#h7n9 — Public Fediverse posts

Prior #immunity to seasonal #influenza #H3N2 virus confers varying levels of cross - #protection against challenge with clade 2.3.4.4b #H5N1, #H7N9, or #H9N2 virus in a #ferret model, https://etidiohnew.blogspot.com/2026/04/prior-immunity-to-seasonal-influenza.html

#Genomic similarity to quantitatively evaluate the #reassortment #potential of #H7N9 with other subtypes of avian #influenza viruses, https://etidiohnew.blogspot.com/2026/04/genomic-similarity-to-quantitatively.html

#Birth #imprinting effects on the #antibody responses of #H7N9 patients from 2013-2018 in #China, https://etidiohnew.blogspot.com/2026/04/birth-imprinting-effects-on-antibody.html

#Birth #imprinting effects on the #antibody responses of #H7N9 patients from 2013-2018 in #China, https://etidiohnew.blogspot.com/2026/04/birth-imprinting-effects-on-antibody.html

#Birth #imprinting effects on the #antibody responses of #H7N9 patients from 2013-2018 in #China, https://etidiohnew.blogspot.com/2026/04/birth-imprinting-effects-on-antibody.html

#Birth #imprinting effects on the #antibody responses of #H7N9 patients from 2013-2018 in #China, https://etidiohnew.blogspot.com/2026/04/birth-imprinting-effects-on-antibody.html

#Birth #imprinting effects on the #antibody responses of #H7N9 patients from 2013-2018 in #China, https://etidiohnew.blogspot.com/2026/04/birth-imprinting-effects-on-antibody.html

Systematic Identification of the Functional lncRNAs During #H7N9 Avian #Influenza Virus #Infection in Mice, https://etidiohnew.blogspot.com/2026/03/systematic-identification-of-functional.html

Evolutionary #lineage and #host origin influence #virulence and #mammalian adaptation of #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2026/02/evolutionary-lineage-and-host-origin.html

#Prognostic factors in #H7N9 avian #influenza: a systematic review based on case reports, https://etidiohnew.blogspot.com/2026/02/prognostic-factors-in-h7n9-avian.html

Intranasal #replicon #vaccine establishes mucosal #immunity and protects against #H5N1 and #H7N9 #influenza, https://etidiohnew.blogspot.com/2026/01/intranasal-replicon-vaccine-establishes.html

Expanding Horizons: #Host Range #Evolution and #Treatment Strategies for Highly Pathogenic Avian #Influenza #H5N1 and #H7N9, https://etidiohnew.blogspot.com/2025/12/expanding-horizons-host-range-evolution.html

Highly Pathogenic Avian #Influenza: #Tracking the #Progression from IAV #H5N1 to IAV #H7N9 and Preparing for Emerging Challenges, https://etidiohnew.blogspot.com/2025/12/highly-pathogenic-avian-influenza.html

Direct #airway delivery of a humanized anti - #H7N9 neutralizing #antibody broadly protects against divergent #H7 #influenza viruses in the mouse model, https://etidiohnew.blogspot.com/2025/11/direct-airway-delivery-of-humanized.html

Cross-Species #Transmission #Risks of a #Quail-Origin #H7N9 #Influenza Virus from #China Between Avian and #Mammalian Hosts, https://etidiohnew.blogspot.com/2025/10/cross-species-transmission-risks-of.html

#Clinical features of a #fatal case of acute #encephalitis associated with a novel influenza #H3N2 #recombinant virus possessing human-origin #H7N9 internal genes: a descriptive study, https://etidiohnew.blogspot.com/2025/07/clinical-features-of-fatal-case-of.html

Metabolomic Profiling of #Plasma Reveals Differential #Disease Severity #Markers in avian #influenza A(#H7N9) infection Patients, https://etidiohnew.blogspot.com/2025/06/metabolomic-profiling-of-plasma-reveals.html

Attenuation of A(#H7N9) #influenza virus #infection in mice exposed to #cigarette smoke, https://etidiohnew.blogspot.com/2025/04/attenuation-of-ah7n9-influenza-virus.html

#FYI #US #USA #disease #diseases #AMA #AmericanMedicalAssociation #AndreaGarcia #ToddUnger #birdflu #avianflu #H7N9 #dengue #denguefever #vaccinate #maskup #wearamask
AMA weekly update infectious diseases 24. March 2025

"Discussing rising measles cases globally, avian flu in chickens, dengue fever news, immune amnesia, and how to get better sleep with the latest sleep trend in 2025."

https://www.youtube.com/watch?v=XdMSOzILssI

#H7N9 #USA #Vogelgrippe bsky.app/profile/drma...

