#subvariants — Public Fediverse posts

#Pathogenicity of #SARS-CoV-2 #Omicron #Subvariants #JN.1, #KP.2, and #EG.5.1 in K18-hACE2 Transgenic #Mice, https://etidiohnew.blogspot.com/2025/08/pathogenicity-of-sars-cov-2-omicron.html

#Pathogenicity of #SARS-CoV-2 #Omicron #Subvariants #JN.1, #KP.2, and #EG.5.1 in K18-hACE2 Transgenic #Mice, https://etidiohnew.blogspot.com/2025/08/pathogenicity-of-sars-cov-2-omicron.html

#Pathogenicity of #SARS-CoV-2 #Omicron #Subvariants #JN.1, #KP.2, and #EG.5.1 in K18-hACE2 Transgenic #Mice, https://etidiohnew.blogspot.com/2025/08/pathogenicity-of-sars-cov-2-omicron.html

#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1

Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.

#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1

Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.

#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1

Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.

#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1

Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.

#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1

Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.

#Durability of #XBB15 #Vaccines against #Omicron #Subvariants, N Engl J Med.: https://www.nejm.org/doi/full/10.1056/NEJMc2402779?query=TOC&cid=DM2342986_Non_Subscriber&bid=-1971795569

Overall, the XBB.1.5 vaccines were effective against omicron subvariants, although less so against #JN1. Effectiveness was greater against #hospitalization and #death than against infection, and it waned moderately from its peak over time. The ramping and waning patterns were broadly similar to those of the bivalent boosters against BQ.1–BQ.1.1 and XBB–XBB.1.5.3

Characteristics of #JN1-derived #SarsCoV2 #subvariants #SLip, #FLiRT, and #KP2 in neutralization #escape, #infectivity and membrane #fusion http://biorxiv.org/cgi/content/short/2024.05.20.595020v1?rss=1

Interestingly, #antibodies in #XBB15 monovalent vaccinated hamster sera robustly neutralized FLiRT and KP.2 but had reduced efficiency for SLip.

Characteristics of #JN1-derived #SarsCoV2 #subvariants #SLip, #FLiRT, and #KP2 in neutralization #escape, #infectivity and membrane #fusion http://biorxiv.org/cgi/content/short/2024.05.20.595020v1?rss=1

Interestingly, #antibodies in #XBB15 monovalent vaccinated hamster sera robustly neutralized FLiRT and KP.2 but had reduced efficiency for SLip.

Characteristics of #JN1-derived #SarsCoV2 #subvariants #SLip, #FLiRT, and #KP2 in neutralization #escape, #infectivity and membrane #fusion http://biorxiv.org/cgi/content/short/2024.05.20.595020v1?rss=1

Interestingly, #antibodies in #XBB15 monovalent vaccinated hamster sera robustly neutralized FLiRT and KP.2 but had reduced efficiency for SLip.

Characteristics of #JN1-derived #SarsCoV2 #subvariants #SLip, #FLiRT, and #KP2 in neutralization #escape, #infectivity and membrane #fusion http://biorxiv.org/cgi/content/short/2024.05.20.595020v1?rss=1

Interestingly, #antibodies in #XBB15 monovalent vaccinated hamster sera robustly neutralized FLiRT and KP.2 but had reduced efficiency for SLip.

Characteristics of #JN1-derived #SarsCoV2 #subvariants #SLip, #FLiRT, and #KP2 in neutralization #escape, #infectivity and membrane #fusion http://biorxiv.org/cgi/content/short/2024.05.20.595020v1?rss=1

Interestingly, #antibodies in #XBB15 monovalent vaccinated hamster sera robustly neutralized FLiRT and KP.2 but had reduced efficiency for SLip.

[Correspondence] Antiviral humoral #immunity against #SARS-CoV-2 #omicron #subvariants induced by #XBB15 monovalent #vaccine in #infection-naive and XBB-infected individuals https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00784-3/fulltext?rss=yes

''Circulation of the #VUM #BA286 is now at 0.2% at national level.'' #italy #subvariants #SARS_COV_2 #update #report

[Correspondence] #Antibody #neutralisation of emerging #SARS-CoV-2 #subvariants: #EG51 and #XBC16 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00555-8/fulltext?rss=yes #research #covid19 #australia

[Correspondence] #Antibody #neutralisation of emerging #SARS-CoV-2 #subvariants: #EG51 and #XBC16 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00555-8/fulltext?rss=yes #research #covid19 #australia

[Correspondence] #Antibody #neutralisation of emerging #SARS-CoV-2 #subvariants: #EG51 and #XBC16 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00555-8/fulltext?rss=yes #research #covid19 #australia

Fall COVID shots will boost protection against latest subvariants, Moderna says - Enlarge / A vial containing Moderna COVID-19 booster vaccine at a vacci... - https://arstechnica.com/?p=1961809 #subvariants #sars-cov-2 #covid-19 #fl.1.5.1 #science #booster #moderna #vaccine #xbb.1.5 #health #pfizer #eg.5 #cdc #fda #who

[Correspondence] #Bivalent #COVID19 #mRNA #vaccine against #omicron #subvariants in immunocompromised patients https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00357-2/fulltext?rss=yes #immunology #publichealth #epidemiology

[Correspondence] #Bivalent #COVID19 #mRNA #vaccine against #omicron #subvariants in immunocompromised patients https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00357-2/fulltext?rss=yes #immunology #publichealth #epidemiology

[Correspondence] #Bivalent #COVID19 #mRNA #vaccine against #omicron #subvariants in immunocompromised patients https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00357-2/fulltext?rss=yes #immunology #publichealth #epidemiology

