#kinetics — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #kinetics, aggregated by home.social.
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We pour hydrogels into the fuel. Polymers swell, arresting combustion. We share a nod—mycelium recognizing its network. 🍄⚙️ #Kinetics #Symbiosis
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Anthony Howe is a kinetic sculptor who creates wind-driven sculptures resembling pulsing, alien creatures and vortices.
Artist's website: https://www.howeart.net/about/
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Anthony Howe is a kinetic sculptor who creates wind-driven sculptures resembling pulsing, alien creatures and vortices.
Artist's website: https://www.howeart.net/about/
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Anthony Howe is a kinetic sculptor who creates wind-driven sculptures resembling pulsing, alien creatures and vortices.
Artist's website: https://www.howeart.net/about/
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Anthony Howe is a kinetic sculptor who creates wind-driven sculptures resembling pulsing, alien creatures and vortices.
Artist's website: https://www.howeart.net/about/
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The last couple of weeks, I was busy preparing for the #CCPEM Spring Symposium and then attending it and presenting at it. So I am only finding time now to share a new preprint that went online earlier this month: https://doi.org/10.64898/2026.04.02.716132
It is about the regulation of CsoSCA, the carbonic anhydrase (CA) found in alpha-carboxysomes. Through a combination of stopped-flow #kinetics, #bioinformatics and #cryoEM, we showed that this enzyme is sensitive to redox conditions. This likely keeps it inactive in the reducing cytosol, where CA activity would short-circuit the CO2 concentration mechanism by turning cytosolic bicarbonate into CO2, which can diffuse through membranes. This redox sensitivity also activates CsoSCA inside mature carboxysomes, because their interior becomes oxidizing as their shell excludes cytosolic reductants.
Overall, CsoSCA's redox sensitivity conditions its activation to its correct encapsulation in carboxysomes.Turns out visualizing a regulatory disulfide by #cryoEM is difficult! In this case, the strongest evidence for it comes from activity measurements and site-directed mutagenesis. But the structures revealed a conformational equilibrium that we would not have suspected, had we not attempted to solve structures of the enzyme in the active and inactive conditions.
This was excellent team work with first author Nikole and all others, with a real cross-talk between the biochemistry and structures!
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The last couple of weeks, I was busy preparing for the #CCPEM Spring Symposium and then attending it and presenting at it. So I am only finding time now to share a new preprint that went online earlier this month: https://doi.org/10.64898/2026.04.02.716132
It is about the regulation of CsoSCA, the carbonic anhydrase (CA) found in alpha-carboxysomes. Through a combination of stopped-flow #kinetics, #bioinformatics and #cryoEM, we showed that this enzyme is sensitive to redox conditions. This likely keeps it inactive in the reducing cytosol, where CA activity would short-circuit the CO2 concentration mechanism by turning cytosolic bicarbonate into CO2, which can diffuse through membranes. This redox sensitivity also activates CsoSCA inside mature carboxysomes, because their interior becomes oxidizing as their shell excludes cytosolic reductants.
Overall, CsoSCA's redox sensitivity conditions its activation to its correct encapsulation in carboxysomes.Turns out visualizing a regulatory disulfide by #cryoEM is difficult! In this case, the strongest evidence for it comes from activity measurements and site-directed mutagenesis. But the structures revealed a conformational equilibrium that we would not have suspected, had we not attempted to solve structures of the enzyme in the active and inactive conditions.
This was excellent team work with first author Nikole and all others, with a real cross-talk between the biochemistry and structures!
-
The last couple of weeks, I was busy preparing for the #CCPEM Spring Symposium and then attending it and presenting at it. So I am only finding time now to share a new preprint that went online earlier this month: https://doi.org/10.64898/2026.04.02.716132
It is about the regulation of CsoSCA, the carbonic anhydrase (CA) found in alpha-carboxysomes. Through a combination of stopped-flow #kinetics, #bioinformatics and #cryoEM, we showed that this enzyme is sensitive to redox conditions. This likely keeps it inactive in the reducing cytosol, where CA activity would short-circuit the CO2 concentration mechanism by turning cytosolic bicarbonate into CO2, which can diffuse through membranes. This redox sensitivity also activates CsoSCA inside mature carboxysomes, because their interior becomes oxidizing as their shell excludes cytosolic reductants.
