profiled in healthy individuals and CLL patients
• T cell cross-recognition of mutated BA.2.86 spike epitopes is largely preserved
• BA.2.86-reactive T cells display features of high functional capacity

#Memory T #cells effectively recognize the #SARS-CoV-2 hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00505-X?rss=yes

• SARS-CoV-2 spike-specific T cells are profiled in healthy individuals and CLL patients
• T cell cross-recognition of mutated BA.2.86 spike epitopes is largely preserved
• BA.2.86-reactive T cells display features of high functional capacity

#Memory T #cells effectively recognize the #SARS-CoV-2 hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00505-X?rss=yes

• SARS-CoV-2 spike-specific T cells are profiled in healthy individuals and CLL patients
• T cell cross-recognition of mutated BA.2.86 spike epitopes is largely preserved
• BA.2.86-reactive T cells display features of high functional capacity

#Memory T #cells effectively recognize the #SARS-CoV-2 hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00505-X?rss=yes

• SARS-CoV-2 spike-specific T cells are profiled in healthy individuals and CLL patients
• T cell cross-recognition of mutated BA.2.86 spike epitopes is largely preserved
• BA.2.86-reactive T cells display features of high functional capacity

Postpandemic #memory T #cell response to #SARS-CoV-2 is durable, broadly targeted, & cross-reactive to hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00498-5?rss=yes

-- Spike-specific T cell memory responses are maintained into post-pandemic period
• T cell cross-recognition is preserved against highly mutated variants such as BA.2.86
• Even prior to Omicron infection, reactivity to Omicron sub-lineages is conserved
• Robust nucleocapsid- and membrane-specific T cells enlarge total T cell response

Postpandemic #memory T #cell response to #SARS-CoV-2 is durable, broadly targeted, & cross-reactive to hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00498-5?rss=yes

-- Spike-specific T cell memory responses are maintained into post-pandemic period
• T cell cross-recognition is preserved against highly mutated variants such as BA.2.86
• Even prior to Omicron infection, reactivity to Omicron sub-lineages is conserved
• Robust nucleocapsid- and membrane-specific T cells enlarge total T cell response

Postpandemic #memory T #cell response to #SARS-CoV-2 is durable, broadly targeted, & cross-reactive to hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00498-5?rss=yes

-- Spike-specific T cell memory responses are maintained into post-pandemic period
• T cell cross-recognition is preserved against highly mutated variants such as BA.2.86
• Even prior to Omicron infection, reactivity to Omicron sub-lineages is conserved
• Robust nucleocapsid- and membrane-specific T cells enlarge total T cell response

Postpandemic #memory T #cell response to #SARS-CoV-2 is durable, broadly targeted, & cross-reactive to hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00498-5?rss=yes

-- Spike-specific T cell memory responses are maintained into post-pandemic period
• T cell cross-recognition is preserved against highly mutated variants such as BA.2.86
• Even prior to Omicron infection, reactivity to Omicron sub-lineages is conserved
• Robust nucleocapsid- and membrane-specific T cells enlarge total T cell response

Postpandemic #memory T #cell response to #SARS-CoV-2 is durable, broadly targeted, & cross-reactive to hypermutated #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00498-5?rss=yes

-- Spike-specific T cell memory responses are maintained into post-pandemic period
• T cell cross-recognition is preserved against highly mutated variants such as BA.2.86
• Even prior to Omicron infection, reactivity to Omicron sub-lineages is conserved
• Robust nucleocapsid- and membrane-specific T cells enlarge total T cell response

Good Morning SARS2PAians!

I hope you're enjoying the milder weather and staying safe. :canparrot:

__________
VOCs

Nationally, nothing really new. JN.1 everywhere, all over the place. Still over 80% of randomly tested sampling.: https://ibb.co/r6wyHdy

In PA, Same thing, reflecting national levels.: https://ibb.co/b78MGWY

There is nothing so far on the mutation horizon that can compete with JN.1. As always there are a few concerning mutations out there, but sample numbers are low and variant hunters have not sent out any immediate warning signals.

__________
Wastewater

Nationally, SARS2 matierial found in wastewater starting to take an unpleasant upturn again. 😓: https://ibb.co/PQkNZs6

Regionally, the decline in levels has evened out again across all non-Eastern regions, and levels are rising in our area.: https://ibb.co/XWGNB1r

In PA,levels rising slightly in Bucks and ChesterCo areas but heeeeeey Lackawanna, please stay safe and use some form of source control! Levels are waaaay up over there.: https://ibb.co/8XLYRgb

The PA Wastewater dashboard has levels staying level for now except in the West Chester area.: https://ibb.co/C0BX4tY

__________
CDC

The New Admits map is looking pretty good, except in the center fo the State and again in SchuylkillCo and the rest of the old coal region west of there, where level increases are substantial. Seems like this rather isolated area still has cases filtering through the health system.: https://ibb.co/vDM2rRL

Lancaster Co also showing significant increases.

