#jn1 — Public Fediverse posts

Cross-neutralization of #SARS-CoV-2 #BA322 #lineage by #JN1 #mRNA #vaccine-induced immunity, https://etidiohnew.blogspot.com/2026/07/cross-neutralization-of-sars-cov-2.html

#Covid #COVID19 #corona #sars #Impfung #biontech #novavax #np8 #np81 #jn1

Impfmöglichkeit Booster Auffrischung 💉Grippe #Sanofi #Novavax #Nuvaxovid #JN.1 #Biontech #Comirnaty #L.P.8.1 📆Termine ab 27.11. 🏥Elefanten Apotheke 📍Dörpfeldstr. 46 12489 #Berlin #Adlershof 📞03067894942 📧 [email protected] #COVID19 #CovidIsNotOver #TeamVorsicht #Impfung #nuvax25 #impflp81

⬆️ Impfmöglichkeit Booster Auffrischung 💉 #Novavax #Nuvaxovid #JN.1 📍 #Aachen #NRW 📆 mit Termin (📞); Termine ab 29.11.25 📞 0241-91993694 🚦Ü12. Stikotreue unklar, gern berichten. @drmccoy.info @safeairdocs.bsky.social @bildungabersicher.net #COVID19 #CovidIsNotOver #TeamVorsicht #Impfung #nuvax25

Falls ihr euch fragt, wie sicher die Impfung ist:

Dänische Forscher:innen haben sich die Boosterimpfung aus der Periode 2024/25 angeschaut. Bei mehr als einer Millione geimpfter Personen wurde kein statistisch auffälliger Wert von unerwünschten Ereignissen im Vergleich zur nicht-geimpften Bevölkerung gefunden.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836889

#JN1 #Impfung #Corona #SARSCoV2

Effectiveness of #BNT162b2 and #mRNA-1273 #JN1-adapted #vaccines against #COVID19-associated #hospitalisation and #death ..., https://etidiohnew.blogspot.com/2025/07/effectiveness-of-bnt162b2-and-mrna-1273.html

#Malaysia, #Covid19: Health Ministry urges high-risk groups to get vaccinated amid #JN1 #subvariant spread https://www.malaymail.com/news/malaysia/2025/06/12/covid-19-health-ministry-urges-high-risk-groups-to-get-vaccinated-amid-jn1-subvariant-spread/180121

Feverʼs pretty much gone. Inanahi was pretty miserable. Still, better than getting the plague. #COVID19 #JN1 #vaccination

Second Ibuprofen dose. Glad I stocked up on this in Sweden last summer. Definitely more feverish with the #JN1 vaccine. #COVID19

Numb arm and fever, but better than getting the actual thing! #COVID19 #JN1 #vaccination

Shot bro. #COVID19 #JN1 #vaccination

#XBB.1.5 monovalent #vaccine induces lasting cross-reactive responses to #SARS-CoV-2 #variants such as HV.1 and #JN1, as well as SARS-CoV-1, but elicits limited XBB.1.5 specific #antibodies, https://etidiohnew.blogspot.com/2025/03/xbb15-monovalent-vaccine-induces.html

Impfaktion am 18.1. 2025 in #berlinmitte

#Comirnaty #JN1 (Alter ab 6 Monate)
und
#Novavax #Nuvaxovid #JN1 (ab 12 Jahren).

Kosten: 15€/Impfling.

Für Voranmeldung Mail-Adresse bei uns erfragen.

👉 [email protected]👈

#BildungAberSicher
#ImpfenSchützt

[Correspondence] #Antiviral humoral #immunity induced by #JN1 monovalent #mRNA #vaccines against SARS-CoV-2 omicron subvariants including #JN1, #KP311, and #XEC https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00810-7/fulltext?rss=yes

Our data suggest that the receptor-binding domain of JN.1 S can effectively induce antiviral humoral immunity against JN.1 subvariants and XEC comparable to the full-length JN.1 S.

Gibt es eigentlich Studien darüber,

a) welche Wirkung es genauer hat, wenn man 7, 8, 9 … Mal geimpft ist;

b) welche Wirkung eine Impfung auf den Verlauf hat, wenn man sich zufällig kurz darauf infiziert?

Beide Fragen scheinen eher unbeachtet.

#CovidIsNotOver #ImpfenSchützt #Kontrollgruppe #Corona #jn1 #kp2

Robust #antiviral humoral #immunity induced by #JN1 monovalent #mRNA #vaccines against a broad range of #SARS-CoV-2 #Omicron subvariants including #JN1, #KP311 and #XEC

Source: BioRxIV, AbstractAs of November 2024, SARS-CoV-2 Omicron JN.1 subvariants, such as KP.2 (JN.1.11.1.2), KP.3 (JN.1.11.1.3), KP.3.1.1 (JN.1.11.1.3.1.1), and XEC, a recombinant lineage between KS.1.1 (JN.13.1.1.1) and KP.3.3 (JN.1.11.1.3.3), have been circulating in several countries. To control…

https://etidioh.wordpress.com/2024/11/21/robust-antiviral-humoral-immunity-induced-by-jn1-monovalent-mrna-vaccines-against-a-broad-range-of-sars-cov-2-omicron-subvariants-including-jn1-kp311-and-xec/

Neutralizing #Activity and Viral #Escape of #Pemivibart by #SARS-CoV-2 #JN1 #sublineages

Source: BioRxIV, AbstractPemivibart (Pemgarda/VYD222) was granted Emergency Use Authorization (EUA) by the U.S. Food and Drug Administration (FDA) on March 22, 2024, for COVID-19 pre-exposure prophylaxis in immunocompromised individuals. However, its efficacy and resistance against JN.1 sublineages have yet to be fully characterized. Here, we first assessed the neutralizing…

https://etidioh.wordpress.com/2024/11/11/neutralizing-activity-and-viral-escape-of-pemivibart-by-sars-cov-2-jn1-sublineages/

#SARS-CoV-2 #JN1 reveals attenuated #pathogenicity and #airborne #transmission

Source: BioRxIV, AbstractJN.1 is a subvariant of SARS-CoV-2 Omicron BA.2.86 lineage that was predominant worldwide in early 2024, of which the in vivo characteristics are largely unknown. Our results demonstrated that the replication of JN.1 was more efficient than that of the parental BA.2 in Vero cells, which demonstrated low dependence on TMPRSS2. Compared to Omicron variants BA.2 and XBB…

https://etidioh.wordpress.com/2024/11/09/sars-cov-2-jn1-reveals-attenuated-pathogenicity-and-airborne-transmission/

Evolving #antibody #response to #SARS-CoV-2 #antigenic #shift from #XBB to #JN1

Source: Nature, AbstractThe continuous evolution of SARS-CoV-2, particularly the emergence of BA.2.86/JN.1 lineage replacing XBB, necessitates re-evaluation of vaccine compositions 1–3. Here, we provide a comprehensive analysis of the humoral immune response to XBB and JN.1 human exposure. We demonstrate the antigenic distinctiveness of XBB and JN.1 lineages in SARS-CoV-2-naive individuals,…

https://etidioh.wordpress.com/2024/11/07/evolving-antibody-response-to-sars-cov-2-antigenic-shift-from-xbb-to-jn1/

#Immunologic and Biophysical #Features of the #BNT162b2 #JN1 – and #KP2-Adapted #COVID19 #Vaccines