Overall, CsoSCA's redox sensitivity conditions its activation to its correct encapsulation in carboxysomes.Turns out visualizing a regulatory disulfide by #cryoEM is difficult! In this case, the strongest evidence for it comes from activity measurements and site-directed mutagenesis. But the structures revealed a conformational equilibrium that we would not have suspected, had we not attempted to solve structures of the enzyme in the active and inactive conditions.
This was excellent team work with first author Nikole and all others, with a real cross-talk between the biochemistry and structures!
-
The last couple of weeks, I was busy preparing for the #CCPEM Spring Symposium and then attending it and presenting at it. So I am only finding time now to share a new preprint that went online earlier this month: https://doi.org/10.64898/2026.04.02.716132
It is about the regulation of CsoSCA, the carbonic anhydrase (CA) found in alpha-carboxysomes. Through a combination of stopped-flow #kinetics, #bioinformatics and #cryoEM, we showed that this enzyme is sensitive to redox conditions. This likely keeps it inactive in the reducing cytosol, where CA activity would short-circuit the CO2 concentration mechanism by turning cytosolic bicarbonate into CO2, which can diffuse through membranes. This redox sensitivity also activates CsoSCA inside mature carboxysomes, because their interior becomes oxidizing as their shell excludes cytosolic reductants.
Overall, CsoSCA's redox sensitivity conditions its activation to its correct encapsulation in carboxysomes.Turns out visualizing a regulatory disulfide by #cryoEM is difficult! In this case, the strongest evidence for it comes from activity measurements and site-directed mutagenesis. But the structures revealed a conformational equilibrium that we would not have suspected, had we not attempted to solve structures of the enzyme in the active and inactive conditions.
This was excellent team work with first author Nikole and all others, with a real cross-talk between the biochemistry and structures!
-
The last couple of weeks, I was busy preparing for the #CCPEM Spring Symposium and then attending it and presenting at it. So I am only finding time now to share a new preprint that went online earlier this month: https://doi.org/10.64898/2026.04.02.716132
It is about the regulation of CsoSCA, the carbonic anhydrase (CA) found in alpha-carboxysomes. Through a combination of stopped-flow #kinetics, #bioinformatics and #cryoEM, we showed that this enzyme is sensitive to redox conditions. This likely keeps it inactive in the reducing cytosol, where CA activity would short-circuit the CO2 concentration mechanism by turning cytosolic bicarbonate into CO2, which can diffuse through membranes. This redox sensitivity also activates CsoSCA inside mature carboxysomes, because their interior becomes oxidizing as their shell excludes cytosolic reductants.
Overall, CsoSCA's redox sensitivity conditions its activation to its correct encapsulation in carboxysomes.Turns out visualizing a regulatory disulfide by #cryoEM is difficult! In this case, the strongest evidence for it comes from activity measurements and site-directed mutagenesis. But the structures revealed a conformational equilibrium that we would not have suspected, had we not attempted to solve structures of the enzyme in the active and inactive conditions.
This was excellent team work with first author Nikole and all others, with a real cross-talk between the biochemistry and structures!
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Modeling of #H5N1 #influenza virus #kinetics during dairy #cattle #infection suggests the timing of infectiousness, https://etidiohnew.blogspot.com/2026/01/modeling-of-h5n1-influenza-virus.html
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Modeling of #H5N1 #influenza virus #kinetics during dairy #cattle #infection suggests the timing of infectiousness, https://etidiohnew.blogspot.com/2026/01/modeling-of-h5n1-influenza-virus.html
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Modeling of #H5N1 #influenza virus #kinetics during dairy #cattle #infection suggests the timing of infectiousness, https://etidiohnew.blogspot.com/2026/01/modeling-of-h5n1-influenza-virus.html
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Modeling of #H5N1 #influenza virus #kinetics during dairy #cattle #infection suggests the timing of infectiousness, https://etidiohnew.blogspot.com/2026/01/modeling-of-h5n1-influenza-virus.html
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Modeling of #H5N1 #influenza virus #kinetics during dairy #cattle #infection suggests the timing of infectiousness, https://etidiohnew.blogspot.com/2026/01/modeling-of-h5n1-influenza-virus.html
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@FotoVorschlag
'Im (Bastel) Keller ' #FotoVorschlagNicht mein Bastelkeller, sondern die Werkstatt eines fabelhaften, genialen #Brompton Künstlers, des wunderbaren #BenCooper von #Kinetics in #Glasgow
So sah es 2016 bei meinem Besuch aus. Inzwischen hat er die Werkstatt nebenan dazu bekommen und etwas mehr Platz.
