#eg51 — Public Fediverse posts

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

Immunogenicity and #efficacy of #XBB15 rS #vaccine against the #EG51 #variant of #SARS-CoV-2 in Syrian #hamsters, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00528-24?af=R

Thus, based on these study results, the protein-based XBB.1.5 vaccine is immunogenic and increased the breadth of protection against the Omicron EG.5.1 variant in the Syrian hamster model.

Increased #pathogenicity {in animal models} and #transmission of #SarsCoV2 #Omicron #XBB19 #sublineage, including #HK3 and #EG51, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.10.598324v1?rss=1

HK.3 and EG.5.1 exhibited greater pathogenicity than XBB.1.9.1 and BA.2 in H11-K18-hACE2 #hamsters. Our studies provide insight into the newly emerging #pathogens HK.3 and EG.5.1.

Evaluating #Humoral #Immunity Elicited by #XBB15 Monovalent #COVID19 #Vaccine, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/6/24-0051_article

We report boosting of #IgG (2.1×), #IgA (1.5×), and total IgG/A/M (1.7×) targeting the #spike receptor-binding domain and neutralizing titers against WA1 (2.2×), XBB.1.5 (7.4×), #EG51 (10.5×), and #JN1 (4.7×) variants.

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

𝗟𝗔𝗧𝗘𝗦𝗧 𝗨𝗞 #COVID19

🧪𝗖𝗮𝘀𝗲𝘀 — weekly
🔻6,117

🧮𝗧𝗼𝗽 𝗩𝗮𝗿𝗶𝗮𝗻𝘁𝘀
#JN1 #HV1 #EG51

🏥𝗛𝗼𝘀𝗽𝗶𝘁𝗮𝗹 𝗔𝗱𝗺𝗶𝘀𝘀𝗶𝗼𝗻𝘀 — weekly
🔻3,298

🕯️𝗗𝗲𝗮𝘁𝗵𝘀 — weekly
🔺301

🕯️𝗧𝗢𝗧𝗔𝗟 𝗗𝗲𝗮𝘁𝗵𝘀
🔺235,028

➡️http://PMP-Magazine.com/covid-19-today/

#COVIDisNotOver 😷

Characterization of a #SARS-CoV-2 #EG51 clinical isolate in vitro and in vivo https://pubmed.ncbi.nlm.nih.gov/38103202/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1lW0W_7uVpSIXMTzSBRwBwOZtB440RAJy7PjxSAyNIBZDMxMlI&fc=None&ff=20231217114409&v=2.18.0

''Omicron #XBB15 #vaccine on days 8–10 strongly + anti-S #IgG in all vaccinees & elicited potent neutralising responses vs previous & contemporary SARS-CoV-2 lineages, including #EG51 & #BA286. ... updated monovalent vaccine mRNA-1273.815 ... also increased nAbs titres against XBB sublineages in manufacturer preprint data. ...these data suggest that XBB.1.5-containing mRNA vax most likely increase protection vs COVID19 caused by currently circulating XBB subv. and emerging BA.2.86.''

[Correspondence] Virus #isolation and #neutralisation of #SARS-CoV-2 #variants #BA286 and #EG51 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00682-5/fulltext?rss=yes

[Correspondence] Virus #isolation and #neutralisation of #SARS-CoV-2 #variants #BA286 and #EG51 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00682-5/fulltext?rss=yes

[Correspondence] Virus #isolation and #neutralisation of #SARS-CoV-2 #variants #BA286 and #EG51 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00682-5/fulltext?rss=yes

[Correspondence] Virus #isolation and #neutralisation of #SARS-CoV-2 #variants #BA286 and #EG51 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00682-5/fulltext?rss=yes

[Correspondence] Virus #isolation and #neutralisation of #SARS-CoV-2 #variants #BA286 and #EG51 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00682-5/fulltext?rss=yes

Corona-Variante „Eris“ kann Antikörpern besser entkommen. Neue Erkenntnisse zur Corona-Variante EG.5.1 und ihrer Fähigkeit zur Immunflucht. #Eris #Corona #EG51 #SARSCoV2 #Pandemie
https://www.scinexx.de/news/medizin/corona-variante-eris-kann-antikoerpern-besser-entkommen/

[Correspondence] #Neutralisation sensitivity of #SARS-CoV-2 lineages #EG51 and #XBB23 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00547-9/fulltext?rss=yes #research #variants #VOIs #antibodies

[Correspondence] #Neutralisation sensitivity of #SARS-CoV-2 lineages #EG51 and #XBB23 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00547-9/fulltext?rss=yes #research #variants #VOIs #antibodies

[Correspondence] #Neutralisation sensitivity of #SARS-CoV-2 lineages #EG51 and #XBB23 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00547-9/fulltext?rss=yes #research #variants #VOIs #antibodies

[Correspondence] #Antibody #neutralisation of emerging #SARS-CoV-2 #subvariants: #EG51 and #XBC16 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00555-8/fulltext?rss=yes #research #covid19 #australia