The Inpatient Bed map also looking better, with some elevated counties up by Potter Co there, also somewhat in Berks. Nothing substantial which is.....OK.: https://ibb.co/12hc0HV

ICU bed use increased substantially in the center of the State (along I-80-ish) in CentreCo and counties west oif there, with smaller increses east of there too.: https://ibb.co/DMskC0W

Berks showing isngificant increases in ICU use. Berks/Lancaster seem to be having a tough time this winter. Please be safe there, get your most current COVID vaccinations and use source control! Don't become a statistic!

Overall, the northern half of the US, including PA, is doing fairly well in controlling ILIs (influenza-like infections).: https://ibb.co/RvkZ8Hw

Keep practing SOME form of source control (wearing a quality respirator, staying home when sick, do NOT send sick kids to school, avoiding large crowds, aware of social contacts, run those air purifiers, wash hands often to control non-SARS stuff like flu/norovirus etc.) and if we all do SOMETHING then we can keep this controlled for the arrival of Spring! 💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Good Morning SARS2PAians!

I hope you're enjoying the milder weather and staying safe. :canparrot:

__________
VOCs

Nationally, nothing really new. JN.1 everywhere, all over the place. Still over 80% of randomly tested sampling.: https://ibb.co/r6wyHdy

In PA, Same thing, reflecting national levels.: https://ibb.co/b78MGWY

There is nothing so far on the mutation horizon that can compete with JN.1. As always there are a few concerning mutations out there, but sample numbers are low and variant hunters have not sent out any immediate warning signals.

__________
Wastewater

Nationally, SARS2 matierial found in wastewater starting to take an unpleasant upturn again. 😓: https://ibb.co/PQkNZs6

Regionally, the decline in levels has evened out again across all non-Eastern regions, and levels are rising in our area.: https://ibb.co/XWGNB1r

In PA,levels rising slightly in Bucks and ChesterCo areas but heeeeeey Lackawanna, please stay safe and use some form of source control! Levels are waaaay up over there.: https://ibb.co/8XLYRgb

The PA Wastewater dashboard has levels staying level for now except in the West Chester area.: https://ibb.co/C0BX4tY

__________
CDC

The New Admits map is looking pretty good, except in the center fo the State and again in SchuylkillCo and the rest of the old coal region west of there, where level increases are substantial. Seems like this rather isolated area still has cases filtering through the health system.: https://ibb.co/vDM2rRL

Lancaster Co also showing significant increases.

The Inpatient Bed map also looking better, with some elevated counties up by Potter Co there, also somewhat in Berks. Nothing substantial which is.....OK.: https://ibb.co/12hc0HV

ICU bed use increased substantially in the center of the State (along I-80-ish) in CentreCo and counties west oif there, with smaller increses east of there too.: https://ibb.co/DMskC0W

Berks showing isngificant increases in ICU use. Berks/Lancaster seem to be having a tough time this winter. Please be safe there, get your most current COVID vaccinations and use source control! Don't become a statistic!

Overall, the northern half of the US, including PA, is doing fairly well in controlling ILIs (influenza-like infections).: https://ibb.co/RvkZ8Hw

Keep practing SOME form of source control (wearing a quality respirator, staying home when sick, do NOT send sick kids to school, avoiding large crowds, aware of social contacts, run those air purifiers, wash hands often to control non-SARS stuff like flu/norovirus etc.) and if we all do SOMETHING then we can keep this controlled for the arrival of Spring! 💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Good Morning SARS2PAians!

I hope you're enjoying the milder weather and staying safe. :canparrot:

__________
VOCs

Nationally, nothing really new. JN.1 everywhere, all over the place. Still over 80% of randomly tested sampling.: https://ibb.co/r6wyHdy

In PA, Same thing, reflecting national levels.: https://ibb.co/b78MGWY

There is nothing so far on the mutation horizon that can compete with JN.1. As always there are a few concerning mutations out there, but sample numbers are low and variant hunters have not sent out any immediate warning signals.