RE: https://bsky.app/profile/did:plc:v4dhmcobzcqmxfkrhxezron4/post/3lklhgdnz6k2p

In den #USA ist in Masthähnchen-Bestand der gefährliche #Vogelgrippe (Subtypus) #H7N9 ausgebrochen. WHO warnt. Diese Virusvariante ist besorgniserregend, weil die meisten Patienten daran schwer erkranken. Demnach sei der Subtyp deutlich tödlicher als die am weitesten Variante H5N1.

Tödliche Vogelgrippe-Variante ...

ABD’de kuş gribi salgını!:  ABD, 2017'den bu yana kümes hayvanı çiftliğinde H7N9 kuş gribi salgınının ilk kez görüldüğünü bildirdi.

HAYVAN SAĞLIĞI HEYETİNDEN AÇIKLAMA

H5N1 kuş gribi salgınıyla mücadele eden ABD, ülkede 2017'den itibaren kümes hayvanı çitliğinde görülen ilk H7N9 salgınını duyurdu. Mississippi Hayvan Sağlığı Heyeti yaptığı açıklamada, "H7N9 virüsü tamamen Kuzey Amerika ve yabani kuş… https://www.eshahaber.com.tr/haber/abd-de-kus-gribi-salgini-212745.html?utm_source=dlvr.it&utm_medium=mastodon EshaHaber.com.tr #kuşgribi #hayvansağlığı #H7N9 #H5N1 #salgın

Source: @www.cidrap.umn.edu

From the article; "The US Department of Agriculture (USDA) today announced the rollout of two biosecurity assessment programs available for commercial poultry farms, one targeting wildlife hazards and the other reviewing biosecurity plans and measures.

"The programs are part of plans to prevent the introduction and spread of highly pathogenic avian influenza and dovetail with up to $1 billion in emergency funding announced last month by USDA Secretary Brooke Rollins.

I"n other avian flu developments, the USDA’s Animal and Plant Health Inspection Service (APHIS) shared more details about the highly pathogenic H7N9 outbreak at a Mississippi broiler farm, and confirmed more detections in poultry and dairy cattle."

#H7N9 #BirdFlu #Virus #Healthcare #MedicalResearch #Science #USDA

https://www.cidrap.umn.edu/avian-influenza-bird-flu/usda-launches-biosecurity-steps-poultry-producers-adds-details-h7n9-avian

46,000 birds died or killed after bird flu in Mississippi.

"...A new strain of a highly pathogenic bird flu known as H7N9 has surfaced at a poultry farm in Mississippi where chickens are raised for breeding...."

https://www.latimes.com/environment/story/2025-03-19/bird-flu-developments-new-strain-discovered-and-research-on-immunity

#birdflu #h5n1 #hpai #h7n9

#Grippe aviaire : qu'est-ce que la #souche #H7N9, transmissible à l'homme {NOT! this is an NA lineage not one of the two China's HP/LP lineages}, qui vient de réapparaître aux Etats-Unis ? https://www.francetvinfo.fr/sante/maladie/grippe-aviaire/grippe-aviaire-qu-est-ce-que-la-souche-h7n9-transmissible-a-l-homme-qui-vient-de-reapparaitre-aux-etats-unis_7138956.html#xtor=RSS-3-[lestitres]

La dernière détection de ce sous-type dans le pays datait d'août 2017, quatre ans après son apparition en Chine, dans la région de Shanghai.

“The #H7N9 #birdflu virus has proved to have a high death rate for humans worldwide killing 616 people, or 39%, of the 1,568 people infected worldwide since it was first detected in 2013 in China, the World Health Organisation said.”

US reports first outbreak of deadly H7N9 bird flu since 2017 | Reuters https://www.reuters.com/business/healthcare-pharmaceuticals/us-reported-first-outbreak-h7n9-bird-flu-farm-since-2017-woah-says-2025-03-17/ https://www.reuters.com/business/healthcare-pharmaceuticals/us-reported-first-outbreak-h7n9-bird-flu-farm-since-2017-woah-says-2025-03-17/#::text=The%20H7N9%20bird%20flu%20virus,the%20World%20Health%20Organisation%20said “The United States reported the first outbreak of the deadly #H7N9 #birdflu on a poultry farm since 2017, as the country continues to grapple with another bird flu strain that has infected humans and caused egg prices to hit record highs.”

