#virulence — Public Fediverse posts

An #NS1-F161L #Substitution Determines #Host-Driven #Virulence Enhancement of #H5N6 Avian #Influenza Virus in #Ducks, https://etidiohnew.blogspot.com/2026/04/an-ns1-f161l-substitution-determines.html

An #NS1-F161L #Substitution Determines #Host-Driven #Virulence Enhancement of #H5N6 Avian #Influenza Virus in #Ducks, https://etidiohnew.blogspot.com/2026/04/an-ns1-f161l-substitution-determines.html

An #NS1-F161L #Substitution Determines #Host-Driven #Virulence Enhancement of #H5N6 Avian #Influenza Virus in #Ducks, https://etidiohnew.blogspot.com/2026/04/an-ns1-f161l-substitution-determines.html

An #NS1-F161L #Substitution Determines #Host-Driven #Virulence Enhancement of #H5N6 Avian #Influenza Virus in #Ducks, https://etidiohnew.blogspot.com/2026/04/an-ns1-f161l-substitution-determines.html

An #NS1-F161L #Substitution Determines #Host-Driven #Virulence Enhancement of #H5N6 Avian #Influenza Virus in #Ducks, https://etidiohnew.blogspot.com/2026/04/an-ns1-f161l-substitution-determines.html

VIRULENCE (Estats Units) presenta nou single: "Epidemic Unleashed" #Virulence #DeathMetal #Abril2026 #EstatsUnits #NouSingle #Metall #Metal #MúsicaMetal #MetalMusic

VIRULENCE (Estats Units) presenta nou single: "Epidemic Unleashed" #Virulence #DeathMetal #Abril2026 #EstatsUnits #NouSingle #Metall #Metal #MúsicaMetal #MetalMusic

How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @olayarendueles &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @PLOSBiology https://plos.io/4s64Ko0

How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @olayarendueles &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @PLOSBiology https://plos.io/4s64Ko0

How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @olayarendueles &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @PLOSBiology https://plos.io/4s64Ko0

How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @olayarendueles &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @PLOSBiology https://plos.io/4s64Ko0

How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @olayarendueles &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @PLOSBiology https://plos.io/4s64Ko0

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

The #ORF6 accessory #protein contributes to #SARS-CoV-2 #virulence and pathogenicity in the naturally susceptible #feline model of infection, https://etidiohnew.blogspot.com/2026/02/the-orf6-accessory-protein-contributes.html

The #ORF6 accessory #protein contributes to #SARS-CoV-2 #virulence and pathogenicity in the naturally susceptible #feline model of infection, https://etidiohnew.blogspot.com/2026/02/the-orf6-accessory-protein-contributes.html

The #ORF6 accessory #protein contributes to #SARS-CoV-2 #virulence and pathogenicity in the naturally susceptible #feline model of infection, https://etidiohnew.blogspot.com/2026/02/the-orf6-accessory-protein-contributes.html

The #ORF6 accessory #protein contributes to #SARS-CoV-2 #virulence and pathogenicity in the naturally susceptible #feline model of infection, https://etidiohnew.blogspot.com/2026/02/the-orf6-accessory-protein-contributes.html

The #ORF6 accessory #protein contributes to #SARS-CoV-2 #virulence and pathogenicity in the naturally susceptible #feline model of infection, https://etidiohnew.blogspot.com/2026/02/the-orf6-accessory-protein-contributes.html

Evolutionary #lineage and #host origin influence #virulence and #mammalian adaptation of #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2026/02/evolutionary-lineage-and-host-origin.html

Evolutionary #lineage and #host origin influence #virulence and #mammalian adaptation of #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2026/02/evolutionary-lineage-and-host-origin.html

Evolutionary #lineage and #host origin influence #virulence and #mammalian adaptation of #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2026/02/evolutionary-lineage-and-host-origin.html

Evolutionary #lineage and #host origin influence #virulence and #mammalian adaptation of #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2026/02/evolutionary-lineage-and-host-origin.html

Evolutionary #lineage and #host origin influence #virulence and #mammalian adaptation of #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2026/02/evolutionary-lineage-and-host-origin.html

#Haemagglutinin 162-164 #deletions enhance #influenza B/Victoria virus #fitness and #virulence in vivo, https://etidiohnew.blogspot.com/2026/01/haemagglutinin-162-164-deletions.html

#Haemagglutinin 162-164 #deletions enhance #influenza B/Victoria virus #fitness and #virulence in vivo, https://etidiohnew.blogspot.com/2026/01/haemagglutinin-162-164-deletions.html

#Haemagglutinin 162-164 #deletions enhance #influenza B/Victoria virus #fitness and #virulence in vivo, https://etidiohnew.blogspot.com/2026/01/haemagglutinin-162-164-deletions.html

#Haemagglutinin 162-164 #deletions enhance #influenza B/Victoria virus #fitness and #virulence in vivo, https://etidiohnew.blogspot.com/2026/01/haemagglutinin-162-164-deletions.html

#Haemagglutinin 162-164 #deletions enhance #influenza B/Victoria virus #fitness and #virulence in vivo, https://etidiohnew.blogspot.com/2026/01/haemagglutinin-162-164-deletions.html

Genotype #B3.13 #influenza #H5N1 viruses isolated from dairy #cattle demonstrate high #virulence in laboratory #models, but retain #avian virus-like properties, https://etidiohnew.blogspot.com/2025/07/genotype-b313-influenza-h5n1-viruses.html

Genotype #B3.13 #influenza #H5N1 viruses isolated from dairy #cattle demonstrate high #virulence in laboratory #models, but retain #avian virus-like properties, https://etidiohnew.blogspot.com/2025/07/genotype-b313-influenza-h5n1-viruses.html

Genotype #B3.13 #influenza #H5N1 viruses isolated from dairy #cattle demonstrate high #virulence in laboratory #models, but retain #avian virus-like properties, https://etidiohnew.blogspot.com/2025/07/genotype-b313-influenza-h5n1-viruses.html

Genotype #B3.13 #influenza #H5N1 viruses isolated from dairy #cattle demonstrate high #virulence in laboratory #models, but retain #avian virus-like properties, https://etidiohnew.blogspot.com/2025/07/genotype-b313-influenza-h5n1-viruses.html

Genotype #B3.13 #influenza #H5N1 viruses isolated from dairy #cattle demonstrate high #virulence in laboratory #models, but retain #avian virus-like properties, https://etidiohnew.blogspot.com/2025/07/genotype-b313-influenza-h5n1-viruses.html

#Aminoacid #mutations #PB1-V719M and #PA-N444D combined with #PB2-627K contribute to the #pathogenicity of #H7N9 in #mice, Vet Res.: https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6

Overall, this study revealed that #virulence in H7N9 is a #polygenic trait and identified novel virulence-related residues (PB2-627K combined with PB1-719M and/or PA-444D) in viral ribonucleoprotein (vRNP) complexes.

Different #genetic #determinants for high #virulence, #transmission and #replication of high pathogenicity #H7N7 avian #influenza virus in #turkeys and #chickens, https://etidiohnew.blogspot.com/2025/03/different-genetic-determinants-for-high.html

Glutamic Acid at Position 343 in #PB2 Contributes to the #Virulence of #H1N1 #Swine #Influenza Virus in Mice, https://etidiohnew.blogspot.com/2025/07/glutamic-acid-at-position-343-in-pb2.html

A comprehensive #review of current #insights into the #virulence factors of #SARS-CoV-2, https://etidiohnew.blogspot.com/2025/01/a-comprehensive-review-of-current.html

#Hemagglutinin with a #polybasic #cleavage site confers high #virulence on #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2025/01/hemagglutinin-with-polybasic-cleavage.html

2 #aminoacid residues in N-terminal region of #polymerase acidic protein determine #virulence of Eurasian avian-like #H1N1 swine #influenza viruses in mice, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.01293-24?af=R

We identified that 2 naturally occurring aa mutations in PA derived from #H1N1/2009 are crucial determinants of virulence of rEA H1N1 viruses & revealed differential mechanism by which these 2 mutations affect transcription & replication of vRNA.

''It is noteworthy that crucial mutations associated with #mammalian #host #adaptation and enhanced #transmission, specifically residues 271A, 292 V, 591 K, 627 K/V/A, 701N, in PB2 (28, 30, 33-35), and 228S, along with the #virulence-increasing residue 66S in PB1-F2(46), were conspicuously absent in all #HPAI virus strains derived from dairy #cattle and #cats. ''

#Virulence and #transmission vary between #Usutu virus #lineages in #Culex pipiens https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012295

Therefore, we found evidence of lineage-specific differences in vectorial capacity and virulence to both the vector and vertebrate host which lead to balanced propagation of both viral lineages.

#Outbreaks of #H5N1 High Pathogenicity Avian #Influenza in #SouthAfrica in 2023 Were Caused by Two Distinct Sub-#Genotypes of Clade 2.3.4.4b Viruses, Viruses: https://www.mdpi.com/1999-4915/16/6/896

South African clade 2.3.4.4b H5N1 viruses had comparatively fewer #markers of #virulence and #pathogenicity compared to European strains, a possible reason why no #spillover to #mammals has occurred here yet.

In #Ovo #Models to Predict #Virulence of Highly Pathogenic Avian #Influenza #H5-Viruses for #Chickens and #Ducks https://pubmed.ncbi.nlm.nih.gov/38675905/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240427100729&v=2.18.0.post9+e462414

@krypt3ia it is all natural - the real fear is with synthetic attentuation studies - 100x the depression factor and the really sad part is it probably already happened once, likely will happen again #woohan #virulence #unknowns

#PB2 residue 473 contributes to the #mammalian #virulence of #H7N9 avian #influenza virus by modulating viral #polymerase activity via ANP32A, J Virol.: https://doi.org/10.1128/jvi.01944-23

-- In this study, we identified PB2 residue 473 as a new determinant of mouse virulence and mammalian #adaptation of the viral polymerase of the H7N9 virus and its non-pathogenic #H9N2 counterparts.

When researchers tried to evolve a #yeast population to stick to plastic, they accidentally increased its ability to cause infection. What more can we learn about ‘accidental #virulence’? #Pathogens #Microbiology #Evolution https://elifesciences.org/articles/94556?utm_source=,astodon&utm_medium=social&utm_campaign=organic_insights

#StaphAureus lipoproteins play unique roles in cellular processes & host interactions. @SchilcherKatrin @Horswill_Lab reveal that #lipoprotein CamS represses toxin production, showing how lipoproteins can affect #virulence & disease outcomes #PLOSBiology https://plos.io/48Of5f3