__________
Wastewater

Nationally, SARS2 matierial found in wastewater starting to take an unpleasant upturn again. 😓: https://ibb.co/PQkNZs6

Regionally, the decline in levels has evened out again across all non-Eastern regions, and levels are rising in our area.: https://ibb.co/XWGNB1r

In PA,levels rising slightly in Bucks and ChesterCo areas but heeeeeey Lackawanna, please stay safe and use some form of source control! Levels are waaaay up over there.: https://ibb.co/8XLYRgb

The PA Wastewater dashboard has levels staying level for now except in the West Chester area.: https://ibb.co/C0BX4tY

__________
CDC

The New Admits map is looking pretty good, except in the center fo the State and again in SchuylkillCo and the rest of the old coal region west of there, where level increases are substantial. Seems like this rather isolated area still has cases filtering through the health system.: https://ibb.co/vDM2rRL

Lancaster Co also showing significant increases.

The Inpatient Bed map also looking better, with some elevated counties up by Potter Co there, also somewhat in Berks. Nothing substantial which is.....OK.: https://ibb.co/12hc0HV

ICU bed use increased substantially in the center of the State (along I-80-ish) in CentreCo and counties west oif there, with smaller increses east of there too.: https://ibb.co/DMskC0W

Berks showing isngificant increases in ICU use. Berks/Lancaster seem to be having a tough time this winter. Please be safe there, get your most current COVID vaccinations and use source control! Don't become a statistic!

Overall, the northern half of the US, including PA, is doing fairly well in controlling ILIs (influenza-like infections).: https://ibb.co/RvkZ8Hw

Keep practing SOME form of source control (wearing a quality respirator, staying home when sick, do NOT send sick kids to school, avoiding large crowds, aware of social contacts, run those air purifiers, wash hands often to control non-SARS stuff like flu/norovirus etc.) and if we all do SOMETHING then we can keep this controlled for the arrival of Spring! 💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Good Morning SARS2PAians!

I hope you're enjoying the milder weather and staying safe. :canparrot:

__________
VOCs

Nationally, nothing really new. JN.1 everywhere, all over the place. Still over 80% of randomly tested sampling.: https://ibb.co/r6wyHdy

In PA, Same thing, reflecting national levels.: https://ibb.co/b78MGWY

There is nothing so far on the mutation horizon that can compete with JN.1. As always there are a few concerning mutations out there, but sample numbers are low and variant hunters have not sent out any immediate warning signals.

__________
Wastewater

Nationally, SARS2 matierial found in wastewater starting to take an unpleasant upturn again. 😓: https://ibb.co/PQkNZs6

Regionally, the decline in levels has evened out again across all non-Eastern regions, and levels are rising in our area.: https://ibb.co/XWGNB1r

In PA,levels rising slightly in Bucks and ChesterCo areas but heeeeeey Lackawanna, please stay safe and use some form of source control! Levels are waaaay up over there.: https://ibb.co/8XLYRgb

The PA Wastewater dashboard has levels staying level for now except in the West Chester area.: https://ibb.co/C0BX4tY

__________
CDC

The New Admits map is looking pretty good, except in the center fo the State and again in SchuylkillCo and the rest of the old coal region west of there, where level increases are substantial. Seems like this rather isolated area still has cases filtering through the health system.: https://ibb.co/vDM2rRL

Lancaster Co also showing significant increases.

The Inpatient Bed map also looking better, with some elevated counties up by Potter Co there, also somewhat in Berks. Nothing substantial which is.....OK.: https://ibb.co/12hc0HV

ICU bed use increased substantially in the center of the State (along I-80-ish) in CentreCo and counties west oif there, with smaller increses east of there too.: https://ibb.co/DMskC0W

Berks showing isngificant increases in ICU use. Berks/Lancaster seem to be having a tough time this winter. Please be safe there, get your most current COVID vaccinations and use source control! Don't become a statistic!

Overall, the northern half of the US, including PA, is doing fairly well in controlling ILIs (influenza-like infections).: https://ibb.co/RvkZ8Hw

Keep practing SOME form of source control (wearing a quality respirator, staying home when sick, do NOT send sick kids to school, avoiding large crowds, aware of social contacts, run those air purifiers, wash hands often to control non-SARS stuff like flu/norovirus etc.) and if we all do SOMETHING then we can keep this controlled for the arrival of Spring! 💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Good Morning SARS2PAians!