[Correspondence] #Antibody #neutralisation of emerging #SARS-CoV-2 #subvariants: #EG51 and #XBC16 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00555-8/fulltext?rss=yes #research #covid19 #australia

[Correspondence] #Antibody #neutralisation of emerging #SARS-CoV-2 #subvariants: #EG51 and #XBC16 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00555-8/fulltext?rss=yes #research #covid19 #australia

''In fact, our #epidemic #dynamics analyses showed that #EG51 exhibits a higher effective reproduction number (Re) compared with #XBB15, #XBB116, and its parental lineage (XBB.1.9.2), suggesting that EG.5.1 will spread globally and outcompete these XBB subvariants in the near future''

''In fact, our #epidemic #dynamics analyses showed that #EG51 exhibits a higher effective reproduction number (Re) compared with #XBB15, #XBB116, and its parental lineage (XBB.1.9.2), suggesting that EG.5.1 will spread globally and outcompete these XBB subvariants in the near future''

''In fact, our #epidemic #dynamics analyses showed that #EG51 exhibits a higher effective reproduction number (Re) compared with #XBB15, #XBB116, and its parental lineage (XBB.1.9.2), suggesting that EG.5.1 will spread globally and outcompete these XBB subvariants in the near future''

Promoting to @novid

Promising news about the upcoming COVID boosters!

H/T @erictopol

#COVID #COVIDVaccine #COVIDBooster #COVIDIsNotOver #WearAMask #XBB #BA286 #EG51 https://mstdn.social/@erictopol/111026999351394228

''Data from July 31 to August 06, a rise in the incidence of several #VOIs has been observed, especially those belonging to #EG5 (a subvariant of #XBB192 with the additional Spike mutation: F456L), #XBB116 and #XBB1166 (with Spike mutation F456L). In particular, among sequenced viruses, #EG5 represented 32,4% (#EG51, 18,9%; #EG511,
13,5%); #XBB116 (18,9%) and XBB.1.16.6, 16,2%.''

''Data from July 31 to August 06, a rise in the incidence of several #VOIs has been observed, especially those belonging to #EG5 (a subvariant of #XBB192 with the additional Spike mutation: F456L), #XBB116 and #XBB1166 (with Spike mutation F456L). In particular, among sequenced viruses, #EG5 represented 32,4% (#EG51, 18,9%; #EG511,
13,5%); #XBB116 (18,9%) and XBB.1.16.6, 16,2%.''

''Data from July 31 to August 06, a rise in the incidence of several #VOIs has been observed, especially those belonging to #EG5 (a subvariant of #XBB192 with the additional Spike mutation: F456L), #XBB116 and #XBB1166 (with Spike mutation F456L). In particular, among sequenced viruses, #EG5 represented 32,4% (#EG51, 18,9%; #EG511,
13,5%); #XBB116 (18,9%) and XBB.1.16.6, 16,2%.''

''Data from July 31 to August 06, a rise in the incidence of several #VOIs has been observed, especially those belonging to #EG5 (a subvariant of #XBB192 with the additional Spike mutation: F456L), #XBB116 and #XBB1166 (with Spike mutation F456L). In particular, among sequenced viruses, #EG5 represented 32,4% (#EG51, 18,9%; #EG511,
13,5%); #XBB116 (18,9%) and XBB.1.16.6, 16,2%.''

''Data from July 31 to August 06, a rise in the incidence of several #VOIs has been observed, especially those belonging to #EG5 (a subvariant of #XBB192 with the additional Spike mutation: F456L), #XBB116 and #XBB1166 (with Spike mutation F456L). In particular, among sequenced viruses, #EG5 represented 32,4% (#EG51, 18,9%; #EG511,
13,5%); #XBB116 (18,9%) and XBB.1.16.6, 16,2%.''

Ein Update in meinem Blog #AllCoronavirusesAreBastards nach meinem Urlaub.

▪️ Der Beginn der neuen #COVID19 Welle
▪️ Die Varianten #EG51 und #FLip
▪️ Ende der #LongCovid Ambulanz der #MedUniWien
▪️ Was geschah mit dem Querdenker Reiner #Fuellmich?

https://allcoronavirusesarebastards.substack.com/p/der-beginn-der-neuesten-covid-19

New coronavirus variant EG.5 gains momentum in Japan.

🔹EG.5 nearly doubled in July to account for 22% of cases in the capital.

🔹EG.5.1 will account for 46% of all cases in Japan in the week through to Sunday.

#COVID19 #Japan #Eris #EG5 #EG51 @auscovid19

Source: https://www.japantimes.co.jp/japan/2023/08/14/science-health/new-coronavirus-variant-eg5-gains-momentum-in-japan/

The WHO is currently monitoring Eris’ spread but was hindered by a drop off in genomic sequencing and sharing of information between countries.