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@FotoVorschlag
'Im (Bastel) Keller ' #FotoVorschlagNicht mein Bastelkeller, sondern die Werkstatt eines fabelhaften, genialen #Brompton Künstlers, des wunderbaren #BenCooper von #Kinetics in #Glasgow
So sah es 2016 bei meinem Besuch aus. Inzwischen hat er die Werkstatt nebenan dazu bekommen und etwas mehr Platz.
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@FotoVorschlag
'Im (Bastel) Keller ' #FotoVorschlagNicht mein Bastelkeller, sondern die Werkstatt eines fabelhaften, genialen #Brompton Künstlers, des wunderbaren #BenCooper von #Kinetics in #Glasgow
So sah es 2016 bei meinem Besuch aus. Inzwischen hat er die Werkstatt nebenan dazu bekommen und etwas mehr Platz.
-
@FotoVorschlag
'Im (Bastel) Keller ' #FotoVorschlagNicht mein Bastelkeller, sondern die Werkstatt eines fabelhaften, genialen #Brompton Künstlers, des wunderbaren #BenCooper von #Kinetics in #Glasgow
So sah es 2016 bei meinem Besuch aus. Inzwischen hat er die Werkstatt nebenan dazu bekommen und etwas mehr Platz.
-
@FotoVorschlag
'Im (Bastel) Keller ' #FotoVorschlagNicht mein Bastelkeller, sondern die Werkstatt eines fabelhaften, genialen #Brompton Künstlers, des wunderbaren #BenCooper von #Kinetics in #Glasgow
So sah es 2016 bei meinem Besuch aus. Inzwischen hat er die Werkstatt nebenan dazu bekommen und etwas mehr Platz.
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#LabPlot at the service of #researchers. :boost_love:
It's rewarding to us to know that #LabPlot was used for the #drug release #kinetics investigation in this recent study on niosomal co-delivery of #metformin and #telaglenastat.
➡️ https://www.sciencedirect.com/science/article/pii/S0753332225010376
#Research #Science #OpenSource #FreeSoftware #FOSS #KDE #FreeOriginProAlternative #BreastCancer #Cancer #Cytotoxicity
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#LabPlot at the service of #researchers. :boost_love:
It's rewarding to us to know that #LabPlot was used for the #drug release #kinetics investigation in this recent study on niosomal co-delivery of #metformin and #telaglenastat.
➡️ https://www.sciencedirect.com/science/article/pii/S0753332225010376
#Research #Science #OpenSource #FreeSoftware #FOSS #KDE #FreeOriginProAlternative #BreastCancer #Cancer #Cytotoxicity
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#LabPlot at the service of #researchers. :boost_love:
It's rewarding to us to know that #LabPlot was used for the #drug release #kinetics investigation in this recent study on niosomal co-delivery of #metformin and #telaglenastat.
➡️ https://www.sciencedirect.com/science/article/pii/S0753332225010376
#Research #Science #OpenSource #FreeSoftware #FOSS #KDE #FreeOriginProAlternative #BreastCancer #Cancer #Cytotoxicity
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#LabPlot at the service of #researchers. :boost_love:
It's rewarding to us to know that #LabPlot was used for the #drug release #kinetics investigation in this recent study on niosomal co-delivery of #metformin and #telaglenastat.
➡️ https://www.sciencedirect.com/science/article/pii/S0753332225010376
#Research #Science #OpenSource #FreeSoftware #FOSS #KDE #FreeOriginProAlternative #BreastCancer #Cancer #Cytotoxicity
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#LabPlot at the service of #researchers. :boost_love:
It's rewarding to us to know that #LabPlot was used for the #drug release #kinetics investigation in this recent study on niosomal co-delivery of #metformin and #telaglenastat.
➡️ https://www.sciencedirect.com/science/article/pii/S0753332225010376
#Research #Science #OpenSource #FreeSoftware #FOSS #KDE #FreeOriginProAlternative #BreastCancer #Cancer #Cytotoxicity
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@margraf
also #FediHire and #fedijobs and #Job and #Jobs
I would also recommend some hashtags related tobthe subject. #maschinelearning and #chemistry and #kinetics would be good subject appropiate ones. -
@margraf
also #FediHire and #fedijobs and #Job and #Jobs
I would also recommend some hashtags related tobthe subject. #maschinelearning and #chemistry and #kinetics would be good subject appropiate ones. -
@margraf
also #FediHire and #fedijobs and #Job and #Jobs
I would also recommend some hashtags related tobthe subject. #maschinelearning and #chemistry and #kinetics would be good subject appropiate ones. -
@margraf
also #FediHire and #fedijobs and #Job and #Jobs
I would also recommend some hashtags related tobthe subject. #maschinelearning and #chemistry and #kinetics would be good subject appropiate ones. -
@margraf
also #FediHire and #fedijobs and #Job and #Jobs
I would also recommend some hashtags related tobthe subject. #maschinelearning and #chemistry and #kinetics would be good subject appropiate ones. -
I replaced vector databases with Git for AI memory (PoC)
https://github.com/Growth-Kinetics/DiffMem
#HackerNews #AI #Memory #Git #Vector #Databases #PoC #Growth #Kinetics
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I replaced vector databases with Git for AI memory (PoC)
https://github.com/Growth-Kinetics/DiffMem
#HackerNews #AI #Memory #Git #Vector #Databases #PoC #Growth #Kinetics
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I replaced vector databases with Git for AI memory (PoC)
https://github.com/Growth-Kinetics/DiffMem
#HackerNews #AI #Memory #Git #Vector #Databases #PoC #Growth #Kinetics
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I replaced vector databases with Git for AI memory (PoC)
https://github.com/Growth-Kinetics/DiffMem
#HackerNews #AI #Memory #Git #Vector #Databases #PoC #Growth #Kinetics
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I replaced vector databases with Git for AI memory (PoC)
https://github.com/Growth-Kinetics/DiffMem
#HackerNews #AI #Memory #Git #Vector #Databases #PoC #Growth #Kinetics
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Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
@velospinner: They're are exaggerating claiming "We made". Actually the #MTBrompton is "Ben Cooper made", they just assembled the kit (but yeah, they mention it, but then again, they don't link to his site): https://www.kinetics-online.co.uk/folding-bikes/brompton/the-mtbrompton/
But yeah, that's a great and hilarious #GCN episode.
You might also enjoy this #BermPeak episode where Seth of Berm Peak takes a standard #Brompton C-Line to a #skatepark 🤪: https://www.youtube.com/watch?v=TLg0NNjDBMQ
Spoiler: It survives. 😉
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@velospinner: They're are exaggerating claiming "We made". Actually the #MTBrompton is "Ben Cooper made", they just assembled the kit (but yeah, they mention it, but then again, they don't link to his site): https://www.kinetics-online.co.uk/folding-bikes/brompton/the-mtbrompton/
But yeah, that's a great and hilarious #GCN episode.
You might also enjoy this #BermPeak episode where Seth of Berm Peak takes a standard #Brompton C-Line to a #skatepark 🤪: https://www.youtube.com/watch?v=TLg0NNjDBMQ
Spoiler: It survives. 😉
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@velospinner: They're are exaggerating claiming "We made". Actually the #MTBrompton is "Ben Cooper made", they just assembled the kit (but yeah, they mention it, but then again, they don't link to his site): https://www.kinetics-online.co.uk/folding-bikes/brompton/the-mtbrompton/
But yeah, that's a great and hilarious #GCN episode.
You might also enjoy this #BermPeak episode where Seth of Berm Peak takes a standard #Brompton C-Line to a #skatepark 🤪: https://www.youtube.com/watch?v=TLg0NNjDBMQ
Spoiler: It survives. 😉
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@velospinner: They're are exaggerating claiming "We made". Actually the #MTBrompton is "Ben Cooper made", they just assembled the kit (but yeah, they mention it, but then again, they don't link to his site): https://www.kinetics-online.co.uk/folding-bikes/brompton/the-mtbrompton/
But yeah, that's a great and hilarious #GCN episode.
You might also enjoy this #BermPeak episode where Seth of Berm Peak takes a standard #Brompton C-Line to a #skatepark 🤪: https://www.youtube.com/watch?v=TLg0NNjDBMQ
Spoiler: It survives. 😉
-
@velospinner: They're are exaggerating claiming "We made". Actually the #MTBrompton is "Ben Cooper made", they just assembled the kit (but yeah, they mention it, but then again, they don't link to his site): https://www.kinetics-online.co.uk/folding-bikes/brompton/the-mtbrompton/
But yeah, that's a great and hilarious #GCN episode.
You might also enjoy this #BermPeak episode where Seth of Berm Peak takes a standard #Brompton C-Line to a #skatepark 🤪: https://www.youtube.com/watch?v=TLg0NNjDBMQ
Spoiler: It survives. 😉