The First Case of #CoInfection with #Omicron #Subvariants #BA5248 and #BF714 — #Chongqing Municipality, #China, February 2023, CCDC: http://dx.doi.org/10.46234/ccdcw2023.046

Annual? Bivalent? For all? Future of COVID shots murky after FDA deliberations - Enlarge / Dr. Peter Marks, director of the Center for Biologics Evaluat... - https://arstechnica.com/?p=1913210 #covid-19vaccines #subvariants #sars-cov-2 #covid-19 #science #omicron #vaccine #fda

People aren’t taking this seriously’: experts say US Covid surge is big risk

In the fourth #year of the pandemic, #Covid-19 is once again spreading across #America and being driven by the recent holidays, fewer precautions and the continuing evolution of Omicron #subvariants of the virus.
New sub-variants are causing concern for their #increased #transmissibility.

https://www.theguardian.com/world/2023/jan/15/covid-19-coronavirus-us-surge-complacency

The BQ and XBB subvariants of COVID are what medical scientists classify as levels 6 and 7 variants.

It is known that these variants can surpass our immune system, meaning those who previously contracted the omicron variant or who have received the bivalent booster (the 4th dose) will still contract these new variants.

The bottom line is, you need to wear an N95 face mask to avoid contracting COVID.

#facemask #covid #subvariants

https://publichealth.jhu.edu/2022/a-bleak-winter-modeling-the-next-six-months-of-covid-flu-and-rsv

https://www.cell.com/cell/pdf/S0092-8674(22)01531-8.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015318%3Fshowall%3Dtrue

''#BQ1 and #XBB are new #subvariants of #Omicron which have become the dominant strains in some overseas countries and regions for their increased #transmissibility and immune escape capacity. ''

#China, #Shanghai has detected the #Omicron #subvariants #BQ1 and #XBB that have been prevailing in some overseas countries but experts said 2 strains were found in imported cases placed under closed-loop management which has not caused local #transmission, saying there is no need to hoard Montmorillonite {?} powder to relieve #diarrhea that can be caused by subvariant #XBB15. GT: https://www.globaltimes.cn/page/202301/1283058.shtml

@vigilance

#immune #escape #vocs / #sarscov2 #variants / #omikron #subvariants

https://www.cell.com/cell/fulltext/S0092-8674%2822%2901531-8

⬆️
@whn

@vigilance
#immune #escape #variants iof #sarscov2 #omikron #subvariants

https://www.news-medical.net/amp/news/20221216/SARS-CoV-2-Omicron-BQ-and-XBB-subvariants-show-exceptional-immune-evasion-properties.aspx

⬆️
@whn

Subvariants spreading "....like shrapnel."

https://www.tiktok.com/t/ZTRq6S71F/

#Covid19
#SARSCoV
#Omicron #subvariants

Three currently circulating #omicron #subvariants of #SARS-CoV-2 – including two that currently make up almost 50% of reported #COVID-19 infections in the U.S. – are better at evading #vaccine and infection-generated neutralizing #antibodies than earlier versions of omicron, new research suggests.
#COVID19 #Virology #Microbiology #sflorg
https://www.sflorg.com/2022/11/vi11222202.html

Bivalent booster is 4x better against BA.5 in older adults, Pfizer says - Enlarge (credit: Getty | Future Publishing)

The new bivalent C... - https://arstechnica.com/?p=1895502 #infectiousdisease #antibodylevels #publichealth #olderadults #sublineages #subvariants #vaccination #antibodies #sars-cov-2 #biontech #bivalent #covid-19 #medicine #vaccines #science #biology #booster #omicron #viruses #bq.1.1 #pfizer #ba.4 #ba.5 #bq.1

With help from BA.5, new COVID hospitalizations quadrupled since April - Enlarge / A thrown-away surgical mask lays on the ground. (credit: Gett... - https://arstechnica.com/?p=1871427 #infectiousdisease #hospitalizations #publichealth #transmission #subvariants #sars-cov-2 #covid-19 #medicine #science #biology #booster #omicron #vaccine #deaths #ba.5

Moderna to make two different omicron boosters: one for US, another for UK, EU - Enlarge / A vial containing Moderna COVID-19 booster vaccine at a vacci... - https://arstechnica.com/?p=1865716 #subvariants #covid-19 #variants #science #booster #moderna #omicron #vaccine #cdc #fda

FDA calls for fall boosters against BA.4/5 as subvariants take over US - Enlarge / Dr. Peter Marks, director of the Center for Biologics Evaluat... - https://arstechnica.com/?p=1863897 #pfizer/biontech #subvariants #boosters #covid-19 #medicine #variants #science #biology #moderna #omicron #vaccine #pfizer #ba.4 #ba.5 #fda

BA.4/BA.5 will soon be dominant in the US. Here’s what that means - Enlarge / A COVID-19 testing tent stands in Times Square on April 27, 2... - https://arstechnica.com/?p=1862621 #coronavirus #subvariants #sars-cov-2 #covid-19 #medicine #variants #science #biology #omicron #helix #ba.4 #ba.5 #cdc

EU warns of BA.4/BA.5 uprising, braces for next wave of cases - Enlarge / Members of the public queue outside a pharmacy to receive COV... - https://arstechnica.com/?p=1860620 #infectiousdisease #publichealth #subvariants #ba.2.12.1 #boosters #covid-19 #medicine #vaccines #science #biology #ba.2 #ba.4 #ba.5 #ecdc #cdc

Moderna’s omicron-combo booster outcompetes current booster - Enlarge / A vial of the current Moderna COVID-19 vaccine. (credit: Gett... - https://arstechnica.com/?p=1859888 #infectiousdisease #subvariants #bivalent #covid-19 #variants #science #booster #moderna #omicron #vaccine #fda