Sinds jaren nog eens een uitbraak van #H7N9 #vogelgriep in de VS. H7N9 heeft bij mensen een #mortaliteit van 25%, maar kwam tot nu toe weinig voor.
Die andere vogelgriep #H5N1 kan ondertussen verrassend genoeg ook katten besmetten.

#davindikstraf

Headline: US reports first outbreak of deadly H7N9 bird flu since 2017

Source: @Reuters

From the article: "PARIS, March 17 (Reuters) - The United States reported the first outbreak of the deadly H7N9 bird flu on a poultry farm since 2017, as the country continues to grapple with another bird flu strain that has infected humans and caused egg prices to hit record highs.

"The spread of avian influenza, commonly called bird flu, has ravaged flocks around the world, disrupting supply and fuelling higher food prices. Its spread to mammals, including dairy cows in the U.S., has raised concerns among governments about a risk of a new pandemic."

#H7N9 #BirdFlu #Virus #Healthcare #MedicalResearch #Science

URL for article because thumbnail is not displaying:
https://www.reuters.com/business/healthcare-pharmaceuticals/us-reported-first-outbreak-h7n9-bird-flu-farm-since-2017-woah-says-2025-03-17/

#USA - High pathogenicity avian #influenza #H7N9 viruses (#poultry) (Inf. with) - Immediate notification, https://etidiohnew.blogspot.com/2025/03/usa-high-pathogenicity-avian-influenza.html

#Hemagglutinin with a #polybasic #cleavage site confers high #virulence on #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2025/01/hemagglutinin-with-polybasic-cleavage.html

#Safety and #immunogenicity of ascending doses of #influenza A(#H7N9) inactivated #vaccine with or without MF59®, https://etidiohnew.blogspot.com/2025/01/safety-and-immunogenicity-of-ascending.html

An intranasal, NLC-delivered self-amplifying #RNA #vaccine establishes protective #immunity against pre-pandemic #H5N1 and #H7N9 #influenza, https://etidiohnew.blogspot.com/2025/01/an-intranasal-nlc-delivered-self.html

Anti- #neuraminidase and anti- #hemagglutinin #stalk responses to different #influenza A(#H7N9) #vaccine regimens, https://etidiohnew.blogspot.com/2025/01/anti-neuraminidase-and-anti.html

Structural basis of different #neutralization capabilities of #monoclonal #antibodies against #H7N9 virus, https://etidiohnew.blogspot.com/2024/12/structural-basis-of-different.html

Structural basis of different #neutralization capabilities of #monoclonal #antibodies against #H7N9 virus, https://etidiohnew.blogspot.com/2024/12/structural-basis-of-different.html

Structural basis of different #neutralization capabilities of #monoclonal #antibodies against #H7N9 virus, https://etidiohnew.blogspot.com/2024/12/structural-basis-of-different.html

Structural basis of different #neutralization capabilities of #monoclonal #antibodies against #H7N9 virus, https://etidiohnew.blogspot.com/2024/12/structural-basis-of-different.html

Structural basis of different #neutralization capabilities of #monoclonal #antibodies against #H7N9 virus, https://etidiohnew.blogspot.com/2024/12/structural-basis-of-different.html

#Age-Dependent #Pathogenesis of #Influenza A Virus #H7N9 Mediated Through #PB1-F2-Induced Mitochondrial DNA Release and Activation of cGAS-STING-NF-κB Signaling

Source: Journal of Medical Virology, ABSTRACTExactly why human infection of avian influenza A virus H7N9 causes more severe disease in the elderly remains elusive. In this study, we found that H7N9 PB1-F2 is a pathogenic factor in 15–18-month-old BALB/C mice (aged mice) but not in 6–8-week-old young adult mice…

https://etidioh.wordpress.com/2024/11/21/age-dependent-pathogenesis-of-influenza-a-virus-h7n9-mediated-through-pb1-f2-induced-mitochondrial-dna-release-and-activation-of-cgas-sting-nf-%ce%bab-signaling/

#Efficacy of the #H7N9 #vaccine as a candidate for the #Korean avian #influenza #antigen bank

Source: Veterinary Immunology and Immunopathology, AbstractThe avian influenza A virus (H7N9), first detected in China in 2013, is a zoonotic virus that remains persistent in bird populations despite a decline in human cases owing to control measures. Therefore, this study aimed to develop a vaccine as one preventive strategy in anticipation of the potential entry of H7N9 into…

https://etidioh.wordpress.com/2024/11/03/efficacy-of-the-h7n9-vaccine-as-a-candidate-for-the-korean-avian-influenza-antigen-bank/

#Serum #proteome reveals distinctive molecular #features of #H7N9 – and #SARS-CoV-2-infected patients

Source: Cell Reports, SummaryThe coronavirus disease 2019 (COVID-19) pandemic has reminded us of human infections with the H7N9 virus and has raised questions related to the clinical and molecular pathophysiological diversity between the two diseases. Here, we performed a proteomic approach on sera samples from patients with H7N9-virus or SARS-CoV-2-virus infection and…

https://etidioh.wordpress.com/2024/11/03/serum-proteome-reveals-distinctive-molecular-features-of-h7n9-and-sars-cov-2-infected-patients/

The #host #tropism of current #zoonotic #H7N9 viruses depends mainly on an acid-labile #hemagglutinin with a single amino acid #mutation in the #stalk region

Source: PLoS Pathogens, AbstractThe incidence of human infection by zoonotic avian influenza viruses, especially H5N1 and H7N9 viruses, has increased. Current zoonotic H7N9 avian influenza viruses (identified since 2013) emerged during reassortment of viruses belonging to different subtypes. Despite analyses of…

https://etidioh.wordpress.com/2024/10/22/the-host-tropism-of-current-zoonotic-h7n9-viruses-depends-mainly-on-an-acid-labile-hemagglutinin-with-a-single-amino-acid-mutation-in-the-stalk-region/

An emerging #PB2-627 #polymorphism increases #pandemic #potential of avian #influenza virus by breaking through ANP32 host restriction in #mammalian & avian hosts, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.07.03.601996v4

by screening the global PB2 seq., we discovered a new independent cluster with PB2-627V emerged in the '10s, which is prevalent in various avian, mammalian, & human isolates of AIVs, including #H9N2, #H7N9, #H3N8, 2.3.4.4b #H5N1, and other subtypes.

An emerging #PB2-627 #polymorphism increases the #pandemic #potential of avian #influenza virus by breaking through ANP32 #host #restriction in #mammalian and avian hosts, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.07.03.601996v3

...we discovered a new independent #cluster with PB2-627V emerged in the 2010s, which is prevalent in various avian, mammalian, and human isolates of AIVs, including #H9N2, #H7N9, #H3N8, 2.3.4.4b #H5N1, and other subtypes.

Experts say #Australia’s current #birdflu #outbreak is ‘unprecedented’ https://cosmosmagazine.com/nature/birds/experts-say-australias-current-bird-flu-outbreak-is-unprecedented/

“This year ACDP has conducted 3,000 tests on 1,000 samples since the first detection of #H7N3 near Meredith in #Victoria in May, and subsequently #H7N9 Terang in Victoria, #H7N8 in #NSW and [#ACT],” says Eagles.

A synthetic #TLR4 agonist significantly increases #humoral immune #responses and the protective ability of an #MDCK-cell-derived inactivated #H7N9 #vaccine in #mice, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06082-8

Antigenically divergent H7N9 viruses pose a potential threat to public #health, with the poor #immunogenicity of candidate H7N9 vaccines demonstrated in clinical trials underscoring the urgent need for more-effective H7N9 vaccines.

#Aminoacid #mutations #PB1-V719M and #PA-N444D combined with #PB2-627K contribute to the #pathogenicity of #H7N9 in #mice, Vet Res.: https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6

Overall, this study revealed that #virulence in H7N9 is a #polygenic trait and identified novel virulence-related residues (PB2-627K combined with PB1-719M and/or PA-444D) in viral ribonucleoprotein (vRNP) complexes.

R229I #substitution from #oseltamivir induction in HA1 region significantly increased the #fitness of a #H7N9 virus bearing NA 292K, Emerg Microbes Infect.: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2373314

It indicated that through the fine-tuning of the HA–NA balance, R229I increased the fitness and change the #antigenicity of a H7N9 virus bearing NA 292 K. Public health attention of this mechanism needs to be drawn.

#Pathogenicity and #transmission of novel highly pathogenic #H7N2 #variants originating from #H7N9 avian #influenza viruses in #chickens, Virology: https://www.sciencedirect.com/science/article/abs/pii/S0042682224001429?via%3Dihub

4 HP H7N2 avian influenza viruses were isolated in #China during 2019. H7N2 isolates were #reassortants with H7N9-derived HA genes and #H9N2-derived NA genes. H7N9-derived HA genes might be a critical virulence contributor to novel H7 avian influenza viruses.