Source: BioRxIV, AbstractVaccines remain a vital public health tool to reduce the burden of COVID-19. COVID-19 vaccines that are more closely matched to circulating SARS-CoV-2 lineages elicit more potent and relevant immune responses that translate to improved real-world vaccine effectiveness. The rise in prevalence of the Omicron JN.1 lineage, and subsequent derivative…

https://etidioh.wordpress.com/2024/11/07/immunologic-and-biophysical-features-of-the-bnt162b2-jn1-and-kp2-adapted-covid19-vaccines/

Neutralizing #antibody #evasion of #SARS-CoV-2 #JN1 derivatives #KP3, #KP311, #LB1, and #XEC

Source: BioRxIV, AbstractThe emergence of SARS-CoV-2 variants poses ongoing challenges to vaccine efficacy. We evaluated neutralizing antibody responses against JN.1 and its derivatives (KP.3, KP.3.1.1, LB.1, and XEC) in healthcare workers who received seven doses of BNT162b2, including XBB.1.5 monovalent vaccine. In COVID-19-naive individuals, KP.3.1.1 and LB.1 showed…

https://etidioh.wordpress.com/2024/11/06/neutralizing-antibody-evasion-of-sars-cov-2-jn1-derivatives-kp3-kp311-lb1-and-xec/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

Structural basis for #receptor-binding domain mobility of the #spike in #SARS-CoV-2 #BA286 and #JN1

Source: Nature Communications, AbstractSince 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD in the down-conformation to…

https://etidioh.wordpress.com/2024/10/07/structural-basis-for-receptor-binding-domain-mobility-of-the-spike-in-sars-cov-2-ba286-and-jn1/

#Impact of #JN1 #booster #vaccination on #neutralisation of #SARS-CoV-2 variants #KP311 and #XEC

Source: BioRxIV, {Excerpt} Conclusion Collectively, we found that the XEC S protein retains the ability to efficiently engage ACE2 and drive cell entry, although entry into Calu-3 lung cells was reduced. Both KP.3.1.1pp and XECpp were generally less well neutralised compared to JN.1pp, indicating elevated immune evasion. Importantly, JN.1-booster vaccination significantly…

https://etidioh.wordpress.com/2024/10/05/impact-of-jn1-booster-vaccination-on-neutralisation-of-sars-cov-2-variants-kp311-and-xec/

#Human and #hamster #sera correlate well in identifying #antigenic #drift among #SARS-CoV-2 #variants, including #JN1

Source: Journal of Virology, ABSTRACTAntigenic assessments of SARS-CoV-2 variants inform decisions to update COVID-19 vaccines. Primary infection sera are often used for assessments, but such sera are rare due to population immunity from SARS-CoV-2 infections and COVID-19 vaccinations. Here, we show that neutralization titers and breadth of matched…

https://etidioh.wordpress.com/2024/10/04/human-and-hamster-sera-correlate-well-in-identifying-antigenic-drift-among-sars-cov-2-variants-including-jn1/

Immune #escape and attenuated #severity associated with the #SARS-CoV-2 #BA286 / #JN1 #lineage

Source: Nature Communications, AbstractThe SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023–24. However, this surge in infections was not accompanied by COVID-19 hospitalizations and mortality commensurate with prior waves. To understand shifts in COVID-19 epidemiology associated with JN.1…

https://etidioh.wordpress.com/2024/10/03/immune-escape-and-attenuated-severity-associated-with-the-sars-cov-2-ba286-jn1-lineage/

Die ganze Kernfamilie war wieder einmal #Covid impfen.

In der Ordination alle Menschen außer uns natürlich ohne Maske (ja, die, die dort arbeiten, die, die behandelt werden, und die, die begleiten; alle). Ist ja nicht so, dass beim Allgemeinmediziny im Wartezimmer kranke Leute wären. 🤦

Dann war ich noch in der Apotheke und im Drogeriemarkt. Auch dort weiß niemand mehr, wie mensch sich einfach und bequem vor Atemwegserkrankungen schützen könnte.

#wien #covid19 #covid19at #impfung #impfen #jn1 #maske #masken #ichMagMeineMasken

#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

[Correspondence] Virological #characteristics of the #SARS-CoV-2 #KP311 #variant https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00505-X/fulltext?rss=yes

SARS-CoV-2 #JN1 variant (#BA28611), arising from BA.2.86.1 with spike protein (S) substitution S:L455S, outcompeted previously predominant #XBB lineages by beginning of 2024. Subsequently, JN.1 subvariants including #KP2 (JN.1.11.1.2) & #KP3 (JN.1.11.1.3), which acquired additional S substitutions (eg, S:R346T, S:F456L, and S:Q493E) have emerged concurrently (appendix pp 19–20).2

#Pemivibart is less active against recent #SARS-CoV-2 #JN1 #sublineages http://biorxiv.org/cgi/content/short/2024.08.12.607496v1?rss=1

Pemivibart neutralized both JN.1 and #KP2 in vitro with comparable activity, whereas its potency was decreased slightly against #LB1, #KP23, and #KP3 but substantially against #KP311. Critically, the 50% inhibitory concentration of pemivibart against KP.3.1.1 was ~6 g/mL, or ~32.7 fold higher than that of JN.1.

An upcoming #vaccine from the biotech co Novavax will target #JN1, a #coronavirus #variant that accounted for the bulk of cases in the #UnitedStates this winter. The Pfizer & Moderna shots coming this fall will target #KP2, a newer offshoot of JN.1 that’s been circulating this summer. The #variants responsible for the largest share of cases in the #US right now, #KP3 & #KP311, are closely related to KP.2 & JN.1.

#health #PublicHealth #medicine #COVID

Mein Hausarzt will nicht mehr impfen und bestellen - leider scheint das kein Einzelfall zu sein. Dabei wäre die Impfung sicher besser, als LongCovid (#MECFS): >>Seit Anfang Juli ist "Comirnaty JN.1" in der Europäischen Union offiziell zugelassen. Laut dem Zentrum für Pandemie-Impfstoffe und -Therapeutika (ZEPAI) am Paul-Ehrlich-Institut ist das neue Vakzin weiterhin in drei Dosierungen erhältlich: für Menschen ab 12 Jahren, für Kinder im Alter von 5 bis 11 Jahren sowie für Säuglinge und Kleinkinder von 6 Monaten bis 4 Jahren.
Der Impfstoff kann sowohl zur Grundimmunisierung als auch für Auffrischimpfungen verwendet werden. Er wurde speziell für die Omikron-Variante JN.1 weiterentwickelt und bietet daher einen verbesserten Schutz gegen die derzeit kursierenden Virusvarianten - im Vergleich zum bisherigen BioNTech-Impfstoff. [...]<< https://www.tagesschau.de/inland/gesellschaft/corona-impftstoffe-100.html
Es wäre hilfreich zu erfahren, wie man einen Arzt motiviert, entsprechende Impfdosen zu bestellen bzw. wie er sein unternehmerisches Risiko senken kann, wenn die Nachfrage nicht so hoch ist, wie es sinnvoll wäre @[email protected] können Sie dazu einmal nachfragen, ob es dafür im Gesundheitsministerium Lösungen / Antworten gibt? Laut meinem Hausarzt gab es im letzten Winter eine Mindesabnahmemenge und er musste viele Dosen wegschmeißen, d.h. machte Verlust - oder zahlt dafür ggf. ein Corona-Hilfs-Fond bzw. eine Versicherung?
#Corona #Coronavirus #JN1 #Flirt #Variante #longcovid #Risikogruppen #Booster #boosterimpfung #gesundheit #gesundheitswesen #sars-cov-2 #sars-cov-2-infektionen #fallzahlen

Reduced #Likelihood of #Hospitalization with #JN1 or #HV1 #SARS-CoV-2 #Variants Compared to #EG5 Variant, J Infect Dis.: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae364/7717186?utm_source=advanceaccess&utm_campaign=jid&utm_medium=email&nbd=25018031857&nbd_source=campaigner

JN.1 and HV.1 variants may be associated with a lower #risk of severe illness. The severity of #COVID19 may have attenuated as predominant circulating SARS-CoV-2 lineages shifted from EG.5 to HV.1 to JN.1.