I hope you're enjoying the milder weather and staying safe. :canparrot:

__________
VOCs

Nationally, nothing really new. JN.1 everywhere, all over the place. Still over 80% of randomly tested sampling.: https://ibb.co/r6wyHdy

In PA, Same thing, reflecting national levels.: https://ibb.co/b78MGWY

There is nothing so far on the mutation horizon that can compete with JN.1. As always there are a few concerning mutations out there, but sample numbers are low and variant hunters have not sent out any immediate warning signals.

__________
Wastewater

Nationally, SARS2 matierial found in wastewater starting to take an unpleasant upturn again. 😓: https://ibb.co/PQkNZs6

Regionally, the decline in levels has evened out again across all non-Eastern regions, and levels are rising in our area.: https://ibb.co/XWGNB1r

In PA,levels rising slightly in Bucks and ChesterCo areas but heeeeeey Lackawanna, please stay safe and use some form of source control! Levels are waaaay up over there.: https://ibb.co/8XLYRgb

The PA Wastewater dashboard has levels staying level for now except in the West Chester area.: https://ibb.co/C0BX4tY

__________
CDC

The New Admits map is looking pretty good, except in the center fo the State and again in SchuylkillCo and the rest of the old coal region west of there, where level increases are substantial. Seems like this rather isolated area still has cases filtering through the health system.: https://ibb.co/vDM2rRL

Lancaster Co also showing significant increases.

The Inpatient Bed map also looking better, with some elevated counties up by Potter Co there, also somewhat in Berks. Nothing substantial which is.....OK.: https://ibb.co/12hc0HV

ICU bed use increased substantially in the center of the State (along I-80-ish) in CentreCo and counties west oif there, with smaller increses east of there too.: https://ibb.co/DMskC0W

Berks showing isngificant increases in ICU use. Berks/Lancaster seem to be having a tough time this winter. Please be safe there, get your most current COVID vaccinations and use source control! Don't become a statistic!

Overall, the northern half of the US, including PA, is doing fairly well in controlling ILIs (influenza-like infections).: https://ibb.co/RvkZ8Hw

Keep practing SOME form of source control (wearing a quality respirator, staying home when sick, do NOT send sick kids to school, avoiding large crowds, aware of social contacts, run those air purifiers, wash hands often to control non-SARS stuff like flu/norovirus etc.) and if we all do SOMETHING then we can keep this controlled for the arrival of Spring! 💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Update for 2/02/2024!

Good Morning SARS2PAians!

I hope you're staying dry with all this winter rain! (Sorry I haven't mirrored on Fedi for a while, i had major important stuff going on.)

There's no new CDC stuff today, but also not much new info to write about in total, JN.1.11 doesn't seem to be taking off right now, and numbers are still doing very well in spite of colder weather (when air cleaning and freshening is a bit more difficult).

THIS IS GOOD! I don't want to have any more news here ever! 🎊

__________
VOCs

Nationally, nothing different yet. JN.1 and JN.1.4 still at the top. JN.1.11 still way down at 0.13% and though it's in 5 states and a few more sequences have been found, it hasn't risen above 1% yet.: https://ibb.co/wgZHftH

__________
Wastewater

Nationally, the decline is starting to level off a bit. Hopefully it continues down after more data is collected.: https://ibb.co/MkcDDX5

Regionally, the West is ticking a bit upwards while everyone else is levelling off.: https://ibb.co/kXdhcTJ

In PA, the 5 stations reporting to Biobot are still doing fabulously. Luzerne and Lackawanna still quite above the national average though.: https://ibb.co/M1KzWJy

According to PA's own wastewater monitoring site numbers are holding steady through the state except thre's an uptick in Franklin Co and over by Pottstown.: https://ibb.co/n3hfVrY

FranklinCo: https://ibb.co/VCb9Z9N

Pottstown: https://ibb.co/0Jg6Gy8

Please use caution to keep these numbers from going back up and causing life, learning, and financial loss.

I just want to shoutout Erie Co since I lost track of there, Erie doesn't report to Biobot but it IS on the PA Wastewater dashboard.

It's not only that Erie's numbers are low, it's that (except for a post-holiday small rise) the absolute baseline there is going down!! Look at that. : https://ibb.co/RyVt4bn

That's amazing. Every county, State, and territories' chart should look like this.

:canparrot: :canparrot: Thank you Erie! :canparrot: :canparrot:

Another short update is a good update. Please keep using caution especially with at-risk people and in large public gatherings. Wear a quality respirator in places where there is tightly enclosed space with little ventilation (elevators, restrooms, large public closets, etc.)

Keep that air fresh and clean and we'll be fantastic by Spring! ❄️❄️🌷

#JN1Eleven

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater