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#xbb — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #xbb, aggregated by home.social.

  1. @JeDi Ich hätte gerne mit Familie und Urlaubsgepäck eine Reservierung. Und nun werden wir wahrscheinlich die gleichen Züge für #FF-#XBB nehmen und nur #FKW-#FF anders fahren, sodass es nicht so krass schlimm wäre ohne Reservierung, aber nun ja, sind halt dann die Hälfte der Züge nicht mehr reserviert.

    (Und ich schrieb vorhin was von Zugbindung, aber das machen wir eh mit Freifahrten / FIP, also ist die auch irrelevant)

  2. #XBB.1.5 monovalent #vaccine induces lasting cross-reactive responses to #SARS-CoV-2 #variants such as HV.1 and #JN1, as well as SARS-CoV-1, but elicits limited XBB.1.5 specific #antibodies, etidiohnew.blogspot.com/2025/0

  3. Evolving #antibody #response to #SARS-CoV-2 #antigenic #shift from #XBB to #JN1

    Source: Nature, AbstractThe continuous evolution of SARS-CoV-2, particularly the emergence of BA.2.86/JN.1 lineage replacing XBB, necessitates re-evaluation of vaccine compositions 1–3. Here, we provide a comprehensive analysis of the humoral immune response to XBB and JN.1 human exposure. We demonstrate the antigenic distinctiveness of XBB and JN.1 lineages in SARS-CoV-2-naive individuals,…

    etidioh.wordpress.com/2024/11/

  4. Effect of wild-type #vaccine doses on #BA5 hybrid #immunity, disease #severity, and #XBB #reinfection risk

    Source: Journal of Virology, ABSTRACTVaccination against the wild-type (WT) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus did not produce detectable levels of neutralizing antibodies (NAbs) against the BA.5 strain before it emerged. However, coronavirus disease-2019 (COVID-19) severity varied highly between unvaccinated, partially vaccinated,…

    etidioh.wordpress.com/2024/11/

  5. #Clinical #profile analysis of #SARS-CoV-2 #community #infections during periods with #omicron #BA2, #BA4/5, and #XBB dominance in #HK: a prospective cohort study

    Source: Lancet Infectious Diseases, SummaryBackgroundExisting studies on SARS-CoV-2 infection have mainly focused on severe clinical outcomes; understanding of the clinical severity profile of general community infections is poor. We aimed to assess and compare the clinical profiles of infections with…

    etidioh.wordpress.com/2024/10/

  6. [Correspondence] Virological #characteristics of the #SARS-CoV-2 #KP311 #variant thelancet.com/journals/laninf/

    SARS-CoV-2 #JN1 variant (#BA28611), arising from BA.2.86.1 with spike protein (S) substitution S:L455S, outcompeted previously predominant #XBB lineages by beginning of 2024. Subsequently, JN.1 subvariants including #KP2 (JN.1.11.1.2) & #KP3 (JN.1.11.1.3), which acquired additional S substitutions (eg, S:R346T, S:F456L, and S:Q493E) have emerged concurrently (appendix pp 19–20).2

  7. [Correspondence] Virological #characteristics of the #SARS-CoV-2 #KP311 #variant thelancet.com/journals/laninf/

    SARS-CoV-2 #JN1 variant (#BA28611), arising from BA.2.86.1 with spike protein (S) substitution S:L455S, outcompeted previously predominant #XBB lineages by beginning of 2024. Subsequently, JN.1 subvariants including #KP2 (JN.1.11.1.2) & #KP3 (JN.1.11.1.3), which acquired additional S substitutions (eg, S:R346T, S:F456L, and S:Q493E) have emerged concurrently (appendix pp 19–20).2

  8. [Correspondence] Virological #characteristics of the #SARS-CoV-2 #KP311 #variant thelancet.com/journals/laninf/

    SARS-CoV-2 #JN1 variant (#BA28611), arising from BA.2.86.1 with spike protein (S) substitution S:L455S, outcompeted previously predominant #XBB lineages by beginning of 2024. Subsequently, JN.1 subvariants including #KP2 (JN.1.11.1.2) & #KP3 (JN.1.11.1.3), which acquired additional S substitutions (eg, S:R346T, S:F456L, and S:Q493E) have emerged concurrently (appendix pp 19–20).2

  9. [Correspondence] Virological #characteristics of the #SARS-CoV-2 #KP311 #variant thelancet.com/journals/laninf/

    SARS-CoV-2 #JN1 variant (#BA28611), arising from BA.2.86.1 with spike protein (S) substitution S:L455S, outcompeted previously predominant #XBB lineages by beginning of 2024. Subsequently, JN.1 subvariants including #KP2 (JN.1.11.1.2) & #KP3 (JN.1.11.1.3), which acquired additional S substitutions (eg, S:R346T, S:F456L, and S:Q493E) have emerged concurrently (appendix pp 19–20).2

  10. A trivalent #protein-based pan- #Betacoronavirus #vaccine elicits cross-neutralizing #antibodies against a panel of coronavirus #pseudoviruses nature.com/articles/s41541-024

    We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of #SARS-CoV, #MERS-CoV, and SARS-CoV-2 #XBB.1.5 with Alum and CpG55.2.

  11. Profiling #SARS-CoV-2-specific #Tcell response, Lancet Infect Dis. {Correspondence}, thelancet.com/journals/laninf/

    #Omicron subvariants that escape #antibody-mediated neutralisation are still recognised by cross-reactive T-cells, & should not be considered antigenically distinct by definition. Vaccination with a monovalent #XBB.1.5 vaccine boosted T-cell responses, including T cells that were cross-reactive with #variants that emerged after XBB.1.5.

  12. #XBB15 monovalent #mRNA #vaccine #booster elicits robust neutralizing #antibodies against #XBB subvariants and #JN1, Cell Host Microbe: doi.org/10.1016/j.chom.2024.01

    • An XBB.1.5 booster markedly enhanced neutralization of SARS-CoV-2, including JN.1
    • An XBB.1.5 booster induced similar antibody titers to XBB infection
    • Omicron infection followed by XBB.1.5 booster yielded the highest antibody titers
    • Our findings supported recommendations for broad use of the updated XBB.1.5 booster

  13. -- Updated monovalent #COVID19 #vaccines provided 54% (95% CI = 46–60%) #protection vs symptomatic #SARS-CoV-2 #infection in persons recently vaccinated compared w/ those who did not receive an updated dose. Vaccination provided protection for infections caused by #JN1 & infections caused by #XBB-related lineages. Waning of effectiveness is expected with additional elapsed time since vaccination, especially against less severe disease.

  14. Wirksamkeit der Boosterimpfung gegen #Corona nun nachgewiesen: >>Eine Studie der Klinik für Rheumatologie und Immunologie der Medizinischen Hochschule Hannover (MHH) schließt nun diese Lücke. In Kooperation mit dem MHH-Institut für Immunologie und dem Deutschen Primatenzentrum Göttingen haben die Forschenden die weltweit erste Publikation über den neuen #XBB.1.5 basierten Impfstoff von Biontech veröffentlicht. Im Rahmen der „#COVID-19 Contact (CoCo)“-Studie der MHH wurden 53 MHH-Beschäftigte untersucht, die den #Impfstoff erhalten haben. Anschließend wurde deren Immunreaktion gemessen. Das Ergebnis: Nach der #Impfung mit dem neuen #Booster waren die Antikörper gegen #Omikron #Varianten deutlich angestiegen. Die Arbeit ist in der renommierten Fachzeitschrift „The Lancet Infection Diseases“ veröffentlicht worden. [.. ]
    „Wir haben nicht nur eine große Menge neutralisierender Antikörper gegen Omikron XBB.1.5 gefunden, sondern auch gegen andere
    #Unter-Varianten“, sagt die Oberärztin Professorin Dr. Alexandra Dopfer-Jablonka, die gemeinsam mit ihrem Klinikkollegen Professor Dr. Georg Behrens die Immunstudie leitet. Das bedeutet, der Impfstoff ruft die Immunabwehr nicht nur gegen die aktuell dominierende Corona-Variante XBB.1.5 auf den Plan, sondern aktiviert die körpereigene Abwehr auch gegen die sich gerade ausbreitende Varianten „#Pirola“ (#BA2.86) und „#Eris“ (#EG1.5). „Die #B-Zellen, die Antikörper gegen Omikron produzieren, wurden signifikant mehr und auch die #T-Zellen wurden durch die Impfung gestärkt“, erklärt die Rheumatologin. „Die Daten zeigen, dass die neue #Booster-Impfung ihr Ziel erreicht und darüber hinaus auch Antikörper gegen neue #SARS-CoV-2 Varianten induziert.“ [..] Eine #Auffrischungsimpfung mit dem neuen, angepassten Impfstoff ist laut Ständiger Impfkommission (#Stiko) für alle empfehlenswert, die 60 Jahre oder älter sind. Zudem sollten sich alle Menschen boostern lassen, die wegen einer #Grunderkrankung ein besonderes Risiko für einen schweren Krankheitsverlauf haben. Außerdem empfiehlt die Stiko die Auffrischungsimpfung für Bewohnerinnen und Bewohner von #Pflegeheimen sowie für# Beschäftigte im Pflege- und Gesundheitsbereich. Die Auffrischungsimpfung sollte jährlich wiederholt werden, vorzugsweise im Herbst. << https://idw-online.de/de/news826159

  15. Evening of our latest #COVID booster day, and it's been one of the easiest for me! My arm isn't even sore, which is rare. That'll prob kick in by morning tho'.

    My very first COVID shot, back when that happened, brought me several hours of fever and bed-shaking shivers before it passed.

    Unfortunately K is having some of that experience this time! Seventh shot for her too, tho 'she weathered all the previous ones very easily. #XBB is a different animal indeed.

    #vaccination #vax

  16. #XBB coursing thru my veins. I am become vaccinated, destroyer of viruses. Roar.

    #vaccination #covid19

  17. (3/3)

    ... auch vor schwerer #Erkrankung durch HV.1 schützt", sagte #Infektiologe #Schaffner today.com. Die neuen Corona-Impfstoffe sind auf die vormals dominierende #Omikron-#Variante #XBB.1.5. angepasst. Da die neuen #Varianten wie HV.1 Omikron-#Sublinien und daher eng verwandt sind, gehen Experten davon aus, dass diesbezüglich keine Gefahr besteht..."

    //

  18. “The National Advisory Committee on Immunization recommends that everyone six months of age and older get the XBB.1.5 vaccine if it has been six months or longer since their last COVID-19 vaccination or COVID-19 infection.
    NACI also recommends the XBB.1.5 vaccine for both children and adults who have never been vaccinated against COVID-19.”

    apple.news/AeHW8fnKFQX65f820lZ

    #COVID19 #vaccine #XBB.1.5 #Canada

  19. Just got my #XBB #COVID jab, you can basically walk into any Shoppers and get it now in #Toronto or anywhere in #Canada although if you want to be sure you can set an appointment online. This city has a number of city run locations as well, look it up. Almost a year since my last shot so I was ready for the updated one!

  20. 10/27/2023

    Good Afternoon SARS2PAians!

    There's no new wastewater or CDC map data today.

    __________
    :ms_arrow_right: VOCs

    Nationally, HV.1 pulling waaaaay ahead of everything else at almost 16% of random sequencing.: ibb.co/P6LfC0t

    Vanilla BA.2.86 is starting to drop off the chart, but its grandchild JN.1 has increased quite a lot this week. No BA.2.86 descendents are above the Tableau graph "fold" yet, though.: ibb.co/WDGqQ0C

    In PA, FL.1.5.1 weirdly more successful here than HV.1, but not by a whole lot. JD.1.1 is another variant that is not good to see here and is specifically being watched for fast progress.

    In NY/NJ, HV.1 and FL.1.5.1 at the top, similar to national testing, but I REALLY want to call your attention to JN.1 which has made it above the fold at .37% already. 👀: ibb.co/QJrmZt4

    __________

    PLEASE get those XBB boosters, flu shots, and some spare quality respirators.

    __________
    :ms_arrow_right: CDC NOWCAST

    The newest CDC NOWCAST is out. Progress of current variants will continue according to their current trajectory, HV.1 taking more of the sequencing share, even ot the point of pushing EG.5 out.: ibb.co/cc8hykc

    JN.1 has not been prevalent enough to add in yet but I am certain once it reaches over 1% it's gonna be on there fast.

    __________
    :ms_arrow_right: Legislation

    10 Democratic Party Senators have helped the GOP approve a bill that would ban the enforcement of mask mandates on public transportation.

    med-mastodon.com/@luckytran/11

    Baldwin (D-WI) Bennet (D-CO Brown (D-OH) Kaine (D-VA) Kelly (D-AZ) Klobuchar (D-MN) Manchin (D-WV) Rosen (D-NV) Shaheen (D-NH) Tester (D-MT)

    Want to remind everyone that Tim Kaine (VA) has long COVID AND all these people that have voted for this measure in both parties have access to top-tier health care and retirement benefits. 🤦🤦🤦🤦🤦🤦🤦🤦

    __________

    This winter is gonna be one crazy Wild West. Wear a quality respirator, be aware of social contacts, and keep that air clean!!

    Currently, we are at the point where infectious disease is at the LOWEST poiint it's gonna be for the rest of year.

    Please be careful and we can keep life, learning, and financial loss to a minimum this winter! 🍁🍁🍁❄️

    #Covid #Covid19 #XBB #BA286 #JN1 #CovidIsNotOver #Democrats #Respirator #MasksWork #VaccinesSaveLives #SARS2PA #Pennsylvania #PA #CDC

  21. Good Morning SARS2PAians!🍁

    There's no new CDC stuff or wastewater today.

    :ms_arrow_right: Since I didn't update this Fediverse version (apologize...meatspace life got in the way) in a while, and things are quiet while watching BA.2.86*, I'll add revelant info from my previous Reddit posts.

    Pretty much only VOCs and specifically to keep track of BA.2.86.x.y.z currently going on.

    _____________________________________________________________________
    VOCs

    Nationally, HV.1 and FL.1.5.1 still making lots of gains even though they're pretty much the largest chuck of random sequencing.: ibb.co/v1GCnyH

    IN PA, the chart reflects naitonal levels but again, seeing JN.anything isn't good.: ibb.co/7Y4F3Lb

    In NY/NJ, chart shows reflection of national levels here, too.: ibb.co/CmYskD2

    _____________________________________________________________________
    Precautions

    Want to remind everyone that upcoming for winter, BA.2.86 and JN.1 (and their relatives!) have a bonkers estimated amount of both ACE2 binding AND also immune escape.👀: ibb.co/fGFG4PZ

    This means it can easily circumvent any current immunity AND potentially settle further down in the lungs, causing more short and long term damage.

    JN.1 is being loudly proclaimed an incoming great concern.: ibb.co/zGkwKyk

    ___________________________________________________________________

    Please get vaccinated with the XBB formula, and also a flu shot, wear a quiality respirator in crowds, keep the air clean and be aware of social contacts.We do not want to deal with XBB, flu, and BA.2.86 all at the same time. That would be bad times.

    Canade is having a horrible time with this fall. In British Columbia it's estimated that 1 in every 14 people are now infected. We don't want this here!: ibb.co/nRFnWx8

    ______________________________________________________________________
    Wastewater (from 10/20 update)

    Thankfully, we have some BioBot info that's bit more recent. (Phew.) Much more thorough and comprehensible than Google can do.

    (Did you know Biobot, first actual wastewater testing company, pioneered using wastewater as a valuable national health tool?): ibb.co/1znxkH8 (Content warning, language, he's REALLY mad here.)

    Nationally, levels going sharply down.: ibb.co/2dgk27W

    Regionally, all regions trending sharply down except the Midwest. (This jives with WastewaterSCAN that still has us at HIGH levels in the Northeast.): ibb.co/ZBrzB0D

    in PA, DauphinCo and ErieCo have not reported to Biobot in way too long. Dauphin reports to WWS though it seems. ibb.co/kXBYN4D

    With what's left, 8/9 sheds sharply decreasing except Westmoreland, which is now above national levels and generally rising...what's going on there?

    Gotta get a hold of that before cold weather hits, Pitt area!

    _________________________________________________________________________

    CDC (from 10/20)

    The New Hospital Admits graph has improved.: ibb.co/Xxb4N3k

    There are still a few counties at HIGH admits levels:

    Susquehanna

    Bradford

    Sullivan

    The old coal region (Schuylkill down to Cumberland and over to Snyder).

    Absolute number of new C19 beds have improved somwehat. Venango, Forest, Clarion cos. still showing HIGH levels.: ibb.co/Qpm9DW7

    Staffed ICU beds have increased along the Northern tier, in the central southern counties. (Somerset to Frankiln, up to Juniata, and over to Cambria.), and over by Easton (Pike down to Lehigh).: ibb.co/hWpypw6

    ___________________________________________________________________________

    Research (from 10/16 reddit post)

    A new COVID research preprint indicates that COVID and Dengue fever actually assist one another through cross-reactive antibodies WE MAKE in order to fight them.: ibb.co/TLMMfVz

    It also potentially induces cytokine storm which basically is the body's way of destroying itself in an attempt to destroy any pathogens in it.: ibb.co/wdmgNx1

    Great explainer Twitter thread: twitter.com/ejustin46/status/1

    As temeratures get warmer (like this summer) due to climate change and the tropical heat belt expands upward, mosquitoes carrying Dengue are going to be more and more of a problem to more areas. Dengue is already on the rise in many areas due to SARS2. Dengue is already spreading to Europe and Southern USA.

    See you on the next update and apoplogize again for shuffling around!

    #SARS2PA #Covid #CovidIsNotOver #vaccine #VaccinesSaveLives #XBB #BA286 #JN1 #Pennsylvania #PA #Pirola

  22. Ich kann doch hoffentlich davon ausgehen, dass bei einem jetzt vereinbarten #Booster-#Impftermin (heute ...) der aktuelle #Omi­cron #XBB.1.5 #Impfstoff gespritzt wird und nicht irgendwelche Restbestände der "alten" Impfstoffe? (Gibt's letztere überhaupt noch zu bestellen?)
    Oder muss/sollte man da fragen? (Käme vermutlich nicht so gut, und ich will den Hausarzt der Eltern nicht verärgern ...)

  23. ''6 Oct. '23 Highlights: * during surveillance week, the incidence of new detected cases of #COVID19 remained low and overall stable. * #Impact on #healthcare system, especially #ICUs was limited. * Predominance of #omicron #XBB lineages was confirmed, especially with #EG5 subvariant, similarly other European regions.'' #surveillance #italy #SARS_COV_2

  24. 4/🧵

    > = already here in the US

    w/484K:
    >EG.6.1.1 (Hyp)
    FL.30 (Hyp)

    No 486P
    >FW.1.1 (XBB.1.28)
    CK.1.1.1 (BA.5.2.24 extention)
    >JH* (BA.5.3.1 extention)

    #COVID #COVID19 #COVIDvariants #COVIDclans
    #Hyperion #Centaurus #EG516 #Kraken #XBB

  25. BA.2.86 fears fizzle as other variants drive up hospitalizations, deaths - Enlarge (credit: Getty | Justin Sullivan)

    Concern over the hig... - arstechnica.com/?p=1966041 #sars-cov-2 #subvariant #boosters #covid-19 #pandemic #vaccines #science #ba.2.86 #omicron #xbb.1.5 #health #eg.5 #who

  26. Fall COVID shots will boost protection against latest subvariants, Moderna says - Enlarge / A vial containing Moderna COVID-19 booster vaccine at a vacci... - arstechnica.com/?p=1961809 #subvariants #sars-cov-2 #covid-19 #fl.1.5.1 #science #booster #moderna #vaccine #xbb.1.5 #health #pfizer #eg.5 #cdc #fda #who

  27. "Look, the wave of this #COVID variant is already flattening in India!"
    **And you reply:**
    "Yes, as long as the kids stay on holiday. Then it will come back..."

    #Lockdown #XBB #Arcturus #MaskUp #CovidIsNotOver #TACT

    Source: tactnowinfo.substack.com/p/why?

  28. XBB.1.5: Still more questions than answers on risk of latest omicron subvariant - Enlarge / A CDC COVID-19 variant testing site inside Tom Bradley Intern... - arstechnica.com/?p=1909381 #infectiousdisease #publichealth #coronavirus #sars-cov-2 #subvariant #covid-19 #science #omicron #xbb.1.5 #ecdc #cdc #who

  29. The #Biden administration on Wednesday extended the #COVID-19 #publichealthemergency until April as “#Kraken#XBB.1.5, the most transmissible #Omicron variant seen yet, drives cases #upward.
    The public health emergency has been extended every 90 days since 2020.
    #ItIsNotOver #kraken #Omicron #PublicHealthProtection

    fortune.com/well/2023/01/11/bi

  30. Sieht so aus als wenn in China die #BA5-Abkömmlinge die Nase vorn hätten und nicht, wie anderswo berichtet, #XBB.
    Das würde bedeuten, dass der anderswo beobachtete Ausbreitungsvorteil der XBB-Linien auf Immunescape basiert und nicht auf intrinsisch besserer Ansteckung.
    Leider ist n bisschen unklar, wie belastbar/repräsentativ die Daten sind.
    mas.to/@kakape/109631413743430

  31. ''#BQ1 and #XBB are new #subvariants of #Omicron which have become the dominant strains in some overseas countries and regions for their increased #transmissibility and immune escape capacity. ''

  32. #China, #Shanghai has detected the #Omicron #subvariants #BQ1 and #XBB that have been prevailing in some overseas countries but experts said 2 strains were found in imported cases placed under closed-loop management which has not caused local #transmission, saying there is no need to hoard Montmorillonite {?} powder to relieve #diarrhea that can be caused by subvariant #XBB15. GT: globaltimes.cn/page/202301/128

  33. Ihr habt sicher die neuen Varianten #BQ.1 / #BQ.1.1 und #XBB / #XBB.1 auf dem Schirm. Der "#Höllenhund“ BQ.1.1 ist nicht nur hochgradig ansteckend und offenbar resistenter gegen eine Behandlung mit antiviralen Medikamenten, ... gelingt es auch verstärkt, sich dem Immunschutz durch eine Impfung oder eine überstandene #Covid19 -Erkrankung zu entziehen.

    Währenddessen titelt der Mannheimer Morgen zu den "schönsten Weihnachtsmärkten" um sich anzustecken und das Deutschlandfunk Magazin titelt "Ausgelassene Stimmung - Festivals mit Live-Publikum".

    Genau das Framing, dass wir für eine schöne Winterwelle brauchen.

    🤷

    www.mannheimer-morgen.de/metro…
  34. Ich bin schockiert wie aufwendig es diesmal ist, den BA.4/ BA.5 - Booster zu bekommen.

    In der Vergangenheit konnte ich mich nie beschweren, habe immer Glück gehabt und willige Ärzte oder Impfzentren gefunden. Derzeit ist es eine Farce. Termin habe ich jetzt endlich nach großen Bemühungen, mal sehen ob ich die Impfung bekomme ...

    #CovidIsNotOver #Booster #Bivalent #BA4 #BA5 #XBB #BQ11 #USW #Bremen #ImpfenSchuetzt #VaccinesPlus

  35. As I tweeted earlier, #22F (#XBB) is a #recombinant variant - the first officially elevated using the #Nextstrain clade designations. You can read more about what that means in my twitter thread below!

    twitter.com/firefoxx66/status/

    3/9