#Virological #characteristics of the #SARS-CoV-2 #KP311 #variant http://biorxiv.org/cgi/content/short/2024.07.16.603835v1?rss=1

KP.3.1.1 exhibited a higher Re, higher pseudovirus infectivity, & higher neutralization #evasion than KP.3. These results align with our recent report that #JN1 subvariants with S:S31del (eg KP.2.3 & LB.1) exhibited enhanced Re and immune evasion compared to other JN.1 subvariants without S:S31del (eg JN.1, KP.2, & KP.3), highlighting evolutionary significance of S:S31del in JN.1 lineages.

Update for 5/24/2024!

Good morning SARS2PAians! (well, afternoon by the time I got all this ready)

I hope you are having a BEAUTIFUL and healthy day. 💐💐💐

_____
VOCs

Nationally, KP.2 is in the lead so far, easily displacng JN.1 variants.: https://ibb.co/JCWtxdr

KP.3 and LB.1 (DeFLiRT) are making FAST gains in the leaderboard, now up to around 5% each nationally.

They are still the top two successful variants that show great potential to take over from even KP.2.: https://ibb.co/kxHkfV1

🔴JN.1.50 is new, and was just designated on 5/18 and though genetically it's as fast as LB.1 and KP.3, it remains to be seen in meatspace how it will spread.

In PA, JN.1 still in the lead here in random sequencing at 20% and KP.2 behind it at 13%.: https://ibb.co/G7Nnft5

Unfortunately KP.3 has been found here. So we now have BOTH very fast DeFLiRT variants here for the summer, KP.3 and LB.1. Take care, keep windows open, clean the air, wear a quality respirator and be aware of social contacts. These two variants might push the numbers up this summer.

In NY/NJ, KP.2 in the lead and look at that LB.1....in second place at 10% of random testing already. Yikes. It's been making very fast gains for a while now there.: https://ibb.co/8xRfkkh

Some parts of Jersey have noticeable upticks of matarial concentraion on WastewaterSCAN.: https://ibb.co/7STgtLZ

__________
Wastewater

Trying to get as much info as possible here since almsot everything useful is being discontinued. 🙄

SARS2 has been bumped up to MEDIUM nationally on WastewaterSCAN.: https://ibb.co/Wf5MdxN

There are noticeable upticks starting to happen in the Harrisburg and Chester areas.: https://ibb.co/g3HQZp0

__________
Non-SARS2 Pathogens

Gastro pathogens Noro and Rotavirus are still in the HIGH category on WastewaterSCAN. Please wash hands carefully, wash fruits and veg, and be aware of kitchen cleanliness discipline to avoid cathing these bugs. Mostly because they're just gross 🤢

🔴Concerning H5N1 (HPAI, "bird flu"), we are NOT in flu season, so seeing upticks for Influenza A is extremely concerning.

This is what the FluA graphs SHOULD look like now in a normal post-FLuA season.: https://ibb.co/X4Q8szS

H5N1 is an influenza A. It's been upgraded to MEDIUM on WastewaterSCAN.: https://ibb.co/wKC300x

However, the online tool makes no differentiation between H5N1 and other types of FLuA. It also cannot tell live virus from inactivated virus or its fragments.

It's extremely telling, though, that the highest concentration of FluA is located exatly where herd breakouts have or are occuring, mostly in the middle of the country in the plains corridor.

To reduce the risk of contracting, transmlitting, or allowing H5N1/HPAI to mutate,

🔴🔴🔴DO NOT DRINK RAW MILK.🔴🔴🔴

I don't give a flying fart if it's legal to sell/buy here in PA. Do NOT be that guy. Do NOT encourage this pathogen to mutate and DO NOT endanger your own life or everyone else's by consuming raw or unpasteurized dairy products.

Use caution in handling raw dairy products, especially meat and milk. Pasteurization has been proven to kill FluA and fluA is very sensitive to heat, but please use caution, fully cook raw meat, and use good sanitary habits when working with raw farm products.

As always, some method of source control is always good to help keep these pathogens in check whether they're just annoying and gross OR have a high kill rate.

I hope you stay safe, enjoy the open windows in Spring, and ARE NOT DRINKING RAW MILK.

Have a great week!!

#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_f456l #spike_r346t

#DeFLiRT #S531del

#FLuQE #SQ493E

#KP3 #LB1 #JNOne50

#IFYouAreDrinkingRawMilk__STOP__DOING__IT

#WearAMask #CleanTheAir #WashHands #StayHomeIfSick !

Good morning SARS2PAians!

I hope your very cloudy annd humid Spring is going well. 💐💐💐

The only thing I have right now are VOC visuals.

Nationally, KP.2 in the lead at 12% of random sequencing. The FLiRT variants are not far behind and VERy fast variants KP.3 and LB.1 are still making fast gains even after only a few days.: https://ibb.co/309Ygcj

In PA, classic JN.1 is still at the lead here. We don't have KP.3 here but we do have fast mover LB.1 which is now over 5% of random sequencing.: https://ibb.co/CpyDWkH

IN NY/NJ, immune evasive variants LB.1 already at over 7% of testing and KP.3 almost at 5%.: https://ibb.co/LZ1hZM7

__________
Wastewater

Biobot has released a statement saying they are stopping keeping up their COVID-19 wastwater visuals. There's still WastewaterSCAN but only three sheds are on there.: https://ibb.co/2tYPPcm

https://biobot.io/from-raw-data-to-actionable-insights-biobots-evolution-of-public-data-sharing/

This is another removal of a GREAT tool that helped everyone stay informed, and gave a heads-up when to buckle down on source control issues.

A very good potential replacement for Biobot is Iowa Covid-19 Tracker and I'll start to try to get familiar with that as soon as I can sit down to do it so the vizzes might look very different soon.: https://iowacovid19tracker.org/

I hope to have more info on Friday, and until then have a GREAT week and safe Spring! 💐💐💐

#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_f456l #spike_r346t

#DeFLiRT #S531del

#FLuQE #SQ493E

#KP3 #LB1

#Biobot #IowaCOVIDTracker

#WearAMask #CleanTheAir #WashHands #StayHomeIfSick !

Update for 5/17/2024!

Good morning SARS2PAians!

I hope you are staying healthy during this very cloudy and rainy period! 🌦🌧☁️☔️

VOCs

Nationally, the FLiRT group (in pink on the graph), which is the first group that can cause a rise in summer numbers in a few wweeks, is still pushing closer and closer to the top of the chart. FLiRT variant KP.2 is already at almost 10% nationally in random sequencing.: https://ibb.co/Wxtgg1N

The second group (KP.3, LB.1, JN.1.32) that can push up summer numbers is not far behind and is FAST.

To complicate issues even more:

It's been advised where I'm cruising around for this info that the second group is not only VERY immune-evasive to current variant antibodies, but also returning to a more lung-based symptom set rather a gut-based set. JN.1 is mainly centered in the gut, which makes wastewater monitoring more sensitive and more accurate.

A return to a more lung-based centered illness is a bad thing and will make wastewater testing not-as-sensitive as it was for JN.1 relatives.

In PA, KP.2 is already in the lead of random sequencing results at 16% of share.: https://ibb.co/6XpWGfF

We already have LB.1 here so it's oging to very important to track this fast moving and immune evasive variant.

In NY/NJ, KP.3 and LB.1 in fifth and sixth places on the leaderboard. Their rise is increasing quickly as they're up to over 4% of varaint share, up from 3% a week ago.: https://ibb.co/9gsdZ0W

A 1% increase in such a short amount of time in a field of already very fast variants is noteworthy. In a race of thoroughbreds, varaints like this are the potential triple-crown winners.

__________
Wastewater

Wastewater levels are still very good (low.) Nationally we're at the same level as last year but not low enough to match 2021 yet.: https://ibb.co/Y3Tv51h

In PA, not much to say. EVERYONE is smashing it. Bucks county area a bit higher than naitonal levels and trending upwards. PLEase use precaution and some sort of source control so these numbers don't go back up.: https://ibb.co/hd2FcNh

__________

That's all I have this morning, so I hope you have a GREAT week! I apologize for not updating consistently as data is harder to obtain and H5N1 takes over the foreground of virology conversations (as it should, understandable)!!

#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_f456l #spike_r346t

#DeFLiRT #S531del

#FLuQE #SQ493E

#KP3 #LB1

#WearAMask #CleanTheAir #WashHands #StayHomeIfSick !

Update for 5/13/2024!

Good Morning SARS2PAians!

I hope your chilly Spring is going well! 💐💐💐

Just a very quick VOC update as there is absolutely nothing really updated to work with this week 🙄

While numbers are still very very low right now (which is great), the virology world and variant hunters are watching a few new mutations lately.

The two most important coming up are KP.3 and LB.1.

Globally, KP.3 is already in 2nd place, very high in places like the UK and Australia, easily growing past previous JN.1 incarnations AND FLiRT variants.: https://ibb.co/ch19ph8

It carries a very rare mutation (S:Q493E) that enhances its fitness and will enable it to grow much fater than previous JN.1 incarnations.: https://ibb.co/9vx0JTn

It is IMMUNE EVASIVE compared to all current acquired immunity, both by vaccination and infection. It's fast enough and evasive enough to probably bump up numbers in June or July.

In the US, KP.3 is in relatively low numbers right now: https://ibb.co/XpRF6D6

BUT KP.3 is growing very quickly as the previous variant snapshot show when put together:

4/01-- 0.34%

4/05-- 0.44%

4/12-- 0.63%

4/19-- 1.17%

4/25-- 1.55%

5/03-- 1.64%

5/06-- 2.23%

5/12-- 3.20%

(This is fast in a landscape that's already thoroughly saturated very very vast variants.)

In PA, variant sequencers have not seen KP.3 pop up yet (doesn't mean it's not here, sequencing and testing are soooooo loooow but at least it's not showing up on the leaderboard.): https://ibb.co/4YzwNFN

However, LB.1 (from the FLiRT group but with an important deletion {S:531del}) is another very fast variant that is probably enough to bump up numbers too.

The summer will probably be FLiRT + FLiRT children vs. KP.3 (nicknamed FLuQE) + FLuQE children.

Those two mutation classes together wil probably start pushing up numbers again in early June.

Unfortunately that's all I have for now as it's getting harder and harder to find updated info.

I hope your Spring continues to be healthy! 💐💐💐

#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_f456l #spike_r346t

#DeFLiRT #S531del

#FLuQE #SQ493E

#KP3 #LB1

#WearAMask #CleanTheAir #WashHands #StayHomeIfSick !

Update for 5/6/2024!

Good Morning SARS2PAians!

Yes I have an update today aaaaand unfortunately that's kinda never a good thing. You DON'T want to hear from me here!

(I am asking you once again....to please make this hobby of mine obsolete 🙏😔 Filter the air, be aware of social contacts, wear a quality respirator, and wash hands for the gastro stuff.)

__________
VOCs

We are dealing with FLiRT now, but there are two groups of incoming variants that are becoming concerningly successful in other countires including right next door in Canada.: https://ibb.co/fkG3gpg

One is an earlier-new group consisting of JN.1.32 and KP.3.

Another, far off-new yet, is KW.1 and its child, KW.1.1.

All of these variants have been proven faster than FliRT in Australia, UK, etc. KP.3 is exceptionally fast.

🔴Due to antigenic drift, vaccines and previous infection are NOT as effective to protect you with these upcoming variants.

🔴This does NOT mean vaccines don't work, so do not go spreading that. (You should also be mightily shunned for spreading that.)

Again: Vaccines are safe and effective...but these incoming variants are starting to yet again DRIFT TOO FAR AWAY from the current XBB vaccines.

I've highlighted the upcoming concerning variants in teal, as opposed to the FLiRT group which is in pink. KW.1.1 isn't above the fold yet nationally at 0.16% so I made a note on the image so I remember to keep track of this number.

Nationally, JN.1.7 and JN.1 are a tthe top of the board. JN.1.32 at 2.23% and KP.3 also at 2.23%. KW.1 at a little under half a percent. These numbers might be higher in actual meatspace because there is not nearly enough labwork/sequencing available to make laser-focused predictions.: https://ibb.co/bRpvDP7

In PA, we do not have group 2 of the far-off variants yet here but we do have KP.2. Gotta watch this one.: https://ibb.co/3kPMBwM

In NY/NJ, whoa, KP.3 already clocking in at over 3%, in the top 10 of random sequencing already. I haven't been watching this one so when I have more time I'll go back and check this one out.: https://ibb.co/qM7C4CY

KP.2 already at over 10%. That's fast, and antigenic drift is absolutely not helping here as any protection we might have had against this new stuff is starting to slip away.

We might be in for a bump up in numbers this spring, as something similar last year happened too.

Just giving everyone a heads-up on what we might be in for this spring/summer.

We can keep it in control by practicing some very comon-sense, easy things!

Have a safe spring!! 💐💐💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Wastewater #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_r346t #spike_f456l

#KP2 #KP3 #JNOne32 #JN132 #KS1

#KW1 #KW11

#WearAMask #CleanTheAir #WashHands #StayHomeIfSick !

Good Morning/Afternoon SARS2PAians!!

I hope you are enjoying this GORGEOUS Spring weather 💐💐💐

1/2 Update for May 3, 2024!

__________
:all_the_things: State of the Subreddit/Fediverse posts:

There's not much new to report for COVID right now except some closely watched new mutations, so basically TL;DR is that COVID levels are very very low, enjoy it but please keep source control safety always on the backburner.

So. I don't mean to only have this as a once-a-week thing but it's kind of turning into that. I also don't mean to have people waste their time checking in here if I don't post, but I'm always hesitant to call it a once-a-week-thing as COVID is so volatile and mutations can always manifest something very weird in a short amount of time.

I have no idea when info will be available so I'm keeping it a "twice-a-week thing", Monday and Friday but sometimes I just don't have enough info/anything new/time for a Monday, so Friday is always much better for a full post for me.

I hope you continue to find this informative useful and I suuuuuper apologize if you check in and I don't post. 🙏

But even better, go check out the links for yourself and follow people smarter than me for COVID stuff!

__________
VOCs

Nationally, JN.1 and JN.1.7 still at the top of the leaderboard. FLiRT variants JN.1.4 and KP.2 keeps chipping away at their lead.: https://ibb.co/JqWkBSD

KP.2 seems to be the fastest mover of the whole FLiRT mutation block and the one the virology world is keeping their eyes on.

In PA, we don't have KP.2 showing up on Rajnarayanan's Tableau site so far, whcih is good but we still have quite a few FLiRTs here.: https://ibb.co/vP5yH4G

In NY/NJ, we can see here KP.2 has climbed above all the other FLiRTs, is in 4th place at >8% and is right behind JN.1 now.: https://ibb.co/ZzLcRxJ

The WHO is now looking to JN.1 being the next mutation that will be the base of the newest COVID vaccine.: https://www.who.int/news/item/26-04-2024-statement-on-the-antigen-composition-of-covid-19-vaccines

🔴PLEASE GET VACCINATED if available. Don't be a tuff guy. Go get it.

Upcoming fast variants are KP.3 and JN.1.32👀, which are not FLiRTs but very fast. I have them highlighted in teal on the charts as they are both already up to almost 5% of national sequencing.

In PA, we have JN.1.32 in low but measurable amounts at a little over 3% of random sequencing and these two variants wil have to be watched.

__________
CDC

CDC has stopped requiring reporting COVID hospital admissions, hospital capacity or hospital occupancy data at the beginning of May. 🙄 This plus nowhere near enough testing and sequencing makes this....hard to keep up with the virus.

"Effective May 1, 2024, hospitals are no longer required to report COVID-19 hospital admissions, hospital capacity, or hospital occupancy data to HHS through CDC’s National Healthcare Safety Network (NHSN). CDC encourages ongoing, voluntary reporting of hospitalization data. Data voluntarily reported to NHSN after May 1, 2024, will be available starting May 10, 2024, at COVID Data Tracker Hospitalizations."

"The source of hospital information on the COVID Data Tracker home page will change from the National Healthcare Safety Network (NHSN) to COVID-NET. Instead of displaying national counts of new hospital admissions, it will show COVID-19 hospitalization rates per 100,000 people. More information on COVID-Net is available on COVID-NET Laboratory-confirmed COVID-19 Hospitalizations."

https://covid.cdc.gov/covid-data-tracker/#datatracker-home 🙄

__________
Other Pathogens

WastewaterSCAN now has SARS2 as LOW! YEAH! :canparrot:

Also FluB and RSV! Woohoo! :canparrot:

Still HIGH though are FluA, Human Metapneumovirus (HMPV), parainfluenza, and gastro bugs Noro and Rotavirus.: https://ibb.co/By0g9Xt

__________
H5N1 follows in second post......

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Wastewater #Pennsylvania #PA #JN1 #FluB #Influenza #Norovirus #HMPV #FLiRT #F456L #R346T #spike_r346t #spike_f456l

#H5N1 #CleanFeedNOW

#WearAMask #CleanTheAir #WashHands #StayHomeIfSick !

Good Afternoon SARS2PAians!

I hope your spring is healthy and productive! 💐💐💐

__________
VOCs

Nationally, the most concerning variants are, as I posted last week, the FLiRT variants that have specific mutations enabling fast transfer. JN.1.4 and KP.2 are already almost at 10% of variant share but remember the amount of testing and sequencing right now is dismal and it makes everything harder to evaluate.: https://ibb.co/KDt0Bh4

FLiRT variants are highlighted in pink on my screenshot. Expect these to push further and further near the top in the next few weeks (and the CDC NOWCAST confirms this prediction.)

In PA, we still have a few FLiRTs here and you can already see them starting to move toward the top of the variant chart.: https://ibb.co/kc9CQyZ

In NY/NJ, FLiRTs KP.2, JN.1.4, JN.1.16.1, and JN.1.18 already account for ~20% of random sequencing.: https://ibb.co/TrcS9rW

__________
Wastewater

The GOOD news is COVID is stil fairly low; we've gone below the higher level of two years ago, and are at the lower level of last year at this time!: https://ibb.co/Q83BR3k

We still must watch to see if the FLiRT crew push this metric upwards.

__________
CDC

The new hospital admits map has changed. High increases all through Central PA excepting Centre Co. and also over tehre in Mercer Co. Philly and Pitt looking very good!: https://ibb.co/Xp8tCJV

The Inpatient Beds Map looks pretty good, some increases in McKean, Potter, and Cameron counties and also around Somerset and Cambria Cos.: https://ibb.co/fD7JYTf

ICU beds over all showing stability, with lots of counties in Central PA and the old coal region on the decrease! Some increases from Lycoming over to McKean though.: https://ibb.co/jMTdyCT

__________
NOWCAST

The CDC Nowcast is now including multiple fast-moving FLiRT variants in its tracking: KP.2, KP.1.1, KQ.1, JN.1.18.: https://ibb.co/wBY45FV

According to current estimates, these variants combined account for over a third of illnesses already.

These are moving FAST.

__________
NonSARS2 Pathogens

More good news: according to WastewaterSCAN, there are now lots of pathogens considered LOW nationally!

Just be warned that they are still showing HIGH in the Northeast, like FluB, which is LOW nationally but regionally still HIGH. Hopefully these numbers will lower even more as the Spring enables more outdoor/well ventilated activity.: https://ibb.co/vYGmTd1

__________
H5N1

H5N1 particles have been found in dairy milk, and are assumed to be inactivated due to the pasteurization process.

We MUST demand healthy cows, testing and tracking of sick herds, and transparency from the meat and dairy insustries.

This is not necessarily to keep H5N1 out of dairy products.

The more IMMINENT concern than being found in dairy milk is letting this thing percolate until it gains new mutations, whether to infect swine or enable human-to-human transfer.: https://ibb.co/FVbNnky

Some things you can do that are obviously proactive and not panicking about this:

🔴Demand clean feed for cattle and swine.

🔴Demand transparent testing, tracing of cattle illness.

🔴Demand high levels of sampling and sequencing of sick herds.

🔴AVOID raw dairy products. Seriously, people, DO NOT contribute to this thing by consuming raw dairy products, even if your State allows its sale (and Pennsylvania DOES as far as I know!)

🔴Try ultra-pasteurized milk, it's the most common milk sold in European countries.

Here's a nifty guide that compares pasteurized/ultra-pasteurized/UHT (ultra high temperature) methods of treating dairy products:

https://www.britannica.com/technology/pasteurization

🔴Avoid undercooked or rare meats. Meats must be heated to 162 degrees for at least 15 seconds to destroy pathogens like tuberculosis.

🔴Switch to providers that are not battery farms and practice humane farming. This is NOT just to be kind to animals (although that's a huge bonus), it is PRACTICAL and keeping herds not densely packed will lessen disease transmission. So far, H5N1 has a 50% kill rate even in non-bird species and we MUST keep outbreaks of it controlled.

I hope you have a FANTASTIC, well-ventilated, healthy and fun Spring!! 💐💐💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Wastewater #Pennsylvania #PA #JN1 #FluB #Influenza #Norovirus #HMPV #FLiRT #F456L #R346T #spike_r346t #spike_f456l

#H5N1 #CleanFeedNOW

#WearAMask #CleanTheAir #WashHands #StayHomeIfSick !

Good Afternoon SARS2PAians!

It's going to get a bit chilly the next few days , butin spite of that I hope you're haivng a great Spring! 💐💐💐

🔴Reminder: If you've built a Corsi-Rosenthal box, you can get lots of seasonal allergy relief by running it! CR boxes have many, many practical uses besides just controlling air particles that carry pathogens.

There was nothing much new to post on Monday plus I had a bunch of family things to handle (and doing this, admittedly takes time) so I apologize again for not posting. But you know the saying "no news is good news" and that defintiely applies to these updates.

I'm going to try and update the link list ASAP.

I hope you still find all this useful and informative. I hope the medical community finds these accurate and reliable.

__________
VOCs

While we are experiencing a MOST welcome lull in COVID numbers right now, disease modelers are predicting a bump up in numbers at the end of this month.: https://ibb.co/YpnpfMF

This is due to a variant block that have specific mutations. Together they are nicknamed the FLiRT group and are named so because their most important mutations are located at S:F456L and S:R346T within the structure of the pathogen.

🔴Right now FLiRT mutes have an 8% advantage even over JN.1. That's fast.: https://ibb.co/NshJLK6

The most important VOCs out there right now are the variants that have the FLiRT designation, and I've highlighted these mutes on these screenshots in pink.

Remember that there is nowhere near the amount of national testing or sequencing that should be implemented, so it makes trying to predict growth activity more difficult.

Nationally, lots of FLiRT mutations out there. It is unknown whether they are fast enough to cause a wave altogether, but they're fast enough to compete with JN.1 to eventually take over quite a bit of the current leaderboard.: https://ibb.co/S7kCkpH

In PA, we have quite a few FLiRT mutation here but these mutes are in relatively low numbers, so far.: https://ibb.co/bdhJwKv

In NY/NJ, FLiRT mute JN.1.4 already in second place on the leaderboard at over 9% of random sequencing. The other FLiRT variants will undoubtedly catch up.: https://ibb.co/ZBgYP2G

Here you can see FLiRT's innate growth advantage compared to JN variants.: https://ibb.co/3swYQ4r

Here you can see JN.1's innate growth advantage compared to older variants.: https://ibb.co/DfH6j53

__________
Wastewater

Nationally we're still on the bottom of the lull. This might be the lowest point of the whole year as our numbers ongoing could match 2022/2023, where we had quite a bump up in the middle of the summer (because, reminder: COVID doesn't have a "season", it can bump those numbers up anytime it gets lucky with a new mutation!).: https://ibb.co/3mVzfx9

In PA, wastewater still low pretty much everywhere which is great. MontCo SMASHING it, going way below national levels!!: https://ibb.co/TbrQgk7

__________
CDC

The counties showing high increase in hospital admits has shifted around. Now the counties with the highest increases are along the NY border and down in the Southwest corner surrounding Greene Co. Adams and York also showing high end increases. Philly corner showing moderate increases.: https://ibb.co/cQRgbwM

The % inpatient beds map looks very good! stable or decreasing everywhere, except some increases in Columbia Co up going Northeast to Wayne Co.: https://ibb.co/Q8JMZvh

Staffed ICU beds in the vast majority of counties steady or going down...except Columbia, Luzerne and Wyoming in the eastern half of the State and Centre, Clearfield and Jefferson in Central PA.: https://ibb.co/5kXgcYR

__________
Other Pathogens

We're still high in non-SARS2 respiratory pathogens according the WastewaterSCAN. FluA, FluB, and Human Metapneumovirus (HMPV) are still HIGH.

Gastro stuff is very high too, Norovirus and Roitavirus.

🔴Keep the air clean, be aware of social contacts and wear a quality respirator in crowds and in places where air filteration is suboptimal. Stay home of you are sick to beat the respiratory stuff.

🔴WASH HANDS with warm water and soap for at least 20 seconds to beat Noro and Rota. Rinse off fruits and veg before you eat them. Be aware of food handling safety in the kitchen. Don't send kids to school with this.

Mostly because...Noro and Rota are not only extremely contagious, they're also just...gross. 🤢

I hope you have a GREAT and safe Spring!! 💐💐💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Wastewater #Pennsylvania #PA #JN1 #FluA #FluB #Influenza #Norovirus #Rotavirus #HMPV #FLiRT #F456L #R346T #spike_r346t #spike_f456l

#WearAMask #CleanTheAir #WashHands #StayHomeIfSick !

Good Morning SARS2PAians!!

I apologize for not typing up a thing for you all on Friday, I got caught up in family stuff. I hope you had a GREAT and SAFE weekend!!
:canparrot:

__________
VOCs

Nationally, JN.1 still at a solid >40% of randomly sequenced samples.: https://ibb.co/s9rZzPq

KP.2 is the next variant to watch and has already had some FAST gains in the past few days.

in PA, both JN.1.16 and KP.2 have already been sequenced here. Control the spread of these potentiall troublesome two mutations by employing SOME form of source control!: https://ibb.co/rtKWn48

in NY/NJ, JN.1 and JN.1.4 at the top as usual but KP.2 already at 1.31% of random sequencing.: https://ibb.co/XDTdCJ8

__________
Lineage News

While other lineages with lab-estimated growth did not seem to contribute to the leaderboard as much as JN.1 continues to do that, its descendant KP.2 is showing extremely fast growth both in lab estimates (with a high confidence level, so this lab data will probably translate more readily into real-world trouble) AND in actual numbers of sequences found.: https://ibb.co/3kyD7Bc

It still has a bonkers high growth advantage rate considering genetics alone and has moved quickly up a couple ranks in actual practice, on the sequencing leaderboard already.

It'll definitely be one to watch.

__________
Wastewater

Nationally, COVID levels continue to decline in wastewater. This will only get better once these cold snaps are done! We're still at a point where we're very high compared to previous years, though.: https://ibb.co/DY8LNMB

Previous years comparison: https://ibb.co/pw8WLjH

Regionally, all regions are declining in found SARS2 material in wastewater. We are still at the highest concentration in the Northeast compared to everyone else, though.: https://ibb.co/8sj4BpS

In PA, Chester Co. is SMASHING IT and levels are absolutely tanking for now! But Bucks, Luzerne, and Lackawanna's levels are still a bit above naitonal averages. Use source control to improve this data point!: https://ibb.co/s65h3yG

__________
CDC

The New Hospital Admits map is showing significant increases in Juniata Co. curving down to Somerset Co and Bedford Co., and also over in Lawrence Co. The rest of the map is pretty good, with overwhelmingly reductions in hospital admits in most counties!: https://ibb.co/sKnLV5X

Staffed Inpatient Beds are showing significant increases in Juniata, Mifflin, Huntingdon and Elk Cos with the rest of our counties stable or slightly decreasing.: https://ibb.co/Yyj4MRr

Quite a lot of ICU bed use increases. From Greene at the southweasternmost corner, all the way diagonally up to Bradford and Susquehanna Cos, increasing levels all the way. Don't be this statistic, folks. Get those XBB/flu/etc. shots.: https://ibb.co/LYkXcKJ

Sadly there have been 1,064 COVID deaths in PA in the last three months and while this number has gone down a bit since last time I posted this, our state remains in the highest category of the 3 month data cycle.: https://ibb.co/8m5SDBY

__________
Non-SARS2 Pathogens

Well, if you want to stick around to read this, I'll post this part up last.

While SARS2/COVID continues to steadily decline, the one pathogen that's still at quite a staggeringly high rate is Norovirus, the "24-hour stomach bug".

Levels of this are still EXTREMELY high, and are slow to start going down, as they had around this time last year.: https://ibb.co/Kqny3QJ

PLEASE WASH HANDS with soap and water. Hand sanitizer is not enough. Norovirus is extremely resistant to alcohol and heat sterilization due to a tough "shell" surrounding the virions.

You MUST wah hands with warm water and soap for 20 seconds to actively contribute to controlling Norovirus.

Wash fruits and veg before you eat them, even if you don't eat the peel (example: clementines, oranges, and grapefruit.)

Don't serve or prepare food if you are sick!

This thing is just gross. 🤢 Make sure everything's clean before you sit down to eat!

Using source control will make numbers for ALL pathogens go downward so we have a healthy (and not gross) Spring! 💐💐💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #JN1 #Influenza #Norovirus #Noro

#KP2

#WearAMask #CleanTheAir #VaccinesSaveLives #WashHands #Wastewater #StayHomeIfSick #SourceControl #USESourceControl #COVIDSourceControl

Update for 3/8/2024!

Good Morning SARS2PAiains!!

I hope you're ready for that time change on Sunday! 🕐🕐🕐

This is a wonderfully short update. I mean, it doesn't look short, but it kinda is. 🤪

There's no new CDC stuff.

There are no new wastewater updates and we are continuing to approach lower levels of previous years as spring gets closer.: https://ibb.co/QfPr8NJ

__________
Lineage News

There's no new immediate variant news as JN.1 is still the only thing all over the place so far.

There are some new varaints being watched as JN.1 (and specifically JN.1.11) seems really capable of producing descendants that worry virologists:

❗️JN.1.16: Concerningly infectious even over very wide areas in China; Lots of this currently being uploaded from what I gather in USA too, already in 9 states.

❗KP.1.1 (which is JN.1.11.1.1.1): this has a potential nuts-level of growth rate going by genetics alone.

❗KP.2 (which is JN.1.11.1.2): seems closely related to JN.1.16 that I was, in my very very unprofessional opinion, concerned about last update.

❗KP.2.1: widespread already in East Asia.

KP.x.y has an extraordinary growth rate only considering mutations but we'll see how any of this checks out in actual biological results.

__________
NON SARS PATHOGENS

There is still a very high amount of total pathogens all around.: https://ibb.co/3sxWQ3C

Respiratory pathogens are still high according to WastewaterSCAN:

❗SARS2

❗RSV

❗Flu A

❗Flu B

❗Parainfluenza, which has been upgraded to HIGH since last update.

Gastro stuff is still very high too!:

❗Norovirus

❗Rotavirus

Noro is thankfully declining at UPark but still in the very high range.: https://ibb.co/CMSGsjg

If we keep using common sense ways to control it, it prevents DAYS of learning/financial loss and potential hospital visits for dehydration. And...it's just gross to deal with. 🤢

Fpr respiratory illnesses, wear a quality respirator, be aware of social contacts, mask/respirator up in crowds and in low ventilation areas (low ceilings, restrooms, elevators, etc.), keep the air clean, get those COVID and flu shots, and STAY HOME if you are sick!

For the gastro stuff, don't prepare food when sick. Don't depend on gloves for sanitizing either! Wash fruits and veg before you eat them.

Wash hands with soap and water for 20 seconds.

❗Hand sanitizer and heat does not work well against Norovirus because the individual virions are very very tough to kill. You MUST wash hands with soap and water.

For all pathogens, cover coughs and sneezes in the elbow crease and not your hands.

We're almost there! :canparrot:

It's Goose flyover season! :cangoose:

We're gonna have a great Spring, and simple, common sense consideration and source control is how we get there! 💐💐💐

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #JN1 #FluA #FluB #Influenza #Norovirus #Noro #Rotavirus

#JN1Sixteen #JN116
#KP1One #KP11
#KP2
#KP2One #KP21

#WearAMask #CleanTheAir #VaccinesSaveLives #WashHands #Wastewater #StayHomeIfSick #SourceControl #USESourceControl #COVIDSourceControl

Update for 2/02/2024!

Good Morning SARS2PAians!

I hope you're staying dry with all this winter rain! (Sorry I haven't mirrored on Fedi for a while, i had major important stuff going on.)

There's no new CDC stuff today, but also not much new info to write about in total, JN.1.11 doesn't seem to be taking off right now, and numbers are still doing very well in spite of colder weather (when air cleaning and freshening is a bit more difficult).

THIS IS GOOD! I don't want to have any more news here ever! 🎊

__________
VOCs

Nationally, nothing different yet. JN.1 and JN.1.4 still at the top. JN.1.11 still way down at 0.13% and though it's in 5 states and a few more sequences have been found, it hasn't risen above 1% yet.: https://ibb.co/wgZHftH

__________
Wastewater

Nationally, the decline is starting to level off a bit. Hopefully it continues down after more data is collected.: https://ibb.co/MkcDDX5

Regionally, the West is ticking a bit upwards while everyone else is levelling off.: https://ibb.co/kXdhcTJ

In PA, the 5 stations reporting to Biobot are still doing fabulously. Luzerne and Lackawanna still quite above the national average though.: https://ibb.co/M1KzWJy

According to PA's own wastewater monitoring site numbers are holding steady through the state except thre's an uptick in Franklin Co and over by Pottstown.: https://ibb.co/n3hfVrY

FranklinCo: https://ibb.co/VCb9Z9N

Pottstown: https://ibb.co/0Jg6Gy8

Please use caution to keep these numbers from going back up and causing life, learning, and financial loss.

I just want to shoutout Erie Co since I lost track of there, Erie doesn't report to Biobot but it IS on the PA Wastewater dashboard.

It's not only that Erie's numbers are low, it's that (except for a post-holiday small rise) the absolute baseline there is going down!! Look at that. : https://ibb.co/RyVt4bn

That's amazing. Every county, State, and territories' chart should look like this.

:canparrot: :canparrot: Thank you Erie! :canparrot: :canparrot:

Another short update is a good update. Please keep using caution especially with at-risk people and in large public gatherings. Wear a quality respirator in places where there is tightly enclosed space with little ventilation (elevators, restrooms, large public closets, etc.)

Keep that air fresh and clean and we'll be fantastic by Spring! ❄️❄️🌷

#JN1Eleven

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Update for 1/22/2024!

Good Morning SARS2PAians!