In the past month, only 25% of countries and territories have reported COVID-19 deaths to WHO and only 11% have reported hospitalisations and ICU admissions,” Director-General Tedros Ghebreyesus said on Wednesday.

Professor Raina MacIntyre from the Kirby Institute at the University of NSW reminded Australians that even mild strains of the disease can do long-term damage.

#COVID19 #Eris #EG51 @auscovid19

Source: https://thewest.com.au/news/public-health/new-coronavirus-sub-strain-eris-is-not-as-foreboding-as-its-name-suggests-but-will-still-take-lives-c-11557595

WHO declares ‘Eris’ Covid strain a variant of interest as cases rise globally.

#COVID19 @WHO #Eris #EG5 #EG51 @auscovid19

Source: https://www.theguardian.com/world/2023/aug/09/who-declares-eris-covid-strain-a-variant-of-interest-as-uk-cases-rise

»‼️Bad news. EG.5.1 escapes both XBB.1.5 and BA.5+XBB.1.5 breakthrough infection sera at unprecedented levels. Expect a big wave, and let’s hope cell-mediated immunity is not as bad.«

https://twitter.com/dfocosi/status/1689347595993288705

Na geil, dann rettet uns der kommende XBB-Booster wohl auch kaum aus diesem Albtraum.
#EG51 #Covid

With the new COVID Variant - Eris - on the rise, New York has recorded a 55% surge in the number of COVID cases reported. As the Eris or EG.5.1 variant becomes more common, the number of hospitalisations have also increased.

#COVID19 #NewYork #Eris #EG51 @auscovid19

Source: https://www.timesnownews.com/world/new-york-records-55-percent-surge-in-covid-cases-as-eris-variant-becomes-common-article-102560954

Wo sind Infos zur Ausbreitung der neuen SARS-Cov-2-Varianten in Deutschland?
In den USA werden die Ansteckungen wieder mehr.

#Covid #XBB15 #EG51

New strain fuels COVID-19 case surge.

A new variant of COVID-19 dubbed Eris (EG.5.1) is spreading in nations as distant as India, the UK and US and in some areas has led to a 100% surge in cases.

The World Health Organsiation (WHO) began monitoring the EG.5.1. variant, derived from Omicron, on July 19.

#COVID19 #Eris #EG51 #auscovid19

Source: https://www.news.com.au/lifestyle/health/health-problems/new-covid19-strain-eris-fuelling-a-surge-in-cases/news-story/2dba921f97d35023ec26ba24a552b8f0

Promoting to @novid

H/T @erictopol

#COVIDIsNotOver #WearAMask #Boosters #XBB #EG51 #Eris #Omicron https://mstdn.social/@erictopol/110849704221812262

Promoting to @novid

Symptoms of a new COVID variant…coming soon to a “it’s-just-really-bad-allergies” theater near you.

H/T @Brad

#COVIDisNotOver #WearAMask #COVID #Omicron #Eris #EG51 https://zeroes.ca/@Brad/110849235226299855

🍵 Updates for 8/7/2023!

1/

VOCS

Nationally, EG.5.1 solidly in 2nd place behind XBB.1.16.: https://ibb.co/BCybDSg

In PA, mostly XBB.1.16 and a mix of variants after that.: https://ibb.co/hKw4ZSR

In NY/NJ, FL.1.5.1 and EG.5.1 solidly right behind XBB.1.16.: https://ibb.co/r04YQHQ

#SARS2PA #covid #Covid19 #CovidIsNotOver
#Pennsylvania #Health #CDC #Vaccines #Booster! #XBB15
#Vaccinessavelives #Vaccineswork

#EG51 #FLIPvariants

🍵 Updates for 8/7/2023!

1/

VOCS

Nationally, EG.5.1 solidly in 2nd place behind XBB.1.16.: https://ibb.co/BCybDSg

In PA, mostly XBB.1.16 and a mix of variants after that.: https://ibb.co/hKw4ZSR

In NY/NJ, FL.1.5.1 and EG.5.1 solidly right behind XBB.1.16.: https://ibb.co/r04YQHQ

#SARS2PA #covid #Covid19 #CovidIsNotOver
#Pennsylvania #Health #CDC #Vaccines #Booster! #XBB15
#Vaccinessavelives #Vaccineswork

#EG51 #FLIPvariants

🍵 Updates for 8/7/2023!

1/

VOCS

Nationally, EG.5.1 solidly in 2nd place behind XBB.1.16.: https://ibb.co/BCybDSg

In PA, mostly XBB.1.16 and a mix of variants after that.: https://ibb.co/hKw4ZSR

In NY/NJ, FL.1.5.1 and EG.5.1 solidly right behind XBB.1.16.: https://ibb.co/r04YQHQ

#SARS2PA #covid #Covid19 #CovidIsNotOver
#Pennsylvania #Health #CDC #Vaccines #Booster! #XBB15
#Vaccinessavelives #Vaccineswork

#EG51 #FLIPvariants