Warmer temperatures are ahead, finally, after this bitter cold spell.❄️❄️❄️

__________
VOCs

There's not much new info out there and of course JN.1 and its child JN.1.4 still dominate the variant leaderboard, so this update will be brief as I have family stuff to do this morning anyway.

It's all going to be about closely watching JN.1.11 (JN-one-eleven).

It's now in 5 states as now it's been found in Washington State, and is spreading blazingly fast in India.

JN.1.11 is now accounting for 0.13% of all random sequencing in the US, up from 0.8%. (Yes, it matters to watch it at those low numbers. Low numbers become top leaderboard numbers eventually!).: https://ibb.co/q92Mccf

__________
CDC

The new hospital admits map looks very much improved since last time. Still some increased activity in Philly, Pike Co, and Lawrence Co. Significant increases in Tioga.: https://ibb.co/n6YqkGj

The Northeast US still struggles with lots of occupied inpatient beds. Lots of increases here as COVID filters through the medical system. Increases from Wayne Co down southwest through Huntingdon Co, over to Jefferson Co and up to Potter and McKean.: https://ibb.co/cyzjP7j

ICU Beds now rising through the State too, especially in Berks, Lancaster, Franklin Co up through to Centre, and the northwest corner of the State excluding Crawford Co.: https://ibb.co/wNWptSH

The 3-month death metric unfortunately remains high in most states including PA, and if you compare to last week, this number is increasing steadily in a lot of States.: https://ibb.co/9TNjnkW

We are sadly experiencing over 300 deaths a month from COVID, 1004 deaths in the past 3 months alone.

❄️❄️❄️Don't become a statistic! Please keep wearing those quality respirators, keep the air clean, be aware of social contacts, and get those vaccinations! 😷❄️❄️❄️

#JN1Eleven

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

𝗟𝗔𝗧𝗘𝗦𝗧 𝗨𝗞 #COVID19

🧪𝗖𝗮𝘀𝗲𝘀 — weekly
🔻6,117

🧮𝗧𝗼𝗽 𝗩𝗮𝗿𝗶𝗮𝗻𝘁𝘀
#JN1 #HV1 #EG51

🏥𝗛𝗼𝘀𝗽𝗶𝘁𝗮𝗹 𝗔𝗱𝗺𝗶𝘀𝘀𝗶𝗼𝗻𝘀 — weekly
🔻3,298

🕯️𝗗𝗲𝗮𝘁𝗵𝘀 — weekly
🔺301

🕯️𝗧𝗢𝗧𝗔𝗟 𝗗𝗲𝗮𝘁𝗵𝘀
🔺235,028

➡️http://PMP-Magazine.com/covid-19-today/

#COVIDisNotOver 😷

Update for 1/19/2024!

Good Morning SARS2PAians!

So. How 'bout that snow? ❄️❄️❄️

Please be cautious and don't travel today if you don't have to! (And don't travel even if you do have to, if you can help it!)

There's no new CDC map stuff today.

__________
VOCs

Nationally, JN.1 at the top of the leaderboard at over 32% of sequencing.: https://ibb.co/vsK3j09

Please remember ALL sequencing is very slow so these numbers are delayed by weeks. Its child JN.1.4 in second place at over 16%.

In PA, JN.1 and its child mutation JN.1.4 at the top of the chart, reflecting naitonal levels.: https://ibb.co/Bcp6Skk

In NY/NJ, numbers also reflect national levels, ans the first few successful lineages are JN.1, JN.1.4, and HV.1.: https://ibb.co/WBk99sG

XDD is a recombinant that has potential to keep up with and even surpass JN.1.

__________
Lineage News

I want to bring your attention to two potentially problematic new mutations: Previously mentioned XDD (a recombo of EG.5.1.1 and JN.1,) and also especially JN.1.11.

Note: That is J-N-ONE-ELEVEN, and I'll hashtag it here on the Fediverse as #JN1Eleven so it won't get confused with other names like JN.1.1.1 or JN.11.1. Understanding the correct lineage name is vital in tracking!

JN.1.11 has a bonkers high estimated fitness (ability to reproduce, infect, take over the lineage leaderboard etc.) based on genomic info alone.: https://ibb.co/J28MbXh

It was only sequenced this month and is already in 5 countries: India, USA, Singapore, Israel, and the UK.

It's already in at least 4 US States: TX, CO, MD and NC.: https://ibb.co/vDhvmX2

Reminder that the JN.x.y series also as a whole has a bonkers high estimated fitness and binding ability based on genomics alone that you can see here on the ACE2/Immune Escape estimation graph.: https://ibb.co/cJ7dLRT

Numbers in wastewater are starting to go down from the original JN.1, but the trouble with this JN.1 clan is it mutates quickly AND all of it is fast. It has the potential to raise the absolute baseline high and keep it there so it never goes down IF we all do not practice some form of source control.

Schools as they open will contribute to rising cases and increased absences all over the place, for kids AND for adults. The way to combat this is source control.

__________
Wastewater

Nationally, SARS2 in wastewater starting to decline.: https://ibb.co/ftKcw5N

Regionally, the Northeast on a sharp downturn and the rest of the regions holding steady or ever so slightly declining.: https://ibb.co/KbjPYLR

Please don't get comfy with this until we know how schoolkids are going to fare.

In PA, the 5/11 Biobot up-to-date sheds are showing a promising downturn, ChesterCo and BucksCo down to meeting the national average level again.: https://ibb.co/0MTv8cm

MontCo is back to smashing it going BELOW national levels!

According to the PA DOH wastewater site (thank you so much to a supercool Fediverse reader that pointed this site out for me!!...thank you lemon❤️️) sheds in CentreCo, near Philly and in MonroeCo are experiencing increases in tested SARS2 material.: https://ibb.co/BgDtfH0

On WastewaterSCAN, levels are still HIGH nationally for SARS2, RSV, and Norovirus (which is the "24hr stomach thing" from tainted surfaces/food). Make sure your utensils and eating places are cleaning things properly...this stuff's just gross 🤢: https://ibb.co/LSnpD2j

We are not out of the woods yet with this illness season. PLEASE practice some source control as this blazing fast JN.x.y clan takes over and can push numbers way up if we get hit with multiple very fit variants at once.
NOWCAST

The latest NOWCAST from CDC is out. JN.1 estimated at 85% of cases this week! 👀🚀👀🚀👀🚀: https://ibb.co/LS53WZH

Lots of junk out there and JN.x.y is some seriously fast business. Please :canparrot: doooooooooo the source control :canparrot: and we can prevent life, learning, and financial loss and have an easy transition into spring! 😷😷😷

(And be careful out there today too ❄️❄️❄️)

#JN1Eleven

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Ein neuer Zangerle ist in der Seuchenkolumne erschienen:

Gute Nachrichten von Covid. Schlechte Nachrichten von der politischen Vernunft
https://www.falter.at/seuchenkolumne/20240119/gute-nachrichten-von-covid-schlechte-nachrichten-von-der-politischen-vernunft

#Seuchenkolumne #zangerle #covid #covid19 #covid19at #österreich #ili #influenzaLikeIllness #influenza #rsv #Abwassermonitoring #bettenbelegung #krankenhausaufnahme #impfung #Auffrischungsimpfung #pravalenzfehler #BaseRateFallacy #jn1